Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of tetracaine hydrochloride powder cas 136-47-0 in China. Welcome to wholesale bulk high quality tetracaine hydrochloride powder cas 136-47-0 for sale here from our factory. Good service and reasonable price are available.
Tetracaine hydrochloride powder, is a 99%+pure substance. We obtained it using our organic chemistry technology. Dicaine hydrochloride is a white crystalline powder, and its appearance is related to its purity. The higher the purity and impurity content, the more yellow the color. Odorless, slightly bitter in taste, with a tingling sensation on the tongue. Easy to dissolve in water and ethanol. Insoluble in ether and benzene. The melting point ranges from 149 ℃ to 153 ℃, with 149 ℃ being the initial melting point and 153 ℃ being the complete melting point. Its melting point increases with the increase of purity, and there is a phenomenon of melting point decrease, which is caused by the presence of impurities. It is relatively stable at temperatures below 150 ℃, but decomposes into HCl and N-acetyl-4-butoxyaniline at higher temperatures. Its thermal stability in air is slightly lower than that in inert gases. In terms of thermal stability, the improvement of purity can have a positive impact on the quality of lidocaine hydrochloride.
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Determination of Tetracaine hydrochloride powder - neutralization titration method
Method principle:
After adding glacial acetic acid and acetic anhydride test solution, the samples were heated and reflux for 2 hours, then cooled. After adding mercury acetate test solution and crystal violet indicator solution, the solution was titrated with perchloric acid titrant (0.1mol/L) until the solution showed blue color. The usage of perchloric acid titrant was recorded and calculated.
Biological reaction properties:
Pharmacodynamic response
Tetracaine Hydrochloride is a local anesthetic that primarily inhibits sodium channels on the neuronal membrane, disrupting the transmission of neural signals, thereby achieving analgesic and anesthetic effects. Its action time is approximately 1-2 hours.
Absorption, distribution, metabolism, and excretion
Tetracaine hydrochloride is broken down into Tetramine and p-aminobenzoic acid within cells and metabolized through the liver and kidneys. It can be excreted through the liver, bile, and kidneys, and can also be absorbed through the skin, muscles, and digestive tract.
Interactions with other drugs
Tetracaine Hydrochloride, unlike most anesthetics, can enhance the effectiveness of other drugs. For example, it can be used in conjunction with adrenaline complexes to shrink blood vessels and reduce bleeding. In addition, Tetracaine Hydrochloride can also be used in combination with other drugs such as promethazine and fentanyl to improve the effectiveness of local anesthesia.
The methods for preparing TCH in other laboratories involve relatively complex synthesis steps. Strong laboratory skills and experience are required to ensure the preparation of high-purity products.
Tetracaine hydrochloride powder is a widely used local anesthetic drug, mainly including the following aspects:
1.Main purpose：
Local anesthesia:
- It achieves anesthesia by blocking nerve conduction, inhibiting the excitation of pain nerves, and causing local areas to lose pain sensation.
- Dicaine hydrochloride emulsion can be used for local lubrication anesthesia during catheterization endoscopy or surgery in the urethra, esophagus, vagina, anus, rectum, and other areas.
- Dicaine hydrochloride injection or injectable lidocaine hydrochloride can be used for epidural block, subarachnoid block, nerve conduction block, mucosal surface anesthesia, etc.
Surface analgesia:
- Tetracaine hydrochloride gel or solution can be used for surface analgesia of superficial surgery, such as skin cutting and suture.
- In the field of medical beauty, such as eyebrow tattooing, tattoos, etc., lidocaine hydrochloride can also be used for surface analgesia.
Genital mucosal surgery:
Can be used for genital mucosal surgery, such as the removal of warts, to alleviate patients' pain and discomfort.
Other treatments:
It can also be used to treat symptoms such as skin itching, herpes virus neuralgia, etc.
2.Usage:
Surface local anesthesia
Spray or apply with 1% of this solution.
Infiltrative local anesthesia
Use 0.025%~0.03% of this solution for infiltration anesthesia.
Nerve Block
Use 0.1% to 0.3% of this solution for nerve block anesthesia.
epidural block
Use 0.15% to 0.3% of this solution for epidural anesthesia.
3.Precautions:
Drug interactions
It has a cross allergic reaction with procaine, so if patients have a history of allergies to procaine or similar drugs, the use of this medication should be prohibited.
dosage
Excessive use of this substance may lead to adverse reactions such as allergic reactions and poisoning. Therefore, strict adherence to the doctor's guidance and usage guidelines should be followed during use.
special populations
Patients with liver and kidney dysfunction should avoid using injections of this substance.
Drug preservation
This substance should be sealed and stored to avoid moisture and direct sunlight.
1.Market demand
Medical field demand
Tetracaine hydrochloride powder, as a local anesthetic, has a wide range of applications in the medical field. With the continuous advancement of medical technology and the increase in surgical volume, the demand for it will also continue to grow. Especially in fields such as ophthalmology and otolaryngology that require surface anesthesia, it has unique advantages.
Research field demand
It also has the function of a calcium channel protein inhibitor, which can block the voltage sensitive release of Ca2+in the sarcoplasmic reticulum. This characteristic makes it have potential application value in the field of scientific research, especially in the research of neuroscience, pharmacology, and other fields.
2.Production and sales
- Production process: Its production process is relatively mature, and the raw materials are easy to obtain. By optimizing production processes and improving production efficiency, production costs can be reduced, product quality can be improved, and market demand can be met.
- Sales channels: Its sales channels mainly include medical institutions such as pharmaceutical companies, hospitals, clinics, as well as research institutions, universities, etc. With the continuous expansion of the medical market and the increasing demand for scientific research, sales channels in this area will also be further expanded.
3.Policies and regulations
Drug registration and approval
As a drug, its production and sales must comply with relevant policies and regulations. With the continuous improvement of the national drug registration and approval system, the registration and approval process of this drug will become more standardized, which will help ensure the quality and safety of the product.
Environmental Protection and Safety Production40
Environmental Protection and Safety Productionffer a variety of transmission components, including sprockets, roller chains, gears, couplings, racks, hubs, pulleys, taper sleeves, bearing seats, and more.
4.Market competition
- Market competition pattern: Currently, its market competition pattern is relatively scattered, with multiple production enterprises. With the continuous expansion of the market and intensified competition, enterprises need to constantly improve product quality and service levels in order to win market share.
- Technological innovation and upgrading: Through technological innovation and upgrading, the production efficiency and product quality of the substance can be improved, production costs can be reduced, and the market competitiveness of the enterprise can be enhanced.
5.Development trend
Market demand continues to grow
With the continuous advancement of medical technology and the increase in surgical volume, as well as the growing demand for scientific research, its market demand will continue to grow.
Product diversification and personalization
In order to meet the needs of different patients and improve the competitiveness of products, enterprises need to continuously introduce diversified and personalized products. For example, different formulations and specifications of products can be developed to meet different surgical and scientific research needs.
international development
With the acceleration of globalization and the continuous expansion of international trade, the internationalization of this drug will become a trend. Enterprises can enhance the visibility and influence of their products by expanding into international markets and participating in international competition.
It has the following advantages compared to other local anesthetics:
Long duration of action
It is an amide local anesthetic with a longer duration of action than lidocaine and cocaine, which gives it an advantage in surgeries or procedures that require longer anesthesia effects.
Metabolic mode
It is metabolized through the hydrolysis of plasma cholinesterase, which may reduce the requirement for liver function compared to other anesthetics that rely on liver metabolism, and may be an advantage for patients with liver dysfunction.
High toxic dose
It is one of the strongest local anesthetics and also the most toxic. The maximum dose is 1mg/kg, which requires strict adherence to dosage guidelines in clinical use to avoid overdose and potential toxic reactions.
High pKa value
It has a high pKa value (8.5), which means it exists less in non ionized form at physiological pH, which may affect its ability to penetrate tissues, but also implies its slow onset and long duration (60-360 minutes).
Security of local applications
In ophthalmic surgery, it is widely used as a local anesthetic, usually in the form of a 0.5% solution for the eye. Studies have shown that its local application is safe, and long-term use is not recommended as it may cause damage to the surface of the eye.
Comparison with other anesthetics
Compared with other local anesthetics, it shows superiority in local application, especially in terms of duration and pain control.
Used for specific programs
It is particularly suitable for ophthalmic surgery and local nasal anesthesia, and its effect is superior to cocaine and lidocaine.
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