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4'-Ethylpropiophenone, molecular formula C11H14O, CAS 27465-51-6, It is a colorless to light yellow transparent liquid with a strong irritating odor. This color may be the result of the combined action of the benzene ring, carbonyl group, and ethyl group in the molecular structure. Its clear and transparent properties indicate that the compound is stable at room temperature and does not contain any insoluble impurities. Soluble in organic solvents, insoluble in water. It is an organic solvent that can dissolve various organic substances. It is easily soluble in organic solvents such as ethanol, ether, acetone, but insoluble in water. This solubility makes p-ethylphenylacetone widely used in organic synthesis, chemical analysis, and other fields. It is an important raw material for synthesizing certain spices, such as jasmine ketone, which synthesizes the aroma of jasmine flowers. This perfume is widely used in perfume, fragrance and other products. It can also be used to synthesize certain dyes, such as methyl violet, which is used to synthesize acidic dyes. These dyes have wide applications in fields such as textiles, printing and dyeing.
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Chemical Formula |
C11H14O |
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Exact Mass |
162 |
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Molecular Weight |
162 |
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m/z |
162 (100.0%), 163 (11.9%) |
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Elemental Analysis |
C, 81.44; H, 8.70; O, 9.86 |
4'-Ethylpropiophenone, as an important organic compound, has a wide range of applications in various fields.
1. The pharmaceutical industry
Drug synthesis: Ethylphenylacetone is an important raw material for synthesizing various drugs, such as epinephrine hydrochloride for the treatment of cardiovascular diseases and sodium phenobarbital for the treatment of epilepsy. These drugs have significant therapeutic effects in the field of medicine.
Pharmaceutical intermediate: As an intermediate in the preparation of drugs for the prevention and treatment of cardiovascular and cerebrovascular diseases, p-ethylphenylacetone plays a crucial role in the drug synthesis process. Epirisone hydrochloride, as a central skeletal muscle relaxant, can improve muscle tension in neck shoulder arm syndrome, shoulder periarthritis, and lower back pain, and alleviate spasmodic paralysis in cerebrovascular disorders, spasmodic spinal cord paralysis, cervical spondylosis, and other conditions.
2. Spice industry
Synthetic spices: p-ethylphenylacetone is an important raw material for synthesizing certain spices, such as jasmine. Jasmonate has a strong jasmine fragrance, which is widely used in perfume, fragrance and other products to add fragrance to people's life.
3. Dye industry
Synthetic dyes: p-ethylphenylacetone can be used to synthesize certain dyes, such as acidic dyes such as methyl violet. These dyes have a wide range of applications in the fields of textiles, printing and dyeing, adding rich colors and patterns to textiles.
4. Plastic industry
Plastic additive: Ethylphenylacetone can be used as a plastic additive, such as a stabilizer and flame retardant for polypropylene. By adding p-ethylphenylacetone, the stability and flame retardancy of plastic materials such as polypropylene can be improved, making them safer and more durable.
5. Other uses
Preparation of organic pigments, coatings, and adhesives: Ethylphenylacetone can also be used to prepare certain organic pigments, coatings, and adhesives, providing important raw material support for industries such as construction, coatings, and printing.
6. Digital information
Purity: Through specific synthesis methods, p-ethylphenylacetone with a purity greater than 98% can be obtained.
Yield: In practical applications, the yield of p-ethylphenylacetone can reach 85%, indicating that this synthesis method has high efficiency and economy.
Scope of sales channels
4 '- Ethylpropiophenone (CAS: 27465-51) is an important organic chemical with wide applications in various fields such as medicine, chemical engineering, and electronics. The following is a detailed analysis of its sales channel scope:
Manufacturer's sales channels
Manufacturers are the source of sales channels, converting raw materials into p-ethylphenylacetone products through their own production facilities and technology. Some large manufacturers, especially those with stable customer bases and strong market influence, will directly sell p-ethylphenylacetone to end users, such as pharmaceutical manufacturing companies, chemical companies, etc. This sales method can reduce intermediate links, improve sales efficiency, and also help manufacturers better understand market demand and optimize product structure. Many manufacturers choose to collaborate with distributors to sell their products to a wider customer base. Distributors usually have a wider sales network and customer resources, which can help manufacturers open up the market faster and increase product sales. Traders play an important role in the chemical sales market, connecting producers and end-users to earn profits through the price difference between buying and selling. Some manufacturers choose to sell their products to traders, who are responsible for further market promotion and sales.
Trading sales channels
Traders are an important link in their sales channels, as they purchase products from manufacturers or other traders and then sell them to end users or lower level distributors. Traders typically have flexible procurement and sales strategies, able to adjust inventory and prices in a timely manner according to changes in market demand, in order to maximize profits. Traders usually maintain cooperative relationships with multiple producers and end-users, and have a wide sales network. This enables them to obtain market information faster and sell their products to a wider range of regions. Due to the fact that traders typically procure products from multiple channels, they are able to compare prices and quality from different manufacturers and select the most competitive products for sale. This gives traders a significant price advantage and can attract more customers.
Dealer sales channels
Distributors are another important link in their sales channels, usually signing long-term cooperation agreements with manufacturers or traders, responsible for selling products in specific regions or fields. Distributors are usually responsible for selling products within a specific region, and they have a deep understanding of the market demand, competitive situation, and sales channels in that area. This enables them to promote and sell products more effectively, increasing market share. Distributors usually provide comprehensive sales services, including product consultation, technical support, after-sales service, etc. They maintain close cooperative relationships with customers, are able to respond promptly to their needs and issues, and improve customer satisfaction. In order to meet the needs of customers, dealers usually maintain a certain level of inventory. This enables them to provide products in a timely manner when customers need them, avoiding sales losses caused by stockouts.
End user sales channels
The end user is its ultimate user, who typically uses the product in fields such as pharmaceutical manufacturing, chemical production, electronic materials, etc. End users typically have stable product demands and regularly purchase p-ethylphenylacetone based on their production plans and market demand. This enables producers and traders to predict market demand and develop reasonable production and sales plans. Due to the critical role of ethylphenylacetone in end-user applications, end-users have very high quality requirements for the product. They usually choose manufacturers or suppliers with good reputation and reliable product quality for cooperation. End users have diverse procurement channels, and they can purchase products through various channels such as manufacturers, traders, and distributors. This enables end users to compare prices and quality across different channels and choose the optimal procurement plan.
Health hazard assessment
4'-Ethylpropiophenone (p-ethylphenylacetone), as an organic compound, has wide applications in industrial production and laboratory research. However, the issue of its health hazards also needs to be given sufficient attention. The following is a comprehensive health hazard assessment of it from aspects such as acute toxicity, skin and eye irritation, long-term exposure effects, reproductive and developmental toxicity, carcinogenicity, and safety operation recommendations.
Acute Toxicity Assessment
At present, the acute toxicity data of p-ethylphenylacetone is relatively limited. Based on the available data, this compound has not yet been clearly classified as a highly toxic substance. However, the lack of specific acute toxicity data (such as LD50 values) indicates that its potential risks have not been fully clarified. During the operation, if accidental ingestion or inhalation occurs, it may cause non-specific symptoms such as nausea, vomiting and dizziness, and immediate medical intervention is required. Due to the lack of a clear toxicity classification, it is recommended to regard it as a potentially low-toxicity substance and take strict protective measures.
Assessment of Skin and Eye Irritation
The irritation of p-ethylphenylacetone to the skin and eyes has not been fully studied, but based on its chemical structure (containing ketone groups and benzene rings), there may be a certain risk of irritation. Contact with the skin may cause mild inflammatory reactions such as redness, swelling and itching, while entering the eyes may lead to irritating symptoms such as conjunctival congestion and tearing. Although there is no clear classification of irritation, protective gloves and goggles should be worn during operation to avoid direct contact. In case of contact, rinse immediately with plenty of water and seek medical help.
Long-term Exposure Impact Assessment
Long-term exposure to p-ethylphenylacetone may have chronic effects on health. Although there is a lack of direct epidemiological data at present, long-term exposure to ketone-like compounds may cause neurological damage (such as headache and memory loss), abnormal liver function (such as elevated transaminase) and immune system suppression. As the metabolic pathway and toxicity mechanism of this compound have not been fully clarified, it is recommended to avoid long-term high-concentration exposure and undergo regular occupational health examinations.
Iv. Reproductive and Developmental Toxicity Assessment
The data on the reproductive and developmental toxicity of p-ethylphenylacetone are extremely limited. At present, there is no evidence to show that it has a direct impact on the human reproductive system or fetal development. However, based on the potential risks of ketone compounds, it is necessary to be vigilant about their potential harm to pregnant women and their fetuses. In the absence of adequate research, it is recommended that pregnant and lactating women avoid exposure to this compound to reduce potential risks.
Carcinogenicity Assessment
The carcinogenicity of p-ethylphenylacetone has not yet been clearly classified by international authoritative institutions such as IARC and NTP. Although there is a lack of direct evidence indicating their carcinogenicity, ketone compounds may produce mutagenic or carcinogenic metabolites under specific conditions. Due to the potential risk of long-term exposure, it is recommended to consider this compound as a possible human carcinogen and take strict protective measures to reduce the exposure risk.
Safety Operation Suggestions
To ensure the safe use of ethylphenylacetone, the following measures need to be taken:
Personal protection: When operating, protective gloves, goggles and protective clothing should be worn to avoid direct contact with the skin, eyes and respiratory tract. Gas masks should be worn in poorly ventilated environments.
Engineering control: Operate in a closed system or local exhaust system as much as possible to reduce steam leakage. Regularly inspect the ventilation equipment to ensure its normal operation.
Operating procedures: Strictly follow the operating procedures and avoid conditions such as high temperatures and open flames that may cause combustion or explosion. Eating, drinking or smoking are prohibited in the operation area.
Emergency response: Develop an emergency response plan and equip with leakage handling tools and first aid equipment. In the event of leakage or accident, immediate isolation, evacuation and clearance measures should be taken and the relevant departments should be informed.
Health monitoring: Regular health check-ups should be conducted for workers who have been exposed to p-ethylphenylacetone for a long time, with a focus on functional indicators of the nervous system, liver and immune system.
Future Research Directions
To assess the health hazards to ethylphenylacetone more comprehensively, the following studies need to be carried out:
Acute toxicity study: Determine its LD50 value through animal experiments and clarify the acute toxicity classification.
Chronic toxicity study: Conduct long-term exposure experiments to assess its potential effects on the nervous system, liver and immune system.
Reproductive and developmental toxicity studies: Evaluate its effects on the reproductive system and fetal development through animal experiments.
Carcinogenicity research: Conduct mutagenicity and carcinogenicity experiments to clarify the carcinogenic risk.
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