Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of mu-conotoxin in China. Welcome to wholesale bulk high quality mu-conotoxin for sale here from our factory. Good service and reasonable price are available.
Mu-conotoxin is a cosmetic-grade biomimetic peptide that targets voltage-gated sodium channels (Nav1.4) to relax facial expression muscles and reduce the appearance of dynamic wrinkles - including forehead lines, crow's feet, and nasolabial folds. As a professional peptide manufacturer, Bloomtechz provides high-purity Mu-conotoxin backed by complete quality reports, mature technical support for formulation development, and one-on-one dedicated sales service - from small-batch sampling to kilogram-scale supply.
Our Products Form
Mu-conotoxin COA
 |
||
| Certificate of Analysis | ||
| Compound name | Mu-conotoxin | |
| Grade | Pharmaceutical grade | |
| CAS No. | 936616-33-0 | |
| Quantity | 20g | |
| Packaging standard | PE bag+Al foil bag | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202601090059 | |
| MFG | Jan 9th 2026 | |
| EXP | Jan 8th 2029 | |
| Structure |
|
|
| Item | Enterprise standard | Analysis result |
| Appearance | White or almost white powder | Conformed |
| Water content | ≤5.0% | 0.39% |
| Loss on drying | ≤1.0% | 0.80% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | ≥99.0% | 99.5% |
| Single impurity | <0.8% | 0.73% |
| Total microbial count | ≤750cfu/g | 80 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 500ppm |
| Storage | Store in a sealed, dark, and dry place below -20°C | |
|
|
||
Mu-conotoxin is a class of active peptide ingredients that has garnered widespread attention in the cosmetic anti-aging sector in recent years. Its name derives from the natural μ-conotoxins found in the venom of marine cone snails - natural toxins that relax prey muscles by blocking voltage-gated sodium channels. The Mu-conotoxin used in cosmetics is not directly extracted from natural cone snails, but rather a biomimetic peptide developed through artificial synthesis technology that mimics the core structure and mechanism of natural μ-conotoxins.The product typically appears as a white or off-white powdery solid with no distinctive odor and hygroscopic properties.
As a highly folded peptide, Mu-conotoxin contains multiple disulfide bonds within its molecule. These bonds maintain the peptide chain's compact three-dimensional conformation, endowing it with good structural stability and targeted binding capacity.Before entering cosmetic formulation production, Mu-conotoxin raw material exists in the form of a refined lyophilized powder.This is the most common as-shipped state for peptide raw materials - through the freeze-drying process, water in the peptide solution is removed via sublimation under low-temperature vacuum conditions, yielding a loose, porous white powder.
The lyophilized powder form maximally preserves the peptide's biological activity, avoiding degradation, oxidation, and microbial contamination that may occur during liquid storage.In terms of physicochemical properties, Mu-conotoxin lyophilized powder exhibits the following characteristics: First, regarding solubility, this peptide is readily soluble in water and water-soluble polyols (such as glycerin, butylene glycol, and propylene glycol), and can dissolve quickly in the aqueous phase of a formulation without the need for special solubilizers.
Second, regarding pH stability, the peptide is relatively stable in neutral to weakly acidic environments (pH 5.0–7.0), while peptide bond hydrolysis or conformational changes may occur under strongly acidic or alkaline conditions.Therefore, attention must be paid to controlling the system pH during formulation. Third, regarding thermal stability, Mu-conotoxin is stable at room temperature for short periods, but long-term exposure to high-temperature environments may accelerate activity decay. Storage under refrigerated conditions at 2–8°C is recommended, and repeated freeze-thaw cycles should be avoided.
Fourth, regarding hygroscopicity, the lyophilized powder has certain moisture-absorbing properties. After opening, it should be used as soon as possible and kept sealed and dry to prevent caking and microbial contamination.
In actual production dosing, Mu-conotoxin lyophilized powder is typically pre-dissolved in a small amount of purified water or polyol to prepare a stock solution of a certain concentration, which is then added to the aqueous phase system at a low-temperature stage (usually below 40°C) and stirred evenly.
This pre-dissolution method helps avoid problems such as uneven dispersion and local caking that may occur when powder is directly dosed, ensuring the active ingredient is distributed in the product.In terms of mechanism of action, the core function of Mu-conotoxin lies in its targeted blockade of voltage-gated sodium channels, particularly the Nav1.4 subtype highly expressed in skeletal muscle. Facial expression wrinkles is closely related to the repeated contraction of facial expression muscles: nerve impulses are transmitted to muscles through neurotransmitters such as acetylcholine, triggering sodium ion influx and action potentials, ultimately leading to muscle contraction.
By occluding the sodium channel pore, Mu-conotoxin reduces sodium ion influx, thereby inhibiting excessive muscle contraction and achieving the effects of relaxing expression muscles and diminishing dynamic wrinkles. Unlike injectable botulinum toxin, Mu-conotoxin, as a topical cosmetic ingredient, acts on muscle ion channels in the superficial skin layers without entering deep nerve tissue, making its method of use gentler and more convenient.
As a company, Bloomtechz specializing in the R&D and production of peptide raw materials, Bloomtechz relies on mature solid-phase peptide synthesis processes and oxidative folding technology to provide high-purity cosmetic-grade Mu-conotoxin raw materials. The company has accumulated rich production experience in the synthesis and folding of disulfide-containing peptides, and can effectively control the correct pairing of disulfide bonds, ensuring stable product structure and batch-to-batch consistency to meet the quality requirements of cosmetic brand owners and formulation engineers.
The core application of Mu-conotoxin in cosmetics is anti-wrinkle, particularly targeting dynamic wrinkles formed by repeated contraction of facial expression muscles, such as forehead lines, glabellar lines, crow's feet, and nasolabial folds. By inhibiting excessive muscle contraction, Mu-conotoxin can keep expression muscles in relaxed state, thereby reducing lines caused by muscle pulling and making the skin appear smoother. Multiple in vitro and preclinical studies have shown that Mu-conotoxin can exert muscle-relaxing effects within a relatively short period, and some users report feeling a reduction in skin tightness and fading of lines within hours after application.
It should be noted that the transdermal absorption depth and action intensity of topical peptides are limited, and their effects differ fundamentally from injectable botulinum toxin; consumers should maintain reasonable expectations.
In actual formulations, Mu-conotoxin is often used in combination with other anti-wrinkle active peptides to achieve multi-target, full-chain anti-wrinkle effects. Common combination ingredients include Acetyl Hexapeptide-8 (a botox-like peptide), Syn-Ake (Dipeptide Diaminobutyroyl Benzylamide Diacetate), and Carnosine.
These ingredients act on different links in nerve signal transmission: Mu-conotoxin mainly blocks sodium channels, Acetyl Hexapeptide-8 inhibits neurotransmitter release, and Syn-Ake competitively binds to muscle acetylcholine receptors. Through scientific combination, muscle contraction can be synergistically inhibited from multiple nodes of signal conduction, thereby enhancing the overall anti-wrinkle effect. In addition, Mu-conotoxin can also be combined with signal peptides such as Palmitoyl Pentapeptide-4 and Palmitoyl Tripeptide-1 to promote collagen synthesis while relaxing muscles, addressing both dynamic and static wrinkles.
As a water-soluble peptide raw material, Mu-conotoxin can be widely applied in various cosmetic forms, including serums, eye creams, face creams, lotions, masks, and ampoules. In formulations, Mu-conotoxin is typically added during the aqueous phase or low-temperature stage to avoid peptide activity loss caused by high temperatures. The recommended addition amount varies depending on product positioning and formulation system, usually within the range of 0.01% to 0.5%.The specific amount should be determined based on the formulator's experimental verification and efficacy test results.
Since peptide raw materials are relatively sensitive to pH and temperature, attention should be paid to compatibility with other ingredients during formulation development, avoiding direct contact with strong acids, strong alkalis, or strong oxidizing ingredients, to ensure the activity stability of the product throughout its shelf life.Cosmetic-grade Mu-conotoxin is a low-activity peptide that has undergone artificial synthesis and structural modification, fundamentally distinct from highly toxic natural conotoxins.
Natural conotoxins possess strong neurotoxicity and cannot be used directly on the skin; cosmetic-grade synthetic peptides, however, have undergone molecular modification and safety assessment, and their safety within the recommended usage concentration range has been supported by multiple in vitro tests and human patch tests. Published test data show that at conventional usage concentrations, Mu-conotoxin does not exhibit significant cytotoxicity, skin irritation, or sensitization.A small number of people with weak skin barriers or sensitive skin may experience transient mild stinging, redness, or itching after using products containing Mu-conotoxin.
This may be related to the penetration irritation of peptide ingredients on the skin or the synergistic stimulation of other ingredients in the formulation (such as preservatives, fragrances, alcohol). It usually resolves spontaneously after discontinuation.Although Mu-conotoxin itself has low sensitization potential, individual differences may cause a very small number of users to develop allergic reactions to the peptide or other ingredients in the formulation, manifesting as erythema, swelling, papules, etc. A patch test behind the ear or on the inner wrist is recommended before first use, observing for 24–48 hours without abnormality before applying to the face.
In cases of high usage concentration or excessive application amount, some users may feel skin tightness or unnatural facial movement, such as a slightly stiff expression when smiling. This condition is usually temporary and can gradually recover as the product is metabolized and absorbed. It is recommended to use the product according to the recommended amount in the instructions and avoid excessive application.f the product accidentally enters the eye, it may cause eye stinging, tearing, and other irritation symptoms. Eye creams or serums containing Mu-conotoxin should be applied avoiding the conjunctiva; if accidental eye contact occurs, rinse immediately with plenty of water.
At the raw material supply level, Bloomtechz provides a complete quality report for each batch of Mu-conotoxin products, covering key indicators such as HPLC purity testing, mass spectrometry molecular weight verification, appearance and solubility inspection, and microbial limit testing, ensuring that every batch of raw materials received by customers has traceable quality data, providing solid raw material support for the compliance filing and efficacy claims of cosmetic products.
reference
1.Conus Venom Peptide Pharmacology
2.Structure and Function of μ-Conotoxins, Peptide-Based Sodium Channel Blockers with Analgesic Activity
3.µ-Conotoxins as Leads in the Development of New Analgesics
4.Neuropharmacology of Voltage-Gated Sodium Channel Inhibition by µ-Conotoxins
5.Sustainable Dynamic Wrinkle Efficacy: Non-Invasive Peptides as the Future of Botox Alternatives
FAQ
Q1: Is Mu-conotoxin safe in skincare?
Yes. Cosmetic-grade Mu-conotoxin is a synthetic, low-activity peptide that acts only on superficial skin muscle channels - unlike highly toxic natural conotoxins. At 0.01%–0.5%, tests show no significant irritation or sensitization. Bloomtechz provides COA and MSDS with every batch for compliance and inspection.
Q2: How well does it work vs. Botox?
It relaxes expression muscles via Nav1.4 channel blocking, reducing dynamic wrinkles like forehead lines and crow's feet. Some users notice lighter lines within hours. However, as a topical peptide its depth and intensity are limited - it cannot match injectable Botox. Best for gentle, non-invasive anti-wrinkle care. Bloomtechz supplies basic product technical data for reference.
Q3: Is it stable in storage and formulation?
Yes. Shipped as lyophilized powder; unopened shelf life is 24 months at 2–8°C, sealed and away from light. It dissolves easily in water/polyols; add below 40°C at pH 5.0–7.0, avoiding strong acids/alkalis. Bloomtechz includes storage instructions and MSDS with each shipment.
Hot Tags: mu-conotoxin, suppliers, manufacturers, factory, wholesale, buy, price, bulk, for sale, iptg powder, Primidone powder, Pyrantel Pamoate Powder CAS 22204 24 6, Scopolamine Butylbromide, tetracaine hcl powder, Zidovudine powder