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Argipressin is an artificially synthesized peptide hormone. Molecular formula C46H65N15O12S2, CAS 113-79-1. White or slightly yellowish amorphous powder with good fluidity. Mainly used to treat diseases related to abnormal antidiuretic hormone function. In clinical practice, it is a drug with multiple uses, mainly used to promote gastric acid secretion, improve gastrointestinal function, and for the diagnosis and treatment of related diseases. However, any medication has certain side effects and risks, so when using pentagastrin, it is necessary to fully understand its mechanism of action and side effects, and use it reasonably under the guidance of a doctor.
At the same time, for patients, it is also necessary to closely monitor their own situation. If there is any discomfort or suspected allergic reaction, they should seek medical attention in a timely manner and inform the doctor of their medication situation. However, it should be noted that the products produced by our company are primary chemicals and are only used for laboratory research purposes.
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Customized Bottle Caps And Corks:
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Chemical Formula |
C46H65N15O12S2 |
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Exact Mass |
1083 |
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Molecular Weight |
1084 |
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m/z |
1083 (100.0%), 1084 (49.8%), 1085 (12.1%), 1085 (9.0%), 1084 (5.5%), 1086 (4.5%), 1085 (2.8%), 1085 (2.5%), 1086 (1.9%), 1086 (1.2%), 1087 (1.1%) |
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Elemental Analysis |
C, 50.96; H, 6.04; N, 19.38; O, 17.71; S, 5.91 |
Argipressin, also known as antidiuretic hormone or antidiuretic hormone, is a peptide hormone released from the posterior pituitary gland. It plays an important role in regulating fluid balance, blood pressure regulation, and neural regulation.
1. Edema treatment: Due to its antidiuretic effect, it can be used to treat edema diseases. It reduces edema symptoms by reducing urine excretion and preventing excessive accumulation of water in the body.
2. Vasoconstrictive effect: It can constrict blood vessels and increase blood pressure. It stimulates smooth muscle contraction of blood vessels, promotes peripheral vascular contraction, thereby increasing peripheral resistance and raising blood pressure. This plays an important role in the treatment of circulatory diseases such as hypotension and shock.
3. Pregnancy and childbirth: play a regulatory role during pregnancy and childbirth. It can promote the contraction of uterine muscles, promote the occurrence and strengthening of contractions, and thus facilitate the progress of childbirth.
4. Blood volume regulation: It also participates in regulating blood volume. It can regulate fluid balance by affecting the reabsorption of water and sodium by the renal tubules, thereby affecting the maintenance of blood volume.
5. Shock treatment: Due to its vasoconstrictive effect, it can be used to treat shock states. In clinical practice, it is often used to treat severe conditions such as hemorrhagic shock and septic shock, where blood pressure drops, to help maintain blood pressure stability.
6. Coagulation function: It also participates in regulating coagulation function. It can stimulate platelet aggregation and release coagulation factors, thereby promoting the blood coagulation process.
In addition, arginine vasopressin acetate is also involved in some other physiological processes and diseases, such as cognitive function, learning and memory, social behavior, and autism. Although relevant research is ongoing, the exact role and mechanism of arginine vasopressin acetate in these fields are not yet fully understood.
Argipressin, also known as antidiuretic hormone (AVP) or arginine vasopressin, is an important neuropeptide hormone. It is a 9-peptide hormone secreted by neurons in the hypothalamic supraoptic nucleus and paraventricular nucleus, involved in the regulation of various physiological functions in the body. The common synthesis methods for arginine vasopressin acetate include the following:
The process for the preparation of this compound
1. Recombinant DNA technology:
By using recombinant DNA technology, arginine vasopressin acetate can be expressed in microorganisms (such as Escherichia coli) or mammalian cells. This method first requires constructing an expression vector containing the acetate arginine vasopressin gene, and then introducing it into host cells for expression. By optimizing expression conditions and purification methods, high-purity arginine vasopressin acetate can be obtained.
2. Biotechnology method
The biotechnology method utilizes biocatalysts (such as enzymes or microorganisms) to synthesize arginine vasopressin acetate. Common biotechnologies include solid-phase peptide synthesis, genetic engineering, and cell culture. Solid phase peptide synthesis is a method of sequentially connecting amino acids to a solid phase carrier, suitable for synthesizing shorter peptides. Genetic engineering is the production of a large amount of protein by expressing the gene for vasopressin acetate in cells through gene recombination technology. Cell culture is a method of producing arginine vasopressin acetate using cultured cells. The advantage of biotechnology is that it can achieve large-scale, efficient, and low-cost production, and the products usually have good biological activity.
3. Combinatorial chemistry method
Combination chemistry is a high-throughput synthesis method that screens and optimizes the structure and activity of arginine vasopressin acetate by simultaneously synthesizing multiple analogues. This method combines the advantages of chemical synthesis and biotechnology, allowing for the synthesis of a large number of analogues in a short period of time, and identifying candidate molecules with excellent performance through biological activity screening. Combination chemistry is suitable for drug discovery and optimization stages.
4. Natural extraction method
The natural extraction method extracts arginine vasopressin acetate from natural sources, such as the posterior pituitary or hypothalamus of animals. This method typically involves steps such as extraction, purification, and crystallization. The advantage of natural extraction method is that it can obtain acetate arginine vasopressin with a structure and activity similar to natural products, but the disadvantage is limited yield and may be limited by the quality and source of raw materials.
In summary, there are many synthesis methods for this, and the specific choice of method depends on the specific needs and goals of research or production. In practical applications, these methods may need to be combined or optimized to achieve optimal results.
Distribution Channel
Key points for choosing a distributor-When choosing an international pharmaceutical distributor, suppliers need to consider factors such as the distributor's reputation, sales ability, market coverage, and after-sales service. A good distributor should have a good market reputation and a stable customer base, and be able to effectively promote and sell Argiphressin products. At the same time, dealers should also have a sound logistics distribution system and after-sales service team to ensure that products can be delivered to customers in a timely and accurate manner, and to solve problems encountered by customers during use in a timely manner.
The role and advantages of distributors:International pharmaceutical distributors play an important bridging role in the international sales of Argiprressin. They usually have a wide sales network and customer resources, and are able to promote suppliers' products to various regions around the world. Distributors can also provide one-stop services such as warehousing, logistics distribution, and market promotion to alleviate the sales pressure on suppliers.
For buyers, purchasing Argiphressin through international pharmaceutical distributors can provide a more stable supply channel and more professional after-sales service.Introduction to well-known dealers-Sigma Aldrich: As a globally renowned supplier of chemicals and biological reagents, Sigma Aldrich has a wide sales network and high-quality product line. The company offers a variety of Argiphressin products in different specifications and purities to meet the needs of different customers. Its product quality is reliable, logistics and delivery are timely, and it enjoys a high reputation in the global scientific research and pharmaceutical fields.
Regulate various bodily functions
This 9-peptide hormone is secreted by specific neurons located in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Its primary functions encompass the regulation of various bodily functions, which are essential for maintaining homeostasis.One of the key roles of it is its involvement in water balance regulation. By acting on the renal collecting ducts, it promotes water reabsorption from the urine, thereby reducing urine volume and preventing dehydration. This action is crucial for maintaining normal hydration levels in the body.Additionally, it also has vasoconstrictive effects, which means it can narrow blood vessels.
This property helps to increase blood pressure in situations where it may be too low, such as during hemorrhage or shock. However, its vasoconstrictive effects are generally more pronounced in certain vascular beds, particularly those of the skin and viscera, while having less impact on skeletal muscle and coronary vessels.
Furthermore, it is also involved in the regulation of other physiological processes, including blood glucose levels and the secretion of certain hormones from the pituitary gland.
For instance, it can stimulate the release of adrenocorticotropic hormone (ACTH) from the anterior pituitary gland, which in turn regulates the production of cortisol and other glucocorticoids that are important for stress response and energy metabolism. Argipressin as an important bioactive substance, has a wide range of application value in fields such as medicine and scientific research. With the continuous development of the global pharmaceutical and research markets, the international market demand for Argiphressin is also gradually increasing.
FAQ
Is this the same as vasopressin?
MECHANISM OF ACTION: Vasopressin, also known as argipressin, is antidiuretic hormone, an endogenous peptide hormone released by the pituitary gland. It is a vasoconstrictor and its mechanism of action includes binding to V1 receptors on vascular smooth muscle to increase arterial blood pressure.
What is the role of it?
Synthesized in the hypothalamus and stored/released from the posterior lobe of the pituitary, it's primary function is regulating extracellular fluid volume. This agent can also act as a vasoconstrictor, increasing blood pressure and systemic vascular resistance.
How to titrate it?
The dose may be titrated between 0.6 units per hour and 2.4 units per hour. Doses above 2.4 units per hour must be discussed with the Consultant Intensivist. Higher doses have been associated with cardiac, digital and splanchnic ischaemia and cardiac arrhythmias, particularly if QTc prolonged.
What is the half life of it?
It has a plasma half-life of about 10 to 20 minutes. Approximately 5% of a subcutaneous dose of it is excreted unchanged in the urine four hours after dosing.
What is this 20 units?
This med AOP is indicated in adults for the treatment of diabetes insipidus, when this is not of nephrogenic origin, and control of bleeding from oesophageal varices. Diabetes Insipidus: A dose of 0.25 ml to 1 ml (5 to 20 units) by subcutaneous or intramuscular injection every four hours.
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