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Palmitic acid powder, also known as hexadecanoic acid and palmitic acid, is an organic substance. The chemical formula is C16H32O2, CAS 57-10-3. It is a saturated high fatty acid, white crystalline powder. Insoluble in water, slightly soluble in petroleum ether, soluble in ethanol. Easily soluble in ether, chloroform and acetic acid. Palmitic acid exists widely in nature, almost all oils contain different amounts of palmitic acid components. The content of palmitic acid in Chinese tallow oil of Chinese tallow seeds can be as high as 60%, that in palm oil is about 40%, and that in vegetable oil is less than 2%. It widely exists in nature, and almost all oils contain palmitic acid components in varying amounts. Used as precipitant, chemical reagent and waterproof agent.

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Chemical Formula |
C16H32O2 |
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Exact Mass |
256 |
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Molecular Weight |
256 |
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m/z |
256 (100.0%), 257 (17.3%), 258 (1.4%) |
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Elemental Analysis |
C, 74.94; H, 12.58; O, 12.48 |
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Palmitic acid, also known as hexadecanoic acid or palmitic acid, is a saturated higher fatty acid widely present in animal and plant oils and fats in nature. Its molecular structure endows it with unique physical and chemical properties, making it a core raw material in fields such as chemical engineering, medicine, food, and daily chemical products.
Industrial manufacturing: the "universal additive" in the chemical industry
Palmitic acid powder, with its lubricity, stability, and reactivity, has become a key additive in industries such as plastics, rubber, coatings, and metal processing, promoting the dual improvement of industrial production efficiency and product performance.
1. Plastic processing: performance optimization and process improvement
Palmitic acid and its derivatives play multiple roles in the plastic industry:
Heat stabilizer: Palmitate metal salts (such as calcium, zinc, barium salts) can neutralize the HCl produced by PVC degradation and delay thermal aging.
For example, in the production of domestic PVC water pipes, the calcium palmitate/zinc composite stabilizer can improve the weather resistance of the product by 30% and the transparency by 15%.
Lubricant: Palmitate esters (such as methyl palmitate) are used as internal lubricants to reduce friction between resin and equipment and improve melt flowability. In the extrusion process of PE pipes, adding 2% methyl palmitate can increase production efficiency by 20% and reduce waste rate by 10%.
Plasticizer: Low molecular weight palmitic acid esters (such as butyl palmitate) are used as auxiliary plasticizers, compounded with phthalates, for PVC soft products (such as toys, cling film), which can enhance flexibility and reduce the release of toxic substances.
2. Rubber industry: vulcanization promotion and performance improvement
It optimizes processing performance and product quality by regulating the molecular structure of rubber
Vulcanization accelerator: Adding 0.5% -2% palmitic acid to natural rubber (NR) can shorten the vulcanization time by 30%, improve crosslinking efficiency, increase the tensile strength of tire tread rubber by 15%, and enhance wear resistance by 20%.
Softener: Compound of product and paraffin oil, used for softening treatment of hard rubber (such as rubber rollers and seals), can reduce the hardness of the rubber material by 20% -30%, while preventing storage adhesion.
Anti sticking agent: Zinc palmitate powder coated on the surface of tire blanks can reduce the adhesion between the tire body and the mold during the production process, and improve the yield rate to over 98%.
3. Coatings and inks: functional enhancement and environmental upgrade
It promotes the development of the industry towards high performance and low pollution by improving the rheological properties of coatings and pigment dispersibility
Defoamer: Butyl palmitate, as a non silicone defoamer, is used in water-based acrylic emulsion paint to eliminate bubbles during the preparation process and improve the surface smoothness of the coating by 40%.
Dispersant: Palmitate amide reacts with hydroxyl groups on the surface of titanium dioxide to form a coating layer, enhancing the dispersion stability of the pigment in the resin. In the production of automotive paint, adding 1% palmitic acid amide can increase pigment dispersion efficiency by 50% and reduce color difference Δ E to below 0.5.
Rust inhibitor: Barium palmitate is used for ship coatings, which can form a dense protective film on the surface of steel substrates, reducing the corrosion rate by 80% in salt spray tests and extending the service life to more than 10 years.
4. Metal processing: lubrication protection and precision control
It and its derivatives ensure the quality of metal processing by reducing friction, inhibiting corrosion:
Cutting fluid: Isooctyl palmitate is used as an oily lubricant for soft metal processing such as aluminum and copper (such as can stamping), which can reduce cutting force by 25% and surface roughness Ra value from 0.8 μ m to 0.3 μ m.
Extreme pressure additive: A compound of palmitic acid amide and sulfur and phosphorus compounds, used for heavy-duty cutting fluids (such as steel processing), can form an adsorption film under high pressure conditions, isolate moisture and oxygen, and extend tool life by 50%.
Rust proof oil: Calcium palmitate is used as a rust proof oil for steel wire ropes, which can form a long-lasting protective film on metal surfaces, extending the corrosion time in salt spray tests from 72 hours to over 500 hours.
Biomedicine: the 'invisible guardian' of the health field
The application of palmitic acid in the pharmaceutical field covers multiple aspects such as drug carriers, antibacterial agents, and skin care, providing innovative solutions for disease treatment and health maintenance.
1. Pharmaceutical excipients: improved stability and bioavailability
Palmitic acid enhances efficacy and safety by improving the physical and chemical properties of drugs
Coating material: Palmitic acid powder is used as a drug capsule coating, which can block moisture and light, extending the shelf life of the drug to more than 3 years.
For example, after a certain brand of antibiotic capsules were coated with palmitic acid, the degradation rate decreased from 15% to 2% under high temperature and high humidity conditions (40 ℃/75% RH).
Emulsifier: As a lotion polymerization emulsifier, sodium palmitate can be used for the preparation of odorless chloramphenicol, making the drug particle size distribution more uniform (D50=2 μ m), and increasing the bioavailability by 30%.
Sustained release carrier: Palmitic acid and polylactic acid (PLA) co polymerize to form nanoparticles for targeted delivery of anticancer drugs (such as paclitaxel), which can increase drug accumulation in tumor tissues by 5 times and reduce systemic toxicity by 60%.
2. Antibacterial and anti-inflammatory: treatment of skin diseases
Palmitic acid has become an important ingredient in skin care by inhibiting the growth of pathogenic microorganisms and alleviating inflammatory reactions
Antibacterial agent: Zinc palmitate is used in medical dressings, with an inhibition rate of over 99% against Staphylococcus aureus and Escherichia coli, and can reduce the infection rate of burn wounds from 15% to 2%.
Anti inflammatory agent: Retinyl palmitate (vitamin A palmitate) is used for the treatment of acne, which can regulate sebum secretion, reduce the incidence of abnormal follicular keratinization by 40%, and reduce inflammatory skin lesions by 60%.
Humectant: Ethyl hexyl palmitate, as the raw material of cosmetics oil phase, can be used for the preparation of lipstick and face cream. Its small molecular structure can penetrate the cuticle, which can increase the skin water content by 20%, and significantly improve the drying and scaling phenomenon.
3. Disease treatment: from metabolic regulation to mental health
Palmitic acid exhibits unique value in the treatment of specific diseases:
Metabolic syndrome: Palmitic acid improves insulin resistance by regulating fat metabolism.
Clinical trials show that daily supplementation of 3g palmitic acid can reduce fasting blood glucose by 15% and glycosylated hemoglobin (HbA1c) by 0.8% in patients with type 2 diabetes.
Schizophrenia: Papanitone Palmitate (INVEGA Sustenna) ®) As a long-acting antipsychotic drug, slow release through intramuscular injection can reduce the recurrence rate of patients by 40% and improve treatment compliance to over 90%.
Cancer adjuvant therapy: Palmitic acid enhances chemotherapy sensitivity by inhibiting tumor angiogenesis. In the breast cancer model, palmitic acid combined with paclitaxel can reduce the tumor volume by 60% and prolong the survival period by 30%.
Food Nutrition: Balancing Health and Function
Palmitic acid is both a traditional raw material and a functional ingredient in the food industry, providing assurance for product taste, shelf life, and nutritional value.
1. Food additives: optimizers of taste and flavor
Palmitic acid improves the physical properties of food and enhances consumer experience:
Chocolate and Candy: Palmitic acid, as a substitute for cocoa butter, can lower the melting point of chocolate from 34 ℃ to 28 ℃, achieving a "melt in the mouth" taste while reducing costs by 30%.
Baked goods: Palmitates (such as palmitic acid stearoyl ester) can be used as emulsifiers in the preparation of bread and cakes, increasing dough extensibility by 20% and final product volume by 15%.
Dairy products: Glycerol palmitate (OPO structural fat) is used in infant formula milk powder, which can simulate the fat structure of breast milk, reduce the incidence of constipation in infants by 50%, and increase calcium absorption by 20%.
2. Nutritional reinforcement: an enabler of health functions
Palmitic acid supports growth, development, and disease prevention by participating in human metabolism.
Energy supply: Palmitic acid is an important form of energy reserve in the human body, providing 9 calories per gram. Adding palmitic acid to sports nutrition can increase athletes' endurance by 15% and shorten muscle fatigue recovery time by 30%.
Vision protection: Retinyl palmitate (a precursor of vitamin A) is converted into retinol in the human body and participates in the regeneration of retinal photoreceptor cells. The daily supplementation of 1.5mg retinyl palmitate can reduce the incidence rate of night blindness by 40%.
Immune regulation: Palmitic acid enhances macrophage phagocytic function by activating Toll like receptors (TLRs). Clinical trials have shown that supplementation with palmitic acid can reduce the incidence of respiratory infections in elderly people by 30% and shorten the course of the disease by 2 days.
3. Food preservation: guardians of safety and quality
Palmitic acid powder prolongs food shelf life by inhibiting microbial growth:
Natural preservatives: A combination of palmitic acid and Nisin can be used for meat preservation, with an inhibition rate of over 99% against Listeria and Salmonella, and an extended shelf life from 7 days to 21 days.
Antioxidants: Palmitic acid works synergistically with vitamin E and can be used for antioxidant purposes in edible oils, reducing the peroxide value (POV) from 10meq/kg to 2meq/kg and delaying the production of halal flavor by 3 months.
Defoamer: Palmitates are used in juice and beer production to eliminate bubbles during fermentation, increase product clarity by 40%, and reduce sediment by 50%.
Environmental Governance: Innovators of Green Technologies
The application of palmitic acid in the field of environmental protection covers wastewater treatment, soil remediation, and the development of biodegradable materials, providing technical support for sustainable development.
1. Wastewater treatment: removal of heavy metals and organic pollutants
Palmitic acid purifies industrial wastewater through chelation and precipitation:
Heavy metal removal: Palmitic acid forms stable complexes with lead and cadmium ions, which can be used for electroplating wastewater treatment.
At pH=5, adding 100mg/L palmitic acid can reduce the lead ion concentration from 50mg/L to below 0.1mg/L, meeting the emission standards.
Organic degradation: Palmitic acid, as a co metabolic substrate, can promote the decomposition of difficult to degrade organic compounds such as phenols and dyes by microorganisms. In the treatment of printing and dyeing wastewater, adding 0.5g/L palmitic acid can increase the COD removal rate from 60% to 85% and reduce chromaticity by 90%.
Sludge resource utilization: The combination of palmitic acid and lime can be used for sludge conditioning, reducing the moisture content of sludge from 85% to 65%, reducing the volume by 40%, and increasing the calorific value of sludge to 15MJ/kg, achieving energy utilization.
2. Soil remediation: solidification and stabilization of heavy metal pollution
Palmitic acid reduces the mobility and bioavailability of heavy metals by altering their forms
Lead pollution remediation: A combination of palmitic acid and phosphate can be used for soil remediation in mining areas. Adding 2% palmitic acid phosphate to lead contaminated soil can reduce the leaching toxicity of lead from 5mg/L to below 0.1mg/L, meeting the safety utilization standards.
Cadmium pollution remediation: The combination of palmitic acid and sodium sulfide can reduce the exchangeable cadmium content in soil by 80% and the cadmium accumulation in rice grains by 60%, ensuring the safety of agricultural products.
Organic pollution remediation: Palmitic acid powder, as an electron donor, can promote microbial degradation of polycyclic aromatic hydrocarbons (PAHs). Adding 1% palmitic acid to oil contaminated soil can increase the degradation rate of PAHs from 30% to 70% and shorten the remediation period by 50%.
3. Biodegradable materials: development of environmentally friendly alternatives
Palmitic acid, as a bio based raw material, can be used to synthesize biodegradable plastics and polyurethanes
Polyhydroxyalkanoates (PHA): co fermented with glucose, palmitic acid can be used for PHA production, with a biodegradation rate of over 90%. It can be completely decomposed into CO ₂ and water within 6 months and is suitable for disposable tableware, packaging materials, and other fields.
Biobased polyurethane: palm acid reacts with polyols and can be used for the preparation of shoe soles and automotive interior materials.
Its tensile strength reaches 20MPa, elongation at break reaches 500%, and its performance is comparable to traditional petroleum based polyurethane, but carbon emissions are reduced by 40%.
Nanocomposite materials: Palmitic acid modified montmorillonite (MMT) combined with polylactic acid (PLA) can increase the thermal deformation temperature of the material from 60 ℃ to 120 ℃ while maintaining biodegradability, making it suitable for high-temperature applications.

From lubricants in industrial manufacturing to targeted carriers in biomedicine, from functional ingredients in food nutrition to green technologies in environmental governance, palmitic acid, with its unique chemical properties and wide application value, has become a "chemical bridge" connecting traditional industries and emerging fields.


Synthesis of palmitic acid powder:
Weigh potassium palmitate based on the content of palmitic acid residues in palm oil stearin protein, so that palmitic acid residues account for 90% of the total fatty acid residues in the reaction system.
Place 1000 grams and 1000 milliliters of palm oil stearaldehyde (N-hexane) into a four necked flask, heat in a water bath until dissolved, and then mix with potassium palmitate.
After introducing nitrogen, stir evenly at a water bath temperature of 35 ° C and a rotation speed of 400r/min. Then add 1 gram of non directed lipase DF "Amano" 15 and stir for 4.5 hours under hot storage.
The supernatant of the organic phase was obtained by centrifugation, and then soap in the organic phase was removed by silica gel adsorption.
The light yellow solid was obtained by concentration. The content of glycerol palmitate in the organic phase is 81.5%, and the content of plutonium-2-position palmitic acid is 89.5%.
Palmitic acid is widely present in nature, and the content of palmitic acid varies in almost all oils and fats. The palmitic acid content in Chinese butter can reach up to 60%, palm oil is about 40%, and vegetable oil is less than 2%.
FAQ
Is palmitic acid good or bad for you?
Palmitic acid has a bad reputation, primarily because it has been shown to have negative health effects. It has been linked to several conditions, including brain diseases and cancer.
Is palmitic acid bad for your skin?
Palmitic Acid is a non-toxic and safe ingredient when used in concentrations of up to 13%. However, excessive use of palmitic acid or its derivatives may contribute to clogged pores and exacerbate acne in some individuals. A patch test is recommended.
What is another name for palmitic acid?
Hexadecanoic acid
Palmitic acid, formally hexadecanoic acid, is a long-chain saturated fatty acid. It exists in nature primarily as a triglyceride and other esters.
Is palmitic acid a vitamin A?
Vitamin A palmitate, scientifically named retinyl palmitate, is an ester created by combining retinol, the active form of vitamin A, with palmitic acid, a naturally occurring fatty acid.
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