GS 441524 Powder is an intermediate of remdesivir, which is a white powder. The professional academic name of the chemical industry is remdesivir related compound 6, and the chemical name is 2-C - (4-aminopyrrolo [2,1-f] [1,2,4] triazin-7-yl) -2,5-hydro-d-altronitrile. Gs-441524 has a strong inhibitory effect on feline infectious peritonitis virus (FIPV), with a corresponding EC50 value of 0.78 μ M is dry and dark, with temperatures ranging from 0 to 4 degrees Celsius in the short term (days to weeks) and -20 degrees Celsius in the long term (months to years).
GS-441524 has strong antiviral activity and can inhibit the replication of various RNA viruses, such as feline infectious peritonitis virus. Therefore, GS441524 is considered a promising antiviral drug. The safety of GS-441524 is also quite high, and the vast majority of patients do not experience any abnormalities in blood indicators during use. However, there may be some possible side effects when using GS441524, including pain at the injection site. It should be noted that GS441524 may affect the development of permanent teeth in young cats without tooth replacement.
At the same time, our company not only provides GS-441524 pure powder, but also offers injections and tablets. If needed, please feel free to contact us.
GS-441524, Price off! 50% discount!!!
After the 3nd factory completed and put into use, the sales volume increased 3 times more during the last 3 months.
In order to growing with our stable clients together, we reset the price for the GS-441524 FIP series products, some items decreased over 50%!
Including API(Pure powder), OEM/ODM: Injection(20mg,30mg,40mg), tablet(25mg,45mg,60mg,70mg) etc.
Client Feedback
|
|
 |
 |
About Shipment
Successfully delivery all over the world:
GS-441524 powder COA
GS 441524 Powder, as a compound with unique chemical structure and significant biological activity, has attracted widespread attention in the pharmaceutical field, especially in the development of antiviral drugs, in recent years. Its unique pharmacological mechanism and broad application prospects make it a shining star in the field of antiviral research and treatment.
Biological activity
This product is a small molecule nucleoside analogue with specific functional groups in its chemical structure that enable it to mimic natural nucleotides, thereby exhibiting a range of unique biological activities in the body. These biological activities mainly include antiviral activity, inhibition of virus replication, and impact on virus life cycle.
This substance exhibits strong antiviral activity against various RNA viruses. This is mainly due to its ability to serve as a substitute substrate and RNA strand terminator for viral RNA dependent RNA polymerase. During virus replication, it can competitively bind to RNA polymerase, thereby interfering with virus RNA synthesis. In addition, it can also be inserted into the RNA strand being synthesized, causing premature termination of the RNA strand and further inhibiting virus replication.
Experimental studies have shown significant inhibitory effects on various RNA viruses, such as SARS coronavirus, Middle East respiratory syndrome virus, Ebola virus, etc. These findings provide a solid theoretical foundation for its application in the development of antiviral drugs.
Has demonstrated outstanding ability in inhibiting virus replication. It effectively inhibits the replication process of the virus by interfering with its RNA synthesis and insertion into RNA strands, leading to strand termination. This inhibitory effect has not only been demonstrated in vitro experiments, but also validated in animal models.
In animal experiments, it was used to treat animals infected with viruses, and the results showed that it could significantly reduce viral load, improve animal condition and survival rate. These results further confirm the effectiveness in inhibiting virus replication.
In addition to directly inhibiting virus replication, it may also exert antiviral effects by affecting the lifecycle of the virus. The lifecycle of a virus includes multiple stages such as virus entry into host cells, replication and transcription of the virus genome, assembly and release of virus particles, etc. It is possible to regulate the lifecycle of the virus by interfering with one or more of these stages.
Specifically, it may exert antiviral effects by affecting the virus's ability to enter host cells, interfering with the replication and transcription processes of the virus genome, or inhibiting the assembly and release of virus particles. The specific ways and effects of these mechanisms still need further research and verification.
Purpose
The unique biological activity makes it have broad application prospects in multiple fields. The following will explore in detail its applications in antiviral drug development, treatment of feline infectious peritonitis, and potential other uses.
GS 441524 Powder, as a small molecule compound with significant antiviral activity, has great potential in the development of antiviral drugs. It can inhibit the replication of various RNA viruses, providing the possibility for the development of broad-spectrum antiviral drugs.
Currently, multiple research teams are conducting drug design and optimization based on its structure and biological activity.
By introducing specific chemical modifications or combining with other antiviral drugs, the antiviral effect can be further improved and its potential side effects can be reduced. In addition, it can also serve as a probe or tool compound for antiviral drug development, used for screening and identifying new antiviral drug targets. By studying its interactions with key enzymes or structures involved in virus replication, new mechanisms of virus replication can be revealed, and new ideas can be provided for the development of novel antiviral drugs.
In addition to the above purposes, it may also have other potential application values. For example, it can be used as a candidate compound for antiviral drugs to prevent and treat other diseases caused by RNA viruses. In addition, it can also serve as a tool compound for biomedical research, used to study the mechanisms of virus replication and host cell interactions.
However, it should be noted that as a novel compound, its safety and efficacy still require further research and validation.
Before applying it to new therapeutic fields, sufficient preclinical and clinical research is needed to ensure its safety and efficacy. GS-441524, as a compound with unique chemical structure and significant biological activity, has broad application prospects in the development of antiviral drugs and the treatment of feline infectious peritonitis. It can inhibit the replication of various RNA viruses, providing the possibility for the development of broad-spectrum antiviral drugs; At the same time, it has also shown significant effects in the treatment of FIP, providing new hope for the treatment of FIP.
Gs-441524 powder. According to the experimental research, he has a strong inhibitory effect on feline infectious peritonitis virus (FIPV) as a raw material drug.
In order to confirm its effect, many in vivo and in vitro experiments have been carried out.
The in vivo experiments were as follows:
10 cats receiving treatment responded quickly to the treatment, and the lymphocyte level and rectal temperature of two asymptomatic cats returned to the level and level before infection. Of the 10 cats receiving treatment, 16-116 (Group A) and 16-127 (Group B) developed recurrent diseases after 4 and 6 weeks of treatment. The two cats received the second treatment within two weeks, and their reaction was the same as that of the first treatment.
So far, all 10 cats that have received one or two treatments have maintained a normal state (more than 8 months after infection). Within 10 seconds after administration, injection of some cats may cause a transient "tingling" reaction. Local and transient pain is characterized by unusual posture, licking the injection site, and/or vocalization lasting 30-60 seconds after injection. Compared with other animals, the injection reaction of some animals is more obvious. The reaction of one injection to another injection is inconsistent and weakens with time.
In vitro experiment:
Cells could grow normally under all concentrations of gs-441524, and could not absorb the fluorescent dye celltox green within 24 hours. Therefore, the cytotoxicity concentration - 50% (cc50) is greater than 100 μ The effective concentration of Mgs-441524-50% (EC50) is calculated as 0.78 μ M Therefore, repeated studies of these two experiments confirmed the inhibitory effect of gs-441524 on viruses in animals.
BLOOM TECH is the supplier of GS-441524 Powder.
Remark: BLOOM TECH(Since 2008), ACHIEVE CHEM-TECH is the subsidiary of us.
The following is a possible method for laboratory synthesis of GS 441524 Powder:
Starting materials: The starting materials required for synthesizing GS-441524 include 2-deoxy-D-ribose-5 '- phosphate, 2-amino-6-hydroxypurine, phosphorus oxychloride, and ammonia water. These raw materials are essential components required in the synthesis process.
Protective group: Before proceeding with the next reaction, the phosphate group needs to be protected to avoid interfering with the subsequent reaction. Common phosphate ester protection groups can be used, such as tosyl group or benzyl group. These protective groups can be removed under specific conditions, thereby restoring the activity of phosphate groups.
Phosphorylation reaction: The key intermediate, 2-deoxy-D-ribose-5 '- phosphate, is synthesized by reacting 2-deoxy-D-ribose-5' - phosphate with phosphorus oxychloride under suitable conditions. This reaction requires strict control of reaction temperature and time to ensure the smooth addition of phosphate groups to sugar groups.
Remove protective groups: After completing the phosphorylation reaction, the previously added protective groups need to be removed. This can be achieved by using specific deprotective reagents and conditions, such as reacting with protective groups using reagents such as sodium methoxide or sodium hydroxide to remove them and restore the activity of phosphate groups.
Purine substitution: Under suitable conditions, 2-amino-6-hydroxypurine is reacted with deprotected 2-deoxy-D-ribose-5 '- phosphate to synthesize the key intermediate 6- (2-deoxy-D-ribose-5' - oxygen) -9- (2,6-bis (2,6-dimethylmorpholine) -9H purine) - N4- (trimethylsilane) -2 '- deoxyadenosine. This reaction requires controlling the reaction temperature, time, and concentration of the raw material to ensure the smooth substitution of purines onto phosphate groups.
Hydrolysis reaction: Under suitable conditions, the key intermediate is reacted with phosphorus oxychloride and ammonia to synthesize GS-441524. This reaction requires controlling the reaction temperature, time, and concentration of raw materials to avoid excessive or incomplete hydrolysis.
Purification: After completing the synthesis, it is necessary to purify GS-441524. Separation and purification methods such as silica gel column chromatography and high-performance liquid chromatography can be used to remove impurities and obtain high-purity GS-441524 products.
It should be noted that the method of synthesizing GS-441524 in the laboratory may vary depending on specific experimental conditions and operating techniques. Therefore, before conducting synthesis experiments, it is necessary to carefully study and design experimental plans to ensure the high-purity GS-441524 product is obtained. Detailed characterization and analysis are also needed to confirm the chemical structure and purity of the synthesized product.
The molecular structure of GS 441524 Powder can be described in different ways. The following is a detailed analysis of its molecular structure:
Molecular configuration
The molecular configuration of GS-441524 is tetrahedral. This configuration is composed of three phosphate groups and two sugar groups. Among them, each phosphate group is connected to the sugar group through a single bond, forming a five membered circular structure.
Molecular composition
GS-441524 is composed of phosphate groups, sugar groups, and nitrogen groups. Among them, the number and position of phosphate groups are one of the key characteristics of this compound. GS-441524 has three phosphate groups located at three different positions in the compound, namely the carbon atom of two sugar groups and the oxygen atom of one nitrogen group.
Molecular formula
The molecular formula of GS-441524 is C10H15N5O10P3, with a molecular weight of 407.23. This means that the compound consists of 10 carbon atoms, 15 hydrogen atoms, 5 nitrogen atoms, 10 oxygen atoms, and 3 phosphorus atoms. The number and type of these atoms are of great significance for the molecular structure and chemical properties of compounds.
Molecular structure
The molecular structure of GS-441524 can be analyzed through its chemical bonds and atomic interactions. There are multiple bonds in the molecular structure of this compound, including carbon carbon single bonds, carbon hydrogen single bonds, carbon oxygen single bonds, carbon nitrogen single bonds, phosphorus oxygen single bonds, and nitrogen hydrogen bonds. The formation and cleavage of these bonds are of great significance for the chemical reactions and biological activities of compounds.
Frequently Asked Questions
How long can a cat go without being dewormed?
+
-
Adult cats must be dewormed either monthly or twice yearly, depending on their lifestyle and environment, while kittens need to be dewormed with the appropriate cat dewormer at two, four, six, and eight weeks of age. Kitten deworming is especially crucial since they can contract worms from their mothers' milk.
Can tapeworms live on a couch?
+
-
Such environments may include contaminated hands, food, drink, bedding, clothing or furniture. It is also important to mention that tapeworm eggs can survive for up to two weeks outside the human body.
How do you know worms are gone in cats?
+
-
Symptoms of worms in cats
Excessive grooming under their tail, possibly causing hair loss. Spaghetti-like roundworms in poo or vomit. Small white things in poo that look like grains of rice are tapeworm segments. Tapeworm segments may also be stuck in the hair around your cat's bottom and tail.
Hot Tags: gs 441524 powder cas 1191237-69-0, suppliers, manufacturers, factory, wholesale, buy, price, bulk, for sale, 3 methyl 4 piperidone, Additive, Synthetic Chemical, 2 Chloro 4 pyridinecarboxylic acid, DIMETHYLPHOSPHINE OXIDE, 3 Phenyltoluene