3,5-Bis(trifluoromethyl)benzyl Chloride CAS 75462-59-8
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3,5-Bis(trifluoromethyl)benzyl Chloride CAS 75462-59-8

3,5-Bis(trifluoromethyl)benzyl Chloride CAS 75462-59-8

Product Code: BM-1-2-121
CAS number: 75462-59-8
Molecular formula: C9H5ClF6
Molecular weight: 262.58
EINECS number: 278-216-1
MDL No.: MFCD00009906
Hs code: 29039990
Main market: USA, Australia, Brazil, Japan, Germany, Indonesia, UK, New Zealand , Canada etc.
Manufacturer: BLOOM TECH Xi’an Factory
Technology service: R&D Dept.-1

Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of 3,5-bis(trifluoromethyl)benzyl chloride cas 75462-59-8 in China. Welcome to wholesale bulk high quality 3,5-bis(trifluoromethyl)benzyl chloride cas 75462-59-8 for sale here from our factory. Good service and reasonable price are available.

 

3,5-Bis(trifluoromethyl)benzyl chloride is an organic compound with the chemical formula C9H5ClF6 and CAS 75462-59-8. It is a colorless to slightly yellow liquid and is a relatively stable compound, but may undergo hydrolysis under strong alkaline conditions. Additionally, it is also relatively stable to light and oxygen in air. It is a flammable liquid that releases toxic fluoride gas when burned. The vapor pressure is low and increases with temperature, with a flash point of 59 ℃, indicating that flashover will occur when encountering open flames or arcs at this temperature. Commonly used as an intermediate in chemical synthesis, it can participate in various organic synthesis reactions and is used to synthesize various complexes, such as drugs, pesticides, dyes, polymer materials, etc. May appear as a component of certain environmental pollutants. In environmental science research, its specific chemical properties can be utilized for the detection and analysis of environmental pollutants. By developing detection methods and technologies based on this compound, rapid and accurate detection of environmental pollutants can be achieved, providing scientific basis for environmental protection and governance. 

 

product introduction

 

CAS 75462-59-8 | Shaanxi BLOOM Tech Co., Ltd

3,5-Bis(trifluoromethyl)benzyl chloride CAS 75462-59-8 | Shaanxi BLOOM Tech Co., Ltd

Chemical Formula

C9H5ClF6

Exact Mass

262

Molecular Weight

263

m/z

262 (100.0%), 264 (32.0%), 263 (9.7%), 265 (3.1%)

Elemental Analysis

C, 41.17; H, 1.92; Cl, 13.50; F, 43.41

Usage

 

3,5-Bis(trifluoromethyl)benzyl chloride, as an organic compound with a special chemical structure, has a wide range of applications in the field of analysis and testing.

 

3,5-Bis(trifluoromethyl)benzyl Chloride uses CAS 75462-59-8 | Shaanxi BLOOM Tech Co., Ltd

Quality control

 

In analytical testing, it is often used as a standard or reference to ensure the accuracy and reliability of the analysis results. A standard substance is a substance with known concentration, purity, and chemical structure, used for calibrating instruments, validating analytical methods, and evaluating analytical performance. By comparing and analyzing with standard samples, it is possible to evaluate whether the concentration, purity, or chemical structure of the test sample is consistent with the target substance.

Calibration work

 

In various analytical techniques such as chromatography, spectroscopy, mass spectrometry, etc., it can be used as a calibration substance. By preparing a series of standard solutions with known concentrations, a quantitative relationship between concentration and response signal can be established, thereby achieving quantitative analysis of unknown samples. This calibration method helps to improve the accuracy and reproducibility of the analysis results.

3,5-Bis(trifluoromethyl)benzyl Chloride uses CAS 75462-59-8 | Shaanxi BLOOM Tech Co., Ltd
3,5-Bis(trifluoromethyl)benzyl Chloride uses CAS 75462-59-8 | Shaanxi BLOOM Tech Co., Ltd

Chromatographic analysis

 

In chromatographic analysis techniques such as gas chromatography (GC) and liquid chromatography (LC), it can be used as a calibration substance or internal standard for chromatographic columns. By adding it to the test sample, the performance changes of the chromatographic column, such as separation degree, sensitivity, etc., can be monitored to ensure the stability and reliability of the analysis results. In addition, it can also be used to optimize chromatographic conditions, such as selecting appropriate mobile phases, adjusting column temperature, etc., to improve analysis efficiency and accuracy.

Spectral analysis

 

In spectral analysis techniques such as UV Vis and IR, specific absorption peaks or vibrational modes can be used as characteristic spectral lines for substance identification or quantitative analysis. By measuring the similarity or difference between the spectra of the test sample and the standard sample, it is possible to determine whether the sample contains the target substance and its content.

3,5-Bis(trifluoromethyl)benzyl Chloride uses CAS 75462-59-8 | Shaanxi BLOOM Tech Co., Ltd
3,5-Bis(trifluoromethyl)benzyl Chloride uses CAS 75462-59-8 | Shaanxi BLOOM Tech Co., Ltd

Mass spectrometry analysis

 

In mass spectrometry (MS), the molecular structure gives it a unique mass spectrum. By comparing and analyzing it with the mass spectrum of the sample to be tested, it can be confirmed whether the compound is present in the sample and its structural information. In addition, mass spectrometry analysis can also be used to study the cracking laws, reaction mechanisms, and other chemical properties of 3,5-ditrifluoromethylbenzyl chloride.

Environmental monitoring

 

In the field of environmental monitoring, this substance or its derivatives may appear as indicators of certain pollutants or pollution sources. By analyzing the content and distribution of the compound in environmental samples, the degree and source of environmental pollution can be evaluated. In addition, it can also be used to develop new environmental monitoring technologies and methods.

3,5-Bis(trifluoromethyl)benzyl Chloride uses CAS 75462-59-8 | Shaanxi BLOOM Tech Co., Ltd
3,5-Bis(trifluoromethyl)benzyl Chloride uses CAS 75462-59-8 | Shaanxi BLOOM Tech Co., Ltd

Food safety

 

In the field of food safety, this substance or its analogues may appear as components of certain food additives, pesticide residues, or industrial pollutants. By accurately measuring and analyzing its content in food, the safety and compliance of food can be ensured. In addition, 3,5-ditrifluoromethylbenzyl chloride can also be used to develop new food safety detection technologies and methods.

Research on synthetic intermediates and reactions

 

Due to its unique chemical structure, it is often used as a key intermediate in organic synthesis. Researchers can utilize the activity of its chlorine atom and trifluoromethyl group to carry out various chemical reactions such as substitution, addition, coupling, etc., to construct more complex organic molecules with specific properties. These molecules have important application value in fields such as medicinal chemistry and materials science. Meanwhile, by studying the conditions, mechanisms, and product distribution of these reactions, we can deepen our understanding of organic chemical reactions and promote the development of organic synthetic chemistry.

3,5-Bis(trifluoromethyl)benzyl Chloride uses CAS 75462-59-8 | Shaanxi BLOOM Tech Co., Ltd
3,5-Bis(trifluoromethyl)benzyl Chloride uses CAS 75462-59-8 | Shaanxi BLOOM Tech Co., Ltd

Exploration of Conversion Paths

 

Exploring new conversion pathways in chemical synthesis is one of the important directions of scientific research. It can serve as a starting point or intermediate, generating various valuable compounds through different conversion pathways. Researchers can explore new conversion pathways and study their reaction mechanisms and product properties by changing reaction conditions, catalyst types, or introducing other reactants. These studies not only contribute to enriching the knowledge system of organic synthesis chemistry, but may also provide new ideas and methods for fields such as drug development and material preparation.

Drug molecular design and synthesis

 

It plays an important role in pharmaceutical chemistry research. Due to the strong electron withdrawing property of its trifluoromethyl group and the electrophilicity of its chlorine atom, this compound has unique advantages in drug molecule design. Researchers can introduce it into drug molecules and design new drugs with specific pharmacological effects by adjusting their chemical structure and biological activity. These new drugs may have better efficacy, lower toxicity, and higher bioavailability, which are of great significance for treating diseases such as cancer, inflammation, and infections.

3,5-Bis(trifluoromethyl)benzyl Chloride uses CAS 75462-59-8 | Shaanxi BLOOM Tech Co., Ltd
3,5-Bis(trifluoromethyl)benzyl Chloride uses CAS 75462-59-8 | Shaanxi BLOOM Tech Co., Ltd

Research on the mechanism of drug action

 

In addition to drug molecule design and synthesis, it can also be used for the study of drug mechanisms of action. Researchers can study the binding mode, site of action, and mechanism of action of drug molecules containing the compound by constructing interaction models with biomolecules such as proteins, DNA, etc. These studies help to reveal the biological activity and mechanism of action of drug molecules, providing theoretical basis for drug development and optimization.

manufacturing information

 

3,5-Bis(trifluoromethyl)benzyl chloride, a key intermediate in organic synthesis, has garnered significant attention due to its unique chemical properties and applications in pharmaceuticals, agrochemicals, and advanced materials. The study of this compound can be traced back to advancements in trifluoromethylation chemistry, a field that has expanded rapidly since the late 20th century.

The introduction of trifluoromethyl groups into aromatic systems became a focal point of research due to the strong electronegativity, high stability, and lipophilicity of the trifluoromethyl moiety. Early efforts in the 1960s and 1970s, such as McLoughlin's nucleophilic substitution using CuCF₃ and Prakash's work with TMSCF₃, laid the groundwork for trifluoromethylated aromatic compound synthesis. However, the specific synthesis emerged from the broader exploration of methods to incorporate multiple trifluoromethyl groups onto benzene rings.

By the 21st century, the development of more efficient trifluoromethylating reagents, including Umemoto reagents and CF₃SO₂Na (Langlois reagent), facilitated the preparation of complex trifluoromethylated compounds. These advancements enabled the synthesis, which has since been utilized in the production of neurokinin antagonists and herbicides. Its chloro substituent allows for further functionalization, making it a versatile building block in organic synthesis.

Recent research has focused on optimizing its synthesis and exploring its derivatives, such as 3,5-bis(trifluoromethyl)benzylamine, which is prepared via amino-dehalogenation reactions. The compound's potential in material science and drug discovery continues to drive its study, reflecting the enduring relevance of trifluoromethylated compounds in modern chemistry.

 

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