Pure NAC Powder CAS 616-91-1

NAC exerts lung protection by clearing free radicals and inhibiting the release of inflammatory factors: NAC directly neutralizes free radicals such as superoxide anions and hydrogen peroxide, reducing oxidative stress damage. NAC can downregulate the nuclear factor kappa B (NF - κ B) pathway and reduce the levels of pro-inflammatory factors such as tumor necrosis factor alpha (TNF - α) and interleukin-6 (IL-6). NAC inhibits elastase activity, reduces alveolar elastin damage, and delays the progression of emphysema. NAC can compensate for the depletion of GSH in ARDS patients and improve systemic oxidative damage. A study on 30 ARDS patients showed that intravenous injection of NAC (150 mg/kg/day) significantly increased plasma GSH levels and reduced the need for mechanical ventilation. NAC combined with pirfenidone (anti fibrotic drug) and nintedanib (tyrosine kinase inhibitor) can optimize efficacy and reduce drug dosage in the treatment of IPF. A phase III clinical trial showed that triple therapy can reduce the annual decline rate of lung function in patients and delay disease progression. In mechanically ventilated patients, NAC reduces alveolar epithelial cell damage by clearing free radicals generated by the high oxygen environment. Animal experiments have shown that NAC pretreatment can significantly reduce the wet/dry weight ratio and degree of pulmonary edema in rats exposed to high oxygen levels.

NAC improves psychiatric symptoms by regulating glutamate and dopamine levels. NAC can reduce rumination (uncontrollable negative self thoughts) and alleviate depressive symptoms. A randomized controlled trial involving 153 patients showed that after 12 weeks of treatment with NAC (2 g/day, oral), patients' depression scores were significantly lower than those in the placebo group. NAC reduces compulsive behavior by inhibiting excessive release of glutamate. Research on patients with gambling disorders has shown that NAC (1.2 g/day, oral) can reduce impulsivity scores and improve social functioning. NAC may protect dopamine neurons through antioxidant effects. A clinical trial involving 80 patients showed that the combination of NAC and antipsychotic drugs significantly improved negative symptoms such as emotional apathy and social withdrawal. NAC reduces neuronal damage by clearing free radicals induced by β - amyloid protein. Animal experiments have shown that NAC can improve cognitive function in Alzheimer's disease model mice and reduce levels of oxidative stress markers in the brain. NAC may protect dopaminergic neurons in the substantia nigra. A study on 40 patients with early Parkinson's disease showed that after 6 months of treatment with NAC (1.2 g/day, oral), the improvement rate of the Unified Parkinson's Disease Rating Scale (UPDRS) score in the patients was significantly higher than that in the control group.

Sports fatigue is the result of the combined effects of energy depletion, accumulation of metabolic products, and central nervous system inhibition. NAC intervenes in the fatigue process through multiple targets: Pure NAC Powder increases GSH levels, enhances mitochondrial respiratory chain complex activity, and promotes ATP synthesis. For example, in endurance athletes, NAC supplementation can delay muscle glycogen depletion and prolong exercise to exhaustion time. NAC promotes lactate dehydrogenase (LDH) activity, accelerates the conversion of lactate to pyruvate, reduces lactate accumulation in muscles, and alleviates soreness. NAC regulates glutamate GABA balance, inhibits exercise induced glutamate excitotoxicity, and improves cognitive function after exercise. For example, in triathletes, NAC supplementation can significantly reduce the incidence of brain fog. A randomized controlled trial (RCT) conducted on football players showed that participants who supplemented themselves with 600mg NAC before the competition increased their high-intensity running distance by 15%, and their post match attention test scores increased by 18% compared to the control group.

Explosive events such as sprinting and weightlifting rely on rapid neuromuscular activation and instantaneous release of energy. NAC enhances explosive performance through the following mechanism: NAC inhibits sarcoplasmic reticulum calcium leakage, enhances the sensitivity of troponin C to calcium ions, and improves muscle contraction efficiency. For example, among sprinters, NAC supplementation can shorten the starting reaction time. NAC increases GABA levels, suppresses pre exercise anxiety, and enhances exercise confidence. Endurance events such as marathons and triathlons rely on fat oxidation for energy supply and an increase in lactate threshold. NAC prolongs exercise time through the following pathways: NAC activates the AMPK signaling pathway, upregulates PPAR - α expression, enhances lipase activity, and improves free fatty acid (FFA) utilization. For example, among cyclists, NAC supplementation can reduce the proportion of carbohydrate oxidation during exercise and prolong muscle glycogen storage time. NAC enhances LDH activity, accelerates lactate clearance, and delays the onset of lactate threshold. For example, in long-distance runners, NAC supplementation can improve pace stability and reduce the phenomenon of "hitting walls".