Artemisinin Powder CAS 63968-64-9

It has been found that the dosage of artemisinin and its derivatives can better inhibit T lymphocyte mitogen and induce the proliferation of spleen lymphocytes in mice without causing cytotoxicity. This finding has a good reference value for the treatment of autoimmune diseases mediated by T lymphocytes. Artemisia glass vinegar has the effect of enhancing non-specific immunity, and can improve the total complement activity of mouse serum.

Dihydroartemisinin can directly inhibit the proliferation of B lymphocytes, thus reducing the secretion of autoantibodies by B lymphocytes, reducing humoral immune response, having a certain inhibitory effect on humoral immunity and reducing the formation of immune complexes. It alleviates immune-mediated tissue injury and provides theoretical basis for treating autoimmune inflammatory disorders.

The antifungal effect of artemisinin also makes artemisinin show certain antibacterial activity. The research confirmed that the residue powder and water decoction of artemisinin have strong bacteriostatic effects on anthrax bacillus, Staphylococcus epidermidis, Catacoccus and Diphtheria Bacillus, and also have certain bacteriostatic effects on tuberculosis bacillus, Pseudomonas aeruginosa, Staphylococcus aureus and dysentery bacillus.

Pseudomonas aeruginosa, Staphylococcus aureus and dysentery bacillus. Its bacteriostatic mechanism is associated with interfering with bacterial membrane lipid homeostasis and blocking energy metabolism pathways, which differs from conventional quinolone antibiotics, offering potential for developing novel anti-infective agents against multidrug-resistant strains.Further exploration is required for its in vivo pharmacodynamic characteristics.

Malaria (commonly known as pendulum cold fever) is a vector borne infectious disease, which is caused by the bite of malaria parasites on the human body. After multiple episodes over a long period of time, it can lead to liver and spleen enlargement, accompanied by symptoms such as anemia. Malaria can be treated to a certain extent, and artemisinin plays an indispensable role. The peroxide bond in the structure of artemisinin is oxidative and is an essential functional group for antimalarial treatment.

The mechanism of action is that artemisinin produces free radicals in the body that bind to malaria parasite proteins, altering the cell membrane structure of the malaria parasite. After binding with malaria parasite protein, free radicals will cause the double layered membrane of mitochondria to swell and eventually detach, leading to the destruction of the cell structure and function of malaria parasites. At the same time, the chromatin in the nucleus will also be affected to some extent.

On the other hand, amino acids are the basic substances that make up proteins, and after the action of artemisinin. The absorption of isoleucine by malaria parasites is reduced, leading to obstruction of protein synthesis in the parasite. Artemisia annua not only kills pathogenic protozoa, but also has anti schistosomiasis, anti Toxoplasma infection, anti Pneumocystis carinii, and anti coccidiosis effects. Clinical trials have shown that artemisinin and its derivatives have not been found to have particularly significant side effects in the treatment of malaria.

Malignant tumors are the number one killer of human health, and if left untreated, they can endanger life safety. In vitro experiments showed that artemisinin at a certain dose could induce apoptosis of many cancer cells, such as liver cancer cells, breast cancer cells, cervical cancer cells, and significantly inhibit the growth of cancer cells. Research has found that artemisinin can regulate the expression of cyclins in tumor cells, enhance the action of CKIs, and lead to tumor cell cycle arrest.

Or it can lead to cell apoptosis, inhibit tumor angiogenesis, etc. to resist the occurrence and development of tumors. Artemisinin is used to treat leukemia by acting on the cell membrane of leukemia cells, increasing membrane permeability, altering osmotic pressure, and causing an increase in intracellular calcium ion concentration. This activates calpain, causing the cell membrane to swell and rupture, while accelerating the release of apoptotic substances and increasing the rate of cell apoptosis.

Pulmonary arterial hypertension (PAH) is a pathological and physiological state characterized by pulmonary artery remodeling and elevated pulmonary artery pressure to a certain threshold, which can be a complication or syndrome. Artemisinin is used to treat pulmonary arterial hypertension: by dilating blood vessels, it reduces pulmonary arterial pressure in PAH patients and improves symptoms. Zaiman et al. found that artemisinin has anti-inflammatory effects.

Artemisinin and its core substances have inhibitory effects on various inflammatory factors and can also inhibit the production of nitric oxide by inflammatory mediators; Artemisinin has immunomodulatory effects; Feng Yibai et al. found through experimental research that artemisinin can inhibit the proliferation of vascular endothelial cells and vascular smooth muscle cells, thereby playing an important role in the treatment of PAH.

Artemisinin powder can inhibit the activity of matrix metalloproteinases, thereby suppressing pulmonary vascular remodeling; Artemisinin can inhibit the expression of PAH related cytokines, further enhancing its anti vascular remodeling effect, ameliorating pulmonary microcirculation disorders and restraining abnormal proliferation of pulmonary artery smooth muscle cells in pathological conditions.