Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of pure aspirin powder cas 50-78-2 in China. Welcome to wholesale bulk high quality pure aspirin powder cas 50-78-2 for sale here from our factory. Good service and reasonable price are available.
Pure Aspirin Powder, also known as Acetylsalicylic acid, Molecular formula C9H8O4, CAS 50-78-2. Aspirin is usually in the form of white crystals or crystalline powder. Aspirin crystals with high purity are in the form of beads, sometimes forming flakes or tablets. It is a commonly used Over-the-counter drug. Because of its special molecular structure, aspirin is not easy to volatilize at room temperature. Has a certain degree of solubility. It can dissolve in water, but its solubility is relatively low, with only 1 to 2 grams of aspirin dissolved per 100 milliliters of water. However, aspirin has a higher solubility in organic solvents such as ethanol, chloroform, and acetone. It is a weak acid. In aqueous solutions, it may slightly acidify and lower the pH value. Its structure is composed of benzene ring, ester group, and carboxyl group. Aspirin crystal structure belongs to Orthorhombic crystal system, with specific cell parameters and Lattice constant. It has anti-inflammatory, analgesic, and antipyretic effects.
The chemical name is 2-(ACETYLOXY)-BENZOIC ACID. Basic acetylsalicylic acid is easy to hydrolyze, but the carboxyl acid is not strong enough ( ester hydrolysis under strong acidic conditions ). Its solution can be slowly hydrolyzed, and it is generally prepared into salt to prevent hydrolysis. Also known as aspirin ( ASA ), is a kind of salicylic acid drugs, usually used as analgesics, antipyretics and anti-inflammatory drugs, can also be used to treat certain inflammatory diseases.
 |
 |
|
Chemical Formula |
C9H8O4 |
|
Exact Mass |
180.04 |
|
Molecular Weight |
180.16 |
|
m/z |
180.04 (100.0%), 181.05 (9.7%) |
|
Elemental Analysis |
C, 60.00; H, 4.48; O, 35.52 |
|
Melting Point |
134-136 ° C (lit.) |
|
Boiling Point |
272.96 ° C (rough estimate) |
|
Density |
1.35 |
|
Refractive Index |
1.4500 (estimated) |
|
Flash Point |
250 ° C |
| Storage Conditions | 2-8°C |
| Solubility | Solubility in water 10 mg/mL at 37 °C |
| Acidity Coefficient (pKa) | 3.5(at 25℃) |
| Water Solubility | 3.3 g/L (20 ºC) |
Acetylation reaction method
C7H6O3+(CH3CO) 2O → C9H8O4+CH3COOH
Weigh approximately 10 grams of salicylic acid into a clean reaction vessel.
Add an appropriate amount of glacial acetic acid to dissolve salicylic acid. It can be carried out under stirring to accelerate the dissolution rate.
Add a few drops of phosphoric acid as a catalyst. Phosphoric acid helps to promote the reaction.
Measure an appropriate amount of anhydrous acetic acid and glacial acetic acid separately, and mix them into another clean glass container. This is the reactant of the acetylation reaction.
Slowly drop the reactants of acetylation reaction into the reaction container containing salicylic acid. Simultaneously use a stirring bar or magnetic stirrer to stir and mix, allowing the reactants to come into full contact.
The mixture usually needs to be kept at a low temperature. The reaction vessel can be placed in an ice bath or cold water bath to control the temperature.
Continue stirring and mixing under cooling conditions to complete the reaction. It usually takes about 30 minutes.
After the reaction is completed, separate the generated aspirin solid from the mixture. Extraction can be carried out through filtering equipment such as cloth filters or funnels.
Wash the separated aspirin solid with an appropriate amount of water to remove impurities. Finally, extract with distilled water to further purify aspirin.
Analgesic and Antipyretic (Pain Reliever and Fever Reducer)
- Mechanism: Aspirin inhibits the synthesis of prostaglandins (PGs), which are involved in pain perception and fever regulation.
- Applications: It is used to alleviate mild to moderate pain, including headaches, muscle aches, toothaches, menstrual cramps, and joint pains. It also effectively reduces fever in patients with colds, flu, or other infections.
Anti-inflammatory and Anti-rheumatic
- Mechanism: By inhibiting PG synthesis, aspirin reduces inflammation and swelling.
- Applications: It is a first-line treatment for inflammatory conditions such as rheumatoid arthritis and acute rheumatic fever. It rapidly improves clinical symptoms in these patients, including joint pain, swelling, and stiffness.
Antiplatelet and Antithrombotic
- Mechanism: Aspirin irreversibly inhibits cyclooxygenase-1 (COX-1), reducing the production of thromboxane A2 (TXA2), a potent platelet aggregator.
- Applications: Small doses of aspirin are used to prevent cardiovascular events such as myocardial infarction (heart attack), stroke, and transient ischemic attacks (TIAs). It is also effective in preventing thrombosis (blood clot formation) in patients with coronary artery disease, atrial fibrillation, and after surgical procedures like coronary artery bypass grafting.
Cancer Prevention
- Research Findings: Studies suggest that aspirin may have chemopreventive effects against certain cancers, particularly colorectal cancer.
- Mechanism: The exact mechanism is not fully understood, but it is believed to involve inhibition of COX-2, which is overexpressed in many tumor cells.
Other Applications
- Ocular Diseases: Aspirin has been shown to reduce the risk of certain ocular diseases, such as age-related macular degeneration and cataracts.
- Neurological Diseases: Some research indicates that aspirin may have neuroprotective effects and may reduce the risk of Alzheimer's disease and dementia.
- Diabetes Complications: Aspirin may help prevent cardiovascular complications in patients with diabetes.
As early as 1853 in Charles, Frederick Gerhardt synthesized Pure Aspirin Powder (acetylated salicylic acid) from salicylic acid and acetic anhydride, but it failed to attract people's attention.
In 1897, the German chemist Felix Hoffman synthesized it again and treated his father with rheumatoid arthritis, with excellent effect.
In 1897, Bayer, Germany, synthesized the main substance of aspirin for the first time.
Aspirin was put on the market in 1898, and it was found that it also had the effect of anti platelet aggregation, so it aroused great interest again. Aspirin and other salicylic acid derivatives are melt esterified with hydroxyl containing polymers such as polyvinyl alcohol and cellulose acetate to make them high molecular. The anti-inflammatory and antipyretic analgesic properties of the products obtained are more long-lasting than those of free aspirin.
By 1899, Bayer sold the drug to the world under the trademark Pure Aspirin Powder.
By 2015, aspirin has been used for 100 years and has become one of the three classic drugs in the history of medicine. So far, it is still the most widely used antipyretic, analgesic and anti-inflammatory drug in the world. It is also a standard preparation for comparing and evaluating other drugs. It has an antithrombotic effect in vivo. It can inhibit the release reaction of platelets and inhibit the aggregation of platelets, which is related to the reduction of TXA2 production. It is clinically used to prevent the onset of cardiovascular and cerebrovascular diseases.
Antithrombotic Applications
Prevention of cerebrovascular disease:
Aspirin can be used to prevent transient ischemic attacks (TIA), or transient ischemic attacks, which are transient neurological deficits caused by localized cerebral or retinal ischemia. By inhibiting platelet aggregation, aspirin reduces the risk of cerebral infarction or recurrence of transient ischemia in patients with TIA.
Prevention of myocardial infarction:
Myocardial infarction is myocardial necrosis caused by acute and persistent ischemia and hypoxia of coronary arteries. Aspirin, through its antiplatelet effect, reduces the risk of recurrent cardiovascular events in patients with myocardial infarction.
Treatment of Atrial Fibrillation:
Atrial fibrillation (AF) is a common cardiac arrhythmia that can increase the risk of thromboembolism. Aspirin use in patients with AF, especially when combined with anticoagulants, significantly reduces the incidence of thromboembolic events.
Prosthetic heart valve and post-surgical prophylaxis:
In patients undergoing prosthetic heart valve replacement or arteriovenous fistula surgery, aspirin protects patients by reducing the risk of postoperative thrombosis.
Treatment of unstable angina:
Unstable angina is a clinical presentation between exertional stable angina and acute myocardial infarction and sudden death. Aspirin reduces the risk of cardiovascular events in patients with unstable angina through antiplatelet therapy.
Frequently Asked Questions
What are the core advantages of high-purity powder compared to tablets when used as a "raw material" for chemical synthesis?
+
-
Avoid large amounts of excipients and impurities in the pills. These excipients can affect the yield, purity, and subsequent separation of the reaction, while high-purity powders can provide determined and controllable stoichiometry and reaction conditions.
Why does it have unique value as a template or intermediate for designing "prodrugs"?
+
-
It has both modifiable carboxyl and phenolic ester bonds. Carboxyl groups can be linked to other drug molecules or targeting groups to form esters, which can be used to make prodrugs to improve the solubility, stability, or targeting of the original drug.
Why can its acetylsalicylic acid structure be used as an "ion pair reagent" or "mobile phase additive" in analytical chemistry?
+
-
Its acidic carboxyl group and aromatic backbone enable it to form reversible ion pairs with certain alkaline analytes in liquid chromatography, thereby improving the retention behavior and peak shape of these analytes.
Why has it ever been used as a "plant growth regulator" or "disease inhibitor" in non-medical traditional fields such as horticulture?
+
-
It can be hydrolyzed into salicylic acid in plants, which is a key signaling molecule for plant systemic acquired resistance. This makes it possible to induce plant disease resistance, alleviate stress, or regulate flowering.
What unknown impact does the "crystal morphology" of its powder have on the production of ideal pills?
+
-
Different crystal forms can affect the flowability, compressibility, and compaction of powders, directly determining whether tablets can be produced smoothly, whether they are prone to cracking, and the dissolution rate of active ingredients.
Hot Tags: pure aspirin powder cas 50-78-2, suppliers, manufacturers, factory, wholesale, buy, price, bulk, for sale, Medetomidine HCl, Iodomethane d3, Pure Tetracaine, Sapropterin Hydrochloride, tetrahydrobiopterin synthesis, pure benzocaine powder