Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of sheep bone collagen in China. Welcome to wholesale bulk high quality sheep bone collagen for sale here from our factory. Good service and reasonable price are available.
Sheep bone collagen peptide is a small molecule oligopeptide complex extracted and purified from sheep bone matrix connective tissue using directed enzymatic hydrolysis technology. Its molecular particle size is concentrated in the range of 200-600Da, and it has excellent water solubility, strong biological permeability, and can be absorbed by the body without deep gastrointestinal lysis. It is a functional active substance suitable for the maintenance of human connective tissue. This active peptide can precisely act on the three major systems of human bone metabolism, joint microenvironment, and dermal connective tissue. Relying on its unique molecular structure and biological activity, it achieves the maintenance effect of bone mineral retention, joint friction loss relief, and skin specific fibrous protein filling. It is a high-quality nutritional matrix for targeted repair of human support and epidermal tissue.
Products Overview
Sheep Bone Collagen COA
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| Certificate of Analysis | ||
| Compound name | Sheep Bone Collagen | |
| Grade | Pharmaceutical grade | |
| CAS No. | N/A | |
| Quantity | Customized | |
| Packaging standard | Customized | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202501090006 | |
| MFG | Jan 9th 2026 | |
| EXP | Jan 8th 2029 | |
| Structure | N/A | |
| Item | Enterprise standard | Analysis result |
| Appearance | White or almost white powder | Conformed |
| Water content | ≤5.0% | 0.54% |
| Loss on drying | ≤1.0% | 0.42% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | ≥99.0% | 99.98% |
| Single impurity | <0.8% | 0.52% |
| Total microbial count | ≤750cfu/g | 95 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 500ppm |
| Storage | Store in a sealed, dark, and dry place, 2-8°C | |
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Consolidate bone minerals and block calcium metabolism loss
The density and stability of bones rely on the orderly deposition and sustained retention of calcium, while sheep bone collagen peptides can intervene in bone metabolism rhythms through multiple biological regulatory pathways, avoid calcium free loss, and build a solid foundation of bone structure. The specific functional logic can be divided into three dimensions:
Targeted chelation of mineral ions, solidification of bone deposition substrate
The peptide substance molecular chain is rich in active functional groups such as hydroxyl and carboxyl groups, which can form stable chelation complexes with calcium ions, change the free state properties of calcium, and avoid the excretion of free calcium with body fluid metabolism. At the same time, it can guide the orderly arrangement of calcium and phosphorus minerals according to the bone lattice structure, optimize the deposition density of hydroxyapatite, and tightly embed calcium into the bone matrix framework, reducing the loose loss of bone minerals from the root and improving the adhesion stability of bone inorganic matter.
Regulating bone metabolism balance and inhibiting bone resorption process
This peptide can target and regulate the RANK/RANKL/OPG signaling pathway in the body, downregulate the proliferation activity and differentiation efficiency of osteoclasts, weaken the metabolic intensity of bone resorption, and maintain the physiological activity of osteoblasts in a steady state, blocking the metabolic pathway of excessive bone breakdown and loss. By balancing the dynamic balance between bone resorption and bone formation, reducing the loss of bone mass caused by daily physiological metabolism and aging, and continuously preserving the inherent calcium reserve of bones.
Repairing bone matrix structure and locking in deep mineral nutrients
The organic matrix of bones is the core carrier of calcium, and this peptide can participate in the repair and reconstruction of bone matrix fiber structure, filling the subtle gaps in bone matrix and optimizing the density of bone tissue. A complete and dense bone matrix network can form a physical calcium locking barrier, firmly fixing deep bone minerals and avoiding calcium infiltration and loss from bone tissue pores, thus maintaining the adequacy and stability of bone calcium reserves in the long run.
Enhance the synthesis and secretion of synovial fluid in joints, and slow down mechanical friction injuries in bones and joints
The flexible operation of human joints relies on the lubrication and buffering effect of synovial fluid in the joint cavity. Insufficient secretion of synovial fluid and decreased viscoelasticity are the core causes of joint dryness and frictional strain. Sheep bone collagen peptide can deeply intervene in synovial metabolism, optimize the physicochemical properties of synovial fluid, and reduce bone joint friction loss.
01.Activation of synovial cell activity and improvement of synovial fluid synthesis efficiency
Small molecule sheep fibrous protein peptide can penetrate the joint cavity barrier, act on synovial epithelial cells, activate the proliferation and secretion functions of synovial cells, promote endogenous synthesis and continuous secretion of synovial fluid, effectively expand the reserve of synovial fluid in the joint cavity, improve joint dryness and insufficient lubrication, and provide a basic lubricating medium for joint flexion and extension activities.
02.Optimize the viscoelasticity of synovial fluid and enhance buffering and lubrication efficiency
This active peptide can upregulate the content of core functional components such as hyaluronic acid and proteoglycans in synovial fluid, optimize the rheological properties of joint synovial fluid, and improve the viscosity and elastic tension of synovial fluid. The improved synovial fluid can form a uniform and dense lubricating film on the bone joint contact surface, weakening the direct hard contact of the bone end face and significantly reducing the mechanical friction during joint movement.
03.Maintain stable joint microenvironment and reduce chronic friction loss
Long term joint activity can easily cause synovial metabolism disorders, synovial fluid component imbalances, and exacerbate cartilage wear. This peptide can regulate the microenvironment of the joint cavity in a steady state, inhibit metabolic disorders caused by free radical accumulation, maintain the stability of synovial fluid composition and secretion rhythm, continuously buffer joint friction pressure caused by daily activities and exercise loads, and reduce progressive joint strain and wear problems.
The efficient protein supply value of adapting ultrafine molecular structure to digest weak populations
The supporting structure of the human dermis is mainly composed of type I and type III fibrous protein proteins. Type I fibrous protein dominates skin firmness and support, while type III fibrous protein determines skin softness and repair ability. The loss and deficiency of both are the core causes of skin aging and sagging. Sheep bone collagen peptide can accurately supply and activate the synthesis of two types of fibrous protein, reconstructing the dermal fibrous protein system.
I.Supplying fibrous protein synthesis substrates to fill the gap in fibrous protein deficiency
After low-temperature enzymatic hydrolysis and purification, the this peptide retains the conserved sequence of glycine proline hydroxyproline tripeptide exclusive to natural animal fibrous protein. This structure is highly compatible with the core substrate required for human dermal fibrous protein synthesis and is an exclusive high-quality raw material for fibroblast synthesis of new fibrous protein. Compared to ordinary large molecule fibrous protein, small molecule peptide structures do not require complex gastrointestinal decomposition and transformation.
They can quickly penetrate and be absorbed, and transported to the skin and dermis tissues through blood circulation, effectively compensating for the daily loss and aging loss of type I and III fibrous protein in the body. Continuous substrate supply can gradually fill the fine gaps formed by the breakage and sparsity of fibrous protein fibers in the dermis, repair the fibrous proteinfracture structure in the dermis, reshape the fullness of the skin's base, and fundamentally improve the problems of skin relaxation, collapse, and dryness caused by fibrous protein deficiency, consolidating the skin's support foundation.
II.Activate fibroblasts and promote endogenous fibrous protein regeneration
Dermal fibroblasts are the core functional cells for the synthesis of endogenous fibrous protein in the human body, and their activity directly determines the efficiency and reserve of fibrous protein production in the skin. The small molecule active peptide segment of this kind peptide can penetrate the surface barrier of the skin, accurately target and enrich in the dermis tissue, specifically bind to functional receptors on the surface of fibroblasts, and thereby activate the TGF - β/Smad core fibrous protein synthesis signaling pathway.
This regulatory mechanism can significantly boost the proliferation and differentiation activity of fibroblasts, awaken the skin's native repair ability, significantly increase the rate and total amount of self synthesized type I and type III fibrous protein in the body, and break the metabolic dilemma of skin fibrous protein being unable to make ends meet. Through the precise supply of exogenous active peptides and the dual synergistic effect of endogenous cell activation and regeneration, the fibrous protein reserve in the dermis is doubly increased, continuously optimizing the skin's fibrous protein metabolism system.
III.Stabilize the fibrous protein fiber structure and delay fibrous protein degenerative loss
The core cause of skin aging is not only insufficient fibrous protein synthesis, but also excessive degradation and structural disorder of fibrous protein fibers. Matrix metalloproteinases are the core enzymes in human dermal tissue that degrade fibrous protein. Their abnormally high activity accelerates the breakdown and loss of normal fibrous protein fibers, disrupting the fibrous protein homeostasis of the skin. Sheep fibrous protein peptide can accurately downregulate the excessive activity of matrix metalloproteinases.
Effectively inhibit the abnormal degradation and fracture aging of type I and III fibrous protein fibers in the dermis, and significantly delay the process of fibrous protein degeneration and loss. At the same time, it can assist in regulating the arrangement order of fibrous protein fibers, making loose and disordered fiber structures dense, uniform, and regular, and building a three-dimensional support network for the dermis layer. It can maintain the elasticity, tension, and fullness of the skin for a long time, gradually improving various signs of skin aging such as fine lines, skin laxity, and dull and rough skin tone, and maintaining the youthful state of the skin for a long time.
References
Fibrous protein Peptides Alleviate Bone Loss via Regulating Osteoblast and Osteoclast Balance in Senile Mice
Mechanism of Sheep Bone fibrous protein Peptide in Improving Joint Cavity Microenvironment and Lubrication Function
Study on the Regulation Effect of Small Molecular fibrous protein Peptides on Dermal Type Ⅰ/Ⅲ fibrous protein Metabolism
Effects of Sheep Bone fibrous protein Peptide on Liver Lipid Deposition in Ovariectomized Rats(https://pubmed.ncbi.nlm.nih.gov/36047104/)
Sheep bone fibrous protein protein peptide ameliorates osteoporosis by regulating RANK/RANKL/OPG signal pathway(https://www.scielo.br/j/cta/a/Tws3z98fdKbTn4dNJf4Q3hj/?format=html&lang=en)
FAQ
Q1: Is the effect of sheep bone fibrous protein peptide calcium locking on bone protection immediate or long-term cumulative?
A1: The calcium fixing and bone protecting effects of this substance mainly rely on long-term cumulative maintenance. It cannot immediately reverse the already formed bone loss, and short-term intake can quickly optimize the calcium deposition environment and reduce the loss of free calcium metabolism; Continuous regular supplementation can gradually optimize bone matrix structure, regulate bone metabolism balance, steadily improve bone density, and achieve long-term calcium locking and bone mass stabilization effects.
A2: It can be effectively improved. It can promote the secretion of synovial fluid in joints, enhance the viscoelasticity of synovial fluid, fill the lubrication gap in joint cavities, and weaken the hard friction of bone joints. Persistently supplementing can gradually eliminate joint dryness and abnormal noise, alleviate friction discomfort during activities, and continuously maintain joint lubrication status.
Q3: Does sheep bone fibrous protein peptide have targeted supplementation of skin type I and III fibrous protein?
A3: It has precise targeting ability. Its unique tripeptide structure can specifically act on skin dermal fibroblasts, regulating only the synthesis and retention of type I and III fibrous protein in the skin, without disrupting the metabolism of other skin tissues. It can accurately repair fibrous protein defects, reconstruct the skin support structure, and achieve more precise and efficient maintenance effects.
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