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Citicoline sodium powder is a monosodium salt of choline cytidine diphosphate, with the chemical formula C14H25N4NaO11P2, CAS 33818-15-4, and a molecular weight of approximately 510.31. White crystalline or crystalline powder; Odorless. Easy to dissolve in water; Insoluble in ethanol and acetone. This product is a sodium salt, which increases its hygroscopicity and makes it easy to form different hydrates. Sodium phosphatidylcholine is a coenzyme nucleoside derivative, an intermediate for endogenous synthesis of phosphatidylcholine, and an important component for constructing biofilms. It is a brain metabolic activator that can enhance the function of the ascending reticular formation activation system, reduce cerebral vascular resistance, increase cerebral blood flow, improve cerebral blood circulation, promote brain substance metabolism, and restore function.
Additional information of chemical compound:
Our Product
Citicoline sodium +. COA
Product Overview
Citicoline Sodium Powder, also known as cytidine diphosphate sodium powder in Chinese, is an important biochemical raw material. Its chemical formula is C₁₄H₂₅N₄NaO₁₁P₂, with a molecular weight of approximately 510.31. It usually exists in the form of white crystals or crystalline powder, odorless, and soluble in water, but insoluble in organic solvents such as ethanol and acetone. Cytidine diphosphate sodium is a derivative of coenzyme nucleic acids, an intermediate in the endogenous synthesis of phosphatidylcholine, and an important component in the formation of biological membranes.
Manufacturing Method
The manufacturing methods of sodium choline phosphate can be generally classified into three approaches: organic chemical synthesis method, microbial fermentation method, and enzymatic synthesis method.
Organic chemical synthesis method:
Principle: Through a series of organic chemical reactions, the raw materials are converted into sodium citosine phosphate.
Problem: This method has issues such as difficulty in separating the product from the condensing agent, unsuitability for medicinal use, low reaction conversion rate, numerous by-products, high cost, and severe environmental pollution.
Microbial fermentation method:
Principle: Utilizing the metabolic activities of microorganisms, the substrate is converted into sodium citosine phosphate.
Problem: This method has issues such as low product concentration and unstable yield.
Enzyme synthesis method:
Principle: Utilizing the catalytic action of enzymes, the substrate is converted into sodium citosine phosphate. For example, biological synthesis can be carried out using microbial sources such as beer yeast sludge.
Advantages: Using free beer yeast sludge cell enzymes for synthesis, the process is simple, the conversion rate is high, and the cost is low.
Process flow:
Raw material preparation: Select appropriate substrates and enzyme sources (such as beer yeast sludge).
Enzyme reaction: Under suitable conditions (such as temperature, pH value, ionic strength, etc.), using the catalytic action of enzymes to convert the substrate into sodium citosine phosphate.
Product separation and purification: Through filtration, centrifugation, chromatography, etc., the sodium citosine phosphate is separated from the reaction mixture and purified.
Drying and packaging: The purified sodium citosine phosphate is dried and then packaged as the final product.
Quality control
In the manufacturing process of sodium citosine phosphate, quality control is of vital importance. This includes quality control of raw materials, quality control of the production process, and quality control of the final product.
Raw material quality control: Ensure that the raw materials used meet the quality standards, free of impurities and pollution.
Production process quality control: Strictly monitor key parameters during the production process (such as temperature, pH value, reaction time, etc.) to ensure the stability and controllability of the production process.
Finished product quality control: Conduct comprehensive quality tests on the finished products, including purity, content, moisture, heavy metals, microbial limits, etc., to ensure that the finished products meet the quality standards.
Application fields
Cytidine diphosphate choline sodium is an important biochemical raw material and is widely used in the fields of medicine, health supplements, and food additives.
Pharmaceutical field: Cytoceramide sodium is a brain metabolism activator that can enhance the function of the ascending reticular activating system, reduce cerebral vascular resistance, increase cerebral blood flow, improve cerebral circulation, promote brain substance metabolism and functional recovery. It is mainly used in clinical practice for the treatment of acute craniocerebral trauma and postoperative consciousness disorders after brain surgery, as well as for the treatment of Parkinson's syndrome, neurogenic deafness, ischemic cerebrovascular diseases and vascular dementia, etc.
Health supplement field: Cytoceramide sodium is believed to have health care functions such as improving memory and enhancing cognitive ability, and is therefore widely used in health supplements.
Food additive field: Cytoceramide sodium can be used as a food additive to improve the taste and nutritional value of food.
Citicoline Sodium Powder is an important neuroprotective agent and bioactive substance. It has shown extensive application prospects in both scientific research and industrial fields. Its unique chemical structure and pharmacological effects make it a research hotspot in multiple fields such as neurosciences, drug development, and health product manufacturing.
Research Applications
Neuroprotective Mechanism Research
Citicoline Sodium is a key intermediate in the endogenous synthesis of phosphatidylcholine, which can promote the synthesis and repair of phospholipids in the neural cell membrane, enhance the antioxidant capacity of neural cells, and thus exert neuroprotective effects. In models of neurological diseases such as acute cerebral ischemia and cerebral hemorrhage, Citicoline Sodium can significantly reduce neuronal damage and improve neurological function. Researchers explore its neuroprotective mechanism through animal experiments and cell culture techniques, providing theoretical basis for the development of new neuroprotective drugs.
Cognitive Function Improvement Research
Citicoline Sodium can promote the synthesis and release of neurotransmitters (such as acetylcholine, dopamine), improve neurotransmitter transmission, and thereby enhance cognitive ability. Clinical studies have shown that Citicoline Sodium has a significant improvement effect on diseases such as Alzheimer's disease and post-stroke cognitive dysfunction. Researchers conduct randomized controlled trials and long-term follow-up studies to evaluate its efficacy and safety, providing new options for the treatment of cognitive disorders.
Anti-inflammatory and Anti-apoptotic Effects Research
Citicoline Sodium has anti-inflammatory effects and can inhibit the production of inflammatory factors, reducing inflammatory responses. In neurological diseases, inflammatory responses often accompany neuronal damage, and the anti-inflammatory effect of Citicoline Sodium helps to alleviate neuronal damage. In addition, Citicoline Sodium can also inhibit cell apoptosis and protect neural cells from damage. Researchers study the molecular mechanisms of its anti-inflammatory and anti-apoptotic effects using molecular biology techniques, providing ideas for the development of new anti-inflammatory drugs.
Neural Regeneration Research
Citicoline Sodium powder can promote the expression of neurotrophic factors (NGF) and accelerate the neural regeneration process. In models of neural injury such as spinal cord injury and peripheral nerve disease, Citicoline Sodium can promote neural regeneration and restore the function of damaged nerves. Researchers study the mechanism of its promoting neural regeneration using tissue engineering technology and gene editing technology, providing new strategies for the treatment of neural injury diseases.
Industrial Applications
Drug Development and Production
Citicoline Sodium holds an important position in the field of drug development. As a neuroprotective agent, it is widely used in the treatment of neurological diseases such as stroke, brain trauma, and cognitive disorders. Pharmaceutical manufacturers optimize the synthesis process and quality control to produce high-purity Citicoline Sodium raw materials and preparations, meeting clinical needs. In addition, Citicoline Sodium is used in combination with other drugs to enhance efficacy and reduce side effects, providing new options for combined drug treatment.
Injection Form: High-purity pharmaceutical-grade Citicoline Sodium is used for clinical injection, featuring rapid onset and high bioavailability, suitable for the treatment of acute neurological diseases.
Oral Form: Citicoline Sodium oral preparations (such as capsules and tablets) are convenient for daily use and suitable for the long-term treatment of chronic neurological diseases and cognitive disorders.
Combined Formulations: Citicoline Sodium is combined with drugs such as mecobalamin and urokinase to form compound preparations, enhancing efficacy and expanding the treatment range.
Health Supplement Manufacturing
Citicoline Sodium, as a bioactive substance with neuroprotective effects, is widely used in health supplement manufacturing. Health supplement enterprises obtain highly active Citicoline Sodium components through extraction and purification technologies, and develop health supplements with functions such as improving memory, enhancing concentration, and delaying aging. These health supplements meet the market demand for brain health products by addressing the needs of different groups such as students, professionals, and the elderly.
Cognitive enhancement health supplements: Citicoline Sodium is the main component used to develop health supplements that enhance memory, attention, and executive functions, suitable for people who require high-intensity mental labor, such as students and professionals.
Anti-aging health supplements: Citicoline Sodium delays the aging process through antioxidant and anti-inflammatory effects, protecting nerve cells from damage, and is suitable for the elderly population.
Functional beverages: Citicoline Sodium is added to functional beverages to enhance their health value and meet consumers' demand for healthy drinks.
Analysis standards and research tools
Citicoline Sodium serves as an analysis standard in the research field and has significant applications. High-purity Citicoline Sodium standards are used for qualitative and quantitative research in liquid chromatography and gas chromatography instruments, providing reliable references for the exploration of the mechanisms of neurological diseases, angiogenesis, and improvement of brain metabolism. In addition, Citicoline Sodium is also used as a research tool for studying biological processes such as neurotransmitter synthesis and neural cell signal transduction.
FAQ
1. What is Cytidine Diphosphate Choline Sodium?
Citicoline Sodium is an endogenous compound naturally present in human cells. Its chemical name is Cytidine-5'-diphosphocholine Sodium. It is a phospholipid of the cell membrane and an important intermediate in the biosynthesis of phosphatidylcholine.
2. What potential benefits does it have for brain health?
Studies have shown that sodium choline phosphocholine possesses neuroprotective and neurorestorative properties. Its main functions include: supporting the repair and stabilization of the neural cell membrane, improving mitochondrial function, serving as the precursor of the neurotransmitter acetylcholine, and exerting anti-excitatory toxicity and antioxidant effects under ischemic conditions. Clinical studies suggest that it has positive effects in supporting memory function, attention, and overall cognitive ability.
3. How is its absorption and utilization situation?
Citicoline sodium is completely absorbed orally and has a high bioavailability. After oral administration, it is broken down into choline and cytidine, which can easily pass through the blood-brain barrier and enter the brain. Once in the brain, they recombine to form citicoline, which participates in crucial biochemical processes.
4. How should it be used in powder form?
Sodium choline citrate powder is usually used for scientific research or as a raw material for dietary supplements. In scientific research, it is necessary to follow the laboratory standard operating procedures. As a supplement, the recommended dosage range is typically between 250 milligrams and 1000 milligrams per day. The specific usage and dosage should be referred to the product instructions or consulted with professionals. It can be taken by mixing with water or juice and drinking.
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