Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of gonadorelin injection in China. Welcome to wholesale bulk high quality gonadorelin injection for sale here from our factory. Good service and reasonable price are available.
Gonadorelin Injection is an artificially synthesized ten-peptide hormone whose chemical structure is exactly the same as the natural gonadotropin-releasing hormone (GnRH) secreted by the human hypothalamus. This drug mainly stimulates the anterior pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in a pulsatile manner by mimicking the physiological pulse pattern of endogenous GnRH. These two gonadotropins then act on the gonads (ovaries or testes), regulating the synthesis and secretion of sex hormones (such as testosterone and estrogen), and promoting the maturation of gametes (sperm or eggs).
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Gonadorelin COA
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Certificate of Analysis |
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Compound name |
Gonadorelin | |
| Grade | Pharmaceutical grade | |
| CAS No. | 33515-09-2 | |
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Quantity |
66g | |
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Packaging standard |
PE bag+Al foil bag | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
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Lot No. |
202601090056 | |
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MFG |
Jan 9th 2026 | |
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EXP |
Jan 8th 2029 | |
| Sturcture |
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Item |
Enterprise standard |
Analysis result |
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Appearance |
White or almost white powder |
Conformed |
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Water content |
≤5.0% |
0.85% |
| Loss on drying |
≤1.0% |
0.32% |
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Heavy Metals |
Pb≤0.5ppm |
N.D. |
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As≤0.5ppm |
N.D. | |
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Hg≤0.5ppm |
N.D. | |
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Cd≤0.5ppm |
N.D. | |
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Purity (HPLC) |
≥99.0% |
99.50% |
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Single impurity |
<0.8% |
0.51% |
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Total microbial count |
≤750cfu/g |
107 |
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E. Coli |
≤2MPN/g |
N.D. |
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Salmonella |
N.D. | N.D. |
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Ethanol (by GC) |
≤5000ppm |
565ppm |
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Storage |
Store in a sealed, dark, and dry place below 2-8°C | |
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| Chemical Formula | C55H75N17O13 | |
| Exact Mass | 1181.57 | |
| Molecular Weight | 1182.31 | |
| m/z | 1181.57(100.0%), 1182.58(59.5%), 1183.58(17.4%), 1182.57(6.3%), 1183.57(3.7%), 1183.58(2.7%), 1184.58(2.5%), 1184.58(1.2%), 1184.58(1.1%) | |
| Elemental Analysis | C,55.87; H,6.39; N,20.14; O,17.59 | |
Clinically, it is mainly used for diagnosing the function of the hypothalamic-pituitary-gonadal axis, such as differentiating whether the cause of hypogonadism is from the hypothalamus or the pituitary itself. Additionally, in certain circumstances, it may also be used for treating certain hypothalamic gonadal hypofunction disorders. Administration requires strict medical supervision. Common adverse reactions may include injection site reactions, nausea, headache, or allergic symptoms. It is worth noting that continuous rather than pulsed administration will produce a completely opposite inhibitory effect. Therefore, its clinical application strictly depends on the precise administration mode and dosage, and must be carried out under the guidance of a professional physician.
In the application of high-end animal husbandry
Against the backdrop of the intensive and refined development model of high-end animal husbandry, reproductive efficiency serves as a core indicator running through the entire breeding chain, directly determining the level of overall production efficiency and the strength of industry competitiveness. As an artificially synthesized analog of gonadotropin-releasing hormone (GnRH), gonadotropin injection, by virtue of its molecular structure that is highly homologous to natural hormones and its stronger receptor-binding capacity, can precisely target the hypothalamic-pituitary-gonadal (HPG) reproductive axis of animals. It achieves accurate regulation of key reproductive processes such as animal estrus, ovulation, and fertilization by modulating the secretion rhythms of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), and has thus become a core technical tool for addressing various reproductive disorders and optimizing full-cycle reproductive management in large-scale breeding scenarios.Here are three core application values:
Overcoming reproductive barriers
For common reproductive problems in female animals, such as anestrus, silent estrus, and delayed ovulation, as well as low libido in male animals, this injection can break the inhibitory state of the animals' own reproductive functions through the precise regulation of exogenous hormones, help the body restore normal reproductive rhythms, and effectively improve the conception success rate of animals of breeding age.
Improving artificial insemination efficiency
In the application process of artificial insemination technology, the injection enables accurate prediction and synchronous regulation of the ovulation time of female animals, allowing the insemination operation to be highly matched with the optimal window period for egg release. This greatly reduces the risk of insemination failure caused by uncertain ovulation time and significantly improves the group conception rate.
Optimizing the reproductive performance of male animals
By regulating the hormone secretion level of the gonads in male animals, the injection can promote the development of the spermatogenic epithelium of the testes, increase sperm count, motility, and the proportion of sperm with normal morphology, providing crucial technical support for the cultivation and propagation of high-quality breeding stock.
Overcoming Reproductive Obstacles: Restarting the Stagnated Reproductive Engine
Low reproductive capacity in female livestock is a common problem in high-end farms, manifested as ovarian atrophy, delayed or blocked follicle development, delayed or impaired ovulation, etc. These problems are often caused by dysfunction of the hypothalamus-pituitary-gonadal axis, resulting in insufficient secretion of gonadotropins (LH/FSH), and preventing follicles from maturing and ovulating.
Mechanism of action:
Gnaronil mimics the endogenous GnRH and directly stimulates the anterior pituitary gland to release LH and FSH, creating a pulsatile hormone peak. This process can "restart" the stalled reproductive axis:
Ovarian arrest: Promotes follicles to enter the development cycle from the dormant state and restores estrus manifestations.
Ovarian cyst: By inducing the LH peak to trigger ovulation, it avoids the continuous enlargement of cysts that leads to infertility.
Delayed ovulation: By injecting gonadotropin-releasing hormone (GnRH) at the late stage of estrus, an artificial LH peak can be created to ensure that the egg is discharged at the optimal time. The ovulation time window of the sows was shortened from the original 48 hours to within 24 hours, and the mating and conception rate increased by 12%, and the average litter size increased by 1.5 piglets.
Clinical case:
A sow farm with 10,000 sows once faced fluctuations in the number of piglets born. After testing, it was found that some sows had delayed ovulation. By injecting 100 μg of GnRH after estrus, the ovulation time window of the sows was shortened from the original 48 hours to within 24 hours, and the mating and conception rate increased by 12%, and the average litter size increased by 1.5 piglets.
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Enhancing the Efficiency of Artificial Insemination: The Core Support for Batch Management
In modern intensive farming, the artificial insemination (AI) technology needs to be combined with the synchronized estrus and timed insemination procedures to achieve centralized mating for a large number of female animals. Gonadotropin-releasing hormone (GnRH) plays the role of a "time controller" in this process:
Simultaneous estrus: By administering gonadotropin-releasing hormone (GnRHa) twice (with an interval of 7-9 days) and combining prostaglandin to dissolve the corpus luteum, the synchronization rate of estrus in the herd of female animals can reach over 90%.
Scheduled insemination: Insemination is carried out 18-24 hours after the second administration of GnRHa, which can precisely determine the ovulation time and avoid mismatches caused by errors in estrus identification.
Technical advantages:
Management convenience: Reduces reliance on individual estrus identification and lowers labor costs.
Reproduction efficiency: Batched insemination shortens the estrus period and increases the annual number of pregnancies by 0.2-0.3 times.
Genetic quality improvement: Ensures efficient utilization of high-quality sire semen and accelerates genetic progress of the population.
Data support:
After a dairy farm of 1,000 cows used gonadotropin-releasing hormone to induce synchronized estrus, the conception rate during the estrus period increased from 58% to 72%, and the total number of calves born per year increased by 15%. At the same time, due to the reduction of ineffective inseminations, each cow saved about 300 yuan in annual feeding costs.
Optimizing the reproductive performance of male livestock: Breaking through the bottleneck of semen quality
The sexual desire and semen quality of breeding bulls directly affect the reproductive efficiency of the entire herd, which is crucial for large-scale breeding and genetic improvement. Gonadorelin, as a synthetic analog of gonadotropin-releasing hormone (GnRH), can effectively improve the reproductive performance of breeding bulls by specifically stimulating the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH), thereby regulating the hypothalamic-pituitary-testicular axis. Its specific effects on related issues are as follows:
Low sexual desire: Gonadorelin stimulates the pituitary gland to secrete LH, which further promotes testicular Leydig cells to secrete testosterone-the key hormone regulating sexual desire in breeding bulls. By increasing serum testosterone levels, it can significantly enhance the mating willingness and mating behavior of bulls with low sexual desire, effectively improving their libido and reducing the occurrence of mating refusal, which is particularly important for breeding bulls in the non-breeding season or those with decreased libido due to physical weakness.
Poor semen quality: FSH secreted under the stimulation of Gonadorelin can promote spermatogenesis in the seminiferous tubules of bulls, while LH cooperates to improve testicular function. This synergistic effect can effectively increase sperm density, enhance sperm motility, and improve the rate of normal sperm morphology. For breeding bulls with low sperm count, poor activity, or high abnormal sperm rate, Gonadorelin can help optimize semen quality, ensuring the fertilization rate of female cattle during artificial insemination or natural mating.
Reproductive disorders caused by stress: Breeding bulls often suffer from reproductive function inhibition due to stress factors such as long-distance transportation, high-temperature environment, and feeding management changes, which may lead to decreased libido and poor semen quality. Gonadorelin can alleviate the inhibitory effect of stress on the hypothalamic-pituitary-testicular axis, regulate the balance of reproductive hormones, and help bulls quickly recover their normal reproductive function, reducing the impact of stress on herd reproductive efficiency.
Application plan:
For male breeding animals with low sexual desire, 100 μg gonadorelin is injected intramuscularly 24-48 hours later. The testosterone level significantly increases and the mating willingness enhances. At the same time, continuous use can improve the sperm production environment and maintain stable semen quality.
Precise Application: Key Elements for Effective Utilization
Gnaronil is an efficient reproductive control tool, but its application must strictly adhere to the "precision" principle:
Timing control
The injection should be administered when the follicle is close to maturity. Administering too early may lead to follicular closure.
Dosage control
For sows, the recommended dosage is 100 μg per time; for cows, it is 100-200 μg per time. Excessive dosage may cause pituitary desensitization.
Etiological diagnosis
Before using, it is necessary to rule out fundamental causes such as nutritional deficiency, uterine diseases, and infectious diseases to avoid "treating the symptoms but not the root cause".
Industry Impact and Future Trends
As the livestock industry develops towards intensification and intelligence, the application scenarios of gonadorelin will continue to expand:
Gene editing breeding
Combined with timed insemination technology, it accelerates the spread of superior genes.
Precise breeding management
Through B-ultrasound monitoring of follicle development, individualized medication plans are achieved.
Animal welfare improvement
Reduces the elimination rate caused by reproductive disorders and extends the lifespan of female livestock.
Conclusion
Gonadorelin Injection has solved the breeding efficiency problem in the livestock industry through scientific mechanisms. Its precise control capabilities not only enhance production efficiency but also drive the industry towards a more efficient and sustainable development direction. In the future, with technological iteration and application deepening, this "reproductive key" will unleash greater value in high-end livestock farming.
Safety
Adverse Reaction Management
Gonadorelin Injection may cause injection site itching, pain or swelling, as well as systemic allergic reactions (such as rash, breathing difficulties) during clinical use. Some patients may experience abdominal discomfort, osteoporosis or thrombotic phlebitis. Long-term use may increase the risk of osteoporosis, and regular monitoring of bone density and calcium supplementation are required. In the livestock industry, using the recommended dose has not reported any serious adverse reactions, but it is necessary to avoid combining with other hormone drugs to prevent interactions.
Contraindications and Protection for Special Populations
Pregnant women, patients with hormone-dependent tumors (such as prostate cancer, breast cancer), and those allergic to Gnarine should not use it. When administering the drug during the follicular phase of the normal menstrual cycle, contraceptive measures should be taken to avoid potential reproductive risks. The safety of the drug use in children, the elderly, and those with impaired liver and kidney function is not yet clear. Clinical use should be evaluated with caution. In prostate cancer treatment, a temporary increase in gonadotropin may cause tumor symptoms to worsen (such as bone pain, difficulty urinating) in the early stage, and it is necessary to combine flutamide or cyproterone acetate to prevent it.
Risk Control Measures
During medication use, regular monitoring of sex hormone levels and bone density should be conducted. Long-term users need to supplement calcium and vitamin D to reduce the risk of osteoporosis. In the livestock industry, it is necessary to strictly follow the dosage and medication procedures to avoid abuse and prevent animal health problems. For example, in the synchronized estrus program of dairy cows, precise injection according to the Ovsynch protocol is required to avoid ovarian overstimulation or disrupted estrus cycles due to improper dosage.
Stability
Gonadorelin Injection is a ten-peptide hormone drug with relatively stable chemical properties. However, it needs to be stored under specific conditions to prevent degradation. The injectable Gnaronil is usually formulated as a freeze-dried powder injection (white or off-white lumps), containing an appropriate amount of D-mannitol as a stabilizer. The product should be stored in a dark place and sealed, and some veterinary formulations require it to be sealed in a cool and dark place (such as 2-8°C) to prevent loss of active ingredients due to light exposure, high temperature, or humid conditions.
After intravenous injection, Gnaronil rapidly metabolizes in the plasma to an inactive fragment and is excreted through urine. There is no risk of accumulation in the body. Its half-life is relatively short (initial phase 2-10 minutes, terminal phase 10-40 minutes), with an action time of approximately 3-5 hours. It needs to be administered strictly according to the treatment course to maintain efficacy. This characteristic enables it to have a predictable duration of therapeutic effect in periodic treatments (such as inducing estrus and promoting ovulation), while reducing the potential impact of long-term residues on animal products.
The stability of Gnaronil injection is significantly affected by storage conditions. The freeze-dried powder injection should be stored in a dark and sealed environment to avoid repeated freezing and thawing, which can lead to a decrease in activity. After reconstitution, it should be used immediately to avoid degradation due to prolonged storage. In the livestock industry, strict temperature control is required during transportation and storage to prevent the impact of environmental changes on drug efficacy. For example, the shelf life of veterinary Gnaronil injection can reach 2 years when stored in a sealed and cool-dark place, but if the storage conditions are not up to standard, the shelf life may be shortened.
In human medicine, when Gnaronil injection is used for diagnosing hypothalamic-pituitary-gonadal dysfunction, it should be injected according to the standard procedure and blood samples should be collected at regular intervals to detect LH and FSH values. Its stability is manifested as an increase in LH value to more than three times the baseline value within 25-45 minutes, and an increase in FSH by more than twice within the same period, ensuring the accuracy of the diagnostic results. In the livestock industry, when used to induce synchronized estrus in dairy cows, it should be precisely injected according to the Ovsynch protocol. Its stability is manifested as an estrus synchronization rate of over 90%, and an increase in mating conception rate of 12%-15%, demonstrating the reliability of the drug in group treatment.
FAQ
Q:Will gonadorelin increase testosterone?
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Gonadorelin works by stimulating the anterior pituitary gland to produce more LH (luteinizing hormone) and FSH (follicle stimulating hormone) which in turn stimulates the testicles to produce more testosterone and sperm, and estrogen. This medication strengthens the natural production pathway much better than HCG does.
Q:Is gonadorelin as good as HCG?
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When prescribed appropriately, gonadorelin can be effective for some men, but its effects are less predictable than HCG. Some men respond well and notice improved testicular fullness and comfort. Others experience minimal or no benefit, even with increased dosing frequency.
Q:What happens after a gonadotropin injection?
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After receiving an injection of human chorionic gonadotropin, ovulation can occur between 24-48 hours, with the average time being within 36 hours. Ovulating as early as 24 hours is less likely, however, it can happen and couples should be prepared.
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