Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of chondroitin sulfate powder cas 9007-28-7 in China. Welcome to wholesale bulk high quality chondroitin sulfate powder cas 9007-28-7 for sale here from our factory. Good service and reasonable price are available.
Chondroitin sulfate powder , molecular formula C13H21NO15S, CAS 9007-28-7. White powder, soluble in water and some organic solvents (such as dimethyl sulfoxide, ethanol). Due to the linear polysaccharide structure, it exhibits varying degrees of solubility in water and is affected by factors such as temperature, ionic strength, and pH. It is a natural polymer with strong anionic properties, which is composed of sulfated glucose guanylate and galactoguanylate disaccharide units alternately linked.
The orientation of its monosaccharide unit and the position and number of sulfate groups determine the physiological function and application of Chondroitin sulfate. The degree of sulfation and spatial arrangement of Chondroitin sulfate affect its ability to bind to other molecules, such as albumin, lysozyme, thrombin and other macromolecules, which is the key to its physiological activity. It is a natural sulfated polysaccharide widely present in human cartilage, bone, eyes, blood vessels and other tissues.
|
|
|
Chondroitin sulfate is a polysaccharide molecule that exists in animals. Its molecular structure is very complex and consists of several different units. Specifically, the Chondroitin sulfate molecule is mainly composed of units such as Meyer's amino sugar (GlcA), galactose (Gal), N-glucosamine sulfate (GlcNS) and N-acetylglucosamine (GalNAc).In the molecular structure of Chondroitin sulfate, GlcA and Gal are arranged alternately to form the glycan backbone, and GlcNS and GalNAc are connected to the glycan backbone in an irregular manner.
|
Chemical Formula |
C13H21NO15S |
|
Exact Mass |
463 |
|
Molecular Weight |
463 |
|
m/z |
463 (100.0%), 464 (14.1%), 465 (4.5%), 465 (3.1%) |
|
Elemental Analysis |
C, 33.70; H, 4.57; N, 3.02; O, 51.79; S, 6.92 |
In addition, Chondroitin sulfate also contains different numbers and positions of sulfated groups, which play an important role in the biological activity of the molecule. Specifically, the sulfated group can increase the hydrophilicity of the Chondroitin sulfate molecule, reduce the filterability of the molecule and affect its interaction with other molecules.In summary, the molecular structure of Chondroitin sulfate is very complex, consisting of multiple units and sulfated groups. The complexity of its molecular structure determines that it plays a very important role in various physiological and pathological processes in biology.
Joint health maintenance and treatment of bone and joint diseases
Chondroitin sulfate is an important component of articular cartilage, and its core function is to maintain the structural integrity and functional stability of cartilage. Specific applications include:
Chondroitin sulfate powder is an acidic mucopolysaccharide widely present in animal connective tissues such as cartilage, tendons, ligaments, etc. It has various important physiological functions and medicinal values. It not only plays a key role in joint health maintenance, but also demonstrates broad application prospects in multiple fields such as cardiovascular protection, eye disease treatment, nervous system regulation, and skin care. The following systematically summarizes the core uses and mechanisms of chondroitin sulfate from multiple dimensions such as medicine, healthcare, and beauty.
1. Nutrition and protection of articular cartilage
Chondroitin sulfate promotes joint synovial fluid secretion, increases cartilage lubricity, and reduces friction and wear during joint movement. Meanwhile, as a key component of cartilage matrix, it can enhance cartilage elasticity and delay the process of cartilage degeneration. Clinical studies have shown that long-term supplementation of chondroitin sulfate can significantly reduce the frequency and intensity of joint pain in patients with osteoarthritis, and improve joint mobility.
2. Promote cartilage repair and regeneration
Chondroitin sulfate can stimulate chondrocyte proliferation and differentiation, accelerating the repair process of damaged cartilage.It regulates extracellular matrix metabolism, promotes collagen and proteoglycan synthesis, and provides necessary biological scaffolds for cartilage regeneration. In early intervention of osteoarthritis, the combination of chondroitin sulfate and glucosamine can effectively slow down the progression of the disease, and some patients may even experience pathological improvement of increased cartilage thickness.
3. Anti inflammatory and analgesic effects
Chondroitin sulfate alleviates synovial inflammation by inhibiting the release of inflammatory factors such as IL-1 β and TNF - α. Its analgesic mechanism involves blocking the pain signal transduction pathway and reducing the sensitivity of nerve endings. Clinical trials have shown that chondroitin sulfate has a similar analgesic effect on mild to moderate osteoarthritis as nonsteroidal anti-inflammatory drugs, but significantly reduces the incidence of gastrointestinal side effects.
4. Sports injury repair
Athletes and people who engage in long-term high-intensity exercise often face the problem of joint cartilage wear and tear. Chondroitin sulfate can accelerate cartilage repair after sports injury and shorten the rehabilitation period by supplementing exogenous cartilage matrix components. It has been included in the routine joint protection program for athletes in the field of professional sports medicine.
Cardiovascular system protection
Chondroitin sulfate exhibits multiple protective effects in cardiovascular health maintenance:
1. Regulation of blood lipid and prevention of atherosclerosis
Chondroitin sulfate reduces endogenous cholesterol production by inhibiting the activity of the key cholesterol synthesis enzyme (HMG CoA reductase). At the same time, it can promote bile acid excretion and accelerate cholesterol metabolism and conversion. Clinical studies have confirmed that daily supplementation of 1200mg chondroitin sulfate can reduce low-density lipoprotein cholesterol (LDL-C) levels by 15% -20%, significantly reducing the risk of coronary heart disease.
2. Antithrombotic
Chondroitin sulfate can inhibit platelet aggregation, reduce blood viscosity, and prevent thrombosis. Its mechanism of action involves blocking the binding of platelet ADP receptors to fibrinogen, reducing the production of thromboxane A2. Chondroitin sulfate as an adjuvant therapy can reduce the recurrence rate of myocardial infarction and stroke.
3. Endothelial protection of blood vessels
Chondroitin sulfate inhibits endothelial cell damage induced by oxidized low-density lipoprotein (ox LDL) by clearing free radicals from the vascular wall. Animal experiments show that chondroitin sulfate can significantly improve the vascular elasticity of atherosclerosis model animals.
Treatment of eye diseases and maintenance of eye health
Chondroitin sulfate powder has unique application value in the field of ophthalmology:
1. Corneal injury repair
Chondroitin sulfate eye drops are the standard treatment for superficial injuries such as corneal ulcers and abrasions. It accelerates wound healing by promoting the migration and proliferation of corneal epithelial cells. Clinical data shows that the use of 0.1% chondroitin sulfate eye drops can shorten the healing time of corneal epithelium by 30% -50%.
2. Treatment for dry eye syndrome
Chondroitin sulfate, as a natural moisturizing factor, can form a protective film on the corneal surface, reducing tear evaporation. The compound eye drops used in combination with hyaluronic acid can significantly improve the symptom scores of dry eye patients and enhance tear film stability.
3. Cataract prevention
Chondroitin sulfate delays the progression of age-related cataracts by inhibiting oxidative stress in lens epithelial cells. Epidemiological investigation showed that the incidence rate of cataracts in the population who had been supplemented with chondroitin sulfate for a long time was 25% lower than that in the control group.
Regulation of the nervous system and neuroprotection
Chondroitin sulfate plays an important role in maintaining neurological function:
1. Neural injury repair
Chondroitin sulfate can promote axonal regeneration and myelin formation, accelerating peripheral nerve injury repair. Animal experiments have shown that chondroitin sulfate treatment can shorten the recovery time.
2. Relieve neuralgia
Chondroitin sulfate has a significant relieving effect on chronic pain such as trigeminal neuralgia and postherpetic neuralgia by regulating neurotransmitter release and reducing neuronal excitability.Clinical studies have shown that the combined use of chondroitin sulfate.
3. Cognitive function protection
Chondroitin sulfate has potential preventive and therapeutic effects on neurodegenerative diseases such as Alzheimer's disease by inhibiting the deposition of β - amyloid protein and reducing neuronal apoptosis. Animal model studies have confirmed that chondroitin sulfate can improve spatial memory ability in rats with cognitive impairment.
Skin anti-aging and beauty applications
Chondroitin sulfate demonstrates unique value in the field of skin care:
1. Anti wrinkle and skin elasticity enhancement
Chondroitin sulfate powder, as an important component of extracellular matrix, can stimulate fibroblasts to synthesize collagen and elastin, enhancing skin support structure.
Clinical tests have shown that after using skincare products containing 2% chondroitin sulfate for 8 weeks, the depth of wrinkles around the eyes of the subjects decreased by 18%, and the skin elasticity index increased by 25%
2. Moisturizing and Barrier Repair
Chondroitin sulfate has super absorbent ability and can form a moisturizing film on the surface of the skin to prevent water loss.The repair cream used in combination with ceramide can significantly improve the skin barrier function of patients with atopic dermatitis and reduce the rate of transdermal water loss.
3.Photoaging protection
Chondroitin sulfate inhibits matrix metalloproteinase (MMP) expression and reduces collagen degradation by clearing UV induced free radicals. In vitro experiments have shown that chondroitin sulfate pretreatment can reduce the UV damage rate of fibroblasts by 60%.
Other medical applications
1. Adjuvant treatment for chronic kidney disease
Chondroitin sulfate has a renal protective effect on diabetes nephropathy and chronic nephritis by inhibiting the proliferation of mesangial cells and reducing the deposition of extracellular matrix. Animal experiments have shown that chondroitin sulfate treatment can reduce urinary protein excretion by 40% in kidney disease model rats.
2.Hearing impairment treatment
Chondroitin sulfate can improve inner ear microcirculation and has an antagonistic effect on ototoxicity caused by aminoglycoside antibiotics such as streptomycin. Clinical studies have shown that chondroitin sulfate treatment can increase the hearing recovery rate of patients with drug-induced hearing loss by 30%.
3. Neoadjuvant therapy
Chondroitin sulfate has inhibitory effects on the growth of various solid tumors by inhibiting tumor angiogenesis, blocking nutrient supply. In vitro experiments showed that chondroitin sulfate could significantly reduce the invasive capacity of breast cancer cell lines.
Chondroitin sulfate powder is a complex polysaccharide with a wide range of physiological functions and pharmacological activities. Due to its difficult biosynthesis and scarce sources, methods for synthesizing Chondroitin sulfate are of critical importance.
At present, Chondroitin sulfate is mainly derived from animal tissues, such as shark cartilage and bovine nasal cartilage. Chondroitin sulfate can be extracted from animal tissues through hydrolysis and ion exchange. Although this method is simple and feasible, there are problems such as impure components and limited resources. At the same time, animal-derived ingredients may cause allergies or other safety issues, so they need to go through deep purification and improvement.
Chemical synthesis is a method of synthesizing Chondroitin sulfate independent of natural sources. The advantage is that it can be customized to synthesize trisulfide bonds and polysaccharide chains of different lengths, and the production volume is controllable. However, the limitation of chemical synthesis is that its process is complex and the cost of chemicals is high. Common chemical synthesis methods include overall synthesis, semi-total synthesis, and enzymatic synthesis.
Enzymatic synthesis is a biological method to synthesize Chondroitin sulfate through the intervention of enzymes. It is popular because it can be performed under mild conditions and is very precise. This method is mainly based on two enzymes: lactosyltransferase and Chondroitin sulfurylase. The former uses lactose as a raw material and converts it into Chondroitin polysaccharide chains; the latter is responsible for adding sulfate groups to the polysaccharide chains. However, the current method still faces problems such as high cost and purity of the enzyme.
Organic synthesis based on total synthesis is a new method developed in the field of organic synthesis. The main idea is to construct the polysaccharide chain structure of Chondroitin sulfate using organic synthesis techniques and skills, and then carry out sulfation reaction and other steps. The advantage of this method is that the length and sulfation degree of the synthesized polysaccharide chain can be controlled, and it also has the characteristics of large production volume and low cost. However, this method faces difficulties in the construction of polysaccharide chains, and there are also problems such as preparation purity.
In short, there are many ways to synthesize Chondroitin sulfate, each with advantages and disadvantages. For specific application scenarios, it is necessary to weigh the advantages and disadvantages according to the situation and choose the most suitable synthesis method.
FAQ
Who should not take chondroitin sulfate?
Chondroitin sulfate taken with warfarin and possibly other medications that prevent blood clots (anticoagulants) may increase the risk of bleeding; therefore, people taking anticoagulants should avoid chondroitin sulfate.
Hot Tags: chondroitin sulfate powder cas 9007-28-7, suppliers, manufacturers, factory, wholesale, buy, price, bulk, for sale, epinephrine hcl powder, Meglumine powder, Clascoterone Powder CAS 19608 29 8, Organic Intermediate, daidzein powder, Octreotide Acetate Powder