AOD 9604 powder, molecular weight 5138.77 g/mol, CAS 221231-10-3, Molecular formula C78H123N23O23S2. This relatively small molecular weight gives it good permeability and absorption in the body. It has good solubility and can dissolve in water and other common solvents. It usually exists in powder form and is redissolved when needed. It has good thermal stability and can be stored and used at higher temperatures within a certain range. However, prolonged exposure to extreme high temperatures may lead to its decomposition and loss of activity. Stable over a wide range of pH, able to maintain certain activity from acidic environments (low pH) to alkaline environments (high pH). In aqueous solutions, it is relatively stable and less prone to degradation and deactivation. This makes it have good stability when preparing injections or other forms of administration. It can form crystal structures and can be prepared into single crystal or polycrystalline forms under appropriate conditions. This is important for some research and analysis methods. It is a type of human growth hormone fragment, also known as a repair type human growth hormone fragment. It is a fragment composed of 44 consecutive amino acid residues, originating from the C-terminal region of human growth hormone.
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AOD 9604 Powder COA
Customized Bottle Caps & Corks
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AOD 9604 powder is a synthetic peptide compound. The chemical name is L-Phenylalanine. L - tyrosyl - L - leucyl - L - arginyl - L - isoleucyl - L - valyl - L - glutaminyl - L - cysteinyl - L - arginyl - L - seryl - L - valyl - L - alpha glutamylglycyl - L -Seryl-L-Cysteinylglycyl -, cyclic (7→14)-disulfide, with the molecular formula C78H123N23O23S2 and a molecular weight of 1815.1. The following elaborates on its chemical properties from multiple aspects.
Appearance and physical condition
AOD 9604 usually exists in the form of white powder and has no obvious odor. Its appearance features are closely related to purity. High-purity products (usually ≥98%) present as uniform and fine white powder, which is convenient for storage and use.
Solubility
The solubility of AOD 9604 in different solvents varies significantly:
DMSO (dimethyl sulfoxide)
Slightly soluble, with a relatively low solubility. To enhance the dissolution efficiency, heating or ultrasonic treatment is required.
Water
Some data indicate that it is soluble in water, but the dissolution rate is relatively slow. The dissolution process needs to be optimized by adjusting the pH value or adding a co-solvent.
Other organic solvents
It has poor solubility in common organic solvents such as ethanol and acetone, which limits its application in certain experimental systems.
Acidity, alkalinity and stability
Acidity coefficient (pKa)
The predicted value is 3.49±0.10, indicating that it is prone to protonation reactions under acidic conditions, affecting the molecular conformation and biological activity.
Thermal stability
It should be stored in a sealed container away from light at -20℃. For long-term storage, it is recommended to refrigerate at -15 to -20℃. High temperatures or light exposure may lead to degradation reactions such as peptide chain breakage and disulfide bond reduction.
Chemical stability
Sensitive to oxidants, disulfide bonds are prone to breakage in strongly oxidizing environments, leading to molecular inactivation. Avoid contact with heavy metal ions, strong acids and strong alkalis.
Molecular structure and functional characteristics
The molecular structure of AOD 9604 contains 15 amino acid residues, which form a cyclic structure (7→14 sites) through disulfide bonds. This special conformation endows it with the following functional characteristics:
Fat metabolism regulation: As a lipolysis fragment of growth hormone (HGH), AOD 9604 can specifically activate β 3-adrenergic receptors, promote fat breakdown and inhibit fat production, and has potential application value in the research of obesity treatment.
Low toxicity: Experiments show that its toxicity is relatively low and it has good safety, but the dosage and route of use need to be strictly controlled.
Storage and usage precautions
Storage conditions
For short-term storage (within one month), it can be kept at -20℃. For long-term storage, it should be stored at -80℃ in deep cold and avoid repeated freezing and thawing.
Solution preparation
It is recommended to dissolve in sterile water for injection or physiological saline. After preparation, it should be aliquoted and stored to avoid cross-contamination.
Safety precautions
Protective gloves and goggles must be worn during operation to avoid inhalation or skin contact. Waste should be treated harmlessly in accordance with the norms for the treatment of chemical reagents.
Application fields and limitations
AOD 9604 is mainly applied in:
Scientific research experiment: As a model compound for studying the mechanism of fat metabolism.
Pharmaceutical development: As a lead compound for potential weight loss drugs, but its clinical safety and efficacy need to be further verified.
Restriction: Currently, AOD 9604 has not been approved by the drug regulatory authorities for human treatment and is only for scientific research purposes. Its biological activity is significantly affected by molecular conformation, purity and storage conditions, and strict quality control is required.
Biological activity of stimulating fat decomposition and combustion
AOD 9604 Powder is a polypeptide substance with significant biological activity of stimulating fat breakdown and combustion, showing unique advantages in the fields of weight loss and weight management. The following elaborates in detail from aspects such as the mechanism of action, experimental evidence, and comparison with conventional methods.
Mechanism of Action
The mechanism by which AOD 9604 stimulates fat breakdown and burning is similar to that of Growth Hormone, mainly achieved by acting on the signaling pathways within adipocytes. It can activate the enzyme system related to fat breakdown within cells, promoting the breakdown of triglycerides in fat cells into free fatty acids and glycerol. This process is similar to the mobilization and utilization of fat by the body during exercise or starvation, transforming fat from a stored state to a state available for energy use.
Specifically, AOD 9604 can regulate the activities of key enzymes in the process of fat metabolism. For instance, it may affect the activity of enzymes such as hormone-sensitive lipase (HSL), which is one of the key enzymes in the fat breakdown process and can catalyze the hydrolysis of triglycerides into diglycerol esters and free fatty acids. AOD 9604 accelerates the decomposition of fat in adipocytes and increases the release of free fatty acids by activating enzymes such as HSL. These free fatty acids then enter the bloodstream and are transported to other tissues, such as muscle tissues, where they are oxidized and decomposed to provide energy for the body.
Experimental Evidence
A number of animal experiments have provided strong evidence for the effect of AOD 9604 in stimulating fat breakdown and combustion. In the study of ob/ob mice (an obese mouse model), AOD 9604 at a dose of 250 µg/kg was administered daily. The results showed that the body weight, epididymal adipose tissue mass and brown adipose tissue weight of the mice all decreased. This indicates that AOD 9604 can effectively promote fat breakdown and reduce the accumulation of fat in the body.
At the cellular level, after AOD 9604 acts on adipocytes, a decrease in triglyceride content within adipocytes and an increase in the release of free fatty acids can be observed. This further confirms the role of AOD 9604 in stimulating fat breakdown. Furthermore, some in vitro experiments have also found that AOD 9604 can affect the expression of related genes in adipocytes, such as promoting the expression of genes related to fat breakdown and inhibiting the expression of genes related to fat synthesis, thereby regulating fat metabolism at the genetic level.
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Comparison with Conventional Weight Loss Methods
Compared with conventional diet and exercise weight loss methods, AOD 9604 has unique advantages in stimulating fat breakdown and burning. Conventional dietary control mainly aims to lose weight by reducing calorie intake, but this approach may lead to a decrease in the body's metabolic rate. Once a normal diet is resumed, weight is prone to rebound. Although exercise for weight loss can increase energy expenditure, for some obese people, due to the heavy physical burden and limited exercise capacity, it is difficult for them to persist in high-intensity exercise.
AOD 9604 can directly act on fat cells, promote fat breakdown and provide energy for the body. The use of AOD 9604 can make people notice more weight loss in a shorter time. Moreover, compared with regular HGH supplements, when people use AOD 9604 for weight loss, they may notice fewer side effects than some people usually experience. This is because AOD 9604 mainly acts on fat metabolism and has a relatively small impact on aspects such as blood sugar and growth.
The Impact of Usage Method and Time on the Effect
AOD 9604 is usually in injection form and is best used on an empty stomach in the morning. When the stomach is empty in the morning, the body is in a relatively hungry state. At this time, using AOD 9604 can enable the drug to enter the bloodstream better and take effect immediately. During this period, the body's metabolism is relatively more active, and drugs can more effectively stimulate fat breakdown and burning.
If it is chosen to be used at other times, such as after meals, the digestion and absorption of food may affect the absorption and utilization efficiency of the drug. Moreover, after meals, the blood sugar level of the body rises and insulin secretion increases. Insulin has the effect of inhibiting fat breakdown, which may weaken the stimulating effect of AOD 9604 on fat breakdown.
Synergistic Effects with Other substances
AOD 9604 can also have a synergistic effect with other substances in stimulating fat breakdown and burning. For instance, when combined with exercise, exercise can increase the body's energy demand and promote the oxidative utilization of free fatty acids. The free fatty acids released by AOD 9604, which promotes fat breakdown, can better meet the energy demands during exercise, thereby enhancing the effect of weight loss.
In addition, some natural weight loss ingredients, such as green tea extract and caffeine, also have a certain effect in promoting fat metabolism. When used in combination with AOD 9604, they may produce a synergistic effect, further enhancing the effect of fat breakdown and burning. However, it should be noted that when using these substances, scientific and reasonable principles should be followed to avoid adverse reactions caused by excessive use.
Safety and Potential Risks
Although AOD 9604 shows good effects in stimulating fat breakdown and burning, it is currently mainly used for scientific research purposes and is not recommended for direct use on the human body. When conducting research with AOD 9604, it is necessary to strictly abide by the relevant safety regulations and operating procedures to ensure the safety of the laboratory personnel.
Because the mechanism of action of AOD 9604 is rather complex, it may have certain effects on the endocrine system of the body, etc. If it is blindly used on the human body without thorough research and verification, it may cause some potential risks, such as endocrine disorders and immune system abnormalities. Therefore, before applying it to the human body, a large number of clinical trials and safety evaluations need to be conducted.
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