Selank(link:https://www.bloomtechz.com/synthetic-chemical/peptide/selank-peptide-cas-129954-34-3.html) is a polypeptide compound with molecular formula C33H57N11O9 and CAS 129954-34-3. White crystal powder. The solubility in water is 3.36 mg/mL and at pH 7.0, 37°C, it is 2.56 mg/mL. In addition, Selank can also be dissolved in organic solvents, for example, the solubility in methanol can reach 19.8 mg/mL.
1. Selank's discovery:
Selank was first discovered in 1982 by Russian scientist E.V. Radionova et al. when they were studying the peptides in the cerebrospinal fluid of rats. They found a seven amino acid peptide in rat cerebrospinal fluid and named it Selank (Sеlеnсеrin).
2. Initial research of Selank:
Since Selank was named, scientists have started research on its pharmacology and clinical application. In earlier studies, scientists found that Selank has a series of biological activities, such as anti-anxiety, anti-depression, improving memory and enhancing immunity.
Among them, the anti-anxiety and anti-depressant effects are one of the hot areas of Selank's extensive research. A number of experimental studies have shown that Selank can reduce obsessive-compulsive disorder-like behavior and depression-like behavior in rats, and it also has a certain relieving effect on human depression patients.
In addition, Selank can also improve immunity, promote the differentiation and proliferation of immune cells, thereby improving the body's resistance, and has the effects of relieving pain, lowering blood pressure and improving sleep. These findings somewhat demonstrate the pharmacological effects of Selank.
3. Clinical application of Selank:
Based on Selank's extensive pharmacological research and potential clinical applications, some clinical studies related to Selank have been carried out. One of the earliest studies was conducted in 2000, which tested Selank injections on healthy people and patients with depression, and found that it could significantly improve the cognitive ability of healthy people and the mental state of patients with depression.
In addition, some preliminary studies on the clinical application of Selank are underway. For example, some scholars are studying the therapeutic effect of Selank on patients with autism and Alzheimer's disease, as well as its protective effect on neurons and heart damage.
4. Synthesis method of Selank:
In order to better develop the pharmacological properties and clinical application of Selank, scientists have further advanced the production method of Selank. Today, there are two main synthesis methods for Selank: solid-phase synthesis and liquid-phase synthesis.
4.1 The solid-phase synthesis method is one of the most commonly used methods, because it can perform high-throughput synthesis and can avoid the influence of thermodynamics and kinetics on peptides in aqueous solution. However, due to the slow reaction rate of the solid-phase method, multiple steps of adding reactants and dissolving are required, which makes the synthesis process more cumbersome.
4.2 The liquid-phase synthesis method is suitable for small-scale synthesis reactions, with simple operation and fast reaction speed. The disadvantage is that it is difficult to control the occurrence of side reactions, and the long-term stay of the polypeptide in solution will cause thermodynamic and kinetic effects.
5. Market prospect of Selank:
With the extensive research and clinical application of Selank, it has a very broad market prospect. Especially in the fields of anti-anxiety and anti-depression, Selank has become one of the best-selling products in pharmacies in various countries. In addition, research on potential application areas such as autism, Alzheimer's disease, and neuronal damage is also expected to advance Selank's market prospects.
Generally speaking, the development history of Selank began with the discovery of scientists and the need to solve practical problems. After years of research and practice, Selank has achieved very significant pharmacological effects and clinical applications. In the future, with the continuous improvement of Selank's production technology and the continuous expansion of related applications, it is believed that Selank's market prospects will become more extensive and diversified. Understanding the chemical properties of Selank is of great significance for its application and research.
1. Molecular structure:
Selank consists of 7 amino acid residues, including 5 fatty amide groups, 1 glycine and 1 alanine. These amino acid residues are connected by amide bonds to form a polypeptide chain. Selank has a molecular formula of C33H57N11O9 and a molecular weight of 751.9. The molecule of Selank contains multiple amino groups and carboxyl groups, and different types of reactions such as hydrogen bonds, condensation reactions, and oxidation reactions can occur between these functional groups, thereby affecting its chemical properties and pharmacological effects.
2. Solubility:
Selank is a hydrophilic molecule that can be dissolved in common solvents such as water, ethanol, and methanol. Selank molecules contain a variety of amino acid residues, among which fatty amide groups have a higher solubility in non-polar solvents. In laboratories and applications, solvents such as water or buffers are usually used to prepare and apply Selank.
3. Acid-base properties:
The molecule of Selank contains multiple amino and carboxyl groups, so it has acid-base properties. In the usual pH range, the carboxyl group of Selank is a negative ion, and the amino group is a positive ion. When the pH of the solution is lower than Selank's isoelectric point, its positively charged amino groups will react more easily with negatively charged molecules. When the pH of the solution is above the isoelectric point, its negatively charged carboxyl groups will react more easily with positively charged molecules. This acid-base property can affect the interactions and reactions between Selank and other molecules.
4. Stability:
The stability of Selank is affected by many factors, such as temperature, light, oxygen, enzymes, etc. In dry state, Selank can be stored for a long time. However, under humid or high temperature conditions, it is affected by oxidation and hydrolysis, resulting in a loss of stability. In addition, in the human body, Selank is easily hydrolyzed by enzymes such as proteolytic enzymes, thereby affecting its pharmacological effects. Therefore, appropriate preservation and use methods are generally required in laboratories and applications to maintain the stability and pharmacological effects of Selank.
5. Other chemical properties:
Selank also has various other chemical properties, such as its ability to carry out coordination reactions with other molecules and form complexes with metal ions. In addition, the molecules of Selank contain more sulfur oxides, and these functional groups are prone to oxidation and alkylation reactions, thereby affecting its pharmacological effects. When applying and researching Selank, it is necessary to consider these chemical properties and their influence, and properly adjust the reaction conditions and methods to ensure its pharmacological effects and quality.