GS-441524 injection,abbreviated as 441, is an antiviral drug that belongs to viral RNA dependent RNA polymerase (RdRP) inhibitors and broad-spectrum antiviral nucleotides. It usually exists in the form of high-purity and stable white or off white powder, which needs to be diluted with a specific solvent to make an injection solution.This substance is converted into active triphosphate metabolites within cells through enzymatic catalysis.
This metabolite competitively inhibits the transcription process of viral RNA, leading to premature termination of transcription and blocking the synthesis of viral RNA. It is an inhibitor of ribonucleotide analogs that can "trick" the virus's RNA dependent RNA polymerase to bind to it, thereby interrupting the replication of RNA viruses. It is mainly used to treat feline infectious peritonitis (FIP) caused by feline coronavirus. It is injected subcutaneously in cats and generally comes in two forms: oil and water. It needs to be stored and transported under ultra-low temperature conditions, usually using ultra-low temperature ice packs for transportation.
At the same time, our company not only provides GS-441524 injections, but also tablets and powders. If needed, please feel free to contact us at any time.
GS-441524, Price off! 50% discount!!!
After the 3nd factory completed and put into use, the sales volume increased 3 times more during the last 3 months.
In order to growing with our stable clients together, we reset the price for the GS-441524 FIP series products, some items decreased over 50%!
Including API(Pure powder), OEM/ODM: Injection(20mg,30mg,40mg), tablet(25mg,45mg,60mg,70mg) etc.
| Price List of GS-441524 CAS 1191237-69-0 | ||||||
| Category | Specification | Package | Oty | Unit | Unit Price (EXW,USD$/Unit) |
Remark |
| Injection |
20mg/6ml
|
10 vials/Box | 1 | Box |
$195/Box $250/Box $330/Box |
(1)Explanation: |
|
40mg/10ml Sometimes white crystals appears, and this specification is being tested... |
We are the R&D company, this is our own technology, previously many buyers want the 40mg injection, we adjusted the proportion of solvent, and we have achieved 40mg.However, recently the temperature is lower, the system is still not stable especially in Europe, so we told all resellers: the 40mg is not availble | |||||
| Tablet | 25mg 45mg 60mg 70mg |
(1)10 PCS/Board (2)12 or 30 PCS/Bottle (3)Customizable |
100 | Pills | $2.5/PCS $2.9/PCS $3.2/PCS $3.5/PCS |
(1)MOQ 100 PCS (2)Printing Customization(Foil blister package of pills) MOQ: 100 PCS, $150//time |
|
API (Pure powder) |
HPLC>99.0% HNMR |
PE bag+Al foil bag |
10 500g |
Gram |
$22.0/Gram $4.0/Gram |
MOQ 10 grams |
Factory supply & Technology support & One-for-one service for you!
GS-441524 injection, tablet & pure powder, the best meds for Cat FIP! BLOOM TECH, the advanced R&D institution for FIP drugs.
(1)If your cat are in emergency! 3-6 days to arrive!
For EU, North America, Middle east, AUS etc., After payment, shipping out in 24h, from our Hong kong & Guangzhou warehouse, International express, FedEx, DHL, UPS etc.
(2)If you buy:
1-9 boxes, shipping cost: $85
10-30 boxes, shipping free.
31-50 boxes, 5% discount.
51-80 boxes, 10% discount.
81-100 boxes, 15% discount.
101+ boxes, 20% discount.
The shipping cost includes:
Shipping, separated packaging, customs clearance, private address delivery fee etc.
Client Feedback
|
|
|
|
GS-441524 powder COA
 |
||
Certificate of Analysis |
||
|
Compound name |
GS-441524 |
|
|
CAS No. |
1191237-69-0 |
|
|
Grade |
Veterinary grade |
|
|
Quantity |
Customized |
|
|
Packaging standard |
Customized |
|
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
|
Lot No. |
20250109001 |
|
|
MFG |
Jan 9th 2026 |
|
|
EXP |
Jan 8th 2029 |
|
|
Structure |
|
|
| TEST STANDARD | GB/T24768-2009 Industry. Stnndard | |
|
Item |
Enterprise standard |
Analysis result |
|
Appearance |
White or almost white powder |
Conformed |
|
Water content |
≤5.0% |
0.31% |
| Loss on drying |
≤1.0% |
0.15% |
|
Heavy Metals |
Pb≤0.5ppm |
N.D. |
|
As≤0.5ppm |
N.D. | |
|
Hg≤0.5ppm |
N.D. | |
|
Cd≤0.5ppm |
N.D. | |
|
Purity (HPLC) |
≥99.0% |
99.9% |
|
Single impurity |
<0.8% |
0.48% |
|
Residue on ignition |
<0.20% |
0.064% |
|
Total microbial count |
≤750cfu/g |
80 |
|
E. Coli |
≤2MPN/g |
N.D. |
|
Salmonella |
N.D. | N.D. |
|
Ethanol (by GC) |
≤5000ppm |
400ppm |
|
Storage |
Store in a sealed, dark and dry place at-20 degrees |
|
|
|
||
|
|
||
| Chemical Formula | C12H13N5O4 | |
| Exact Mass | 291.1 | |
| Molecular Weight | 292.1 | |
| m/z | 291.1(100.0%), 292.1(13.0%),292.09(1.8%) | |
| Elemental Analysis | C,49.48; H,4.50; N,24.04; O,21.97 | |
GS-441524 injection, abbreviated as 441, is an antiviral drug mainly used to treat feline infectious peritonitis (FIP).
Treatment of feline infectious peritonitis (FIP)
Feline infectious peritonitis (FIP) is a fatal feline disease caused by a variant of feline coronavirus (FCOV), which was once considered a terminal illness in the feline family. However, with the emergence of the antiviral drug it, there is new hope for the treatment of FIP.
It is mainly used to treat feline infectious peritonitis (FIP) caused by feline coronavirus. Whether it is wet FIP (mainly manifested as ascites, pleural effusion, and dyspnea) or dry FIP (which may involve multiple organs such as the eyes, central nervous system, and kidneys), it has shown significant therapeutic effects It is usually administered by subcutaneous injection.
The injection site can be chosen from 2 centimeters behind the cat's scapula to the mid waist area, half the distance from the adjacent chest and side abdomen. Before injection, the medication needs to be diluted to an appropriate concentration and injected using a sterile syringe and needle.
Practitioners need to softly grasp slack dermal tissue on the designated area to create a hypodermic space, and steer clear of penetrating muscular tissue, an action that will bring intense discomfort and hinder pharmaceutical uptake. Sanitize the injection region with alcohol pads to remove superficial microbes and stop localized edema or inflammatory flare-ups.
Following gradual infusion of the agent, rub the skin delicately to distribute the solution uniformly. Monitor the feline for a few minutes to detect unwanted responses such as erythema, pruritus or emesis, and log the injection timing and drug quantity to maintain consistent therapeutic records.
The dosage of GS-441524 injection is usually determined based on the weight and condition of the cat. It is generally recommended to use 4-5 milligrams per kilogram of body weight per day, and severe neurological or eye symptoms may require an increase to 6-8 milligrams per kilogram of body weight per day. There are also studies indicating that subcutaneous injection of 5.0mg/kg-7.0mg/kg every 24 hours seems to have better efficacy and shorter medication duration. The recommended treatment period is at least 12 weeks. During the treatment process, it is necessary to regularly monitor the clinical symptoms and biochemical indicators of cats in order to adjust the treatment plan in a timely manner.
Some cats may experience relapse after treatment, and may require further treatment. In the process of treating FIP, in addition to using it, combination therapy can also be chosen according to the individual situation of the cat. For example, adjunctive treatment can be carried out in combination with medication such as feeding (cat food, canned food), nourishing blood (nourishing liver essence), nutrition (nutritional cream, nutrient solution), and immune enhancers (sheep placental transfer factor). For cats with jaundice, drugs such as bile acids and Dannos can also be used to protect the liver, eliminate ascites and jaundice.
Potential Other Applications
As research deepens, scientists have discovered that the antiviral activity of GS-441524 is not limited to FIPV, and it also demonstrates potential application value in multiple other fields.
Canine coronavirus (CCV) is a virus that causes intestinal diseases in dogs, leading to symptoms such as diarrhea and vomiting. Although most dogs are capable of self-healing, CCV infection can be fatal for puppies or immunocompromised dogs. Due to its significant inhibitory effect on feline coronavirus, scientists speculate that it may also have a similar effect on canine coronavirus. At present, there is a lack of systematic clinical trial data on the specific application effect of it in the treatment of canine coronavirus infection.However, some veterinarians have started trying to use GS-441524 to treat cases of canine coronavirus infection and have reported positive treatment outcomes.
Besides cats and dogs, other animals may also be infected with coronavirus and cause diseases. For example, domestic animals such as pigs, cows, sheep, and certain wild animals may become hosts of the coronavirus. The broad-spectrum antiviral activity of it suggests that it may also have therapeutic effects on coronavirus infections in these animals.
Feline calicivirus (FCV) is a common virus in felines that can cause diseases such as stomatitis and pneumonia in cats. Although FCV usually does not cause death in cats, cats with severe conditions may experience serious clinical symptoms such as oral ulcers, difficulty breathing, etc. Studies have shown that it also has a certain inhibitory effect on feline calicivirus. Feline immunodeficiency virus (FIV) is a chronic viral infectious disease in felines, which has similar infection mechanism and clinical manifestations to human AIDS virus (HIV).
FIV infection can cause symptoms such as immunodeficiency and opportunistic infections in cats, seriously affecting their quality of life and lifespan. At present, the application of it in the treatment of feline immunodeficiency virus infection is still in the preliminary research stage.There are studies indicating that it may have a certain inhibitory effect on FIV, but its specific mechanism and effect still need further investigation.
Feline herpesvirus (FHV) is a common virus in feline animals, which can cause diseases such as conjunctivitis, keratitis, and rhinitis in cats. FHV infection is widely present in cat populations and poses a serious threat to the health of cats. Due to its inhibitory effect on various RNA viruses, scientists speculate that it may also have a certain therapeutic effect on FHV.
Multiple in vitro experiments have shown that GS-441524 injection has significant inhibitory effects on various human coronaviruses. For example, research has found that it can effectively inhibit the replication of severe acute respiratory syndrome coronavirus (SARS CoV) and Middle East respiratory syndrome coronavirus (MERS CoV) in Vero E6 cell line. These viruses and the novel coronavirus (SARS-CoV-2) belong to the coronaviridae family, and have similar structures and replication mechanisms.
Therefore, the inhibitory effect of it on SARS-CoV and MERS CoV suggests that it may also have potential therapeutic effects on SARS-CoV-2.Further research indicates that it also has a significant inhibitory effect on SARS-CoV-2. In vitro experiments have shown that it can dose dependently inhibit the replication of SARS-CoV-2 in various cell lines, including Vero E6, Calu-3 (human lung adenocarcinoma), and Caco-2 (colorectal adenocarcinoma). These research results indicate that it has high antiviral activity against SARS-CoV-2 in vitro.
The use of human coronavirus treatment
Scientists use animal models to evaluate the efficacy of it in the treatment of human coronavirus. For example, studies have utilized adenovirus associated virus (AAV) vectors expressing human angiotensin-converting enzyme 2 (ACE2) to construct transduced mouse models to support SARS-CoV-2 infection and pathogenesis. The research results show that administration of it before infection can significantly reduce the viral load in the lungs of mice and alleviate lung pathological damage. These research results indicate that it has a significant therapeutic effect on SARS-CoV-2 infection in animal models.
Apart from pre-exposure drug delivery, matching remedial trials after viral exposure were set up to mirror authentic clinical circumstances where infected human patients obtain timely therapeutic agents post-diagnosis. Rodents received its one day after viral exposure for five straight days. Tissue examinations uncovered drastically restrained viral reproduction in the respiratory passages and lung tissues of treated subjects.
Inflammatory cell infiltration and alveolar deterioration, hallmark pulmonary damages triggered by COVID-19, were far less severe in treated groups versus untreated control cohorts. Compared with blank lab subjects, medicated rodents suffered milder weight loss, displayed delayed emergence of infection-linked discomforts including breathing difficulty and listlessness, and recovered much faster, thoroughly validating the dual preventive and early remedial merits of this compound.
Even though lab animal trials generated encouraging datasets, research specialists highlight that these favorable outcomes cannot be simply regarded as equivalent to therapeutic effectiveness on human patients. Clear interspecies gaps exist between rodents and humans in metabolic speed, drug uptake and bodily dispersion, as well as immune reaction pathways. The subcutaneous injection mode and safe tolerable dose range of it still demand validation through multi-stage human clinical trials.
Existing lab animal research only supplies critical theoretical support for follow-up anti-coronavirus drug creation. Further refinement of medicinal formulations, precise measurement of safe human dosing limits, and long-term evaluation of liver and kidney harmful side effects are mandatory to judge whether this chemical compound possesses clinical application prospects for curing human coronavirus-related illnesses.
Comparison of the advantages and disadvantages of GS-441524 injection oil and water agents
GS-441524 injection (abbreviated as 441) has two main types of drug forms: oil and water. Here are the advantages and disadvantages of its two dosage forms:
oiling agent
This stable, low-volatile oil formula preserves drug activity well for easy storage and transport. Slow absorption brings long-lasting effects, cutting doses for chronic illnesses via deep subcutaneous injection.
Oil shots quickly hit effective levels in cats to curb viruses, lower illness relapse with sustained drug concentration, and are widely used clinically for feline infectious peritonitis.
Oil injections hurt cats badly and may trigger swelling, ulcers and local inflammation. The 6ml (20% concentration) product costs 150–200 with minor price swings.
aqueous solution
Water agents absorb fast to hit therapeutic levels rapidly and support subcutaneous or IV injection, yet they are less stable and demand stricter production and storage standards.
Water injections cause mild pain and little local skin irritation, dissolve powder well with high bioavailability, and now have a 4-month shelf life thanks to technical upgrades.
Unstable water agents risk crystal precipitation that harms efficacy and safety, deliver inconsistent effects, and generally cost more than oil injections for heavier financial burdens.
Frequently Asked Questions
What are the side effects of Bova GS-441524 almond oil?
+
-
What side effects can be seen with its use? Potential side effects include changes in blood test results (mild elevation in liver enzymes and changes in while blood cells) that generally have no effect on a cat's health. Diarrhea may occur too.
How long does it take GS-441524 to work?
+
-
This medication should take effect quickly and improvement in clinical signs may be seen in as few as 2 to 5 days with obvious improvement in 1–2 weeks. During the first 1–2 weeks, additional FIP-related clinical signs may appear.
Hot Tags: gs-441524 injection, suppliers, manufacturers, factory, wholesale, buy, price, bulk, for sale