Eriodictyol glycoside is a flavonoid isolated from the lemon. It is a flavone-7-O-glycoside between flavonoid ursodiol and disaccharide rutose. It is a powerful antioxidant. Light yellow powder, soluble in methanol, ethanol, DMSO, and other organic solvents, derived from lemon and citrus fruit trees. Eriocitrin inhibits the proliferation of hepatoma cells by upregulating p53, cyclin A, cyclin D3, and Cdk6. Eriocitrin triggers apoptosis by activating intrinsic signaling pathways involved in mitochondria. It is common in lemons. It is commonly known as lemon flavone or citrus flavone. It is one of the plant pigments that bring color to fruits and flowers. This antioxidant is also dominant in peppermint infusion (38% in one study). The compound has a lipid-lowering effect in hepatocytes. As a dietary supplement, it is usually used in combination with B, C vitamins, and other substances on the market, but there is no established medical use or FDA-approved application of the compound.
ERIOCITRIN Extracted chemicals Remark: Firstly, in China market, it haa not been widely used in China market, we are the largest manufacturer, and the general qty of per order is gram grade. We have two specifications on sale: (1)HPLC>95.0%, 100-120g in stock 100g, Unit price: $100/g, Total price: $10,000 1kg, if you confirm to purchase 1kg, we arrange our R&D Dept. calculate the cost for you. (2)HPLC>98.0%, as the standard substance for Analysis. 20mg/bottle, $82/bottle, EXW price above, if need to purchase, welcome send what qty you want, we calculate the shipping cost. HS Code: 2915709000 Dangerous goods: No general goods Valid period of quotation: 7 days.
|
C.F |
C27H32O15 |
|
E.M |
596 |
|
M.W |
597 |
|
m/z |
596 (100.0%), 597 (29.2%), 598 (3.1%), 598 (2.7%), 598 (1.4% |
|
E.A |
C, 54.36; H, 5.41; O, 40.23 |
|
|
|
Melting point 161-190 ° C , boiling point 956.9 ± 65.0 °C ( Predicted ) , Density 1.77 , Storage conditions Inert atmosphere, 2-8 ° C , Acidity coefficient ( pKa ) 7.15 ± 0.40 ( Predicted ) , shape neat , BRN 1304401 , Safety instructions 22-24 / 25 , WGK Germany 3 , F 10-21
Eriodictyol glycoside can inhibit oxidative stress injury induced by acute exercise in rat liver, and reduce blood lipid. The antioxidant capacity of saintoside is stronger than that of hesperidin and naringin. Saintoside can inhibit oxidative stress injury induced by acute exercise in rat liver and reduce blood lipid. Saintoside has a stronger antioxidant capacity than hesperidin and naringin. The preparation method of saintoside includes the following steps: demethylation reaction, preparation of crude products, and refinement. Hesperidin was obtained from hesperidin by demethylation. The preparation method of saint grass glycosides is a one-step reaction to prepare saint grass glycosides. Hesperidin is demethylated by demethylation reagent to obtain saint grass glycosides. The raw material of hesperidin is cheap, the demethylation reaction steps are less, the treatment is simple, and the yield and product quality are suitable for large-scale production.
Displaying significant antioxidant activity can help eliminate free radicals and alleviate the damage of oxidative stress to human cells. Eriocitrin is a compound formed by ester bonding between Eriodictyol and sugar molecules. As a plant secondary metabolite with rich medicinal value, Eriocitrin have wide applications in fields such as medicine, health products, and cosmetics.
1. Anti inflammatory activity:
Eriocitrin have good anti-inflammatory properties and can inhibit inflammatory reactions and the release of inflammatory mediators. This makes it an ideal ingredient for manufacturing anti-inflammatory drugs and skincare products.
2. Anti allergic activity:
Eriocitrin have anti allergic effects and can alleviate allergic reactions and symptoms. It is widely used in the manufacture of anti allergic drugs and allergen blockers.
Shengcao glycoside has strong pharmacological effects, mainly reflected in the following aspects:
Antioxidant effect
Shengcao glycoside is an effective antioxidant that can eliminate free radicals in the body and protect cells from oxidative damage. Its antioxidant capacity is stronger than other flavonoids such as hesperidin and naringin. Therefore, sage glycoside is widely used as an antioxidant in the food and beverage industry to extend the shelf life and stability of products..
Inhibit oxidative stress damage
Research has shown that Shengcao glycoside can inhibit oxidative stress damage induced by acute exercise in rat liver. Oxidative stress is a pathological state in which the body produces excessive amounts of highly active molecules such as reactive oxygen species and reactive nitrogen species when subjected to various harmful stimuli, leading to an imbalance between the oxidative and antioxidant systems and causing tissue damage. Shengcao glycoside can alleviate oxidative stress damage and protect the normal function of organs such as the liver through its antioxidant effect.
Hypolipidemic effect
Shengcao glycoside also has the effect of lowering blood lipids. Hyperlipidemia refers to the increase of plasma cholesterol or triglyceride levels, which is an important risk factor for cardiovascular diseases such as atherosclerosis and coronary heart disease. Shengcao glycoside can prevent the occurrence of cardiovascular disease by regulating lipid metabolism, reducing cholesterol and triglyceride levels in plasma.
Application Fields
Eriodictyol glycoside has a wide range of applications in multiple fields due to its unique pharmacological effects.
Food and beverage industry
Shengcao glycoside, as a natural antioxidant, is widely used in the food and beverage industry. It can be added to various foods, such as oils, meat products, dairy products, baked goods, etc., to extend the shelf life and stability of the product. At the same time, Shengcao glycoside can improve the color and taste of food, and enhance the quality of products. In the beverage industry, sage glycoside can be used as an additive in functional beverages, providing health benefits such as antioxidant and lipid-lowering effects.
Medical field
Shengcao glycoside also has potential application value in the field of medicine. Due to its antioxidant and lipid-lowering effects, Shengcao glycoside can be used to treat diseases related to oxidative stress and dyslipidemia. For example, it can be used as an auxiliary treatment drug for the prevention and treatment of cardiovascular diseases, diabetes, obesity and other diseases. In addition, Shengcao glycoside can also be used as a raw material for health products to develop health products with antioxidant and lipid-lowering functions.
Cosmetics industry
Shengcao glycoside also has a wide range of applications in the cosmetics industry. Because of its antioxidant effect, Shengcaoside can be added to various cosmetics, such as face cream, eye cream, lipstick, etc., to provide anti-aging, whitening and other effects. At the same time, Shengcao glycoside can enhance the stability and safety of cosmetics, and improve the quality of products.
In the field of agriculture
Shengcao glycoside also has potential application value in the agricultural field. Research has shown that Shengcao glycoside has a certain inhibitory effect on plant pathogens, and therefore can be used as a biological control agent for plant diseases. In addition, Shengcao glycoside can also serve as a plant growth regulator, promoting plant growth and development, and improving crop yield and quality.
Specific products and application examples
Functional beverages
Shengcao glycoside can be used as an additive in functional beverages, providing health benefits such as antioxidant and lipid-lowering effects. For example, some sports drinks and energy drinks contain sage glycosides to help athletes relieve exercise fatigue and improve athletic performance. At the same time, these beverages can also provide rich nutrients such as vitamins and minerals, meeting the energy needs of athletes during exercise.
Health products
Shengcao glycoside can be used as a raw material for health products, and is used to develop health products with antioxidant and lipid-lowering functions. For example, some anti-oxidation capsules, lipid lowering capsules and other products have added Shengcaoside to help people prevent cardiovascular diseases, diabetes and other chronic diseases. These health products usually have the advantages of being convenient to carry and easy to take, suitable for people of all ages.
Cosmetics
Shengcaoside can be added to various cosmetics, such as face cream, eye cream, lipstick, etc., to provide anti-aging, whitening and other effects. For example, some high-end face cream and eye creams have added secoside to help people improve skin relaxation, wrinkles and other problems, so that the skin is more compact and smooth. At the same time, these cosmetics can also provide moisturizing and nourishing effects, meeting people's needs for skin care.
Plant disease control agents
Shengcao glycoside can be used as a biological control agent for plant diseases, for the prevention and control of various plant diseases. For example, some fruit trees and vegetables use sage glycosides in disease prevention and control to inhibit the growth and reproduction of pathogens, reduce the occurrence and spread of diseases. This biological control agent has advantages such as environmental protection and safety, and is harmless to the environment and human health.
Research and development trends
With the continuous improvement of people's pursuit of health and quality of life, the application prospects of Shengcao glycoside, as a natural and healthy compound, are becoming increasingly broad. In the future, the research and development of Shengcao glycoside will present the following trends:
In depth study of its pharmacological mechanism of action
At present, the pharmacological mechanism of Shengcao Ci glycoside is not deep enough. In the future, it is necessary to further strengthen the research on its antioxidant and lipid-lowering effects, providing theoretical basis for the development of new drugs and health products.
Develop new application areas
In addition to the food and beverage industry, pharmaceutical industry, cosmetics industry, and agricultural industry, the future can also explore the application of Shengcao Ci glycoside in other fields such as feed industry and environmental protection to expand its application scope.
Improve extraction and purification techniques
At present, there are still some problems with the extraction and purification technology of Shengcao glycoside, such as low extraction efficiency and difficult purification. In the future, it is necessary to further improve extraction and purification technologies to increase the yield and purity of Shengcao glycoside and meet market demand.
Strengthen international cooperation and exchanges
As a compound with broad application prospects, the research and development of Shengcao glycoside require international cooperation and exchange. In the future, we can strengthen cooperation and exchanges with international peers to jointly promote the research and development of Shengcao glycoside.
We are the supplier of Eriodictyol Glycoside.
Using hesperidin (Eriodictyol) as a raw material, the steps of synthesizing the medicinal natural product eriocitrin (Euxanthone) through aluminum trichloride-pyridine demethylation reaction are as follows:
Hesperidin + 3AlCl3 + 3C5H5N → eriocitrin + 3HCl + 3C5H6N
Dissolve hesperidin in a dry organic solvent, such as dichloromethane or diethyl ether, to prepare a reaction substrate solution. Make sure that the hesperidin is fully dissolved in the solution.
Slowly add aluminum trichloride (AlCl3) dropwise to the hesperidin solution while keeping the temperature of the reaction system below 0°C. Aluminum trichloride is the catalyst for this reaction and can catalyze the demethylation reaction.
After the dropwise addition of aluminum trichloride, continue to slowly add pyridine dropwise into the reaction substrate solution. Pyridine is an alkaline reagent that neutralizes the HCl generated in the reaction and provides alkaline conditions.
Continue to stir the reaction mixture and keep the temperature below 0°C. The reaction usually needs to be carried out under low temperature conditions to control the side reactions of the reaction and improve the purity of the product.
After the reaction was completed, ice water was slowly added dropwise to the reaction mixture to hydrolyze unreacted aluminum chloride and methylated products. Continue to stir the reaction mixture to ensure complete hydrolysis.
The organic layer and the aqueous layer in the reaction mixture were separated by an extraction method. The organic layer contains the target product eriocitrin (Euxanthone), while the aqueous layer contains inorganic salts and other water-soluble impurities.
Transfer the organic layer to a rotary evaporator, remove the organic solvent and allow to dry. The obtained solid can be subjected to further purification steps such as column chromatography, crystallization, etc. to increase the purity and purity of the product.
Hot Tags: eriodictyol glycoside cas 13463-28-0, suppliers, manufacturers, factory, wholesale, buy, price, bulk, for sale, tetrahydrobiopterin synthesis, Tetracaine hydrochloride powder, Pure Tetracaine, Medetomidine HCl, Peptide, epinephrine hydrochloride powder