Homosalate is a chemical widely used in sunscreen and other daily cosmetics. Its main uses include the following:
1. Sunscreen agent: Homeosalate is an ultraviolet absorbent that can absorb ultraviolet radiation at UVB wavelength, thus protecting the skin from the sun.
2. Stabilizer: Homeosalate can play a stabilizing role in sunscreen and other cosmetics to prevent changes during storage and use.
3. Humectant: Homeosalate can also be used as a humectant in cosmetics to increase the water retention and softness of skin.
4. Solvent: Homeosalate can be used as a solvent in some cosmetics to help dissolve other ingredients.
Homeosalate is a common sunscreen, whose main function is to absorb ultraviolet B (UVB) radiation. Homeosalate has certain reaction properties. Here are some possible reactions:
1. Photodegradation: Homeosalate may undergo photodegradation reaction when exposed to ultraviolet radiation, thus losing its sunscreen effect.
2. Oxidation reaction: Homeosalate may be oxidized, thus losing its sunscreen effect. This oxidation reaction may be initiated by oxygen, hydrogen peroxide or other oxidants.
3. Thermal decomposition reaction: Homeosalate may undergo decomposition reaction at high temperature, thus losing its sunscreen effect.
4. Chemical reaction: Homeosalate may react with other chemicals, for example, when mixed with some surfactants or other sunscreen agents, chemical reaction may occur, resulting in damage to its sunscreen effect.
The synthesis route of Homeosalate (4-hydroxybenzoate) can be realized through the following steps:
1. Synthesis of 4-hydroxybenzoic acid: reaction of benzoic acid and sodium hydroxide to produce sodium benzoate. Subsequently, under alkaline conditions, sodium benzoate is oxidized with hydrogen peroxide or other oxidants to produce 4-hydroxybenzoic acid.
2. Synthesis of octanol acid: reaction of octanol and sodium hydroxide to produce sodium octanol. Then, use carbon dioxide or other acidizing agent to acidify sodium octanol to produce octanol acid.
3. Synthesis of Homeosalate: 4-hydroxybenzoic acid is reacted with octanoic acid, and esterification is carried out under the catalysis of acid to generate Homeosalate.
Homeosalate, also known as octyl 4-hydroxybenzoate, is a chemical widely used in sunscreen and other daily cosmetics. It is prepared by the following synthetic route:
1. Benzyl alcohol (C6H5CH2OH) and cuprous bromide (CuBr) are reacted in ethanol to produce benzyl bromide (C6H5CH2Br).
2. Benzyl bromide is cyclized with magnesium sulfate (MgSO4) and carbon tetrachloride (CCl4) in dichloromethane to produce 1-phenyl-1,4-propanediol diphenylmethane (C6H5CH2C (CH2Ph) 2OH).
3. Reaction of 1-phenyl-1,4-propanediol diphenylmethane with chloroacetic acid (ClCH2CO2H) in trichloromethane to produce 1-phenyl-1,4-propanedione diphenylmethane (C6H5CH2C (CH2Ph) 2COCH2Ph).
4. The reaction of 1-phenyl-1,4-propanedione diphenylmethane with antimony tetroxide (Sb2O4) and octanol (C8H17OH) in toluene yields Homeosalate (C15H22O3).
Homeosalate was first discovered in 1958 by American chemist Alfred Albert in a study. At that time, he was studying the permeability of various chemicals to the skin and whether they had the ability to protect the skin.
In this study, Albert tested a variety of different chemicals, including 4-hydroxybenzoic acid (4-hydroxybenzoic acid), the precursor of Homeosalate, and found that they all have the ability to protect skin from UV damage. He also found that when these chemicals were mixed with other sunscreen ingredients, their protective effects were more effective.
In the following decades, Homeosalate has been widely used in sunscreen and other daily cosmetics, and has been further studied and developed. With the increasing awareness of ultraviolet radiation, people's demand for sunscreen is also increasing. As an effective ultraviolet absorber, Homeosalate has become one of the indispensable ingredients in daily cosmetics.
At present, as people pay more attention to skin health and environmental protection, the demand for sunscreen is also increasing. As a common sunscreen ingredient, Homeosalate will continue to have broad prospects for development in the future.
However, it should be noted that Homeosalate also has some problems and challenges. On the one hand, Homeosalate may have a negative impact on the environment, such as damage to coral reefs. On the other hand, excessive use or long-term exposure of Homeosalate may cause adverse effects on human health, for example, it may interfere with the normal function of the endocrine system.
Therefore, in the future development, it is necessary to further explore and study more environmentally friendly and safe alternative sunscreen ingredients, and explore more intelligent and customized sunscreen technology. At the same time, it is necessary to strengthen the supervision and safety assessment of commonly used sunscreen ingredients such as Homeosalate to ensure their safety and effectiveness in use.