Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of pentapeptide-18 in skin care in China. Welcome to wholesale bulk high quality pentapeptide-18 in skin care for sale here from our factory. Good service and reasonable price are available.
Pentapeptide-18, a synthetic enkephalin analog, is widely used in in vitro cell models to study the regulatory mechanisms of neuropeptide-mediated facial muscle contraction signal transduction.
BLOOM has extensive experience in the Chinese market and has therefore developed international trade. Fine chemicals/pharmaceutical intermediates/custom organic synthesis/new compounds from lab to mass production.
Our Products Form
pentapeptide-18 COA
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| Certificate of Analysis | ||
| Compound name | Pentapeptide-18 | |
| Grade | Pharmaceutical grade | |
| CAS No. |
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| Quantity | 64g | |
| Packaging standard | PE bag+Al foil bag | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202601090058 | |
| MFG | Jan 9th 2026 | |
| EXP | Jan 8th 2029 | |
| Structure |
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| Item | Enterprise standard | Analysis result |
| Appearance | White or almost white powder | Conformed |
| Water content | ≤5.0% | 0.69% |
| Loss on drying | ≤1.0% | 0.55% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | ≥97.0% | 99.56% |
| Single impurity | <0.8% | 0.54% |
| Total microbial count | ≤750cfu/g | 80 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 470ppm |
| Storage | Store in a sealed, dark, and dry place below -20°C | |
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Pentapeptide-18 in Neuromodulation Mechanism Research
Verification Experiments on Opioid Receptor-Mediated Neural Signaling Pathways
As a synthetic enkephalin analog, Pentapeptide-18 acts as a specific tool ligand for the activation effect validation of delta-opioid receptors in in vitro neuron cell models.
BLOOM Researchers can quantitatively observe the changing pattern of downstream cAMP signaling pathways after receptor activation, and clarify its regulatory effect on neurotransmitter release.
Research on Local Skin Nerve-Muscle Signal Interaction Mechanism
Leveraging its characteristic of acting on superficial skin nerve endings, Pentapeptide-18 can be applied to construct an in vitro co-culture cell model (keratinocytes - Schwann cells - skeletal muscle cells).
It is used to analyze the regulatory logic of local skin nerve signals on facial expression muscle contraction, and clarify the quantitative correlation between acetylcholine release volume and dynamic wrinkle formation.
Exploration Experiments on Neurogenic Inflammation Regulatory Mechanism
In the UVB-induced skin photodamage inflammation model, Pentapeptide-18 can be used to verify its effect of down-regulating the release of neurogenic inflammatory factors such as substance P and calcitonin gene-related peptide (CGRP) through neural pathways. It helps researchers analyze the cross-action mechanism between neuromodulation pathways and skin photoaging.
Control Studies on the Structure-Activity Relationship of Peptide-Based Neuromodulators
With its defined YAGFL pentapeptide sequence and opioid receptor binding motif, BLOOM Pentapeptide-18 serves as a standard reference sample for the structure-activity relationship screening experiments of similar short peptides with neuromodulatory activities.
Structure-Activity Relationship of Peptide Neuromodulators
Take well-characterized classic neuromodulatory peptides such as Pentapeptide-18 as the fixed control sample, establish a unified activity evaluation baseline, and eliminate result deviations caused by different experimental systems.
Generate a series of structural derivatives through site-directed substitution of key amino acids, truncation of peptide chain length, introduction of D-amino acid modifications and other approaches, and compare the differences in receptor binding affinity among different structural variants one by one.
Synchronously compare the performance of different derivatives in three core dimensions: opioid receptor binding rate, downstream cAMP signal regulation intensity, and neurotransmitter release inhibition efficiency, to locate the key structural sites that determine the biological activity.
Screen out optimized peptide sequences with high selectivity and low off-target side effects based on the control experiment results, and provide direct experimental basis for the molecular design of new-generation lead compounds targeting neuromodulation.
Core Differences Between Pentapeptide-18 and Other Similar Neuromodulatory Peptides
BLOOM Pentapeptide-18, also known as Leuphasyl, is fundamentally different from other mainstream neuromodulatory anti-wrinkle peptides represented by Acetyl Hexapeptide-8 in its core action target. It targets delta-opioid receptors and regulates neurotransmitter release through an endogenous enkephalin-mimetic pathway, rather than the SNARE protein complex blocking mechanism adopted by most similar products. This unique mechanism endows it with irreplaceable value in scientific research.
Terms of research uniqueness
Pentapeptide-18 acts as a standard reference tool for studies on opioid receptor-mediated neuromodulation mechanisms, filling the long-standing research gap of non-SNARE pathway anti-wrinkle peptides. Other similar peptides are mostly only applicable to SNARE pathway intervention experiments and cannot support in-depth exploration of opioid-related neuroscience research directions.
Experimental application scope
Pentapeptide-18 covers 5 major research directions: opioid receptor signaling pathway validation, skin local nerve-muscle signal interaction analysis, neurogenic inflammation regulation mechanism exploration, peptide structure-activity relationship control study, and preliminary exploratory research on peripheral nerve injury repair. In contrast, most similar products are limited to conventional anti-wrinkle formulation development and simple efficacy verification experiments, with very narrow research coverage.
Research data completeness
Pentapeptide-18 has complete batch traceability, and a large number of publicly published academic literatures support its clear dose-dependent regulatory effect on the cAMP signaling pathway and intracellular calcium flux.
Most other similar products only have public data focused on cosmetic efficacy, and lack systematic and complete research support for neuroscience-related mechanisms.
Brief Service for Pentapeptide-18
Every batch of Pentapeptide-18 (purity ≥98%) is supplied with complete COA, HPLC chromatogram, mass spectrometry validation report and full traceability documents, which fully meet the data traceability requirements for high-level academic paper publication.
We provide full-process cold-chain transportation for global orders, with 3-7 working days standard delivery for North America and Europe. Complete SDS, customs declaration documents and all required export qualification certificates are supplied to ensure smooth customs clearance.
Version of Pentapeptide-18 Transportation Process
Pentapeptide-18 is first vacuum-sealed in a sterile aluminum foil bag with moisture-proof and light-shielding treatment, then packed into a customized foam insulation box with sufficient professional cold storage ice packs and temperature monitoring labels. Complete shipping documents including SDS, customs declaration forms, batch COA and full export qualification certificates are prepared synchronously.
In-Transit Monitoring
The whole transportation process supports real-time logistics tracking. The built-in temperature monitoring label can record the temperature change in the package throughout the journey, to ensure that the product is always kept in a low-temperature environment that meets the specifications, and avoid the activity attenuation caused by high temperature exposure.
Post-Delivery Confirmation
After the customer signs for the package, the after-sales team will follow up to confirm the integrity of the package, the status of the ice packs and the product appearance.
References
1. What is "Pentapeptide-18" and what is its use?
2.Pentapeptide-18 as an anti-aging candidate: Spectroscopic characterization and molecular interaction analysis
3.7What is "Pentapeptide-18" and what is its purpose?
4. Pentapeptide-18 (Leuphasyl) - Premium Anti-Aging Peptide Active
5.Pentapeptide-18: The Anti-Aging Ingredient You Need to Know Abou
FAQ
Q: What is the basic product specification and quality standard of your Pentapeptide-18?
A: Our Pentapeptide-18 has a defined sequence of Tyr-D-Ala-Gly-Phe-Leu, with a minimum purity of 98% verified by HPLC and mass spectrometry. It is supplied as lyophilized sterile powder for research use, with endotoxin strictly controlled below 0.1 EU/μg. Every batch comes with a complete COA, HPLC chromatogram, mass spectrum validation report and full traceability documents, which fully meet the data requirements for high-impact academic paper publication.
Q: What unique research values does your Pentapeptide-18 have compared with other similar neuromodulatory peptides on the market?
A: Different from most similar peptides that only target the SNARE protein pathway, our Pentapeptide-18 acts on delta-opioid receptors through an endogenous enkephalin-mimetic mechanism. It is the ideal standard reference tool for opioid receptor-mediated neuromodulation research, which cannot be replaced by conventional anti-wrinkle peptides. It supports 5 core research directions including opioid signaling pathway verification, skin nerve-muscle interaction study and neurogenic inflammation mechanism exploration, far beyond the application scope of ordinary similar products.
Q: What is the recommended storage condition and shelf life of this product?
A: The long-term recommended storage condition is -20°C, protected from light and moisture. Under properly sealed conditions, the unopened product has a 24-month shelf life. After being reconstituted with sterile deionized water, it is recommended to aliquot and store at -20°C, and avoid repeated freeze-thaw cycles to maintain its biological activity.
Q: What is the global shipping arrangement for international orders?
A: For customers in North America and Europe, we can arrange room-temperature or cold-chain express delivery with standard 3-7 working days delivery time. We provide complete SDS, customs declaration documents and all required export qualification certificates to ensure smooth customs clearance of your research reagent shipment.
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