Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of TB 500 Peptide CAS 107761-42-2 in China. Welcome to wholesale bulk high quality TB 500 Peptide CAS 107761-42-2 for sale here from our factory. Good service and reasonable price are available.
TB 500 peptide is a low-molecular-weight protein with 43 amino acid residues, naturally present in human tissues and cells. As a key actin regulatory molecule, it possesses versatile biological functions and plays vital roles in core physiological and pathological processes, including wound healing, tissue regeneration, inflammation regulation, angiogenesis. Backed by professional peptide R&D and production strength, Bloomtechz provides reliable, high-quality TB 500 peptide products and one-stop customized supporting services for global customers. We implement strict full-process quality control from raw material screening, standardized synthesis purification to finished product testing, ensuring high purity, stable activity and consistent batch quality of all products.
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Customized Bottle Caps And Corks:
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Amyloid β-Peptide (1-42) (human) COA
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| Certificate of Analysis | ||
| Compound name | Amyloid β-Peptide (1-42) (human) | |
| Grade | Pharmaceutical grade | |
| CAS No. | 107761-42-2 | |
| Quantity | 18g | |
| Packaging standard | PE bag+Al foil bag | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202601090075 | |
| MFG | Jan 9th 2026 | |
| EXP | Jan 8th 2029 | |
| Structure |
N/A |
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| Item | Enterprise standard | Analysis result |
| Appearance | White or almost white powder | Conformed |
| Water content | ≤5.0% | 0.78% |
| Loss on drying | ≤1.0% | 0.86% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | ≥99.0% | 99.96% |
| Single impurity | <0.8% | 0.65% |
| Total microbial count | ≤750cfu/g | 637 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 858ppm |
| Storage | Store in a sealed, dark, and dry place below -20°C | |
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TB 500 peptide, as an important bioactive peptide, has various pharmacological effects and clinical application values. Its immunomodulatory effect can enhance the body's resistance, and has a good effect on the treatment of tumors, infectious diseases, autoimmune diseases, etc; Its neuroprotective effect can improve cognitive function, memory ability, etc., and has a good effect on treating neurodegenerative diseases, cerebral ischemia, and other diseases; Its cardiovascular protective effect can lower blood pressure, improve vasomotor function, and have good effects on preventing and treating cardiovascular diseases.
Promoting cell migration and adhesion
BT 500 peptide binds to G-actin in an extended configuration, which is hindered by spatial resistance and salt induced actin polymerization. The aggregation and depolymerization of actin subunits are T β A major mechanism that promotes cell migration. Research has shown that T β 4 can significantly increase the proliferation, colony formation, migration, and adhesion abilities of EPCs (endothelial progenitor cells) in a dose-effect relationship.
Promoting vascular regeneration, cell differentiation, and tumor metastasis
Currently, there are concerns about best place to buy tb 500 studies have found that it plays an important role in vascular regeneration,
and both in vitro and in vivo experiments have found that T β 4 can promote the proliferation, migration, and enhancement of endothelial cell lumen formation ability,and can also promote neovascularization by promoting the differentiation, homing, and other processes of endothelial progenitor cells β When the expression of 4 is low, angiogenesis is significantly affected.
Prevent cell apoptosis, promote cell survival and tissue regeneration
T β 4 can reduce the proapoptotic effect of alcohol on human corneal epithelial cells in vitro, which is achieved by reducing damaged mitochondrial changes, releasing cytochrome C from mitochondria, increasing the expression of bcl-2 and aspartate enzyme activity.
Reduce inflammatory response, inhibit the migration and adhesion of inflammatory cells
Studies have found that in samples of skin, cornea, and heart damage and endotoxin-induced sepsis, T β 4 shows the ability to downregulate inflammatory mediators and reduce the infiltration of inflammatory response cells.
T β 4. Stimulate hair follicle development
Research has shown that T β The expression level of 4 is highest in the degenerative and quiescent stages of the first hair follicle development cycle, indicating that it has the most significant regulatory effect on hair follicles during the degenerative and quiescent stages. TB500 affects hair follicle growth by acting on the JNK and Notch signaling pathways.
Thymosin β 4 is a peptide substance secreted by the thymus gland, which has various biological activities and pharmacological effects, and is widely used in fields such as medicine and biotechnology. Next, we will investigate the effects of thymosin β Provide a detailed description of all uses of T β 4.
Immunomodulatory effect
Thymosin β 4 is an important immune regulator that can regulate the body's immune response. It activates the signal transduction pathway of immune cells by binding to receptors on their surface, thereby affecting the activation and function of immune cells. Thymosin β It can promote the differentiation and maturation of T cells, enhance the ability of T cells to kill tumor cells, and inhibit inflammatory reaction and autoimmune reaction. It has a good effect on the treatment of tumors, infectious diseases, autoimmune diseases, etc.
Neuroprotective effect
TB 500 for sale has also been found to have neuroprotective effects, which can protect neurons from damage. It reduces neuronal damage and promotes the regeneration and repair of nerve cells by inhibiting inflammatory and oxidative stress responses. Thymosin β 4 can be used to treat neurodegenerative diseases, cerebral ischemia and other diseases, and has a good effect on improving cognitive function, memory ability, etc.
Cardiovascular protective effects
Thymosin β 4 also has cardiovascular protective effects, which can protect the heart and blood vessels from damage.It reduces damage to myocardial cells, lowers blood pressure, and improves vasodilation and contraction function by inhibiting inflammatory and oxidative stress responses.
Thymosin β 4 can be used to treat diseases such as myocardial ischemia and myocardial infarction, and has good effects on improving myocardial function and preventing cardiovascular diseases.
Other pharmacological effects
In addition to the aforementioned pharmacological effects, thymosin β 4 also has other pharmacological effects. For example, it can inhibit the growth and metastasis of tumor cells, and has a good effect on treating tumors; It can promote wound healing and has a good effect on treating ulcers, burns, etc; It can inhibit bone resorption and has a good effect on treating diseases such as osteoporosis; It can promote the metabolism and detoxification function of the liver, and has a good effect on treating hepatitis, cirrhosis, etc.In addition, thymosin β 4 can also be used to treat diseases such as ulcers, burns, osteoporosis, and has broad application prospects for improving human health.
Synthesis Steps
TB 500 Peptide is a 43‑amino‑acid peptide. The mainstream production method is Solid Phase Peptide Synthesis (SPPS), using Fmoc protecting group strategy.
Resin Preparation Select suitable solid phase resin (e.g., Rink amide resin). Swell the resin in DCM and DMF solvent system for sufficient time, then wash thoroughly to activate resin sites for amino acid coupling.
Fmoc Deprotection Treat resin with 20% piperidine in DMF to remove Fmoc protecting group on the terminal amino group. Wash resin with DMF after deprotection, verify deprotection completion.
Amino Acid Coupling Add the corresponding Fmoc-protected amino acid, coupling reagent (HBTU/HOBt) and DIPEA. Allow reaction under stirring. Perform Kaiser test to confirm coupling success. Wash resin to remove residual reagents.
Repeat deprotection + coupling cycles sequentially from C-terminal to N-terminal until all 43 amino acids are assembled on resin.
Final N-terminal Deprotection After the last amino acid coupling, remove the N-terminal Fmoc group, then wash and dry the peptide-resin.
Cleavage & Side Chain Deprotection Treat peptide-resin with cleavage cocktail (TFA-based mixed solution) to cut peptide from resin and remove all side-chain protecting groups. Filter out resin, precipitate crude peptide with cold ether, collect precipitate by centrifugation.
Crude Peptide Washing & Drying Wash the precipitated crude TB 500 peptide multiple times with cold ether, then vacuum dry to obtain crude peptide powder.
Purification Purify crude product via Preparative Reverse Phase High Performance Liquid Chromatography (RP-HPLC). Collect target fractions according to chromatogram.
Desalting & Lyophilization Desalt the purified peptide solution, filter sterilely, then freeze-dry to get white TB 500 peptide solid powder.
Quality Testing & Release Test finished product by analytical HPLC for purity, MS for molecular weight confirmation, moisture content and endotoxin inspection.Bloomtechz strictly controls every synthesis stage.
We provide full batch COA, HPLC & MS spectra, and support custom purity specifications & bulk peptide orders for research use.
Preparation of resin:
Place a certain amount of resin (such as 500mg) into a glass tube or beaker, and add an appropriate amount of dichloromethane to soak to remove residual Boc protective groups. Then rinse the resin with methanol and acetonitrile to remove unreacted amino acids and other impurities.
Amino acid condensation:
React the required amino acids one by one with the resin in order to form peptide chains. The condensation reaction of each amino acid typically takes 2-3 hours. After the reaction is completed, rinse the resin with DCM to remove unreacted amino acids and other impurities.
Deprotection:
Use pyridine to remove the Boc protective group from the amino acid residues on the resin. The deprotection reaction usually takes 2-3 hours. After the reaction is completed, rinse the resin with DCM to remove unreacted pyridine and other impurities.
Acid cutting:
Using trifluoroacetic acid to cut the connection between the peptide chain and the resin, releasing the peptide chain from the resin. The acid cutting reaction usually takes several hours. After the reaction is completed, rinse the resin with DCM to remove unreacted trifluoroacetic acid and other impurities.
Recrystallization:
Dissolve the released peptide chain in an appropriate amount of water or a mixed solvent (such as ether: n-hexane=1:1), and then slowly add glycine or acetonitrile to allow the peptide chain to crystallize and precipitate. After recrystallization, rinse the beaker with ether and acetonitrile to remove the amorphous solution and impurities.
Purification:
Dissolve the crystalline peptide in an appropriate amount of water or mixed solvent, and purify it through column chromatography. Wash the purified peptide column with methanol and collect the purified peptide solution.
Quality Control
At Bloomtechz, we believe that premium peptides are defined by rigorous oversight at every stage of production.
Our comprehensive quality control protocol begins at the source, where all amino acid raw materials undergo purity, optical rotation, and impurity testing before entering the warehouse, with only high-grade materials of ≥99% purity accepted to eliminate batch-to-batch variation from the outset. During synthesis, amino acid analysis is performed after each condensation step to verify that residues are connected in the exact expected sequence, preventing errors from compounding as the chain grows.Once the peptide completes deprotection, acid cleavage, and purification, Reverse Phase High-Performance Liquid Chromatography (RP-HPLC) is employed to assess purity by comparing retention times and peak shapes against certified standards, identifying any truncated sequences or by-products.
This is followed by high-precision mass spectrometry, which detects the exact molecular weight and fragment ion patterns to provide definitive structural confirmation of the peptide's identity. Before release, every finished batch undergoes final inspection for moisture content, endotoxin levels, microbial limits, and visual appearance. If any checkpoint reveals impurities, incorrectly connected residues, or deviations from specifications, the entire synthesis and quality control process is restarted from scratch. At Bloomtechz, we never compromise-only batches that pass every stage are released with a complete Certificate of Analysis, ensuring you receive peptides that are scientifically verified, consistently reliable, and produced under the highest standards of manufacturing integrity.
Reference
[1]Esposito S, Deventer K, Goeman J, Van der Eycken J, Van Eenoo P. Synthesis and characterization of the N-terminal acetylated 17-23 fragment of thymosin beta 4 identified in TB-500, a product suspected to possess doping potential. Drug Test Anal. 2012 Sep;4(9):733-8. doi: 10.1002/dta.1402. PMID: 22962027.
[2]Ho EN, Kwok WH, Lau MY, Wong AS, Wan TS, Lam KK, Schiff PJ, Stewart BD. Doping control analysis of TB-500, a synthetic version of an active region of thymosin β₄, in equine urine and plasma by liquid chromatography-mass spectrometry. J Chromatogr A. 2012 Nov 23;1265:57-69. doi: 10.1016/j.chroma.2012.09.043. PMID: 23084823.
[3]Goldstein AL, Hannappel E, Kleinman HK. Thymosin beta4: actin-sequestering protein moonlights to repair injured tissues. Trends Mol Med. 2005 Sep;11(9):421-9. doi: 10.1016/j.molmed.2005.07.004. PMID: 16099219.
[4]Crockford D, et al. Thymosin beta4: structure, function, and biological properties supporting current and future clinical applications. Ann N Y Acad Sci. 2010 Apr;1194:81-6. doi: 10.1111/j.1749-6632.2010.05479.x. PMID: 20536453.
[5]Sosne G, et al. Thymosin beta 4 promotes corneal wound healing and modulates inflammatory mediators in vivo. Exp Eye Res. 2001;73(4):487-94. PMID: 11566087.
Frequently Asked Questions
Q1: Is there any scientific basis for TB-500? How is the quality of Bloomtechz's products verified?
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A: TB-500 is an active fragment of thymosin β4, derived from the core active amino acid sequence of seven residues (Ac-LKKTETQ). Its stability is enhanced through N-terminal acetylation, preserving the parent molecule's key functions of inducing cell migration, promoting angiogenesis, and regulating inflammation. Both animal experiments and in vitro studies have confirmed its role in promoting wound healing and collagen deposition. Every batch of Bloomtechz products comes with a complete mass spectrometry analysis report confirming a molecular weight of 889.01 and a purity of ≥99.5%. The lyophilized powder is white; when reconstituted, the solution is clear, colorless, and free of visible particles. All data is traceable and verifiable, making both the scientific basis and quality transparent.
Q2: What is the difference between TB-500 and BPC-157? Can they be used together?
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A: Their mechanisms are complementary, making them the popular "Wolverine Combo" in the sports rehabilitation community. BPC-157 primarily promotes angiogenesis by upregulating VEGFR2, focusing on "repairing the vascular network"; TB-500 maintains intracellular fluidity by chelating G-actin, enabling repair cells to rapidly migrate to the site of injury, focusing on "mobilizing the repair team." Bloomtechz offers compliant specifications for both products. The lyophilized powders are white and become clear and colorless upon reconstitution, allowing customers to flexibly combine them according to their actual needs.
Q3: There are many counterfeit peptide products on the market. How can I be sure that what I buy from Bloomtechz is genuine?
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A: This is the most critical issue regarding peptide products, and Bloomtechz treats "quality transparency" as its top priority. In response to the industry's chaotic state-where over 40% of market samples fail to meet standards and 15% test positive for bacterial endotoxins-Bloomtechz provides a complete Certificate of Analysis (COA), third-party testing reports, and batch traceability information for every batch. Product molecular weight is confirmed via mass spectrometry, with a purity of ≥99.5%, and no visible particles are present after reconstitution. When you choose Bloomtechz, you're getting more than just a product-you're getting a complete set of traceable, verifiable quality records.
Q4: How exactly is TB-500 used? What are the dosage and storage requirements?
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A: Based on current research data, the standard dosage for TB-500 is 2–6 mg per administration, twice weekly. Due to a saturation effect at the actin-binding site, doubling the dose does not double the effect. Bloomtechz's lyophilized powder must be reconstituted with sterile water or saline solution. After reconstitution, it should be aliquoted and stored at -20°C to -80°C to prevent degradation caused by repeated freeze-thaw cycles. For first-time use, it is recommended to start with a lower dose to monitor the response. The Bloomtechz customer service team is available at any time to provide professional guidance on storage and reconstitution.
Q5: What are the contraindications and precautions for using TB-500?
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A: There are four key points to note: First, TB-500 is listed on WADA's Prohibited List and is prohibited for competitive athletes; second, thymosin β4 has multifaceted effects that promote cell migration and angiogenesis, so individuals with a personal or family history of cancer should exercise caution; third, long-term human safety data for the TB-500 fragment is still being accumulated, so it is recommended to use it under professional guidance; Fourth, the reconstitution process must be strictly sterile to prevent bacterial contamination. Bloomtechz adheres to the principle of "no exaggeration, no concealment." While providing high-quality research-grade products, we openly disclose all known information, enabling customers to make informed decisions.
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