Octreotide Acetate Powder is an artificially synthesized analogue of somatostatin. It is an octapeptide compound composed of amino acids connected by peptide bonds. Its molecular formula is C53H74N10O13S2 • C2H4O2, CAS 83150-76-9, with a relative molecular weight of 1129.38. Due to the presence of multiple peptide and thioether bonds in its structure, its chemical properties are relatively stable and it has a certain tolerance to light, heat, and acidity. It is a colorless or almost colorless clear liquid due to its high solubility in aqueous solutions and relatively stable solution. The solubility in water is relatively high, but it is also easily soluble in commonly used organic solvents such as ethanol and acetone. This excellent solubility allows Octreotide acetate to be easily mixed with other drugs or solvents. The chemical properties are relatively stable, but under extreme conditions such as high temperature, strong acid or strong base, decomposition or polymerization reactions may occur. The viscosity is affected by temperature and concentration. At low temperatures, its viscosity may increase; At high temperatures or concentrations, its viscosity may decrease.
|
Chemical Formula |
C51H70N10O2S2 |
|
Exact Mass |
1078 |
|
Molecular Weight |
1078 |
|
m/z |
1078 (100.0%), 1019 (53.0%), 1020 (13.8%), 1020 (9.0%), 1021 (4.8%), 1019 (3.7%), 1020 (2.1%), 1020 (2.0%), 1019 (1.6%), 1021 (1.5%), 1022 (1.2%), 1021 (1.1%) |
|
Elemental Analysis |
C, 57.74; H, 6.53; N, 13.74; O, 15.70; S, 6.29 |
|
|
|
Octreotide acetate powder is used to inhibit growth hormone, gastrointestinal and pancreatic peptide secretion. In view of the drug use of this product, it is necessary to conduct research in vivo.
The specific experiments are as follows:
Octreotide can significantly reduce the blood glucose level of obese rats in HFD group. Octreotide intervention significantly reduced serum insulin concentration; However, serum TG, TC, FFA, ALT and AST levels did not decrease significantly. Octreotide significantly inhibited HOMA index. Octreotide reduced ipgtt and ipitt AUC, but not significantly. Octreotide improved the fatty degeneration of HFD induced obese rats and the accumulation of lipid droplets in PA treated HepG2 cells. Octreotide can promote Akt and GSK3 in HFD induced obese rats β Phosphorylation and GSmRNA expression. Compared with the vehicle treatment group (control group), octreotide reduced body weight and wet kidney weight. PAS and octreotide/PAS treatment reduced the cAMP level of PCK rats, but octreotide alone did not reduce it. The number of PS6 positive cells in octreotide/PAS group was significantly less than that in PAS group alone, so it proved that the product had a certain inhibitory effect on gastrointestinal pancreatic secretion peptide.
Octreotide Acetate Powder is an artificially synthesized analogue of somatostatin.
1. Treatment of gastrointestinal and pancreatic endocrine tumors:
As a specific and high affinity ligand for somatostatin receptor (SSTR), it can bind to SSTR on the surface of tumor cells, inhibit the proliferation and secretion function of tumor cells, and thus play a role in the treatment of gastrointestinal and pancreatic endocrine tumors. Its efficacy has been confirmed by multiple clinical trials and can be used to treat various gastrointestinal and pancreatic endocrine tumors, such as gastrinoma, vasoactive intestinal peptidoma, etc.
2. Relieve symptoms:
It can inhibit the secretion function of gastrointestinal and pancreatic endocrine tumors, thereby alleviating symptoms caused by excessive hormone secretion by the tumor, such as diarrhea, abdominal pain, and intestinal ringing. Meanwhile, it can also alleviate symptoms such as diarrhea and abdominal pain caused by other reasons.
3. Auxiliary diagnosis:
It also has certain application value in diagnosing gastrointestinal and pancreatic endocrine tumors. For example, in somatostatin receptor imaging technology, it can serve as a tracer to help doctors detect the location and size of tumors, providing a basis for developing treatment plans. In addition, it can also be used to detect the expression level of somatostatin receptors in tumor cells, predict treatment response and prognosis.
4. Prevention of complications:
It can inhibit the secretion function of gastrointestinal and pancreatic endocrine tumors, thereby reducing the risk of complications caused by excessive hormone secretion by tumors, such as hypoglycemia, water electrolyte disorders, etc. For patients who have already developed complications, symptoms can also be alleviated and the condition improved.
5. Control hormone levels:
It can bind to multiple hormone receptors, thereby playing a role in regulating hormone levels. For example, it can inhibit the secretion of gastrin, glucagon and other hormones, which helps to control blood sugar levels and improve the symptoms of diabetes. In addition, it can also inhibit the secretion of thyroid stimulating hormone, which helps to treat thyroid diseases.
6. Treatment of portal hypertension in liver cirrhosis:
It can reduce the portal vein pressure of patients with portal hypertension in liver cirrhosis, and improve the symptoms and signs caused by portal hypertension. Its mechanism of action includes inhibiting the secretion of hormones such as glucagon and vasoactive intestinal peptide, as well as reducing the dilation of visceral blood vessels.
7. Treatment of non-small cell lung cancer:
Recent studies have shown that it can inhibit the proliferation and migration of non-small cell lung cancer cells, and induce their apoptosis. Its mechanism of action may be related to regulating signal transduction pathways and gene expression within tumor cells. Although further clinical trials are needed to verify the efficacy of octreotide acetate uses in the treatment of non-small cell lung cancer, this discovery provides new ideas and methods for the treatment of lung cancer.
We are the supplier of Octreotide Acetate Powder.
Remark: BLOOM TECH(Since 2008), ACHIEVE CHEM-TECH is the subsidiary of us.
Octreotide acetate, also known as octreotide acetate in Chinese, is an artificially synthesized analogue of somatostatin. The following is the laboratory synthesis method for its substance:
1. Raw materials and reagents:
Required reagents: L-threonine, L-valine, L-tyrosine, L-glycine, L-cysteine, L-phenylalanine, glycinamide, D-mannose, acetic anhydride, etc.
Required reagents: sodium hydroxide, hydrochloric acid, anhydrous ethanol, ether, etc.
2. Synthesis steps:
Step 1:
Synthesize precursors of somatostatin analogues. This step involves connecting various amino acids in a specific order to form the structure of an octapeptide. This step usually requires the use of protective groups to protect the active groups of certain amino acids, in order to avoid side reactions during the linking process.
Step 2:
Remove the protective group and undergo acetylation reaction. In this step, strong acid or base is used to remove the protective group, and the obtained octapeptide is acetylated with acetic anhydride or other acetylation reagents to obtain Octreotide acetate. The specific reaction conditions and operating steps may vary depending on the experimental conditions and equipment.
Step 3:
Purification and Crystallization: Purify the obtained Octreotide acetate through methods such as recrystallization and chromatography to improve its purity and crystallinity. The specific purification method depends on the properties of the target product and experimental conditions.
3. Structural characterization:
Use spectroscopic methods such as nuclear magnetic resonance hydrogen spectroscopy and mass spectrometry to characterize the obtained Octreotide acetate to confirm whether its structure matches expectations.
4. Quality testing:
Quality testing is carried out on the obtained Octreotide acetate through methods such as melting point measurement and elemental analysis to ensure that its quality and purity meet the requirements.
Chemical equation
Due to the multiple steps and specific experimental conditions involved in the synthesis of Octreotide acetate, it is difficult to describe the entire synthesis process using a single chemical equation. However, some chemical equations for key steps can be provided as references:
The chemical equation for connecting amino acids to form octapeptides: This step typically involves the formation of peptide bonds, which can be facilitated by the use of condensation agents such as DCC (N, N '- dicyclohexylcarbamide) and HOBt (hydroxybenzotriazole). The specific chemical equation is as follows:
X-Y+Z → X-Y-Z+H2O
Among them, X, Y, and Z represent different amino acid residues, and "-" represents the formation of peptide bonds.
The chemical equation for removing protective groups and acetylation: This step typically involves the use of strong acids or bases to remove protective groups, followed by acetylation reaction with acetic anhydride or other acetylation reagents. The specific chemical equation is as follows:
X-Y-Z+CH3COOH → X-Y-Z-CH3COOH+H2O
Among them, X-Y-Z represents the octapeptide without removing the protective group, and "- CH3CO -" represents the acetyl group.
Hot Tags: octreotide acetate powder cas 83150-76-9, suppliers, manufacturers, factory, wholesale, buy, price, bulk, for sale, Articaine Hcl powder, raloxifene powder, larocaine hydrochloride, Tetrahydrobiopterin BH4 Powder, tetravisc, epinephrine powder