Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of butafosfan powder in China. Welcome to wholesale bulk high quality butafosfan powder for sale here from our factory. Good service and reasonable price are available.
From the perspective of the obscure aspect of the drug delivery system, the physical form of Butafosfan Powder itself is a neglected advantage. Its micron-sized powder particles have an extremely high specific surface area, which not only ensures rapid dissolution and uniform distribution in feed or drinking water, but more importantly, optimizes the absorption kinetics in the gastrointestinal tract. As an organic phosphorus compound, its absorption is not a simple passive diffusion, but may involve a carrier-mediated active transport process. The powder form avoids the possible chemical degradation of the solution formulation, maintains the stability of the phosphorus molecule and the vitamin B12 complex, allowing them to reach the absorption site more completely. This physical form also facilitates the development of new delivery routes, such as encapsulating it in the core of feed particles through electrostatic adsorption technology to achieve masking of taste and sustained release, improving palatability and bioavailability.
Our product
Additional information of chemical compound:
| Product Name | Butafosfan Powder | Butafosfan Injection |
| Product Type | Powder | Injection |
| Product Purity | ≥99% | ≥99% |
| Product Specifications | Customizable | Customizable |
| Product Package | Customizable | Customizable |
Our Product
Butafosfan+. COA
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Certificate of Analysis |
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Compound name |
Butafosfan | |
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CAS No. |
17316-67-5 | |
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Grade |
Pharmaceutical grade | |
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Quantity |
Customized | |
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Packaging standard |
Customized | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
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Lot No. |
20250109001 |
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MFG |
Jan 12th 2025 |
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EXP |
Jan 8th 2029 |
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Structure |
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| TEST STANDARD | GB/T24768-2009 Industry. Stnndard | |
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Item |
Enterprise standard |
Analysis result |
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Appearance |
White or almost white powder |
Conformed |
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Water content |
≤4.5% |
0.30% |
| Loss on drying |
≤1.0% |
0.15% |
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Heavy Metals |
Pb≤0.5ppm |
N.D. |
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As≤0.5ppm |
N.D. | |
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Hg≤0.5ppm |
N.D. | |
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Cd≤0.5ppm |
N.D. | |
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Purity (HPLC) |
≥99.0% |
99.5% |
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Single impurity |
<0.8% |
0.48% |
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Residue on ignition |
<0.20% |
0.064% |
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Total microbial count |
≤750cfu/g |
80 |
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E. Coli |
≤2MPN/g |
N.D. |
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Salmonella |
N.D. | N.D. |
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Ethanol (by GC) |
≤5000ppm |
400ppm |
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Storage |
Store in a sealed, dark and dry place at-20 degrees |
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Heat stress response refers to the total response of the body to any demands made by the heat environment when it is in a high temperature environment, characterized by an increase in the synthesis of heat shock proteins (HSPs). It is a highly programmed series of processes triggered within biological cells, which play a protective role in stress outcomes. Research has shown that heat stress can cause dysfunction in the body's respiratory, digestive, circulatory, endocrine, and immune systems, such as increased breathing and heart rate, and elevated body temperature.
Scientists' research on animals such as sheep and cows under high temperature stress has found that butafos can prevent reduced food intake, slowed weight gain, decreased heart rate, increased respiration, decreased cortisol secretion caused by heat stress, and can also inhibit antibody dependent cytotoxicity induced by heat stimulation.
Hassulong et al. used yellow feathered broiler chickens as the research object to detect the changes in various indicators before and after the action of butafos. The results showed that butafos can exert its anti stress effect by adjusting the serum hormone content and changing some biochemical indicators of broiler chickens.
At present, the anti stress effect of butafos has been widely applied. For example, when beef cattle enter captivity or are reorganized, butafos helps to cope with stress, enhance immunity and other performance parameters, enabling beef cattle to adapt to new environments faster. In addition, Butafosfan powder has a good relieving effect on horses that are in a highly tense state during competitions, and can prevent premature fatigue of horses. In China, Vietnam, and South Korea, the main use of butafos to resist high temperature stress, transportation stress, and cow delivery stress has achieved ideal results.
In addition to enhancing the body's endurance, butafos can also increase the reserve of liver glycogen and muscle glycogen, promote the synthesis of adenosine triphosphate (ATP) and adenosine diphosphate (ADP), increase energy load, and affect the ultrastructure and quantity of mitochondria to enhance energy metabolism in animal bodies. Due to the fact that the liver and muscles are direct tissues for energy storage and utilization in the body, and the oxidation and utilization of glycogen are the main forms of metabolism and energy supply for exercise. Therefore, it is of great significance to enhance metabolism and prolong exercise time through the use of certain drugs, and butafos can precisely increase ATP and ADP content by increasing the body's glycogen reserves, playing a role in anti fatigue and improving energy load.
Research has shown that butafos injection can improve the cold, heat, and hypoxia tolerance of mice, significantly prolong their load swimming time, and significantly increase the content of liver glycogen and muscle glycogen, as well as the ATP and ADP content of liver and muscle tissues. However, it has no significant effect on the content of adenosine monophosphate (AMP) in liver tissue, but has a certain reducing effect on the AMP content in muscle tissue. In 2011, E.M. Hanafi et al. found that the application of butafos in suckling piglets mainly manifested in its ability to significantly increase piglet weight, enhance energy metabolism, and promote sufficient milk production for newborn piglets.
The function of butafos in the body's immune system is to enhance the body's non-specific defense function, specific cellular immune response, and specific humoral immune function.
Specific manifestations: Butaphosphat not only enhances the resistance of animal organisms, but also increases the phagocytic index of phagocytic cells, increases serum hemolysin content, thereby improving humoral immune ability and the percentage of CD4+and T lymphocytes to CD4+/CD8+ratio.
Scholars have studied the changes in immune function of mice after using compound butazone. Compound butazone can increase the phagocytic index and hemolysin content of mononuclear macrophages, and the experimental group has an increase of 4-5 times compared to the negative control group and 2.7-3.5 times compared to the positive control group. Inject 20mL of butafos subcutaneously every 3 weeks into cows 7 weeks before delivery, and measure the immunoglobulin content in colostrum. The results showed that the IgG and IgA levels in the experimental group were higher than those in the control group. Therefore, in clinical practice, Butaphosphat injection can be used as an adjuvant therapy for many immune deficiency diseases caused by bacterial infections.
3. Application of Butaphosphat in Animal Fertility
At present, there are mainly restrictive problems such as reproductive dysfunction, mastitis, and metabolic disorders in the cattle breeding industry, which hinder the smooth development of the dairy industry. Butaphosphat injection has become a research hotspot due to its good regulatory effect on physiological stress states such as metabolic disorders, reproduction, pregnancy, childbirth, and lactation in dairy cows. For example, the injection of butafos before and after the delivery of cows can significantly stabilize the fluctuation of serum glutamic oxaloacetic transaminase content, so that it will not increase due to the delivery, reduce the incidence rate of reproductive dysfunction syndrome, and at the same time shorten the interval between calving without affecting the amount of milk production, thus improving economic efficiency.
Research has found that the effect of compound butafos injection in reducing metabolic disorders in dairy cows reaches 80%. Compared with cows that did not use compound butazone, the probability of ovarian dysfunction, convulsions, and acetone urine decreased by 22% after use.
The incidence of infertility and uterine diseases in the control group cows was 2-4 times higher than that in the compound butazone injection treatment group.
In pig production, butafos is mainly used for the prevention and treatment of diseases such as uterine inflammation, mastitis, absence of milk syndrome in sows, weaning stress and herd switching stress in piglets, low feed intake, poor growth and development, and low libido in male livestock. The use of butafos injection during the perinatal period in sows can effectively prevent obstetric diseases, shorten the delivery process, promote estrus and placental discharge. If used in conjunction with antibiotics, it can also effectively prevent birth canal infections. This is the most important reason for the widespread use of butafos injection during the perinatal period in foreign cows and sows. In China, many pig farms prevent obstetric diseases and restore the physical fitness of sows during delivery by intramuscular injection or intravenous drip of Ketuzhuang, so that sows can feed as soon as possible after delivery.
4. Application of Butaphosphat in Other Aspects
Butaphosphat injection also has the effects of enhancing metabolism, promoting chicken synthesis metabolism and growth, increasing egg production rate, and enhancing stress resistance and disease resistance in chickens. Injecting butafos into laying hens can achieve a 90% egg production rate and significantly improve the quality of eggshells. Butafosfan powder can also increase the weight gain rate of broiler chickens by 8.62%, improve feed efficiency, and prevent the occurrence of anal pecking and feather pecking among meat chicks. Meanwhile, Butaphosphat injection can improve meat quality by repairing muscle cells and tissues, and accelerate the regeneration of damaged skeletal muscles.
Research has shown that injecting butafos and cobalamin into piglets can promote phagocytosis and cell proliferation, thereby accelerating the regeneration of damaged skeletal muscle. If a solution of butafos is used for broiler chickens, it can stimulate the growth of chest and leg muscles. Specifically, the weight of leg and chest muscles in the experimental group of broiler chickens is 23.9% and 24.7% higher than that in the control group. In order to solve the problems of high energy demand during the spawning season and high mortality rate during early development of Nile tilapia, injecting a certain amount of butafos injection into Nile tilapia can improve spawning rate and reproductive performance, reduce mortality rate, increase metabolic activity, and induce growth of young. Therefore, it has largely solved the difficulties in the fish farming industry.
Butafosfan, as an organic phosphorus compound, exhibits unique pharmacological activity in the field of veterinary medicine. Its mechanism of action involves multiple aspects such as energy metabolism, immune regulation, and stress response.
Molecular level regulation of energy metabolism
Butaphosphat directly stimulates animal feeding behavior by increasing serum insulin concentration. Experimental data shows that the use of butafos increases the feed intake of pigs by 15% -20%, which may be related to the increased phosphorylation level of insulin receptor substrate (IRS). After activation of insulin signaling, it can promote the translocation of glucose transporter 4 (GLUT4) to the cell membrane, accelerate glucose uptake, and provide substrates for energy metabolism.
Butaphosphorus, as an organic phosphorus compound, can participate in the phosphorylation process of the tricarboxylic acid cycle (TCA cycle). It enhances the activity of the pyruvate dehydrogenase complex, promotes the conversion of pyruvate to acetyl CoA, and increases the TCA cycle efficiency by 20% -30%. This metabolic enhancement effect is particularly significant during the developmental stage of young livestock, increasing ATP production by 25% -35% to meet the energy requirements for rapid growth.
Butaphosphat can upregulate the activity of glycogen synthase (GS) and inhibit the activity of glycogen phosphorylase (GP), thereby promoting the synthesis of liver glycogen and muscle glycogen. In cow experiments, the use of butafos increased liver glycogen reserves by 30% -40%, providing a guarantee for energy supply under stress. In addition, butafosfan powder can also activate adenylate activated protein kinase (AMPK) to promote glycogen breakdown in response to acute energy demands.
Cellular level immune regulatory network
Butaphosphat can activate the mononuclear phagocytic cell system, increasing the phagocytic index of macrophages by 30% -40%. The mechanism involves the following pathways:
Upregulation of surface receptor expression: increases the expression of TLR4, CD14 and other receptors on the surface of macrophages, enhancing the recognition ability of pathogen associated molecular patterns (PAMPs).
Enhanced respiratory burst: By increasing NADPH oxidase activity, the production of reactive oxygen species (ROS) increases by 50% -60%, enhancing bactericidal ability.
Cytokine secretion regulation: promotes the secretion of pro-inflammatory factors such as IL-1 β and TNF - α, while inhibiting the overexpression of anti-inflammatory factors such as IL-10, maintaining immune balance.
Butaphosphat has a bidirectional regulatory effect on T lymphocyte subsets:
CD4+T cell proliferation: By upregulating the expression of IL-2 receptor (CD25), it promotes the proliferation and differentiation of CD4+T cells, increasing the proportion of CD4+T cells by 10% -15%.
Maintenance of CD8+T cell function: While enhancing CD4+T cell activity, avoid immune pathological damage caused by excessive activation of CD8+T cells, and optimize the CD4+/CD8+ratio.
B-cell antibody generation: synergizes with vitamin B12 to promote the differentiation of B cells into plasma cells, increasing serum hemolysin levels by 25% -35% and enhancing humoral immune response.
Butaphosphat can increase the activity of antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GPx), reducing oxidative stress levels in the body by 20% -30%. Butafosfan powder protects immune cells from oxidative damage and maintains the stability of immune function by clearing free radicals and reducing the production of lipid peroxidation products (MDA).
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