Melanotan II was first developed at the University of Arizona. Various studies conducted at the institution confirmed that the best defense against skin cancer was melanin activated in the skin, a tan. The researchers assumed that an effective procedure to reduce the rates of skin cancer in individuals would be by inducing the body’s natural pigmentary system to produce a tan that would be protective before exposure to UV. Melanogenesis is a process by which the skin’s pigment cells (melanocytes) produce the hormone α-MSH naturally causes the skin's pigment (melanin).
After numerous clinical trials by administration of the endogenous hormone to the body, the scientists found that though it appeared to work, α-MSH had a very short half-life in the body to be practical as a therapeutic drug. Therefore, they opted to look for a more stable and potent alternative that would be more practical. Subsequently, after numerous trials, they developed Melanotan I, and after it.
It is used for tanning the skin and producing erections in men with erectile dysfunction when administered as a shot under the skin. It is safe when used under strict medical supervision for treating erectile dysfunction. However, it may cause stomach cramps, tiredness, nausea, spontaneous erections of the penis, and darkened skin. the benefits of it are as follows：
n Darker tan with less exposure to UV radiation
n Tanning without sunburn, even for fair-skinned individuals
n Possible reduction in the risk of Melanoma (skin cancer)
n Possible reduction in the incidence of sun-damaged skin
n Possible reduction in body fat
n No sunburn, n tan lines
n No sunless tanning streaks or fake tan removal
n Possible increase in libido
n During clinical trials for its use as a tanning agent, It was found to be a potent stimulator of male erections. It has also been shown to increase female sexual desire in patients with sexual arousal disorder).
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