Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of 4-(trifluoromethoxy)phenyl isocyanate cas 35037-73-1 in China. Welcome to wholesale bulk high quality 4-(trifluoromethoxy)phenyl isocyanate cas 35037-73-1 for sale here from our factory. Good service and reasonable price are available.
4-(Trifluoromethoxy)phenyl Isocyanate, molecular formula C8H4F3NO2, CAS 35037-73-1, molecular weight 215.12 g/mol. It is an organic compound, a colorless to light yellow liquid. It can be dissolved in organic solvents. It is relatively stable at room temperature, but dangerous reactions may occur when encountering high temperatures, open flames, or oxidants. It should also avoid prolonged exposure to the air to prevent harmful substances from reacting with water. It is a harmful substance and appropriate safety operations and protective measures should be taken in the laboratory, including wearing chemical protective gloves, goggles, and protective clothing. It is an organic compound with multiple uses. In addition to its applications in fields such as pesticides, pharmaceuticals, organic synthesis, and materials science, it can also be used as a chemical intermediate, catalyst, laboratory reagent, and starting material or intermediate for the production of other compounds.
|
|
|
|
Chemical Formula |
C8H4F3NO2 |
|
Exact Mass |
203 |
|
Molecular Weight |
203 |
|
m/z |
203 (100.0%), 204 (8.7%) |
|
Elemental Analysis |
C, 47.31; H, 1.99; F, 28.06; N, 6.90; O, 15.75 |
4-(Trifluoromethoxy)phenyl isocyanate is an organic compound with special structure and properties, which can play an important role in polymer synthesis. The functional groups in this compound have reactive activity and can react with various compounds, including alcohols, amines, carboxylic acids, etc. Through these reactions, various polymers with excellent properties can be synthesized.
1. Synthesis of fluorinated polymers:
Due to the presence of fluorine atoms in this product, fluorinated polymers can be synthesized by reacting with other fluorinated monomers. These fluoropolymers typically have low surface energy, excellent oil resistance, chemical resistance, and thermal stability, making them widely used in paint, coatings, inks, and other fields.
2. Synthesis of high transparency polymers: They can react with certain monomers with high transparency, such as styrene and methacrylate, to synthesize high transparency polymers. These polymers have wide applications in optical components, automotive glass, and other fields.
3. Synthesis of high barrier polymers: By reacting with other monomers, high barrier polymers can be synthesized. These polymers have characteristics such as high oxygen permeability and high water permeability, and can be applied in fields such as food packaging and pharmaceutical packaging.
4. Synthetic high-temperature resistant polymer: Due to its presence of benzene ring and fluorine atoms, it has good high-temperature resistance performance. Therefore, high-temperature resistant polymers can be synthesized by reacting with other high-temperature resistant monomers. These polymers can be used in high-temperature environments and applied in fields such as aerospace, automotive, and electronics.
5. Organic synthesis: It can be used as a component of synthetic masonry materials to prepare various organic compounds. It can be used as an intermediate to synthesize other compounds with specific functions or uses, such as drugs, pesticides, materials, etc. By selecting different masonry materials and reaction conditions, various types of compounds can be synthesized, including carboxylic acids, alcohols, amines, etc.
6. Laboratory research: It can be used as a reagent or tool in the laboratory to study certain reactions or processes in fields such as organic chemistry, materials science, and drug development. It can be used to synthesize new compounds, study reaction mechanisms, and explore new synthesis methods. In the laboratory, the use of this reagent requires strict safety measures, such as wearing gloves, goggles, and protective clothing, and using appropriate experimental equipment and instruments. eius assumenda eaque ea ducimus expedita explicabo cumque magni.
A commonly used synthesis method is to generate 4-(Trifluoromethoxy)phenyl isocyanate by reacting phenol with trifluoromethoxy chloride, and then converting it to 4- (Trifluoromethoxy) phenyl isocyanate through cyanide reagents.
C6H5OH+CF3COCl → CF3COOC6H4OCF3+HCl
In this reaction, the hydroxyl group of phenol reacts with the acyl chloride group of trifluoromethoxy acyl chloride to produce 4- (trifluoromethoxy) phenyl trifluoroacetyl ester, while releasing hydrochloric acid (HCl). This reaction usually needs to be carried out in organic solvents, commonly used solvents include dichloromethane, chloroform, etc. At the same time, in order to avoid the direct reaction between the hydroxyl group of phenol and the acyl chloride group to generate the chloride of phenol, it is often necessary to add a small amount of alkali, such as sodium hydroxide, potassium hydroxide, etc.
CF3COOC6H4OCF3+PhNCO → C6H4OCF3NCO+CF3COOH
In this step, the cyanide reagent can be an aqueous solution of cyanide such as sodium cyanide, potassium cyanide, or ammonium cyanide. 4- (Trifluoromethoxy) phenyl trifluoroacetate (CF3COOC6H4OCF3) undergoes a nucleophilic substitution reaction with phenyl isocyanate (PhNCO) to produce 4- (Trifluoromethoxy) phenyl isocyanate (C6H4OCF3NCO), while also producing trifluoroacetic acid (CF3COOH) as a byproduct. This reaction requires controlling a certain temperature and time to avoid the generated isocyanate from self polymerization or side reactions with other substances.
Another commonly used synthesis method in the laboratory is to react phenol with trifluoromethoxy to generate 4- (trifluoromethoxy) phenyltrifluoromeoatamide, which is then converted to 4- (trifluoromethoxy) phenylisocyanate through cyanide reagents.
C6H5OH+CF3CONH2 → CF3CONHC6H4OCF3+H2O
This reaction generally requires heating and catalysts, commonly used catalysts include organic or inorganic acids. During the reaction, the hydroxyl group of phenol reacts with the amide group of trifluoromethane amide to produce 4- (trifluoromethoxy) phenyltrifluoroacetamide. Simultaneously release water molecules (H2O).
CF3CONHC6H4OCF3+PhNCO → C6H4OCF3NCO+CF3COOH
In this step, 4- (Trifluoromethoxy) phenyltrifluoroacetate (CF3CONHC6H4OCF3) reacts with phenyl isocyanate (PhNCO) to undergo a nucleophilic substitution reaction, generating 4- (Trifluoromethoxy) phenylisocyanate (C6H4OCF3NCO) and trifluoroacetic acid (CF3COOH) as a byproduct. In this reaction, the cyanide reagent can be an aqueous solution of cyanide such as sodium cyanide, potassium cyanide, or ammonium cyanide.
Through the above two reactions, we successfully prepared 4-(Trifluoromethoxy)phenyl isocyanate. It is worth noting that the reaction conditions, reagents, and specific operations involved in this synthesis route may vary depending on the specific laboratory or industrial production. In addition, attention should also be paid to environmental protection and safety production during the synthesis process. For laboratory scale production, the reaction is usually carried out in a fume hood and appropriate protective measures are used, such as wearing gloves, goggles, etc. For large-scale production, stricter safety regulations and environmental protection measures need to be established to ensure the safety and environmental protection of the production process.
Adverse reactions
The mechanism of action of adverse reactions
Stimulating effect on the skin
When 4- (Trifluoromethoxy) phenyl isocyanate comes into contact with the skin, its isocyanate groups can react with active hydrogen containing components such as proteins and amino acids in the skin, forming covalent bonds. This combination can disrupt the normal structure and function of the skin, leading to damage to the skin barrier and causing symptoms such as redness, swelling, itching, and pain. In addition, intermediate products or by-products that may be generated during the reaction process may also cause further irritation and damage to the skin.
Stimulating effect on respiratory tract
This substance is volatile and easily exists in gaseous form in the air. When the human body inhales gas containing 4- (Trifluoromethoxy) phenyl isocyanate, the isocyanate groups will react with proteins, mucus, and other substances on the respiratory mucosa, causing inflammation of the respiratory mucosa. Inflammatory reactions can cause congestion, edema, and increased secretion of respiratory mucosa, leading to symptoms such as cough, difficulty breathing, and chest tightness. Long term or high concentration exposure may also lead to chronic respiratory inflammation and lung function damage.
Stimulating effect on the eyes
If 4- (Trifluoromethoxy) phenyl isocyanate splashes into the eyes, its isocyanate groups will react with proteins and tears on the surface of the eye, causing damage to eye tissues such as the cornea and conjunctiva. After stimulation of the eye tissue, symptoms such as eye pain, tearing, photophobia, and blurred vision may occur. In severe cases, it may lead to serious consequences such as corneal ulcers and perforation.
Allergic reaction mechanism
Some individuals may experience allergic reactions to 4- (Trifluoromethoxy) phenyl isocyanate. Allergic reactions are immune-mediated reactions in which the immune system recognizes a substance as a foreign antigen and produces specific antibodies (primarily IgE antibodies) when the body first comes into contact with it. When exposed to the substance again, the antigen binds to the antibody, activating mast cells and eosinophils, releasing inflammatory mediators such as histamine and leukotrienes. These inflammatory mediators can cause physiological reactions such as vasodilation, increased permeability, and smooth muscle contraction, leading to allergic symptoms such as skin itching, rash, difficulty breathing, and anaphylactic shock.
Preventive measures for adverse reactions
Engineering control measures
Sealed operation
During production and use, sealed equipment should be used as much as possible to reduce the volatilization and leakage of the substance. For example, using closed containers such as reaction vessels and pipelines for chemical reactions and material transportation.
Local exhaust
Install local exhaust devices such as exhaust fans, fume hoods, etc. in positions where the substance may leak or evaporate, to promptly exhaust harmful gases outdoors and reduce the concentration of the substance in the workplace air.
Automated control
Adopting an automated control system to reduce manual operations and minimize the chance of personnel coming into contact with the substance. For example, automatic feeding of materials, automatic control of reaction processes, and automatic discharge of products can be achieved through automated instruments and control systems.
Personal protective measures
Skin protection
When in contact with this substance, protective clothing, gloves, etc. should be worn to avoid direct skin contact. Protective clothing should be made of materials that are resistant to chemical corrosion, such as rubber, polyethylene, etc. Protective gloves should have good chemical resistance and flexibility, such as nitrile gloves, latex gloves, etc.
Respiratory protection
Suitable respiratory protective equipment such as gas masks and air respirators should be worn in environments where the substance gas may be produced. Respiratory protective equipment should be selected based on the concentration and toxicity of the substance in the workplace air, using appropriate filter canisters or filter boxes.
Eye protection
Wear chemical safety goggles or face shields to prevent the substance from splashing into the eyes. Protective goggles should have good sealing and impact resistance, and the face mask should be able to cover the entire face, providing comprehensive eye protection.
Management measures
Training and education
Provide safety training to personnel who come into contact with the substance, enabling them to understand its properties, hazards, protective measures, and emergency response methods. The training content should include chemical knowledge, operating procedures, and the use and maintenance of personal protective equipment.
Health monitoring
Conduct regular health checks and establish health records for personnel who come into contact with the substance. The health examination items should include skin, respiratory, eye and other related examinations, as well as lung function, blood routine and other related examinations. Timely discover occupational contraindications and early health damage, and take corresponding measures.
Emergency plan
Develop a comprehensive emergency plan, clarify emergency response procedures and division of responsibilities. Equip necessary emergency rescue equipment and drugs, such as eye wash stations, sprinkler systems, first aid drugs, etc. Regularly organize emergency drills to improve the emergency response capabilities of staff.
Measures for handling adverse reactions
Handling of skin contact
Immediately remove contaminated clothing
Avoid further contact between pollutants and the skin to reduce the degree of skin damage.
Rinse with plenty of water
Quickly rinse the contact area with plenty of flowing water for at least 15 minutes. When flushing, attention should be paid to protecting the eyes and respiratory tract, avoiding the flushing solution from flowing into the eyes or being inhaled into the respiratory tract.
Medical treatment
If there is still discomfort or skin lesions on the skin after rinsing, seek medical attention promptly. Doctors may prescribe appropriate medication based on the condition, such as topical hormone ointments, antibiotic ointments, etc.
Inhalation treatment
Quickly evacuate the scene
transfer the patient to a place with fresh air and keep their respiratory tract unobstructed.
Rest and observation
Allow the patient to rest quietly and observe their vital signs such as breathing and heart rate. If the patient experiences symptoms such as difficulty breathing and worsening cough, timely treatment such as oxygen therapy should be given.
Medical treatment
If the symptoms are severe or persist, they should be promptly taken to the hospital for further treatment. Doctors may conduct chest X-rays, lung function tests, and other related examinations, and give corresponding medication treatments based on the condition, such as bronchodilators, glucocorticoids, etc.
Handling of eye contact
Immediately lift the eyelids
Rinse the eyes thoroughly with plenty of flowing water or saline solution for at least 15 minutes. When rinsing, rotate the eyes to ensure that all parts of the eyes are rinsed.
Medical treatment
If there are still symptoms such as pain and blurred vision in the eyes after flushing, seek medical attention promptly. Doctors may conduct eye examinations and prescribe appropriate medication based on the condition, such as eye drops, eye ointments, etc. In severe cases, surgical treatment may be necessary.
Handling of Allergic Reactions
Immediately stop contact
Once an allergic reaction is detected, contact with 4- (Trifluoromethoxy) phenyl isocyanate should be stopped immediately to avoid further aggravation of the allergic reaction.
Antiallergic therapy
Administer appropriate anti allergic medication based on the severity of the allergic reaction. Mild allergic reactions can be treated with oral antihistamines such as loratadine and cetirizine; Severe allergic reactions should be treated immediately with adrenaline injection, as well as corticosteroids, oxygen therapy, and other treatments.
Medical treatment
If the symptoms of allergic reactions are severe or life-threatening situations such as anaphylactic shock occur, the patient should be immediately sent to the hospital for emergency treatment.
Hot Tags: 4-(trifluoromethoxy)phenyl isocyanate cas 35037-73-1, suppliers, manufacturers, factory, wholesale, buy, price, bulk, for sale, 2 4 Quinolinediol, Synthetic Chemical, 2 Chloro 4 pyridinecarboxylic acid, DIMETHYLPHOSPHINE OXIDE, 2 6 Pyridinedicarboxylic acid, Methylamine hydrochloride powder