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Deoxyuridine Powder (2 '- Deoxyuridine Powder) is a naturally occurring deoxynucleoside composed of uracil bases and 2-deoxy-D-ribose linked by β - N-glycosidic bonds. It belongs to the pyrimidine nucleoside class and appears as a white or off white crystalline powder at room temperature. It is easily soluble in water and methanol, with a water solubility of up to 300g/L at 20 ℃. It is recommended to store it at 0-6 ℃ to avoid decomposition or deterioration.
As an analog of thymidine deoxyribonucleoside (dT), Deoxyuridine can be misidentified by DNA polymerase and incorporated into DNA strands, leading to base mismatches and affecting the accuracy and stability of DNA replication. In cell biology research, Deoxyuridine (especially its brominated derivative BrdU, i.e. 5-bromodeoxyuridine) is often used as a marker for cell proliferation. BrdU can replace thymine to infiltrate into replicating DNA molecules during the S phase of DNA synthesis, and then stain with anti BrdU monoclonal antibodies to display proliferating cells. It can determine the proliferation status and rate of cells by detecting the incorporation of BrdU, which is of great significance for studying cell dynamics. Deoxyuridine and its derivatives also have potential applications in antiviral and anticancer research. For example, certain Deoxyuridine derivatives can inhibit the synthesis of viral DNA or interfere with the DNA replication process of tumor cells.
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Additional information of chemical compound:
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Product Name |
Deoxyuridine Powder |
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Product Type |
Powder |
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Product Purity |
100g/1kg/etc. |
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Product Form |
Organic synthesis |
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Deoxyuridine Powder
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Deoxyuridine Powder has multiple important applications in scientific research, particularly playing a crucial role in cell biology, molecular biology, pharmacology, and medical research. The following is a detailed explanation of its purpose:
Cell proliferation detection
Determine the type of proliferating cells: By combining with other cell markers for double staining, such as Ki-67, PCNA, etc., the type of proliferating cells can be determined. For example, in tumor research, different tumor cells may have different proliferation characteristics. By using double staining with BrdU and other markers, the proliferation of tumor cells and normal cells can be distinguished.
Analyzing proliferation rate: By detecting the incorporation of BrdU, the proliferation rate of cells can be analyzed.
In cell culture experiments, adding BrdU at different time points and then detecting the amount of BrdU incorporation in cells can draw a cell proliferation curve to understand the cell proliferation rate and cycle.
Assessing tumor cell proliferation ability: The proliferation ability of tumor cells is an important indicator for evaluating the malignancy and prognosis of tumors. By using BrdU detection method, the proliferation ability of tumor cells can be evaluated, providing a basis for the diagnosis and treatment of tumors. For example, in the research of breast cancer, lung cancer and other tumors, BrdU detection is often used to evaluate the proliferation activity of tumor cells.
By using BrdU detection method, the proliferation of tumor cells before and after drug treatment can be detected to evaluate the efficacy of drugs. For example, in the study of chemotherapy drugs, BrdU detection method can be used to detect the inhibitory effect of drugs on tumor cell proliferation.
Research on the proliferation and differentiation of neural stem cells: In neuroscience research, BrdU is often used to label the proliferation and differentiation of neural stem cells. By detecting the incorporation of BrdU, the proliferation dynamics, differentiation direction, and neural regeneration process of neural stem cells can be studied.
For example, in the study of nerve regeneration after brain injury, BrdU detection method can be used to detect the proliferation and differentiation of neural stem cells, providing new ideas for the treatment of nerve injury.Research on neurological diseases: Some neurological diseases, such as Alzheimer's disease, Parkinson's disease, etc., are related to abnormal proliferation and differentiation of nerve cells. By using BrdU detection method, the proliferation and differentiation of nerve cells in these diseases can be studied, providing a basis for the study of disease pathogenesis and treatment.
Efficient and fast: Compared with BrdU detection method, EdU detection method is faster, more sensitive, and more accurate. EdU is very similar to T, and EdU dye is only 1/500 of BrdU antibody, making it easy to diffuse within cells without DNA denaturation (acid hydrolysis, pyrolysis, enzymatic hydrolysis, etc.), effectively avoiding sample damage, and reflecting DNA replication activity more quickly and conveniently at the cellular and tissue levels. For example, in drug screening experiments, it is necessary to quickly detect the effect of drugs on cell proliferation, and the EdU detection method can meet this requirement.
Suitable for multiple cell types: suitable for in vivo injection in various animals, with good stability and no significant side effects on living organisms. The target tissue can be prepared as paraffin or frozen tissue slices for detection; It is also applicable for cell proliferation detection in vitro culture.
Drug screening: In the process of drug development, it is necessary to screen drugs that have inhibitory effects on cell proliferation. Through EdU detection method, the inhibitory effect of drugs on cell proliferation can be quickly detected, improving the efficiency of drug screening. For example, in the development of anti-tumor drugs, EdU detection method can be used to screen compounds with anti-tumor activity.
Evaluating the mechanism of drug action: By detecting the incorporation of EdU, we can understand the mechanism by which drugs affect cell proliferation. For example, certain drugs may inhibit cell proliferation by suppressing DNA synthesis, and the EdU detection method can observe a decrease in EdU incorporation in cells after drug treatment, thereby inferring the mechanism of action of the drug.
Studying cell proliferation during embryonic development: Cell proliferation is a crucial process during embryonic development. By using the EdU detection method, the cell proliferation of different tissues and organs during embryonic development can be studied, and the mechanism of embryonic development can be understood.
For example, in studying the development process of embryonic nervous system, EdU detection method can be used to detect the proliferation and differentiation of neural stem cells.
Research on cell proliferation during tissue regeneration: Cell proliferation is the foundation of tissue repair and regeneration during tissue regeneration. By using the EdU detection method, the dynamic changes in cell proliferation during tissue regeneration can be studied, providing a basis for tissue regeneration therapy. For example, during the repair process of skin injury, EdU detection method can be used to detect the proliferation of skin cells.
The purpose of other applications
Recent studies have shown that Deoxyuridine Powder is closely associated with neurological disorders. As a brain permeable pyrimidine nucleotide, it can cross the blood-brain barrier and enter brain tissue, affecting the metabolism and function of nerve cells. Research has found that 2-deoxyuridine can regulate glycolytic metabolism, reduce activation of microglia, and improve oxidative stress damage.
These characteristics demonstrate potential therapeutic value in the study of neurological diseases such as Alzheimer's disease (AD). In the study of Alzheimer's disease, 2-deoxyuridine has provided a new research direction for the treatment of the disease due to its ability to regulate glycolytic metabolism, reduce the activation of microglia in A β 25-35 brain injury, and improve oxidative stress damage. Through in-depth research on the mechanism of action of 2-deoxyuridine in the nervous system, it is expected to develop new therapeutic methods for neurological diseases.
Deoxyuridine is an important precursor for various antiviral and anti-tumor drugs, such as FUDR, IDUR, etc. Based on the structure and biological activity of 2-deoxyuridine, novel antiviral, anti-tumor, and neuroprotective drugs can be developed to meet clinical needs. Drug developers can use it as a basis for structural modification and optimization, developing drugs with stronger specificity and better efficacy. In the process of drug development, Deoxyuridine can be used to study the effects of drugs on processes such as cell proliferation, DNA synthesis, and repair, thereby revealing the mechanism of action of drugs. For example, by detecting the incorporation of Deoxyuridine, the inhibitory or promoting effects of the drug on cell proliferation can be understood, providing a basis for drug screening and efficacy evaluation.
biochemical research
Deoxyuridine Powder can be used as a raw material or inhibitor for DNA synthesis in biochemical research. By precisely controlling the incorporation of Deoxyuridine, specific modifications or synthesis of DNA sequences can be achieved. This is of great significance for gene function research, gene therapy, and the construction of synthetic biological systems. For example, in the study of DNA replication and repair mechanisms, Deoxyuridine serves as an important tool for tracking and analyzing newly synthesized DNA. Deoxyuridine can also be used to study the interactions between biomolecules, such as the interactions between DNA and proteins. By labeling Deoxyuridine onto specific biomolecules, its distribution within cells and binding with other molecules can be observed, thereby gaining a deeper understanding of the functions and regulatory mechanisms of biomolecules.
Frequently Asked Questions
What is deoxyuridine?
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Deoxyuridine - an overview | ScienceDirect Topics
In subject area: Pharmacology, Toxicology and Pharmaceutical Science. BrdU, or 5-bromo-2′-deoxyuridine, is a nucleoside analog used to detect and quantify newly synthesized DNA in proliferating cells, serving as an alternative to traditional methods like the EdU proliferation assay.
What is deoxycytidine used for?
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A nucleoside component of DNA composed of CYTOSINE and DEOXYRIBOSE. Dexelvucitabine has been used in trials studying the treatment of HIV Infections and Human Immunodeficiency Virus. A pyrimidine nucleoside used to treat thymidine kinase 2 deficiency.
Where is deoxyribose sugar found?
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Deoxyribose is a biologically important molecule of the DNA. The string of units present in DNA are called nucleotides, and they contain deoxyribose. Nucleotides contains a phosphate group and a nitrogenous base attached to a sugar.
What is deoxythymidine?
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Deoxythymidine is the DNA nucleoside T, which pairs with deoxyadenosine (A) in double-stranded DNA. In cell biology it is used to synchronize the cells in G1/early S phase. The prefix deoxy- is often left out since there are no precursors of thymine nucleotides involved in RNA synthesis.
Does deoxyribose sugar regrow hair?
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Findings from the study show that the deoxy ribose sugar is as effective at regrowing hair as Minoxidil - an existing drug used to treat hair loss.
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