Ipamorelin peptide(link:https://www.bloomtechz.com/synthetic-chemical/peptide/lpamorelin-powder-cas-170851-70-4.html). our supplier of Ipamorelin, we have Ipamorelin for sale. A white solid, easily soluble in polar solvents such as water and methanol. It has a pKa value of 9.76 and its charge state is cationic in pH 7.4 buffer solution. In addition, Ipamorelin has an optical rotation of +79° (c=1, anhydrous alcohol), indicating that it is an optically active peptide.
Chemical structure:
The chemical formula of Ipamorelin is C38H49N9O5, the relative molecular mass is 711.86, and it consists of 17 amino acid residues. Its structure is:
H2N-(His-D-2-Nal-Ala-Trp-D-Phe-Lys)-NH2
Among them, D-2-Nal represents D-2-naphthylalanine, and D-Phe represents D-phenylalanine. In addition, the peptide also contains two unnatural amino acids, namely D-2-naphthylalanine and D-phenylalanine. The introduction of these unnatural amino acids makes Ipamorelin more resistant to degradation by proteases, thereby increasing its bioavailability and half-life.
Ipamorelin is a growth hormone releasing peptide (GHRP) that has been extensively studied and used to treat a variety of diseases. Its main function is to improve protein synthesis, bone density, muscle mass and other functions in the body by promoting the secretion of growth hormone in the body. The application of Ipamorelin in various diseases will be introduced in detail below.
1. Enhance immunity and anti-aging:
Ipamorelin can enhance immunity and disease resistance by promoting the secretion of immune regulatory factors such as thymosin and human thymosin (h-Tα1). In addition, Ipamorelin can also achieve anti-aging effects by increasing the level of antioxidants and reducing the damage of free radicals to the body.
2. Improve memory, sleep and mood:
Ipamorelin also has the function of improving memory, sleep and mood. Studies have shown that Ipamorelin can promote the occurrence and proliferation of hippocampal neurons, and increase the number of neurons in the hippocampal region. At the same time, it can also affect neurotransmitters in the brain, such as dopamine, norepinephrine, and serotonin, thereby improving sleep and mood.
3. Reduce the symptoms of cardiovascular disease:
Ipamorelin can reduce the symptoms of cardiovascular diseases by promoting the proliferation of endothelial cells, strengthening the function of endothelial cells and reducing hypertension and other factors. Studies have shown that Ipamorelin can improve vascular endothelium-dependent relaxation response, reduce systolic and diastolic blood pressure, and obtain certain anti-atherosclerotic effects.
4. Treatment of obesity:
Ipamorelin has also been extensively studied and used to treat obesity. Its main role is to reduce body weight and body fat while maintaining muscle mass by promoting glycogen synthesis and fatty acid utilization. In addition, Ipamorelin can also promote the secretion of insulin-like growth factor (IGF-1), thereby improving insulin receptor sensitivity and metabolism.
5. Improve bone density and osteoporosis:
Ipamorelin is also used to improve bone density and conditions such as osteoporosis. Studies have found that Ipamorelin can promote the proliferation and differentiation of osteoblasts, while inhibiting the activity of osteoclasts, thereby increasing bone mass and bone density. In addition, it can improve calcium absorption and storage, thereby reducing the condition of osteoporosis.
6. Improves muscle mass and athletic performance:
Ipamorelin is also able to improve muscle mass and athletic performance. Studies have shown that Ipamorelin can promote protein synthesis and muscle cell proliferation, while inhibiting protein degradation and muscle atrophy. In addition, it improves muscular strength and endurance, thereby improving athletic performance and fitness.
7. Treats Pain and Inflammation:
Ipamorelin is also used to treat conditions such as pain and inflammation. Studies have shown that Ipamorelin can promote the apoptosis and clearance of inflammatory cells, while reducing the level of inflammatory factors. In addition, it can also improve the function of the immune system, so it also has certain effects on antibacterial, antiviral and antifungal.
In conclusion, Ipamorelin is widely used as a ghrelin in many fields. Its main function is to promote the secretion of growth hormone in the body, thereby improving the functions of protein synthesis, bone density, and muscle mass in the body, and improving immunity, anti-aging, memory, sleep, cardiovascular disease, obesity, and bone density. , muscle mass, athletic performance, pain and inflammation all play a role. At the same time, in order to ensure the above activities, the product also has a variety of corresponding properties, which are introduced as follows regardless of the nature.
Chemical stability:
Ipamorelin is relatively stable in vivo and is mainly affected by factors such as gastric acid, digestive enzymes and proteases. Studies have shown that the half-life of the peptide is about 2 hours, and its main metabolites are amino acids and peptide chain fragmentation products.
Pharmacokinetics:
Ipamorelin has good pharmacokinetic properties. After subcutaneous or intravenous injection, it rapidly enters the circulatory system and reaches peak concentration within 30 minutes. Its bioavailability is about 90%, while Tmax and T1/2 are 15 and 120 minutes, respectively. In addition, the peptide is mainly metabolized by the liver, in which the CYP450 enzyme system plays an important role.
Pharmacodynamics:
Ipamorelin, as ghrelin, has various pharmacodynamic effects. Its main function is to stimulate the production and release of growth hormone-releasing hormone (GHRH) in the anterior pituitary gland, thereby prompting the anterior pituitary gland to secrete growth hormone (GH). Growth hormone primarily acts on the liver and other tissues in the body, promoting the body's growth and repair processes.
The pharmacodynamic effects of Ipamorelin can be divided into the following aspects:
1. Promote protein synthesis:
Ipamorelin can promote protein synthesis, thereby increasing muscle mass, improving bone density and treating pain, etc. Studies have shown that the peptide stimulates nutrient uptake and utilization, increases oxidative metabolism and ATP synthesis, thereby promoting the protein synthesis process.
2. Improve immunity:
Ipamorelin can improve immunity, thereby increasing the body's disease resistance. Studies have shown that this peptide can promote the secretion of immune regulatory factors such as thymosin and human thymosin, and enhance immune function.
3. Improve metabolism:
Ipamorelin can increase the metabolic level, thereby promoting the reduction of body weight and the treatment of obesity. Studies have shown that the peptide can promote glycogen synthesis and fatty acid utilization, reduce fatty acid synthesis and storage, thereby reducing body weight and body fat.
4. Improve sports performance:
Ipamorelin can improve athletic performance, thereby increasing functions such as muscle strength and endurance. Studies have shown that the peptide can promote the proliferation and differentiation of muscle cells, increasing muscle mass and strength.
In conclusion, Ipamorelin has good pharmacokinetic properties and various pharmacodynamic effects, and can be used to treat various diseases. Its chemical stability and physical properties also make it ideal for the preparation of growth hormone.