Antioxidant 1520 (4,6-di(octylthiomethyl)o-cresol), molecular formula C21H34O2S2, CAS 110553-27-0, indicates that it is composed of four elements: carbon, hydrogen, oxygen, and sulfur. It is a white or light yellow oily liquid or crystal with a special odor. Easy to dissolve in organic solvents such as ethanol, benzene, and chloroform, but with low solubility in water, hydrolysis or decomposition may occur under strong acid or alkali conditions. It is a new type of rubber anti-aging agent. Mainly used in synthetic rubbers such as butadiene rubber, styrene butadiene rubber, ethylene propylene rubber, nitrile rubber, thermoplastic elastomers, etc. Low dosage, good oxygen blocking effect, can improve the stability of plastics or synthetic plastics. Belonging to environmentally friendly antioxidants, it has achieved the transformation of rubber products from universal to environmentally friendly. This product should be stored in a clean and dry place, protected from rain; When handling this product, avoid strong collisions.
|
Chemical Formula |
C25H44OS2 |
|
Exact Mass |
424 |
|
Molecular Weight |
425 |
|
m/z |
424 (100.0%), 425 (27.0%), 426 (9.0%), 426 (2.7%), 427 (2.4%), 425 (1.6%) |
|
Elemental Analysis |
C, 70.70; H, 10.44; O, 3.77; S, 15.10 |
|
|
|
Density 1.0±0.1 g/cm3, boiling point 532.2±45.0 °C at 760 mmHg, Molecular formula C25H44OS2, molecular weight four hundred and twenty-four point seven four-six, flash point 257.9±27.4 °C, Precise quality four hundred and twenty-four point two eight three three five-six, PSA seventy point eight three zero zero zero, LogP ten point zero seven, Vapor pressure 0.0±1.5 mmHg at 25°C, Refractive index one point five three two, Boiling point 532.2 ± 45.0 ° C (predicted), Density 0.990 ± 0.06 g / cm3 (predicted), Acidity coefficient (PKA) 9.94 ± 0.50 (predicted)
To synthesize the liquid antioxidant Antioxidant 1520, the following steps can be followed:
1. Preparation of raw materials
Required raw materials: o-cresol, n-octyl mercaptan, paraformaldehyde, reaction solvent (such as toluene), water, and organic amine catalyst.
2. Feeding
Mix ortho cresol, n-octyl mercaptan, and polyformaldehyde in the reaction vessel according to the ratio of the substance's quantity or mass, usually in a ratio of 1:1:1. The mass ratio of each component in the mixture can be adjusted according to actual needs.
3. Add reaction solvents and catalysts
Add an appropriate amount of reaction solvent (such as toluene) to promote the progress of the chemical reaction. If necessary, you can add an appropriate amount of water. At the same time, strong bases and weak acid salts such as sodium hydroxide and sodium bisulfate are added to solid catalysts to accelerate chemical reactions.
4. Mixing and heating
Start stirring to ensure that all raw materials are mixed evenly and there are no precipitates or solid particles. Then start heating up and heat the reaction mixture to a reflux state. Reflux reaction helps to promote the progress of chemical reactions and improve the purity of products.
5. Dropwise addition of organic amine catalyst
In the reflux state, continuous addition of organic amine catalysts (such as n-hexane) usually requires a certain amount of time to complete this step. The function of a catalyst is to promote the progress of chemical reactions, improve the yield and purity of products.
6. Reaction completion and product separation
After the reaction is completed, the obtained product will be purified and refined to remove impurities and by-products. Distillation, extraction, and other methods can be used for separation and purification. Finally, quality analysis and characterization of the obtained liquid antioxidant 4,6-bis (octylmethyl) o-cresol were carried out to ensure that its quality and performance meet the expected requirements.
Antioxidant 1520 has a wide range of applications in the chemical industry, mainly as a stabilizer for antioxidants and other polymer materials. The following are its specific applications in the chemical industry:
|
|
|
|
In the synthetic rubber industry, it is used as an antioxidant to prevent oxidation and aging of rubber during processing and long-term use. It slows down the oxidation process of rubber by capturing free radicals and inhibiting chain reactions, thereby improving the stability and durability of rubber. This antioxidant is particularly suitable for synthetic rubbers such as butadiene rubber, styrene butadiene rubber, ethylene propylene rubber, and nitrile rubber, and can effectively extend the service life of rubber products.
In the plastic industry, as a stabilizer, it can inhibit the oxidative degradation of polymer materials during processing and use. It can work synergistically with other components in polymer materials to improve the thermal stability, photostability, and oxygen resistance of the material, thereby extending the service life of plastic products. This stabilizer is particularly suitable for plastic materials such as polyethylene, polypropylene, and polyvinyl chloride.
In the coatings and ink industry, it can be used as an additive in coatings and inks. It can improve the antioxidant and weather resistance of products, and prevent ink and coatings from deteriorating due to oxidation during use. In addition, it can also improve the drying speed and adhesion of ink and coatings, and enhance the quality and stability of products.
In the fiber industry, it can be used in the production process of synthetic fibers. It can be added as an additive to the spinning solution to improve the fiber's oxygen resistance and stability. This helps to extend the service life of fiber products and maintain their original performance.
It can be used as a catalyst in certain specific organic synthesis reactions. By promoting the progress of chemical reactions, it can improve reaction efficiency and product purity. This catalytic effect is of great significance in the synthesis of fine chemicals and the preparation of specific polymer materials.
Adding 4,6-di (octylthiomethyl) o-cresol to fuel oil can enhance its antioxidant performance and reduce the oxidation and deterioration of the oil during storage and use. This helps to maintain the quality and performance of fuel oil, extending its service life.
Due to their antioxidant and low irritation properties, they are also used as ingredients in cosmetics and personal care products, such as skincare products and shampoo. It can protect the skin and hair from damage from free radicals, and delay the aging process of the skin and hair.
Adverse reactions
Antioxidant 1520 is a new type of high molecular weight liquid antioxidant widely used in the stabilization treatment of polymer materials such as rubber, plastics, lubricants, etc. Its molecular structure contains hindered phenolic and thioether groups, endowing it with excellent antioxidant properties. However, with the expansion of its application scope, attention to its adverse reactions has gradually increased. The following is a detailed description of its adverse effects:
|
|
|
|
|
Potential adverse reactions of Antioxidant 1520
Symptoms: Long term exposure or high concentration exposure may cause allergic reactions such as skin redness, itching, and rash.
Mechanism: The thioether groups in Antioxidant 1520 may cause irritation to the skin of certain individuals, especially those who are sensitive to sulfur compounds.
Case: A worker at a rubber factory was diagnosed with contact dermatitis due to long-term exposure to Antioxidant 1520 without wearing protective gloves, resulting in redness, swelling, and peeling of the skin on the hands.
Symptoms: Inhalation of vapor or dust from Antioxidant 1520 may cause respiratory irritation symptoms such as coughing, chest tightness, and difficulty breathing.
Mechanism: Volatile organic compounds (VOCs) may cause irritation to respiratory mucosa, especially during high-temperature processing.
Case: During the high-temperature extrusion process at a plastic factory, the volatilization of Antioxidant 1520 caused an increase in air concentration in the workshop, resulting in respiratory discomfort for multiple workers.
Aquatic toxicity: Antioxidant 1520 may cause acute or chronic toxicity to aquatic organisms such as fish and algae.
Mechanism: Sulfide groups and hindered phenolic groups may interfere with the normal physiological functions of organisms.
Experimental data: The LC ₅₀ (96 hours) for zebrafish is 10 mg/L, indicating moderate toxicity to aquatic organisms.
Health effects: Long term low-dose exposure may lead to chronic health problems such as liver and kidney function damage.
Mechanism: Antioxidant 1520 may be metabolized as an active intermediate in vivo, causing oxidative stress or cytotoxicity.
Animal experiment: Rats were orally administered 50 mg/kg/d Antioxidant 1520 for 90 consecutive days, resulting in hepatic vacuolization and renal tubular epithelial cell degeneration.
Synergistic effect with heavy metals: Antioxidant 1520 may exhibit synergistic toxicity with heavy metals such as lead and mercury, enhancing damage to living organisms.
Mechanism: Sulfide groups may form stable complexes with heavy metals, promoting their accumulation in the body.
Experimental data: When Antioxidant 1520 was combined with lead exposure, the degree of liver damage in mice was significantly higher than that in the single exposure group.
Monitoring and management of adverse reactions
Occupational Exposure Monitoring
Air concentration monitoring: Regularly monitor the concentration of antioxidant 1520 in the workshop air to ensure it does not exceed the occupational exposure limit (OEL).
Biological monitoring: Evaluating workers' exposure levels through the detection of metabolites in urine or blood.
personal protective measures
Skin protection: Operators should wear chemical resistant gloves and protective clothing to avoid direct skin contact.
Respiratory protection: In high-temperature processing or dusty environments, gas masks or respirators should be worn.
Eye protection: Wear chemical protective goggles to prevent steam or dust from entering the eyes.
Emergency response measures
Skin contact: Immediately rinse with plenty of water and seek medical attention if necessary.
Eye contact: Immediately rinse with plenty of water for at least 15 minutes and seek medical attention as soon as possible.
Inhalation: Quickly leave the scene to a place with fresh air, keep the respiratory tract unobstructed, and administer oxygen if necessary.
Environmental management
Wastewater treatment: Antioxidant 1520 production wastewater should be treated to ensure compliance with discharge standards.
Waste residue treatment: Waste residue should be managed according to hazardous waste management to avoid arbitrary disposal.
Recommendations for Safe Use of Antioxidant 1520
Reasonably control the dosage
Reasonably determine the dosage of Antioxidant 1520 based on the type of material and processing conditions to avoid excessive use.
01
Optimize processing technology
During high-temperature processing, ventilation should be strengthened to reduce the concentration of antioxidant 1520 in the air.
02
Alternative development
Develop less toxic and environmentally friendly antioxidants to reduce reliance on Antioxidant 1520.
03
Regulations and Standards
Comply with national and local environmental regulations to ensure that the production, use, and emissions of Antioxidant 1520 meet standards.
04
Future research directions
Toxicity mechanism research
In depth study of the toxicity mechanism of Antioxidant 1520, particularly the impact of its metabolites on living organisms.
Low dose long-term exposure study
Conduct animal experiments on low-dose long-term exposure to evaluate its impact on chronic health.
Alternative development
Develop antioxidants based on natural products or biobased materials to reduce reliance on chemically synthesized antioxidants.
Research on Environmental Behavior
Study the migration, transformation, and fate of antioxidant 1520 in the environment, and evaluate its long-term impact on ecosystems.
FAQ
Q1: What is Antioxidant 1520?
A: It is a type of high-molecular hindered phenolic antioxidant. Its chemical name is usually β-(3,5-dibutyl-4-hydroxyphenyl) propionic acid pentaerythritol ester. It is mainly used in polymer materials (such as plastics, rubber, and fibers) to prevent thermal oxidative degradation during processing and use.
Q2: Can Antioxidant 1520 be used in food or health supplements?
A: Absolutely not. It is an industrial chemical additive and not a food or pharmaceutical-grade raw material. Using it for human ingestion, skincare, or as a health supplement is an extremely dangerous act that could cause serious harm to one's health.
Q3: What are its main functions and advantages?
A: In the industrial field, it can effectively prevent the yellowing, brittleness and strength reduction of materials caused by heat and oxygen. It has the advantages of low dosage, good compatibility and high extractability resistance. It is widely used for the stabilization of plastics such as polyethylene and polypropylene.
Q4: What should be noted when using Antioxidant 1520?
A: During operation, one should follow the safety guidelines for industrial chemicals to avoid inhaling dust or coming into contact with the skin or eyes. The most important point is that the industrial uses of these chemicals must be strictly distinguished and they must not be confused with concepts such as food, medicine, dietary supplements, etc. They should be stored away from living areas.
Hot Tags: antioxidant 1520 cas 110553-27-0, suppliers, manufacturers, factory, wholesale, buy, price, bulk, for sale, gs 441524 remdesivir, 2 6 Pyridinedicarboxylic acid, 3 Phenyltoluene, 2 4 Quinolinediol, Additive, squaric acid treatment