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Pyridoxine hydrochloride powder, Also known as vitamin B6, 5-hydroxy-6-methyl-3,4-pyridine dimethyl alcohol hydrochloride Adermine hydrochloride, It is an important chemical substance. The appearance is a white or off white crystalline or crystalline powder, odorless, with a sour or slightly salty taste, gradually changing in color when exposed to light. Easy to dissolve in water, slightly soluble in ethanol and acetone, insoluble in ether and chloroform. The aqueous solution exhibits a slightly acidic reaction. It is an alcoholic vitamin with a relatively stable structure that can withstand heat in acidic or alkaline solutions. Stable at room temperature and pressure, so it should be sealed in a cool, dry place and stored away from light. It is mainly used in the pharmaceutical field for the synthesis of drugs such as pyridoxal phosphate and brain rejuvenation, and plays an important role in the treatment of certain diseases. It can also be used as a feed nutrient enhancer, which can promote the metabolism of amino acids in animals and improve the utilization rate of feed. It is also used to enhance solid beverages, infant and toddler food, and modified milk powder to increase the nutritional value of food. It is also used as a UV absorber in cosmetics, with a wide range of applications.
Additional information of chemical compound:
|
Chemical Formula |
C8H12ClNO3 |
|
Exact Mass |
205.05 |
|
Molecular Weight |
205.64 |
|
m/z |
205.05 (100.0%), 207.05 (32.0%), 206.05 (8.7%), 208.05 (2.8%) |
|
Elemental Analysis |
C, 46.73; H, 5.88; Cl, 17.24; N, 6.81; O, 23.34 |
|
Melting point |
214-215 °C(lit.) |
|
Density |
1.2784 (rough estimate) |
 |
 |
Pyridoxine hydrochloride powder is a form of vitamin B6 with multiple uses. The following is a detailed introduction to its main uses:
Treatment of diseases: Pyridoxine hydrochloride can be used to treat diseases caused by vitamin B6 deficiency, such as neuropathy, dermatitis, anemia, etc. It participates in various metabolic processes in the body and is crucial for maintaining the normal function of the nervous system.
Auxiliary drugs: In the field of medicine, pyridoxine hydrochloride can also be used as an auxiliary ingredient for various drugs, such as synthesizing pyridoxal phosphate, brain rejuvenation, etc., to enhance drug efficacy.
Feed additives
Nutritional Fortification: As a feed nutrient enhancer, pyridoxine hydrochloride can promote the metabolism of amino acids in animals, improve feed utilization, and thus enhance animal growth performance and health status.
Disease prevention: Adding an appropriate amount of pyridoxine hydrochloride to feed can also prevent diseases in animals caused by vitamin B6 deficiency, such as neurological disorders and anemia.
Fortified nutrition: Pyridoxine hydrochloride can be used to enhance solid beverages, infant and toddler foods, and modified milk powder to increase the nutritional value of food and meet the specific needs of people for vitamin B6.
Improving taste: Pyridoxine hydrochloride can also be used as a flavoring agent in food processing to enhance the taste and flavor of food.
Cosmetic additives
Skincare benefits: Pyridoxine hydrochloride has antioxidant and moisturizing effects and can be added to cosmetics to help improve skin condition, reduce skin inflammation and dryness.
Sunscreen effect: In addition, pyridoxine hydrochloride can also be used as a UV absorber to help protect the skin from UV damage.
What are the side effects of this compound?
Neurological abnormalities
Excessive pyridoxine hydrochloride may interfere with the synthesis and metabolism of neurotransmitters, leading to symptoms such as headaches, dizziness, and mental disorders. May affect central nervous system function, leading to cognitive decline and emotional fluctuations, and patients may experience symptoms such as lack of concentration, depression, or anxiety. Long term high-dose intake may also lead to nerve damage, such as sensory abnormalities or numbness.
Gastrointestinal discomfort and skin reactions
Pyridoxine hydrochloride may stimulate gastrointestinal mucosal tissue, causing discomfort symptoms such as nausea and vomiting.
There may also be decreased appetite, diarrhea, and other conditions. Skin reactions may be caused by allergic reactions and are related to the body's immune response to certain components in the medication. It can manifest as non-specific dermatitis symptoms such as itching, erythema, and urticaria.
Abnormal blood system and other side effects
This powder may affect the proliferation and differentiation of bone marrow hematopoietic stem cells, leading to blood system diseases such as anemia. Long term excessive intake may also lead to leukopenia, affecting immune function. Long term excessive intake of pyridoxine hydrochloride may lead to peripheral neuropathy, manifested as limb numbness, pain, and other symptoms. Some patients may develop blood system diseases such as thrombocytopenic purpura.
Precautions
When using pyridoxine hydrochloride, it is essential to follow the guidance of a doctor and strictly adhere to the prescribed dosage and usage. Patients who have been using pyridoxine hydrochloride for a long time should be regularly monitored for potential side effects, especially in special populations such as children, pregnant women, and lactating women. A balanced diet can usually meet the daily needs of vitamin B6, so in general, there is no need to supplement with pyridoxine hydrochloride. If you need to supplement, you should also consult a doctor or nutritionist for advice first.
What are the sales channels for this compound?
Pyridoxine hydrochloride powder, It is called vitamin B6. It is an important water-soluble vitamin that serves as a coenzyme for various enzymes in the body, participates in various biochemical reactions, and plays an important role in maintaining normal physiological functions of the human body. The following is relevant information about the sale of this compound:
Manufacturer direct sales
Many manufacturers of Pyridoxine hydrochloride have their own sales teams or official websites that can directly provide products to customers. These manufacturers usually have a large production scale and supply capacity, and can provide high-quality products and excellent after-sales service. Customers can make purchases by contacting the manufacturer's sales department or visiting their official website.
Distributors and agents
In addition to direct sales from manufacturers, there are also many distributors and agents who sell Pyridoxine hydrochloride. These distributors and agents typically collaborate with multiple manufacturers, providing a wider range of product choices and more flexible purchasing options. Customers can obtain purchasing channels by searching for relevant dealer and agent information, or consulting industry professionals.
E-commerce platform
With the rapid development of e-commerce, more and more sellers of Pyridoxine hydrochloride are using e-commerce platforms for sales. These platforms typically provide convenient online purchasing processes, rich product information, and transparent pricing systems. Customers can search and compare products of different brands and specifications on these platforms, and choose the most suitable purchasing plan for themselves.
International Trade and Import/Export Corporation
For customers who need to import or export Pyridoxine hydrochloride, international trade and import-export companies are an important sales channel. These companies usually have rich international trade experience and professional logistics service capabilities, which can provide customers with comprehensive support from procurement, customs clearance, transportation to after-sales service.
Industry exhibitions and conferences
In addition, industry exhibitions and conferences are also important ways to obtain sales channels for Pyridoxine hydrochloride. At these exhibitions and conferences, customers can directly communicate face-to-face with manufacturers, distributors, agents, etc. to learn about the latest developments, technological advancements, and market trends of products. Meanwhile, these exhibitions and conferences also provide opportunities for sellers to showcase their products and expand their markets.
Precautions
Pyridoxine hydrochloride should be stored in a sealed, dark, high-temperature, and cool place to ensure product quality and stability. The shelf life of products from different manufacturers may vary, usually 2 years. Please use within the validity period to ensure the safety and effectiveness of the product. Although pyridoxine hydrochloride is one of the essential vitamins for the human body, excessive intake may also cause side effects. Therefore, when using, it is necessary to strictly follow the recommendations of medical advice or product instructions.
The analytical methods of Pyridoxine Hydrochloride Powder mainly include the following types, which are widely used in purity detection, structure confirmation and content determination, etc.
Purity Detection Methods
High Performance liquid Chromatography (HPLC)
Application: HPLC is a common method for detecting the purity of the Powder. By choosing the appropriate chromatographic column and mobile phase, the separation of Pyridoxine Hydrochloride from other impurities can be achieved, thereby accurately determining its purity.
Features: HPLC is characterized by high separation efficiency, fast analysis speed and high sensitivity, and can accurately determine the content and purity of Pyridoxine Hydrochloride.
Ultraviolet spectrophotometry
Application: Pyridoxine Hydrochloride has an absorption peak at a specific wavelength, so it can be quantitatively analyzed by ultraviolet spectrophotometry.
Features: This method is simple and fast to operate, but its sensitivity is relatively low. It is suitable for occasions where the purity requirement is not particularly high.
Methods for Structural Confirmation
Nuclear magnetic resonance method (NMR)
Application: NMR can provide information on the relative positions and chemical environment between atoms in Pyridoxine Hydrochloride, which is very useful for confirming its three-dimensional structure.
Characteristics: NMR is non-destructive, has high resolution and can provide rich structural information, making it an important means to confirm the structure of compounds. Through NMR spectra, the chemical shifts of each hydrogen and carbon atom in Pyridoxine Hydrochloride can be analyzed, thereby inferring its molecular structure.
Infrared spectroscopy (IR)
Application: IR spectroscopy can provide information on the chemical bonds and functional groups in Pyridoxine Hydrochloride, which is helpful for confirming its molecular structure.
Characteristics: This method is simple and rapid to operate, and can provide characteristic absorption peaks of compounds, which is of great significance for the preliminary confirmation of compound structures.
Content Determination Method
Hydrogen nuclear magnetic resonance quantitative method (qNMR)
Application: qNMR is a simple and rapid content determination method that does not require reference substances. The content of Pyridoxine Hydrochloride can be calculated quickly through the internal standard method.
Features: qNMR is characterized by high accuracy and good reproducibility, and it does not require the use of high-purity reference substances. However, it should be noted that low-field nuclear magnetic resonance spectrometers are only suitable for compounds with relatively simple structures. While high-field nuclear magnetic resonance spectrometers can provide more accurate results, they are large in size and have high maintenance costs.
High Performance Liquid Chromatography-ultraviolet Detection Method (HPLC-UV)
Application: By combining the separation capability of HPLC and the sensitivity of the UV detector, the content of Pyridoxine Hydrochloride can be accurately determined.
Characteristics: This method features high separation efficiency, high sensitivity and good reproducibility, and is one of the commonly used methods for content determination.
Non-aqueous titration method
Application: Non-aqueous titration is a classic content determination method, suitable for the content determination of organic compounds such as Pyridoxine Hydrochloride.
Features: This method is easy to operate and cost-effective, but it requires precise control of titration conditions to ensure the accuracy of the results.
Pyridoxine hydrochloride powder (C ₈ H ₁ NO ∝ · HCl) is a form of vitamin B6 and an essential micronutrient for humans and animals.
At the end of the 19th century, scientists realized that certain foods contained "cofactors" necessary for sustaining life. In 1926, Dutch scientist Christiaan Eijkman (who had won the Nobel Prize) discovered that rough rice could prevent beriberi, indicating the presence of unknown nutrients in food.
In 1934, Hungarian biochemist Paul Gy ö rgy discovered a water-soluble substance that could cure skin lesions while studying dermatitis in rats, and named it "vitamin B6" (at that time, the vitamin B family had not yet been subdivided). This discovery marks the beginning of research on pyridoxine.
In 1936, Samuel Lepkovsky (University of California, Berkeley) first isolated crude extracts of vitamin B6 from rice bran.
In 1938, Richard Kuhn (Nobel laureate in Chemistry) and Karl Wendt independently isolated a pure product in Germany and named it "Pyridoxine", derived from its pyridine ring structure.
In 1939, Esmond Snell discovered that vitamin B6 was not a single substance, but a family that included pyridoxine, pyridoxal, and pyridoxamine.
During World War II, the US military discovered that soldiers were suffering from symptoms such as neuropathy and anemia due to a monotonous diet, and urgently needed vitamin B6 supplements.
In 1942, Karl Folkers' team from Merck Pharmaceuticals first analyzed the chemical structure of pyridoxine and found that its hydrochloride form (Pyridoxine Hydrochloride) was more stable and suitable for industrial production.
In 1945, Harris and Folkers completed the complete chemical synthesis of pyridoxine, laying the foundation for large-scale production. Its hydrochloride form has become the standard due to the following advantages:
High solubility: easily soluble in water, suitable for injection or oral formulations.
Stability: More resistant to high temperatures and oxidation than free pyridoxine.
In the 1950s, BASF in Germany and Hoffmann La Roche in the United States achieved commercial production, promoting the application of vitamin B6 in global food and medicine.
This powder is a versatile and important compound with a wide range of applications in the pharmaceutical, dietary supplement, food, and cosmetic industries. Its chemical properties, such as high water - solubility and stability, make it suitable for various formulations. The physiological functions of pyridoxine hydrochloride, including its role in amino acid metabolism, heme synthesis, neurological function, and immune function, highlight its significance for human health. While it is generally safe when taken within the recommended dosage range, high - dose supplementation can lead to toxicity and drug interactions. As the demand for vitamin B6 continues to grow, the market for the powder is expected to expand, driven by technological advancements and increasing awareness of its health benefits.
FAQ
1. What are the main applications of pyridoxine hydrochloride powder?
As a supplement of vitamin B6, it is used in the medical field to prevent and treat vitamin B6 deficiency-related disorders such as peripheral neuritis. It is also an indispensable coenzyme in the metabolism of amino acids, neurotransmitters, and other substances.
2. How to store this powder correctly?
To ensure its stability, the powder should be placed in a sealed container and stored in a dark, cool and dry place to prevent deterioration upon exposure to light or decomposition due to moisture absorption.
3. How soluble is this powder in water?
It has excellent water solubility and is easily soluble in water, allowing it to be formulated into clear solutions. This makes it highly suitable for various applications in the fields of pharmaceuticals and biochemical research.
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