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BPC 157 Powder, also known as Body Protection Compound 15 or Pentadecapeptide BPC 157, is a specific peptide derived from human gastric juice protein BPC, which is composed of 15 amino acids. Unlike other peptides, it is effective without the need for a carrier molecule. It can remain stable in human gastric juice for over 24 hours, indicating its resilience to the harsh environment of the stomach. This stability allows it to maintain its biological activity and efficacy, even in the presence of proteolytic enzymes that degrade other proteins. Thanks to its stability, it demonstrates good oral bioavailability. This means that it can be effectively absorbed into the bloodstream when administered orally, allowing for convenient and non-invasive therapeutic administration. The stability and bioavailability contribute to its ability to exert beneficial effects throughout the gastrointestinal tract. It has been shown to promote healing and protect the integrity of the gastrointestinal mucosa.
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BPC-157 Powder COA
Sealing test method
As a bioactive polypeptide, the packaging sealing property of BPC 157 powder is crucial to the product quality. The sealing property test aims to ensure the integrity of the packaging without leakage and prevent external moisture, oxygen, etc. from affecting the purity and biological activity of the powder. The following introduces the sealing test methods applicable to the packaging of BPC 157 powder and the key points of operation.
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Vacuum attenuation method
Principle: By creating a pressure difference between the inside and outside of the package through vacuuming, if there is a leakage and the gas escapes, causing a change in vacuum degree, the instrument can detect the pressure attenuation and calculate the leakage rate.
Applicability: It is suitable for vacuum-packed BPC 157 powder, with high detection sensitivity and strong repeatability, especially for low-viscosity products.
Operation steps:
Put the packaged samples into the vacuum chamber and connect the test system;
Start the vacuum pump and evacuate the air to the set pressure (such as below 10^-4Pa);
Monitor the changes in vacuum degree. If the pressure drop exceeds the allowable leakage rate (such as 0.1%), it is determined as leakage.
Record the location of the leakage (located by a helium mass spectrometer leak detector) and mark it.
Advantages: Non-destructive testing, suitable for quality control in mass production.
Bubble Method (Water Immersion Method)
Principle: Immerse the packaging in water and create a pressure difference by applying internal pressure (such as inflation or vacuuming). If there is a leakage, the gas will escape and form bubbles.
Applicability: Suitable for inflatable packaging or BPC 157 powder packaging with gas inside.
Operation steps:
Immerse the packaged samples completely in water to ensure no bubbles adhere.
A pressure difference is formed by external vacuuming or internal inflation (such as 0.5MPa);
Observe for 5 minutes. If continuous bubbles emerge, it is determined to be a leakage.
Record the leakage location and mark it.
Advantages: Simple operation, low cost, and suitable for packaging with large leakage.
Limitations: It has low detection sensitivity for tiny leaks (pore size <0.1mm) and is prone to misjudgment.
Negative Pressure Method (Vacuum Test)
Principle: Apply negative pressure inside the package and observe whether there is any deformation or bubbles emerging.
Applicability: Suitable for liquid packaging or BPC 157 powder packaging with liquid inside.
Operation steps:
Put the packaged samples into the vacuum chamber and connect the test system;
Start the vacuum pump and evacuate to the set pressure (such as -0.08MPa);
Maintain the pressure for 5 minutes and observe whether the packaging deforms or bubbles emerge.
If deformation or bubbles continue to emerge, it is determined as a leakage.
Advantages: Suitable for liquid packaging, it allows for direct observation of leakage phenomena.
Color Water Method (Tracer Solution Method)
Principle: Immerse the packaging in the colored liquid, evacuate the air, and then observe whether there is any colored water invading the interior.
Applicability: It is suitable for the pharmaceutical industry, especially for hard packaging such as ampoules and vials.
Operation steps:
Immerse the packaged samples in a colored liquid (such as water containing methylene blue);
Evacuate to the set pressure (such as -0.09MPa) and maintain for 10 minutes;
Take out the package, dry the surface and observe whether there is any colored water invading inside.
If colored water invades, it is determined as a leakage.
Limitations: Low detection sensitivity, significant influence from human factors, and prone to missing minor leaks.
High-voltage Discharge Method
Principle: By filling the packaging with high-pressure gas, the electrical signal changes at the leakage point are detected.
Applicability: It is suitable for glass packaging such as ampoules and vials, with fast detection speed and high accuracy.
Operation steps:
1.Put the packaged samples into the high-voltage discharge detector;
2.Fill in high-pressure gas (such as 0.1MPa) and start the detection;
3.The instrument locates the leakage point through the change of electrical signals.
4.Record the leakage location and mark it.
Advantages: Non-destructive testing, suitable for high-demand sealing testing.
Suggestions for the Selection of Detection Methods
Vacuum packaging
The vacuum attenuation method is preferred, featuring high sensitivity and strong repeatability.
Inflatable packaging
The bubble method is adopted, which is simple to operate and has a low cost.
Liquid packaging
Use the negative pressure method or the color water method to observe the leakage phenomenon directly.
Glass packaging
The high-voltage discharge method is adopted, which features fast detection speed and high accuracy.
Requirements for Testing Environment and Equipment
Environmental requirements
The test should be conducted in a clean environment with constant temperature and humidity (such as 25°C±2°C, 50%RH±5%RH), avoiding external vibrations and air flow interference.
Equipment requirements
Testing equipment (such as vacuum pumps, pressure sensors, and leak detectors) should be calibrated regularly to ensure that the accuracy meets the requirements.
Safety requirements
Operators should wear protective equipment to prevent injury caused by the leakage of high-pressure gas or liquid.
BPC 157 Powder is a stable gastric fifteen-peptide with various biological activities. Its stability is crucial for maintaining its biological activity and function. The following is a detailed introduction from aspects such as physical stability, chemical stability, biological stability, factors affecting stability, and methods for maintaining stability.
Physical Stability
Appearance and form
This powder is usually a white or grayish-white solid powder. During storage, if the physical stability is affected, phenomena such as powder caking and discoloration may occur.For instance, when powder is exposed to a humid environment, moisture may cause the powder particles to stick together, leading to caking. This not only affects the appearance of the powder but may also alter its physical properties such as solubility.
Solubility
This powder has a certain solubility, and its solubility varies in different solvents.At 25°C, it is slightly soluble in water, with a solubility of approximately 100 mg/mL (70.44 mM). The solubility in dimethyl sulfoxide (DMSO) is 50 mg/mL (35.22 mM). The solubility in ethanol is 12 mg/mL (8.45 mM). Its solubility is affected by factors such as temperature and the type of solvent. If the storage conditions are improper, such as excessively high or low temperatures, it may cause changes in the solubility of the powder, affecting its performance in experiments or applications.
Chemical Stability
Molecular structure
The molecular formula of BPC 157 is C62H98N16O22, and its molecular weight is 1419.536 (there is also a claim that it is 1419.56). Its chemical stability is mainly reflected in whether the molecular structure remains intact during storage and use. Under normal storage conditions, the molecular structure of this powder is relatively stable.However, under certain extreme conditions, such as strong acid or strong alkali environments, or affected by factors like high temperature and light, its molecular structure may change, leading to alterations in chemical properties and thereby affecting its biological activity.
Impurities and degradation products
Chemical stability also involves whether impurities or degradation products will be generated in the powder. If the storage conditions are not good, the powder may degrade, generating some impurities or degradation products. These impurities and degradation products not only reduce the purity of the powder, but also may pose potential risks to human health. For example, some degradation products may be toxic or immunogenic.
Biological Stability
Biological activity retention
The biological stability of this powder is mainly reflected in whether its biological activity can be maintained during storage and use. It has a variety of biological activities, such as promoting tissue repair, anti-inflammation, and neuroprotection. If the biological stability is affected, its biological activity may decrease or be lost, thus failing to achieve the expected therapeutic or research effect. For instance, during storage, if the powder is affected by factors such as oxidation and hydrolysis, it may lead to changes in its bioactive components and reduce its ability to promote tissue repair.
Impact on biological systems
Biological stability also involves the stability and safety of the powder in biological systems.After entering the biological system, it needs to maintain a certain stability in order to accurately exert its biological functions. At the same time, it must not have adverse effects on the biological system, such as causing immune responses, toxic reactions, etc.
Factors Affecting Stability
Temperature: Temperature is one of the important factors affecting the stability of BPC 157 powder. Generally speaking, low temperature is conducive to maintaining its stability. At higher temperatures, the molecular movement of the powder intensifies, which may accelerate the occurrence of chemical reactions, leading to the destruction of molecular structure or the generation of degradation products. For example, placing the powder in a high-temperature environment may reduce its biological activity. Low-temperature storage (such as freeze-drying at -20°C and keeping away from light) can slow down the rate of chemical reactions and extend the shelf life of the powder.
Illumination: Light exposure can also affect the stability of the powder.Light of certain wavelengths may trigger photochemical reactions, causing changes in the molecular structure of the powder. Therefore, during storage, it needs to be kept away from light to minimize the impact of light on its stability.
Humidity: Humidity is another important influencing factor. A high-humidity environment may cause the powder to absorb moisture, leading to problems such as caking and deterioration. Moisture may also participate in chemical reactions and accelerate the degradation of the powder. Therefore, this powder needs to be stored in a dry environment. It is usually recommended that the storage conditions be freeze-dried at -20℃ and kept away from light.
Packaging materials: The choice of packaging materials will also affect the stability of BPC 157 powder. Appropriate packaging materials can provide good sealing to prevent the entry of moisture, oxygen and light, thereby protecting the stability of the powder. For instance, by using low-temperature and vacuum packaging, and with precision to the milligram as required, the contact of the powder with the external environment can be reduced, thereby extending its shelf life.
Methods for Maintaining Stability
Appropriate storage conditions
In order to maintain the stability of the powder, appropriate storage conditions need to be provided.As mentioned earlier, it is generally recommended to store it in a low-temperature environment of -20°C, and keep it away from light and sealed. For long-term storage, it is also possible to consider keeping it at -20°C with inert gas to further reduce the impact of oxygen on its stability.
Avoid repeated freezing and thawing
Repeated freezing and thawing may have an adverse effect on the stability of BPC 157 powder. When taking the powder, the number of freeze-thaw cycles should be minimized as much as possible. If you need to take it out multiple times, you can consider dividing it into small portions and storing them separately. In this way, when taking it out, only the required part needs to be thawed, avoiding repeated freezing and thawing of the entire sample.
Regular inspection
Regular inspection of this powder can enable timely understanding of its stability and quality changes.The testing items can include appearance, purity, solubility, biological activity, etc. Through regular testing, problems can be identified and measures taken promptly, such as adjusting storage conditions or replacing samples, to ensure the quality and stability of the powder.
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