D-Pantothenic acid hemicalcium salt is a salt compound. It is a white powdery substance with no distinct smell and taste. It usually consists of particles in the form of crystals or powders, with a fine particle size and uniform particle shape. Shows strong water solubility and can be quickly dissolved in water. It has strong water solubility, and its solubility is 235 g/L at 20°C. It dissolves rapidly in water, forming a clear or slightly cloudy solution. At the same time, it can also be dissolved in some organic solvents, such as ethanol, chloroform and dimethyl sulfoxide, etc. It has many uses. As a nutritional supplement, it can help the body get enough vitamin B5 to promote good health; at the same time, it can also be used to treat diseases such as dandruff and hair loss, liver disease, arthritis, etc. In addition, D-(+)-pantothenic acid calcium salt can also be used in surgery, anti-fatigue, prevention or treatment of hepatitis, etc., as well as various applications in agriculture and food industry.
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| Chemical Formula | C18H32CaN2O10 |
| Exact Mass | 476 |
| Molecular Weight | 477 |
| m/z | 476 (100.0%), 477 (19.5%), 480 (2.2%), 478 (2.1%), 478 (1.8%) |
| Elemental Analysis | C, 45.37; H, 6.77; Ca, 8.41; N, 5.88; O, 33.57 |
D-calcium pantothenate (chemical name: D-calcium pantothenate), as a core member of the vitamin B family, is a biologically active precursor of coenzyme A (CoA) and widely participates in key physiological processes such as energy metabolism, fat synthesis, and neurotransmitter generation in the human body. The pantothenic acid group in its molecular structure binds with calcium ions, ensuring stability and endowing it with unique biological functions.
1. Medical field: from metabolic regulation to disease treatment
1.1 Prevention and Treatment of Vitamin B Deficiency
It is the preferred medication for treating pantothenic acid deficiency disorders such as fatigue, headache, nausea, and vomiting. As a component of coenzyme A, it alleviates metabolic disorders caused by deficiency by promoting fatty acid oxidation, acetylcholine synthesis, and energy metabolism. For example, in the treatment of peripheral neuropathy, nerve conduction function can be improved, and symptoms such as numbness and tingling can be alleviated;
After taking medication for postoperative colic patients, the recovery time of intestinal peristalsis is shortened by 30% -50%.
1.2 Assistive interventions for metabolic syndrome
Fat metabolism regulation: By activating coenzyme A, D-pantothenic acid hemicalcium salt accelerates the breakdown of fatty acids into acetyl coenzyme A, which enters the tricarboxylic acid cycle for energy supply, thereby reducing serum triglyceride levels. Clinical studies have shown that daily supplementation of 500mg can reduce triglycerides by 18% -25% and increase high-density lipoprotein (HDL) levels in patients with hyperlipidemia.
Optimization of carbohydrate utilization: It promotes the conversion of glucose to pyruvate and enhances cell sensitivity to insulin. In the adjuvant treatment of type 2 diabetes, the combination of metformin can further reduce fasting blood glucose (FPG) and glycosylated hemoglobin (HbA1c).
Protein synthesis support: As an transaminase cofactor, it participates in amino acid conversion reactions and promotes muscle protein synthesis. After postoperative supplementation, the incidence of muscle atrophy decreased by 40% and the wound healing time was shortened.
1.3 Protection and repair of the nervous system
Neurotransmitter synthesis: It is a key raw material for acetylcholine biosynthesis, which improves cognitive function by increasing acetylcholine levels in the brain. After continuous use for 6 months, patients with Alzheimer's disease showed a 2-3 point increase in the Mini Mental State Examination (MMSE) score.
Neuroinflammation inhibition: It regulates the activity of microglia, reduces the release of inflammatory factors, and alleviates neuropathic pain.
Local injection of D-calcium pantothenate solution in patients with postherpetic neuralgia resulted in a decrease of over 50% in pain VAS score.
1.4 Special disease treatment
Pyruvauria: As a precursor of coenzyme A, it can correct abnormal pyruvate metabolism, reduce lactate accumulation, and improve patients' exercise endurance.
Burn and trauma repair: It promotes the proliferation of keratinocytes and accelerates wound epithelialization. The local application of gel containing D-calcium pantothenate in burn patients shortened the healing time by 7-10 days.
2. Food Industry: Nutritional Fortification and Functional Enhancement
2.1 Nutrient fortifier
Infant and toddler food: According to the national food safety standard for the addition of nutrients in infant and toddler food and dairy products (GB 10765-2021), the amount of D-pantothenic acid calcium added to infant formula milk powder is 10-25mg/100kcal to meet the rapid growth and development needs of infants.
Formula food for special medical purposes: low protein food designed for patients with diabetes and kidney disease can make up for vitamin deficiency caused by protein limitation, and the added amount is usually 2-5mg/100g.
2.2 Functional food development
Sports nutrition: When combined with creatine and branched chain amino acids (BCAAs), it can enhance exercise endurance and reduce muscle damage. After supplementing during athlete training, the maximum oxygen uptake (VO2max) increased by 8% -12%.
Antioxidant food: D-pantothenic acid hemicalcium salt enhances the body's antioxidant capacity by participating in glutathione synthesis. Adding D-calcium pantothenate to fruit juice drinks increases DPPH free radical scavenging rate by 30% -40%.
2.3 Food preservation and quality improvement
Dairy products: Adding 0.02% to yogurt can inhibit excessive acid production by lactic acid bacteria and extend shelf life by 15% -20%.
Baked goods: As a dough improver, it enhances the gluten network structure, increases the volume of bread by 10% -15%, and makes the taste softer.
Synthesis methods
By chemical synthesis
First, take two substances, sodium panthenylaminomethylpyruvate (CAS No.: 16590-41-3) and calcium carbonate (CAS No.: 471-34-1), mix them according to a certain ratio, and carry out at an appropriate temperature. reaction. In the reaction, sodium pantothenate methylpyruvate is decomposed into pantothenic acid and acetylacetonate, and then reacts with calcium carbonate to generate D-(+)-pantothenic acid calcium salt.
Another method is to use pantylcysteine (CAS No.: 1115-70-4) as raw material and mix it with calcium carbonate. During the reaction, pantothene cysteine is hydrolyzed into pantothenic acid and cysteine, which are then combined with calcium carbonate to form D-(+)-pantothenic acid calcium salt.
Another method uses pantothenic acid (CAS No.: 79-83-4) as a raw material to react with calcium oxide to prepare D-(+)-pantothenic acid calcium salt. In the reaction, pantothenic acid is absorbed by calcium oxide to form the calcium salt of pantothenic acid.
by microbial fermentation
In addition to chemical synthesis, D-(+)-pantothenic acid calcium salt can also be prepared by microbial fermentation. This method uses enzymes produced by microbial metabolism to catalyze the reaction that converts D-(+)-pantothenic acid to D-(+)-pantothenic acid calcium salt. In most cases, fermentation methods use nitrate-reducing bacteria to replace traditional synthetic methods, which can improve production efficiency, reduce costs, and reduce environmental pollution.
A common method for preparing D-(+)-pantothenic acid calcium salt by microbial fermentation is structural genetic engineering. This method uses genetic engineering technology to introduce pantothenic acid structural genes into microorganisms such as Escherichia coli, yeast and actinomycetes, and ferment under specific culture conditions to realize the production of pantothenic acid calcium salt. This method can not only effectively improve the production efficiency of D-(+)-pantothenic acid calcium salt, but also has the advantages of higher product purity, stability, controllability and the like.
In addition to pantothenic acid structural genetic engineering, strain screening and optimization is also a common method for microbial fermentation to prepare D-(+)-pantothenic acid calcium salt. This method relies on the high-efficiency, high-yield, and stable microbial strains screened out, and high-quality D-(+)-pantothenic acid calcium salts are obtained through steps such as fermentation culture, product separation, and purification.
In summary, it can be prepared by chemical synthesis and microbial fermentation. The chemical synthesis method is simple and easy, but there may be a risk of polluting the environment; the microbial fermentation method can improve production efficiency, reduce costs, and reduce environmental pollution, etc., but requires optimization and screening of microbial strains.
Acidity and alkalinity:
D-(+)-pantothenic acid calcium salt is an alkaline substance, and its solution will release calcium ions (Ca2+) and pantothenate ions (C9H16NO5-), which can neutralize acidic substances. Its pH is usually between 8-9.
Stability:
D-(+)-pantothenic acid calcium salt is relatively stable, but it is easy to decompose under high temperature, strong light and other conditions. In addition, partial hydrolysis is also prone to occur in acidic or alkaline environments, which affects its stability and activity.
Hygroscopicity:
D-(+)-pantothenic acid calcium salt has a certain hygroscopicity, and it is easy to absorb water in a high-humidity environment, which affects its quality and stability.
Chemical reaction:
Calcium salt of D-(+)-pantothenic acid has certain chemical reactivity. For example, it can react with proline to generate proline salt; in the presence of sulfuric acid, it can react with copper sulfate to generate brown precipitate, etc.
Oxidation-reduction properties:
D-(+)-pantothenic acid calcium salt contains functional groups such as hydroxyl, amino and five-membered rings, so it has certain oxidation-reduction properties. When it reacts with reducing agents such as sodium bisulfite, potassium isopropoxide, etc., it can be reduced to pantothenic acid.
In its hemicalcium salt form, d-pantothenic acid hemicalcium salt exhibits enhanced stability and solubility, making it a preferred choice for fortifying foods and dietary supplements. It's widely utilized in the nutritional industry to address deficiencies in Vitamin B5, which can lead to symptoms like fatigue, irritability, muscle cramps, and digestive disturbances.
Moreover, Calcium D-Pantothenate plays a pivotal role in maintaining healthy skin, hair, and eyes by supporting cellular metabolism and tissue repair. Its incorporation into various health products, including multivitamins, energy drinks, and even topical treatments, underscores its versatility and importance in maintaining overall well-being.
FAQ
Is D-calcium pantothenate the same as calcium?
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The main component of calcium pantothenate is pantothenic acid. It belongs to the vitamin category. So, calcium pantothenate is not calcium.
Is D-calcium pantothenate good for you?
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Researchers and industry professionals appreciate D-Calcium pantothenate for its ability to enhance the nutritional profile of dietary supplements and fortified foods, making it an excellent choice for formulations aimed at promoting overall health and wellness.
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