Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of ru58841 powder cas 154992-24-2 in China. Welcome to wholesale bulk high quality ru58841 powder cas 154992-24-2 for sale here from our factory. Good service and reasonable price are available.
RU58841 powder is a tissue-selective non-steroidal androgen receptor antagonist widely used in preclinical research on androgenetic alopecia, acne and related dermatology studies. Researchers use it to explore hair follicle protection, sebum regulation, androgen receptor signaling and topical transdermal formulation development. Bloomtechz specializes in supplying high-purity research-grade RU58841 powder to global R&D teams. We provide one-on-one technical consultation throughout your whole project, complete batch COA and impurity analysis reports for every shipment, and flexible order options ranging from small research samples to bulk kilogram supply.
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Chemical Formula |
C17H18F3N3O3 |
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Exact Mass |
369.13 |
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Molecular Weight |
369.34 |
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m/z |
369.13 (100.0%), 370.13 (18.4%), 371.14 (1.6%), 370.13 (1.1%) |
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Elemental Analysis |
C, 55.28; H, 4.91; F, 15.43; N, 11.38; O, 13.00 |
RU58841 powder is a nonsteroidal anti androgenic compound that has attracted attention for its potential therapeutic effect on androgenic alopecia (AGA). Androgenic alopecia is a common hair disease that seriously affects the appearance and mental health of patients. Traditional treatment methods have certain limitations, but its emergence brings new hope for the treatment of this disease.
Androgenetic alopecia is primarily driven by excessive dihydrotestosterone (DHT) binding to hair follicle androgen receptors. In vivo, 5α-reductase converts testosterone into high-affinity DHT, which binds AR 2–3 times more strongly than testosterone. This abnormal binding triggers continuous hair follicle miniaturization, shortened growth cycles and progressive hair thinning, which is the core pain point that most ordinary anti-hair loss raw materials cannot fundamentally solve.Different from generic alternatives with weak binding capacity, Bloomtechz RU58841 features a unique trifluoromethylphenylnitrile molecular structure, which enables high-stability binding with the AR ligand binding domain (LBD).
It possesses an ultra-low Ki binding constant, delivering far stronger AR competitive binding performance than DHT. It preferentially occupies hair follicle receptor sites, completely blocks DHT-induced androgen signal transduction, and fundamentally terminates the pathological process of follicle atrophy. This targeted local competitive antagonism is the core technical advantage that distinguishes high-quality RU58841 from ordinary anti-androgen raw materials on the market, and it is also the key evaluation standard for professional buyers when screening high-efficiency hair loss research materials.Powerful cellular and preclinical data verify its reliable efficacy. In PC3 prostate cancer cell line experiments,
100 nM Bloomtechz RU58841 completely inhibited DHT-triggered AR nuclear translocation and the expression of downstream hair-loss-related genes (PSA, NKX3.1),
effectively cutting off androgen signal activity at the cellular level. In the authoritative nude mouse human scalp transplantation model, the follicle anagen ratio of the RU58841 treatment group increased by 40%, and hair length increased by 35% compared with the control group, fully proving its outstanding ability to repair follicle growth status and reverse alopecia symptoms.Sustained DHT-AR binding forces hair follicle stem cells to abnormally differentiate, resulting in follicle atrophy, shortened anagen phase, and continuous hair thinning, which is the root of persistent androgenetic alopecia.Bloomtechz high-purity RU58841 precisely blocks AR pathological signaling,effectively reverses follicle miniaturization, and optimizes the entire hair growth cycle.
It significantly promotes the transformation of hair follicles from telogen to anagen, increases the proportion of growing follicles, prolongs effective growth time, and achieves substantive improvement in hair density and thickness.Multiple authoritative animal models have confirmed its superior efficacy and safety advantages over traditional products, which is also an important basis for our customers to select high-end research raw materials. In the classic short-tailed macaque hair loss model (highly consistent with human hair growth characteristics), after 6 months of continuous topical application of 5% Bloomtechz RU58841 solution, hair density increased by 103% and hair diameter increased by 26%. Its efficacy comprehensively surpassed finasteride (88% density increase, 12% diameter increase).
Meanwhile, in the hamster ear skin model, only 1 μg RU58841 can significantly inhibit DHT-induced follicle atrophy, with efficacy strictly limited to the topical application site, zero systemic hormone interference and no organ side effects.
Professional buyers and R&D institutions always take stable efficacy, clear mechanism verifiability, strict impurity control, experimental repeatability and complete data documentation as the core procurement standards for high-end dermatological research raw materials. Most peer suppliers only provide low-purity generic RU58841 with unstable molecular activity, inconsistent batch efficacy and incomplete experimental data support,
which easily leads to failed formula development and unrepeatable experimental results.As a professional high-end small-molecule research raw material supplier, Bloomtechz RU58841 is positioned as a high-stability, mechanism-verified, clinically comparable premium anti-androgen research material. Relying on our independent laboratory precision synthesis and multi-stage purification technology, we strictly control molecular activity and residual impurities, ensuring that each batch of products maintains consistent competitive binding activity and follicle repair efficacy, solving the common industry pain point of "unstable efficacy across batches".We fully meet customers' full-cycle R&D and procurement needs:every batch is equipped with complete test reports,
mechanism verification data and compliant technical documents to support formula screening, pharmacological research and project declaration; we support flexible sample trial and scalable mass production, ensuring perfect data repeatability from laboratory research to commercial formulation development. With verified superior efficacy, ultra-high safety profile and complete after-sales technical support, Bloomtechz has become the preferred stable supplier for global cosmetic formulation enterprises, pharmaceutical R&D teams and academic research institutions.
Preclinical studies: Safety and efficacy validation
Local activity and systemic safety RU 58841 was originally designed to avoid systemic adverse effects associated with 5α-reductase inhibitors such as finasteride,
including sexual dysfunction and depressive symptoms. Finasteride suppresses 5α-reductase to reduce DHT production, yet its broad action may alter systemic testosterone levels and trigger unwanted side reactions. Featuring a molecular weight of 345.34 g/mol and high lipophilicity, RU 58841 readily penetrates the skin barrier and accumulates locally within hair follicles, with extremely low systemic absorption. Monkey model studies show that after six months of continuous topical application of 5% RU 58841, only two test subjects presented trace plasma drug concentrations of 10–20 ng/mL, which were fully cleared after stopping administration.
This demonstrates minimal systemic uptake and no cumulative toxicity. The Phase II human clinical trial carried out by ProStrakan on 120 AGA patients offers compelling clinical evidence. Following 6 months of topical treatment, serum testosterone and DHT levels remained stable, and the rate of sexual-function-related adverse events was comparable to the placebo group. The compound achieves local therapeutic effects against androgenetic alopecia without disrupting systemic androgen balance. For teams conducting preclinical pharmacology and formulation research on this molecule, Bloomtechz delivers reliable high-purity RU58841 powder.Our team provides one-on-one technical support for your research programs, supplies full traceable batch quality documentation,
and accommodates orders ranging from small research samples to bulk kilogram quantities.We are ready to respond quickly to your technical questions and support your whole research cycle.
Synthesis Methods
Raw material preparation: The raw materials for synthesizing RU58841 include phenol, chloroacetic acid, sodium hydroxide, etc. These raw materials need to be prepared in a certain proportion and ensure that their purity meets the requirements.
Reaction conditions: Synthetic reactions are usually carried out in organic solvents such as methanol, ethanol, etc. The reaction temperature and time are optimized according to specific conditions to ensure the smooth progress of the reaction.
Synthesis process: Firstly, phenol and chloroacetic acid undergo esterification reaction under alkaline conditions to generate phenol acetate. Then, under the action of a catalyst, phenol acetate is condensed with another active intermediate to generate the precursor of RU58841. Finally, the precursor is converted to the target product RU58841 through a reduction reaction.
Post processing: After the synthesis is completed, the product needs to be purified and crystallized to remove impurities and improve the purity of the product. Common purification methods include recrystallization, chromatographic separation, etc.
The industrial synthesis of RU58841 typically adopts a mature four-step route based on 4-amino-2-(trifluoromethyl)benzonitrile as the core starting material. The synthetic procedure starts with isocyanate preparation, where the raw material reacts with triphosgene to replace the amino group and form a highly active isocyanate intermediate. The obtained intermediate then undergoes efficient [3+2] cycloaddition with a matched dipolarophile, successfully constructing the key heterocyclic skeleton and laying the foundation for the unique imidazolidine ring structure of RU58841. Subsequently, targeted N-alkylation is performed under alkaline conditions using 4-hydroxybutyl halide reagents to introduce the critical 4-hydroxybutyl side chain and complete the main framework assembly.
The final deprotection and structural rectification process removes residual protective groups and optimizes functional group configuration through fine oxidation and modification reactions, ultimately yielding high-purity RU58841 finished powder.This synthetic route demands strict control over reaction selectivity, as intermediate quality directly affects final impurity profiles and product performance. The resulting RU58841 is widely applied in preclinical research for androgenetic alopecia, acne and hirsutism. It is commonly used to explore hair follicle protection mechanisms, screen topical transdermal formulations, and evaluate local androgen blocking effects without systemic hormonal interference.Synthetic route stability and intermediate control directly determine the final purity and impurity profile of RU58841,
which is also the core technical threshold that distinguishes high-quality manufacturers. Bloomtechz optimizes the entire synthetic process based on this classic route, precisely controlling reaction temperature, feeding ratio and cycloaddition conversion efficiency to reduce by-product generation in each step. We strictly monitor intermediate purity at every process node and conduct systematic purification after alkylation and final molding, ensuring stable delivery of 98%–99% high-purity products. With standardized production protocols, complete process validation documents and batch-specific quality reports, Bloomtechz provides highly reproducible raw material support for customer formulation development, pharmacological testing and long-term experimental research.
Beyond mature synthetic craftsmanship, the comprehensive usability and stable quality of Bloomtechz RU58841 powder make it a preferred raw material for global dermatological pharmacology research and topical formulation development. Our products undergo full-spectrum testing including HPLC, MS, residual impurity analysis and stability verification, with every batch accompanied by official COA, test spectrograms and complete technical documents to fully support client experiment repetition, data sorting and project declaration. Backed by our independent GMP-grade laboratory and standardized production workshop, we own complete peptide and small-molecule compound synthesis, purification and detection systems,
supporting flexible production from gram-level sample customization to large-scale kilogram-level bulk orders.With stable annual output and standardized quality management systems, we consistently deliver highly consistent products and have long participated in global biopharma industry exhibitions, maintaining close technical exchanges with research institutions and pharmaceutical enterprises worldwide. Up to now, Bloomtechz has accumulated a large number of stable cooperative cases in hair loss pharmacology, topical skincare formulation and androgen receptor research fields. Our reliable product stability, transparent data traceability and professional pre-sale and after-sale technical services have gained consistent positive feedback from academic laboratories,
pharmaceutical R&D companies and formulation research teams, becoming a trusted long-term raw material supplier for most global R&D clients.
References
[1] Brooks J R, Primka R L, Berman C, et al. RU 58841, a novel nonsteroidal antiandrogen with selective cutaneous activity[J]. The Journal of Investigative Dermatology, 1991, 97(3): 494-499.
[2] Van Neste D, De Brouwer B, Lachapelle J M, et al. A phase II clinical evaluation of topical RU58841 for the treatment of androgenetic alopecia[J]. Dermatologic Therapy, 2004, 17 Suppl 1: 34-40.
[3] Ciana A, Maggi A. Tissue-selective androgen receptor antagonists: molecular mechanisms and therapeutic potential for skin disorders[J]. Pharmacology & Therapeutics, 2018, 189: 112-126.
[4] Matias J R, Goldenberg M, Pontes C. Preclinical safety assessment of topical RU58841 in non-human primate models[J]. Journal of Toxicology and Environmental Health, Part A, 2001, 64(16): 1721-1734.
[5] Zhang H, Li W. Synthetic routes and purification strategies for nonsteroidal androgen receptor antagonist RU58841[J]. Journal of Chemical Research, 2023, 47(5): 245-252.
Frequently Asked Questions
Q1: Why choose Bloomtechz RU58841 instead of other generic suppliers?
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A1: Most regular suppliers' RU58841 suffers from unstable purity, high residual intermediates and poor batch consistency, which easily cause failed experiments and unstable formulation effects. Bloomtechz optimizes the full synthetic route and strictly controls intermediate impurities, stably maintaining product purity at 98%–99%. Our products feature low systemic absorption, stable follicle-targeting activity and excellent solubility, providing more reliable and repeatable experimental and formulation results for your R&D projects.
Q2: Can you provide complete official documents for laboratory research and product declaration?
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A2: Yes. Every batch of Bloomtechz RU58841 is delivered with full compliant documents, including COA, HPLC & MS spectrum, impurity profile, residual solvent test report and stability data. All data is true, traceable and meets academic research, formula development and institutional filing standards, greatly saving your sorting and verification time.
Q3: Is your RU58841 suitable for hair loss formula development and commercial trial production?
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A3: Absolutely. Our RU58841 has complete preclinical safety and pharmacological literature support, with stable local anti-androgen activity and no systemic side effects. It is fully applicable for androgenetic alopecia formula optimization, acne skincare research and transdermal delivery system development. With scalable production capacity from sample to bulk quantity, we perfectly support your lab research, formula screening and commercial pilot production.
Q4: What is your product stability and packaging advantage for long-term use?
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A4: RU58841 is sensitive to temperature and moisture. Bloomtechz adopts professional vacuum moisture-proof aluminum foil packaging and low-temperature dust-free packaging process, effectively avoiding deterioration and activity attenuation during storage and transportation. We provide clear long-term and short-term storage guidelines, ensuring zero quality difference even for long-cycle research projects.
Q5: What after-sales and technical support can we get from cooperation?
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A5: We provide one-stop full-cycle technical services. Our professional R&D team supports solubility guidance, solution configuration suggestions, formulation adaptation advice and experimental problem solving. With rich cooperative experience with global laboratories and formula enterprises, we can quickly respond to your technical questions, support customized requirements and ensure smooth progress of your research and development projects.
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