Eriodictyol powder, light yellow crystalline powder, easily soluble in methanol, slightly soluble in boiling water, hot ethanol, ether, and glacial acetic acid, and soluble in dilute alkali. Polyphenols and flavonoids are widely distributed in fruits and vegetables, mainly in lemon and peanuts. It has the functions of anti-oxidation, anti-inflammatory, analgesic, and improving diabetes and diabetes complications. It comes from the holy grass of the Tianma family. It has antioxidant, anti-inflammatory, and analgesic It can improve diabetes and complications of diabetes. Some studies have found that it can effectively protect keratinocytes from UV-induced death by inhibiting the cleavage of pro-caspase-3 or pro-caspase-9 and the release of cytochrome c. it can resist bacteria and inflammation and plays a crucial role in the pathogenesis of diabetes. It can inhibit type I allergic reaction induced by immunoglobulin E (Ig E) /antigen (Ag), At the same time, it has analgesic and warming effects.
|
|
|
|
Chemical Formula |
C15H12O6 |
|
Exact Mass |
288 |
|
Molecular Weight |
288 |
|
m/z |
288 (100.0%), 289 (16.2%), 290 (1.2%), 290 (1.2%) |
|
Elemental Analysis |
C, 62.50; H, 4.20; O, 33.30 |
Eriodictyol is a naturally occurring flavonoid, belonging to the flavone subclass of flavonoids, widely distributed in various plants, particularly in citrus fruits such as lemons, limes, and oranges. This compound is recognized for its potent antioxidant and anti-inflammatory properties, making it a subject of interest in the fields of nutrition, herbal medicine, and pharmaceutical research.
Structurally, eriodictyol features a backbone of two aromatic rings linked by a three-carbon bridge, with hydroxyl groups attached to several positions, conferring its hydrophilic nature and enhancing its ability to scavenge free radicals. These free radical-scavenging capabilities are crucial in mitigating oxidative stress, a precursor to numerous chronic diseases including cancer, cardiovascular ailments, and neurodegenerative conditions.
Beyond its antioxidant activities, eriodictyol has demonstrated promising effects in modulating immune responses and exhibiting antimicrobial properties, potentially useful in combating infections. Studies suggest it may also play a role in regulating blood sugar levels and improving insulin sensitivity, which is beneficial for diabetes management.
Moreover, eriodictyol's anti-inflammatory actions have been investigated for their potential to alleviate conditions like asthma, rheumatoid arthritis, and inflammatory bowel disease. Its ability to modulate signaling pathways involved in inflammation highlights its therapeutic potential.
In summary, eriodictyol, with its multifaceted biological activities, stands out as a valuable natural compound for promoting health and wellness. Ongoing research continues to unravel additional mechanisms through which this flavonoid exerts its beneficial effects, paving the way for potential applications in functional foods, dietary supplements, and pharmaceutical preparations.
in the cosmetics industry
It has received widespread attention due to its powerful antioxidant function. Free radicals are one of the main culprits of skin aging, which can damage skin cells and lead to aging phenomena such as sagging, increased wrinkles, and deepening pigmentation. As an antioxidant, it can effectively eliminate free radicals, protect skin cells from oxidative damage, and thus delay the process of skin aging. Adding it to cosmetics can help keep the skin youthful, reduce the appearance of fine lines and wrinkles, and also help fade pigmentation and brighten the complexion.
It also has antibacterial properties and can inhibit the growth of various bacteria and fungi. Adding it to cosmetics can help reduce the number of bacteria and fungi on the surface of the skin, preventing the occurrence of skin infections.
It also has significant anti-inflammatory effects. When the skin is exposed to external stimuli such as ultraviolet radiation, chemicals, pollutants, etc., an inflammatory response can occur, leading to discomfort symptoms such as redness, swelling, stinging, itching, etc. It can inhibit the release of inflammatory factors, reduce skin inflammation, and alleviate skin discomfort symptoms. Adding it to cosmetics can help sensitive and damaged skin quickly recover to a healthy state, reduce discomfort symptoms such as redness, swelling, and stinging, and also help improve skin tolerance.
It can also improve skin quality, making the skin more delicate, smooth, and elastic. It can promote the renewal and metabolism of skin cells, accelerate the shedding of aging cells, and also help promote the synthesis and secretion of collagen, making the skin firmer and more elastic.
Anti aging products
In anti-aging products, it is usually one of the main antioxidant ingredients. For example, some high-end brands have added anti wrinkle essence, face cream and other products. These products can penetrate deep into the skin, effectively eliminate free radicals, reduce the appearance of fine lines and wrinkles, and also help brighten skin tone and fade pigmentation.
Sensitive skin products
In products targeting sensitive skin, it is often used as the main soothing ingredient. For example, some face cream, lotion and other products specially designed for sensitive skin have added products. These products can alleviate skin inflammation, relieve discomfort symptoms such as redness, swelling, and stinging, while also helping to improve skin tolerance.
Antibacterial products
In antibacterial products, it is usually used together with other antibacterial ingredients to enhance the antibacterial effect of the product. For example, some cleansers, toners, and other products with antibacterial properties have added sage phenols. These products can reduce the number of bacteria and fungi on the surface of the skin, preventing the occurrence of skin infections.
Improve skin quality products
It is often used as the main active ingredient in products that improve skin quality. For example, some products with whitening, moisturizing, exfoliating and other effects have added products. These products can promote the renewal and metabolism of skin cells, accelerate the shedding of aging cells, and also help promote the synthesis and secretion of collagen, making the skin more delicate, smooth, and elastic.
Eriodictyol powder is an effective antioxidant that can eliminate free radicals, prevent oxidation reactions of lipids, proteins, carbohydrates, etc. in food, thereby extending the shelf life of food and maintaining its nutritional value. In the process of food production and processing, coumarin is often added to easily oxidizable foods such as oils, meats, dairy products, baked goods, etc. to slow down oxidation reactions and maintain the freshness and quality of food.
in the food industry
Oils and fats are important components in food, but they are prone to oxidation reactions, leading to a decrease in quality and loss of nutritional value. As an antioxidant, holy grass phenol can effectively inhibit the oxidation reaction of oil and prolong the shelf life of oil. For example, adding holy grass phenol to edible vegetable oil can slow down the oxidation and decomposition of the oil, prevent the production of bad flavors and harmful substances, and maintain the clarity and stability of the oil.
Meat products are easily affected by factors such as oxidation and microbial contamination during storage and processing, leading to a decrease in quality and a shortened shelf life. As an antioxidant and antibacterial agent, holy grass phenol can inhibit the oxidation reaction and microbial growth of meat, prolong the shelf life of meat, and maintain its freshness. For example, adding resveratrol to meat products can reduce fat oxidation and protein denaturation, prevent odor and discoloration, while inhibiting bacterial growth and extending the shelf life of meat products.
Dairy products such as milk, yogurt, cheese, etc. are rich in protein and lipids, which are prone to oxidation reactions, leading to a decrease in quality and nutritional value. Shengcao phenol, as an antioxidant, can be added to dairy products to inhibit the oxidation reactions of lipids and proteins, maintaining the freshness and nutritional value of dairy products. For example, adding resveratrol to milk can slow down fat oxidation and protein denaturation, prevent milk from producing odors and layering, while maintaining the milk's milky whiteness and taste.
Baked foods such as bread and cakes are rich in oil and sugar, which can easily undergo oxidation and browning reactions, leading to a decrease in quality and a deterioration in taste. Shengcao phenol, as an antioxidant, can be added to baked goods to inhibit oxidation and browning reactions, maintaining the freshness and taste of baked goods. For example, adding resveratrol to bread can slow down oil oxidation and sugar browning, prevent bread from producing odors and hardening, while maintaining the softness and aroma of the bread.
Adding Holy Grass Phenol to Edible Vegetable Oil
In the production process of edible vegetable oil, adding resveratrol as an antioxidant to the oil can significantly improve its stability and extend its shelf life. A certain edible oil production enterprise added a certain amount of holy grass phenol to soybean oil during production. After experimental comparison, it was found that the oxidation degree of soybean oil with added holy grass phenol was significantly reduced during storage, and the color and flavor remained good. The shelf life was extended to more than 18 months.
Adding Holy Grass Phenol to Meat Products
In the production process of meat products, adding resveratrol as an antioxidant and antibacterial agent can significantly improve the quality and shelf life of meat products. A certain meat product manufacturing enterprise added a certain amount of holy grass phenol to sausages during production. After experimental comparison, it was found that the addition of holy grass phenol significantly reduced the degree of fat oxidation during storage, maintained good color and taste, and inhibited bacterial growth, extending the shelf life of sausages to more than 3 months.
Adding Holy Grass Phenol to Dairy Products
In the production process of dairy products, adding resveratrol as an antioxidant can significantly improve the quality and nutritional value of dairy products. A certain dairy production enterprise added a certain amount of holy grass phenol to milk during milk production. After experimental comparison, it was found that the addition of holy grass phenol significantly reduced the degree of fat oxidation during storage, maintained good milk whiteness and taste, and maintained the stability of nutrients such as calcium and vitamin D in milk.
Adding phenol to baked goods
Adding resveratrol as an antioxidant to baked goods during the production process can significantly improve the quality and taste of baked goods. A certain baking food production enterprise added a certain amount of holy grass phenol to bread during production. After experimental comparison, it was found that the bread with added holy grass phenol had a significantly reduced degree of oil oxidation during storage, maintained good softness in taste, and maintained the aroma and color of the bread.
Adding Holy Grass Phenol to Beverages
Adding resveratrol as an antioxidant to beverages during the production process can significantly enhance their color and nutritional value. A certain beverage production enterprise added a certain amount of resveratrol to fruit juice during production. After experimental comparison, it was found that the degree of oxidation and decomposition of vitamin C in fruit juice with added resveratrol was significantly reduced during storage, and the color and flavor remained good, while maintaining the acidity, sourness, and taste of the juice.
Synthesis methods
Eriodictyol is a kind of flavonoid compound that can be isolated from herbal medicine, which has the functions of anti-oxidation, anti-inflammation, analgesia, and improvement of diabetes and diabetic complications. There are mainly two synthetic methods reported in the literature at present:
The first one uses luteolin as a raw material, methanol as a solvent, and uses gigantic carbon hydrogenation to reduce the double bond, and then needs to be purified by a silica gel column for post-treatment to obtain eriodictol. The reaction formula is as follows:
The second one uses hesperetin as a raw material, uses pine as a solvent, adds anhydrous aluminum chloride and heats at 70°C, and then treats with hydrochloric acid to obtain eriodictyol. The reaction formula is as follows:
Using hesperetin as a raw material, adding anhydrous aluminum chloride (AlCl3) to the vine solvent, heating to 70 degrees Celsius, and treating with hydrochloric acid to obtain eriodictyol. The following is a detailed step-by-step description:
Chemical formula:
C16H14O6 + 3 AlCl3 → intermediate product
Intermediate + HCl → C15H12O6 + AlCl3 + H2O
Reaction system preparation
Dissolve an appropriate amount of hesperetin in pyridine, ensuring full dissolution.
01
Add Anhydrous Aluminum Chloride
Slowly add anhydrous aluminum chloride (AlCl3) to the reaction system while mixing the reactants with magnetic stirring to ensure uniform mixing.
02
Heating the reaction
The reaction system was heated to 70 degrees Celsius, and reacted at this temperature for a certain period of time. The heating process can use heating plate or oil bath to control the temperature.
03
Hydrochloric acid treatment
After the reaction was completed, the reaction mixture was cooled to room temperature, and dilute hydrochloric acid (HCl) was slowly added dropwise while stirring to neutralize the inorganic salt product in the reaction system and precipitate it.
04
Isolation and Purification
The resulting precipitate is separated by centrifugation or filtration, and washed and purified with an appropriate solvent. The eriodictol product with higher purity can be obtained by column chromatography, crystallization and other methods.
05
Other properties
Eriodictyol powder is a naturally occurring flavonoid derived primarily from citrus fruits, such as lemons and limes, renowned for its myriad health benefits and diverse applications in the wellness industry. This fine, white to yellowish powder possesses potent antioxidant properties, making it a valuable addition to dietary supplements, cosmetics, and functional foods.
Its primary attribute lies in its ability to scavenge free radicals, thus protecting cells from oxidative stress and potential damage that may lead to chronic diseases. Eriodictyol has also been shown to exhibit anti-inflammatory and anti-cancer activities, supporting immune health and promoting overall well-being.
In skincare products, it serves as a natural brightening agent, helping to reduce hyperpigmentation and enhance skin radiance. Its gentle yet effective nature makes it suitable for various skin types, including sensitive ones.
Moreover, its incorporation into food and beverage formulations not only boosts their nutritional profile but also contributes to a fresh citrus aroma and flavor, enhancing the overall consumer experience.
Manufactured through advanced extraction techniques to ensure purity and potency, eriodictyol powder is a versatile and potent natural ingredient that continues to gain traction in the health and beauty markets due to its comprehensive health benefits and safety profile. As consumer awareness about natural and healthy living grows, which stands out as a key player in promoting a holistic lifestyle.
adverse reaction
Eriodictyol is a naturally occurring flavonoid compound widely found in citrus fruits (such as sweet oranges), peanuts, and certain medicinal plants (such as North American holy grass). Its chemical name is (2S) -2- (3,4-dihydroxyphenyl) -5,7-dihydroxy-2,3-dihydro-4H-1-benzopyran-4-one, with a molecular formula of C ₁₅ H ₁₂ O ₆ and a molecular weight of 288.25 g/mol. Eriodictyol has attracted research attention due to its antioxidant, anti-inflammatory, anti diabetes and other biological activities, and has been developed as a dietary supplement or functional food raw material.
Known pharmacological effects associated with potential risks
Antioxidant and anti-inflammatory effects
Eriodictyol exerts anti-inflammatory effects by clearing free radicals, inhibiting the release of oxidative stress-related enzymes (such as NADPH oxidase) and inflammatory mediators (such as TNF - α, IL-6). However, excessive suppression of inflammatory response may weaken the body's defense against pathogens, especially in immunocompromised populations, and long-term high-dose use may increase the risk of infection. In addition, antioxidants may interfere with the oxidative stress dependent anticancer mechanisms of certain chemotherapy drugs, and drug interactions should be monitored.
Anti diabetes effect
Eriodictyol reduces postprandial blood glucose levels by inhibiting alpha glucosidase activity, promoting glucose uptake, and improving insulin resistance. This mechanism of action is similar to commonly used alpha glucosidase inhibitors in clinical practice, such as acarbose. Potential risks include hypoglycemia (especially when combined with other hypoglycemic drugs) and gastrointestinal discomfort (such as bloating and diarrhea), which are associated with the inhibitory effect of the drug on carbohydrate digestion.
Liver metabolic dependence
Eriodictyol is mainly metabolized in the body through the liver cytochrome P450 (CYP) enzyme system (such as CYP3A4, CYP2C9). When used in combination with CYP enzyme inducers (such as rifampicin) or inhibitors (such as ketoconazole), it may significantly alter the blood drug concentration of Eriodictyol, leading to reduced efficacy or increased toxicity. In addition, long-term high-dose use may increase the metabolic burden on the liver, especially in patients with liver dysfunction, which requires caution.
Vasodilatory effect
Eriodictyol exerts vasodilatory effects by inhibiting calcium ion channels and promoting the release of nitric oxide (NO). Patients with hypotension or those currently using antihypertensive drugs may experience symptomatic hypotension (such as dizziness and fatigue) due to cumulative effects, and blood pressure changes need to be monitored.
Hot Tags: eriodictyol powder cas 552-58-9, suppliers, manufacturers, factory, wholesale, buy, price, bulk, for sale, 4 Methylpropiophenone, levamisole hydrochloride powder, Tetracaine hydrochloride powder, Xylazine hcl, Tetrahydrobiopterin BH4 Powder, pure aspirin powder