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October 28th, 2025
Pure propionyl chloride is an organic compound with the chemical formula C3H5ClO. Colorless transparent liquid with a spicy or irritating odor. It dissolves in water, benzene, ether, etc., and then rapidly decomposes, producing toxic and corrosive gases. When exposed to open flames and high heat, it is flammable and can react strongly with oxidants. When exposed to water, it generates heat and releases toxic corrosive gases. If exposed to high heat, the pressure inside the container increases, posing a risk of cracking and explosion. Used as an introduction agent for organic synthesis to obtain propionylation agents and propionic anhydride, flavoring and pharmaceutical raw materials, pesticide herbicide raw materials, and polymerization initiator raw materials. It needs to be stored in a cool, dry, well ventilated warehouse, with sealed containers, and should not be stored for a long time to avoid spoilage.
|
Chemical Formula |
C3H5ClO |
|
Exact Mass |
212 |
|
Molecular Weight |
212 |
|
m/z |
92 (100.0%), 94 (32.0%), 93 (3.2%), 95 (1.0%) |
|
Elemental Analysis |
C, 38.95; H, 5.45; Cl, 38.32; O, 17.29 |
Pure Propionyl Chloride, as an important organic chemical raw material and intermediate, has a wide range of applications in multiple fields. Here are some of the main uses:
1.Pharmaceutical industry
It is an important raw material for the production of antiepileptic drug metformin.
It is also used to produce cholecystokinin, a drug used to treat biliary tract diseases.
In addition, it is also used in the production of pharmaceutical products such as the anti adrenergic drug methoxyamine hydrochloride.
2.Pesticide industry
In the field of pesticides, it is a key raw material for the production of pesticide dichlorvos. Diquat is a selective systemic herbicide mainly used for weed control in rice fields.
3.Organic synthesis
It has a wide range of applications in organic synthesis as a propionylation reagent. It can react with various alcohols, amines, and other compounds to generate corresponding propionic acid derivatives.
For example, it can react with phenol to produce phenylacetone, which is an important organic chemical raw material and fragrance.
In addition, it can also be used to synthesize other organic compounds, such as propionyl hydrazine, propionamide, etc.
4.Dye and pigment industry
In the field of dyes and pigments, this substance can serve as an intermediate for the synthesis of certain dyes and pigments.
5.Other applications
It can also be used to prepare certain surfactants, plasticizers, lubricants, and other chemicals.
In the laboratory, this substance is also commonly used in the research and teaching of organic chemical reactions.
What are the side effects of this compound?
Regarding the safety of Pure Propionyl Chloride, the following are some key safety data and preventive measures:
Material Safety Data Sheet (MSDS):
According to its MSDS, it is a highly flammable and corrosive liquid that reacts violently with water and alcohol, producing corresponding acids and hydrogen chloride.
Personal protective equipment
When operating, appropriate personal protective equipment should be worn, including chemical protective clothing, goggles, face shields, gloves, and positive pressure respirators if necessary.
Storage and transportation
It should be stored in an environment below 30 ° C to avoid decomposition or increased reactivity.
Health hazards
It has serious irritation to the eyes and skin, inhalation may cause severe respiratory damage, and ingestion may lead to serious health problems.
First-aid measures
After skin contact, rinse immediately with plenty of water for at least 15 minutes and seek medical assistance. After eye contact, rinse immediately with plenty of water or saline solution for at least 15 minutes and seek emergency medical assistance. After inhalation, the patient should be quickly moved to fresh air and artificial respiration should be provided. If the patient stops breathing, do not perform mouth to mouth breathing, but use appropriate medical equipment for artificial respiration.
Fire protection measures
Due to the intense reaction between the substance and water, carbon dioxide, dry powder, or dry sand should be used for extinguishing fires, and water should not be used.
environmental impact
It mainly exists in gaseous form in the atmosphere and degrades through reactions with hydroxyl radicals, with a half-life of about 27 days.
ACCIDENTAL RELEASE MEASURES
Immediate isolation measures should be taken in case of leakage, all ignition sources should be eliminated, and appropriate protective equipment should be used. Use foam to reduce vapor, but do not let water come into contact with leaking substances.
Applications in the pharmaceutical industry
It is used as an acylating agent in the pharmaceutical industry to synthesize acetyl groups in drug molecules. For example, it can convert anisole into 4-methoxypropylketone, which is an intermediate in the production of fragrances and drugs. This compound has important applications in the pharmaceutical industry, indicating that its demand in the field of pharmaceutical synthesis will continue to grow.
Application of Electrochemical Perfluorination
Its application in the electrochemical perfluorination process provides a new pathway for the synthesis of fluorinated compounds. Perfluorinated compounds have a wide range of applications in medicine, pesticides, and materials science, indicating their promising prospects in this field.
Role in Environmental Chemistry
It and its derivatives play a role in atmospheric chemistry, especially in the degradation of halogenated hydrocarbons in the atmosphere, where they may participate in chemical reactions in the atmosphere through reactions with low-energy electrons. This research direction helps to understand the degradation mechanism of atmospheric pollutants and may promote the development of new environmental protection technologies.
Diversified Applications in Organic Synthesis
It is not only used in acylation reactions in organic synthesis, but also in the synthesis of pesticides, dye intermediates, textile auxiliaries, and peroxide compounds. The development of these application fields will further drive the demand for this substance.
Technological innovation and application expansion
Its application is not limited to the traditional field of organic synthesis, and with the development of new technologies, its application scope is expected to further expand. For example, new application scenarios may be discovered in the fields of materials science, energy, and new drug development.
International competitive situation
In the global market, the production and sales of this substance face fierce international competition. The chemical industry in countries such as the United States and Europe is well-developed, and research in this area started early with advanced technology, making it highly competitive on a global scale. However, with the rapid economic development of developing countries such as China and India, their production capacity and technological level are also constantly improving, gradually becoming important participants in the global market.
The potential uses of Pure Propionic Chloride in the field of environmental protection mainly include the following aspects：
1.Improve the efficiency and stability of solar cells:
It is used as a passivator to improve the efficiency and stability of perovskite solar cells by introducing a propionyl chloride passivation layer
This application helps to develop more environmentally friendly and efficient energy technologies.
2.Green Chemical Synthesis：
In Friedel Crafts acylation reactions, it can be used together with solid superacid catalysts to replace traditional, environmentally harmful homogeneous catalysts and reduce pollution. This green chemistry method helps reduce waste generation and environmental impact during chemical synthesis processes.
3.Atmospheric chemistry and pollutant degradation:
It and its derivatives play an important role in atmospheric chemistry, especially in the degradation of halogenated hydrocarbons in the atmosphere. The study of photodissociation of propionyl chloride helps to understand the degradation mechanism of pollutants in the atmosphere, which may promote the development of new environmental protection technologies.
4.Synthesis of environmentally friendly materials
It can be used to synthesize various environmentally friendly materials, such as applications in polymers and functional materials. These materials may have biodegradability or low toxicity, with minimal impact on the environment.
5.Replace hazardous chemicals
In certain chemical reactions, it can serve as a more environmentally friendly alternative to some highly toxic and volatile chemicals, such as sulfonyl chloride and dichloromethyl ether, for acyl chloride reactions.
pay attention to：
The potential uses demonstrate the importance and application prospects of this substance in the field of environmental protection, especially in the development of greener and more sustainable chemical synthesis methods and materials. Simultaneously toxic, attention should be paid to safety and standardized operation during operation to prevent explosions.
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