3-Bromo-1-propanol CAS 3084-40-0

1. Intermediate of antiviral drugs
It is a key intermediate for synthesizing nucleoside antiviral drugs. For example, in the synthesis of Tenofovir, the compound is linked to a nucleotide base and undergoes multiple reactions to obtain a drug with anti HIV activity. A listed pharmaceutical company increased the yield of key steps from 67% to 82% by optimizing the reaction conditions of the intermediate.

2. Development of anti-tumor drugs
L-selectin inhibitor: used for synthesizing dendritic polyglycerol anions, inhibiting adhesion between white blood cells and endothelial cells, reducing inflammation and tumor metastasis. In vitro experiments have shown that the inhibitor has a 78% inhibition rate on TNF - α - induced HUVEC cell adhesion.
Platinum complex anticancer drug: Its derivatives form complexes with platinum, which have shown significant inhibitory effects on lung cancer cell line A549 in vitro experiments. According to a 2023 article in the Journal of Medicinal Chemistry, its IC50 value is 0.8 μ M, which is 1.8 times lower than traditional cisplatin (1.5 μ M).

3. Anti inflammatory and immune regulation
The dendritic polyglycerol anion used for synthesizing L-selectin inhibitors has dual effects of anti-inflammatory and anti-tumor metastasis. By inhibiting the adhesion between white blood cells and endothelial cells, reducing inflammatory reactions, and suppressing tumor cell metastasis.
4. Modification of nucleic acid drugs
As a phosphorylation reagent, it is used to modify the 5 'end of siRNA or mRNA, improving the stability and cellular uptake rate of nucleic acid drugs. A gene therapy company used this technology to extend the half-life of siRNA in serum to 48 hours.

1. Precursors of insecticides
As a key precursor of organic phosphorus pesticides, this product is involved in the synthesis of highly efficient insecticide "Phosphorus". According to the statistics of Guangxi Plant Protection Station in 2022, the control effect of this pesticide on rice planthoppers reached 94.6%, and its toxicity to non target organisms (such as fish) was lower than that of similar products.

Synthesis of Chlorpyrifos: As a key precursor of organophosphorus pesticides, it participates in the synthesis of highly efficient insecticide "Chlorpyrifos". According to the 2022 statistics from Guangxi Plant Protection Station, the control effect of this pesticide on rice planthoppers reached 94.6%, and its toxicity to non target organisms such as fish was lower than that of similar products.
Mechanism of action: Fuling inhibits acetylcholinesterase activity, leading to the accumulation of the neurotransmitter acetylcholine in pests and causing overexcitation induced death.

2. Research and development of herbicides
Ethylphosphazone: Its derivatives have selective killing effects on malignant weeds such as barnyard grass and horseweed. An experiment conducted by a certain agricultural science institute in North China showed that the weed control rate increased to 89% after use in corn fields, without affecting the normal growth of corn.
Selective principle: This herbicide interferes with the shikimic acid pathway in weeds, inhibits the synthesis of aromatic amino acids, and leads to weed death.

3. Plant growth regulators
By reacting with plant hormone analogues, compounds with growth regulating functions are synthesized to promote crop growth, improve stress resistance and yield. The complex formed by coordination with rare earth elements can regulate plant hormone levels, promote root development and stress resistance. An experiment conducted by an agricultural technology company showed that tomato plants treated with this regulator had a 25% increase in drought resistance index.

1. Flame retardant materials
The 3-bromo-1-propanol based flame retardant prepared from this substance has been successfully applied as a material for electric vehicle battery pack shells. A test conducted by a new energy vehicle company shows that composite materials with 3% of the flame retardant have passed UL94V-0 certification.

2. Polymer modification
As a Mitsunobu reagent, it is used for the synthesis of phosphorylated norbornene copolymers. This copolymer has excellent thermal stability and mechanical properties, and can be used to prepare high-performance composite materials.

3. Lithium battery electrolyte additives
Its phosphate derivatives, as additives, can significantly improve the high-temperature cycling performance of batteries. According to test data from a certain research institute, after 500 cycles at 55 ℃, the battery capacity retention rate increased from 77% to 92%.

4. Light stabilizer
A new type of light stabilizer is prepared by reacting with hindered amine substances, effectively extending the service life of engineering plastics in outdoor environments. In 2021, test data from a certain automotive material supplier showed that ABS plastic with the added ingredient had a UV aging resistance time of 1800 hours.

1. Chemical reagents
In organic synthesis, it is commonly used as an important reagent for ester exchange reactions, alkylation reactions, etc. For example, ester exchange reactions occur with alcohol compounds under the action of catalysts, generating new ester compounds.

2. Catalyst
In the synthesis of polyurethane catalysts, the use of isocyanates in combination can significantly improve foaming efficiency. A well-known chemical enterprise's 2020 patent shows that the combination of this substance with isocyanates can increase foaming efficiency by 23%.

3. Metal surface treatment
The corrosion inhibitor formed by coordination with rare earth elements can reduce the corrosion rate of marine steel in 3.5% NaCl solution to 0.08 mm/a. After being applied by a certain shipping company in Qingdao, the equipment maintenance cycle has been extended to 2.3 times the original.

4. Chemical nickel plating stabilizer
Its unique molecular structure can effectively suppress the occurrence of side reactions and improve the service life of the plating solution. The production practice of a certain electroplating enterprise shows that the service life of the plating solution has been extended from 12 cycles to 18 cycles, and the porosity of the nickel layer has decreased by 40%.

1. Flame retardant materials
Phosphorus based flame retardants: copolymerized with nitrogen-containing compounds (such as melamine) to prepare phosphorus nitrogen synergistic flame retardants. A test conducted by a new energy vehicle company shows that PC/ABS composite materials with 3% of the flame retardant have passed UL94 V-0 certification.

Flame retardant mechanism: Phosphoryl groups decompose at high temperatures to form polyphosphoric acid, which promotes surface carbonization of the material and forms an insulation layer; Nitrogen releases non combustible gases, diluting the concentration of oxygen.

2. Catalyst
Mitsunobu reaction: As a nucleophilic reagent, it reacts with alcohols and phenols to form phosphate esters. A certain fine chemical enterprise utilized this reaction to synthesize polymers containing phosphate groups, with a yield of 92%.
In this reaction, diethyl hydroxymethylphosphonate reacted with phenol in the presence of diethyl azodicarboxylate (DEAD) to produce diethyl phenyl phosphate with a yield of 85%.

3. Functional polymer materials
3-Bromo-1-propanol copolymer: Introducing phosphate groups to endow the material with ion exchange properties. The copolymer prepared by a certain research team has an adsorption capacity of 1.2 mmol/g for Cu ² ⁺.

Biomedical application: this material can be used as a drug controlled release carrier. Phosphoric acid group and calcium ion cross link to form a gel to achieve drug sustained release.