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(R)-(+)-1-Phenylethylamine, also known as R (+) -1-phenylethylamine or (R) - (+) -1-phenylethylamine, is a colorless liquid that can be mixed with alcohol ethers, soluble in water, strongly alkaline, capable of absorbing CO2 from the air, and has an aromatic odor. The molecular formula of R (+) - alpha methylbenzylamine is C8H11N, with a molecular weight of 121.18 and a CAS of 3886-69-9. It has optical rotation and a specific optical rotation of 40 º (near). Other physical data include a density of 0.952 g/mL at 20 ℃ (lit.), a melting point of -10 ℃, and a boiling point of 187-189 ℃ (lit.). With the rapid development of stereochemistry, the creation of optically active pesticides has become a hot topic in the field of pesticide research. Due to its high efficiency, low toxicity, low residue, low cost, and strong market competitiveness, it has attracted the attention of scientists from various countries. It is predicted that by 2025, 20% of pesticide products in the international market will produce and use single enantiomers, which is one of the directions for the development of new pesticide technologies. R (+) - alpha methylbenzylamine is a commonly used chiral reagent.
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Chemical Formula |
C8H11N |
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Exact Mass |
121.09 |
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Molecular Weight |
121.18 |
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m/z |
121.09 (100.0%), 122.09 (8.7%) |
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Elemental Analysis |
C, 79.29; H, 9.15; N, 11.56 |
(R)-(+)-1-Phenylethylamine, also known as R (+) -1-phenylethylamine, is a chemical substance with multiple application values.
As an important chiral additive, it plays a crucial role in the field of chemical synthesis. Chiral adjuvants refer to compounds with specific chiral structures that can participate in asymmetric synthesis reactions and help generate products with specific stereo structures. This characteristic makes it widely applicable in drug synthesis, pesticide synthesis, and the preparation of other fine chemicals.
In drug synthesis, chiral drugs often have higher biological activity and lower toxicity and side effects. By using R as a chiral adjuvant, precise control of the three-dimensional structure of drug molecules can be achieved, thereby improving the efficacy and safety of drugs. In addition, it can also be used to synthesize pesticides with specific chiral structures, which typically have higher insecticidal activity and lower environmental pollution.
It is also a chiral amine used to determine the purity of acid enantiomers. In chemical analysis, enantiomers refer to compounds with the same molecular formula but different stereostructures. Due to their different physical and chemical properties, it is necessary to separate and determine their purity in practical applications.
By using this substance as a chiral amine, specific derivatives can be formed with acid enantiomers, enabling their separation and purity determination. This method has the advantages of easy operation, high sensitivity, and good accuracy, and has wide application value in fields such as drug analysis, pesticide analysis, and environmental monitoring.
The application in drug synthesis is very extensive. Here are some specific examples:
(1) Intermediate for synthesizing bortezib: borteib is an important anti-tumor drug that requires the use of this substance as an intermediate during its synthesis process. High optical purity bortib related substances can be prepared by addition reactions, sulfonation or halogenation reactions with 3-methylbutanal and bis (cyclopentadienyl) boronic acid ester, followed by amination reactions and catalytic hydrogenation debenzylation reactions. This method is not only cost-effective and easy to obtain raw materials, but also has mild reaction conditions and high optical purity, making it very suitable for industrial production.
(2) Synthesis of other drugs: In addition to borteib, it can also be used to synthesize various other drugs. For example, it can be used to synthesize compounds such as (1R, 2R) -1,2-cyclohexanedimethanol dimethyl sulfonate, which have important application value in drug synthesis.
It also has important applications in the preparation process of organic-inorganic hybrid lead-free piezoelectric crystals. Piezoelectric crystal is a material that can convert mechanical energy and electrical energy into each other, and has broad application prospects in fields such as sensors and actuators. However, traditional piezoelectric crystals often contain lead elements, which pose potential hazards to the environment and human health. Therefore, the development of lead-free piezoelectric crystals has become a current research hotspot.
R(+)-alpha methylbenzylamine can be mixed uniformly with raw materials such as bismuth oxide and hydrobromic acid, and then heated and cooled twice in an oven to prepare organic-inorganic hybrid lead-free piezoelectric crystals. This crystal not only has excellent piezoelectric properties, but also achieves lead-free preparation, making it more environmentally friendly. Therefore, it has important application value in the preparation process of organic-inorganic hybrid lead-free piezoelectric crystals.
(R)-(+)-1-Phenylethylamine (R(+)-1-phenylethylamine) is an important chiral compound with wide applications in drug synthesis, pesticide preparation, and organic-inorganic hybrid materials. There are various synthesis methods, and the following is a detailed introduction to several common synthesis methods.
Optical splitting method
Optical splitting is a commonly used method for preparation. This method mainly utilizes the optical activity differences of mixed spinning α - methylbenzylamine under specific conditions for separation. The specific process is as follows:
(1) Salt formation and separation:
Reacting mixed spinning α - methylbenzylamine with a chiral acid (such as camphorsulfonic acid, tartaric acid, 2-phenylpropionic acid, etc.) to form enantiomeric salts with different solubilities.
Separate by utilizing the solubility differences of these salts in specific solvents such as ethanol, methanol, etc.
(2) Hydrolysis and Purification:
Hydrolyze the separated salt to release this product or S (-) - alpha methylbenzylamine.
Obtain high-purity substances through further purification steps such as distillation, recrystallization, etc.
The advantage of optical separation method is that it can efficiently prepare substances with high optical purity. However, this method requires the use of specific chiral separating agents, and the separation process may be complex and costly.
There are various synthesis methods, including optical separation, chiral synthesis, chemical separation and recombination, enzyme catalysis, and other synthesis methods. These methods each have their own advantages and disadvantages, and are suitable for different synthesis needs and conditions. In practical applications, it is necessary to select the most suitable synthesis method based on specific circumstances, optimize reaction conditions and purification steps, in order to obtain high-purity and high-yield (R)-(+)-1-Phenylethylamine. With the continuous advancement of science and technology and the increasing awareness of environmental protection among people, there may be more innovative, efficient, and environmentally friendly synthetic methods developed in the future to meet the demand for high-purity chiral compounds in different fields.
What are the sales channels for this compound?
(R)-(+)-1-Phenylethylamine, Also known as R (+) - alpha methylbenzylamine, its sales channels mainly include the following:
Manufacturer direct sales
Professional manufacturers: Many professional chemical reagent or API manufacturers, such as Wuhan Dingxintong Pharmaceutical Co., Ltd., produce and sell this substance. These manufacturers usually have a complete production chain and quality inspection system, able to provide high-quality products, and provide quality inspection forms and charts along with the goods. Manufacturer direct sales have advantages such as price transparency, reliable quality, and stable supply, making them the preferred choice for many buyers.
Factory Direct Shipping: Some manufacturers also offer factory direct shipping services to ensure product freshness, reduce intermediate links, and lower costs.
Distributors of chemical reagents and active pharmaceutical ingredients
Chemical reagent distributors: well-known chemical reagent distributors such as Aladdin reagent and McLean reagent also sell various chemical reagents including them. These distributors usually have a rich product line that can meet the diverse needs of buyers.
API distributors: API distributors also sell this compound, and they typically collaborate with multiple manufacturers to provide a variety of product options in terms of specifications and packaging.
E-commerce platform
Chemical e-commerce platform:Professional chemical e-commerce platforms such as ChemicalBook and Gade Chemical provide rich information on chemical reagents and active pharmaceutical ingredients, including this substance. Buyers can view product details, prices, supplier information, and directly contact and purchase from suppliers on these platforms.
Integrated e-commerce platforms: Some integrated e-commerce platforms also involve the sales of chemical reagents and active pharmaceutical ingredients, but compared to professional chemical e-commerce platforms, their product lines may be more extensive, and their professionalism may be slightly lower.
International Trade and Import Channels
International trading companies: Some international trading companies specialize in the import and export of chemical reagents and active pharmaceutical ingredients. These companies usually have rich international trade experience and resources, and can provide convenient import and export services to customers.
Overseas procurement: For some high-quality products, buyers can also choose to purchase directly from overseas manufacturers or distributors. Overseas procurement may require consideration of transportation costs, tariffs, customs clearance, and other issues, but it can provide more diverse product choices and more favorable prices.
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