GS-441524 injection,abbreviated as 441, is an antiviral drug that belongs to viral RNA dependent RNA polymerase (RdRP) inhibitors and broad-spectrum antiviral nucleotides. It usually exists in the form of high-purity and stable white or off white powder, which needs to be diluted with a specific solvent to make an injection solution.This substance is converted into active triphosphate metabolites within cells through enzymatic catalysis.
This metabolite competitively inhibits the transcription process of viral RNA, leading to premature termination of transcription and blocking the synthesis of viral RNA. It is an inhibitor of ribonucleotide analogs that can "trick" the virus's RNA dependent RNA polymerase to bind to it, thereby interrupting the replication of RNA viruses. It is mainly used to treat feline infectious peritonitis (FIP) caused by feline coronavirus. It is injected subcutaneously in cats and generally comes in two forms: oil and water. It needs to be stored and transported under ultra-low temperature conditions, usually using ultra-low temperature ice packs for transportation.
At the same time, our company not only provides GS-441524 injections, but also tablets and powders. If needed, please feel free to contact us at any time.
GS-441524, Price off! 50% discount!!!
After the 3nd factory completed and put into use, the sales volume increased 3 times more during the last 3 months.
In order to growing with our stable clients together, we reset the price for the GS-441524 FIP series products, some items decreased over 50%!
Including API(Pure powder), OEM/ODM: Injection(20mg,30mg,40mg), tablet(25mg,45mg,60mg,70mg) etc.
| Price List of GS-441524 CAS 1191237-69-0 | ||||||
| Category | Specification | Package | Oty | Unit | Unit Price (EXW,USD$/Unit) |
Remark |
| Injection | 20mg/6ml 30mg/8ml 40mg/10ml |
10 vials/Box | 1 | Box | $195/Box $250/Box $330/Box |
(1)Explanation: e.g:20mg/6ml,Effective substance(GS 441524):20mg,total 6ml solution per vial. (2)MOQ 1 Box(10 vials) (3)Printing Customization(Injection vials' body) MOQ:10 boxes, extra $140//time |
| Tablet | 25mg 45mg 60mg 70mg |
(1)10 PCS/Board (2)12 or 30 PCS/Bottle (3)Customizable |
100 | Pills | $2.5/PCS $2.9/PCS $3.2/PCS $3.5/PCS |
(1)MOQ 100 PCS (2)Printing Customization(Foil blister package of pills) MOQ: 100 PCS, $150//time |
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API (Pure powder) |
HPLC>99.0% HNMR |
PE bag+Al foil bag |
10 500g |
Gram |
$22.0/Gram $4.0/Gram |
MOQ 10 grams |
Factory supply & Technology support & One-for-one service for you!
GS-441524 Injection, tablet & pure powder, the best meds for Cat FIP! BLOOM TECH, the advanced R&D institution for FIP drugs.
(1)If your cat are in emergency! 3-6 days to arrive!
For EU, North America, Middle east, AUS etc., After payment, shipping out in 24h, from our Hong kong & Guangzhou warehouse, International express, FedEx, DHL, UPS etc.
(2)If you buy:
1-9 boxes, shipping cost: $85
10-30 boxes, shipping free.
31-50 boxes, 5% discount.
51-80 boxes, 10% discount.
81-100 boxes, 15% discount.
101+ boxes, 20% discount.
The shipping cost includes:
Shipping, separated packaging, customs clearance, private address delivery fee etc.
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GS-441524 powder COA
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Certificate of Analysis |
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Compound name |
GS-441524(GS441) |
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CAS No. |
1191237-69-0 |
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Grade |
Veterinary grade |
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Quantity |
339.3kg |
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Packaging standard |
25kg/drum |
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| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
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Lot No. |
20250109001 |
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MFG |
Jan 9th 2025 |
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EXP |
Jan 8th 2028 |
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Structure |
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| TEST STANDARD | GB/T24768-2009 Industry. Stnndard | |
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Item |
Enterprise standard |
Analysis result |
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Appearance |
White or almost white powder |
Conformed |
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Water content |
≤5.0% |
0.31% |
| Loss on drying |
≤1.0% |
0.15% |
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Heavy Metals |
Pb≤0.5ppm |
N.D. |
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As≤0.5ppm |
N.D. | |
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Hg≤0.5ppm |
N.D. | |
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Cd≤0.5ppm |
N.D. | |
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Purity (HPLC) |
≥99.0% |
99.4% |
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Single impurity |
<0.8% |
0.48% |
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Residue on ignition |
<0.20% |
0.064% |
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Total microbial count |
≤750cfu/g |
80 |
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E. Coli |
≤2MPN/g |
N.D. |
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Salmonella |
N.D. | N.D. |
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Ethanol (by GC) |
≤5000ppm |
400ppm |
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Storage |
Store in a sealed, dark and dry place at-20 degrees |
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GS-441524 Injection, abbreviated as 441, is an antiviral drug mainly used to treat feline infectious peritonitis (FIP). The following is a detailed explanation of its purpose:
Treatment of feline infectious peritonitis (FIP)
Feline infectious peritonitis (FIP) is a fatal feline disease caused by a variant of feline coronavirus (FCOV), which was once considered a terminal illness in the feline family. However, with the emergence of the antiviral drug GS-441524 (abbreviated as 441), there is new hope for the treatment of FIP.
GS-441524 is mainly used to treat feline infectious peritonitis (FIP) caused by feline coronavirus. Whether it is wet FIP (mainly manifested as ascites, pleural effusion, and dyspnea) or dry FIP (which may involve multiple organs such as the eyes, central nervous system, and kidneys), GS-441524 has shown significant therapeutic effects It is usually administered by subcutaneous injection. The injection site can be chosen from 2 centimeters behind the cat's scapula to the mid waist area, half the distance from the adjacent chest and side abdomen. Before injection, the medication needs to be diluted to an appropriate concentration and injected using a sterile syringe and needle.
Clinical application in the treatment of FIP
The dosage of GS-441524 is usually determined based on the weight and condition of the cat. It is generally recommended to use 4-5 milligrams per kilogram of body weight per day, and severe neurological or eye symptoms may require an increase to 6-8 milligrams per kilogram of body weight per day. There are also studies indicating that subcutaneous injection of 5.0mg/kg-7.0mg/kg every 24 hours seems to have better efficacy and shorter medication duration. The recommended treatment period is at least 12 weeks. During the treatment process, it is necessary to regularly monitor the clinical symptoms and biochemical indicators of cats in order to adjust the treatment plan in a timely manner. Some cats may experience relapse after treatment, and may require further treatment. In the process of treating FIP, in addition to using GS-441524, combination therapy can also be chosen according to the individual situation of the cat. For example, adjunctive treatment can be carried out in combination with medication such as feeding (cat food, canned food), nourishing blood (nourishing liver essence), nutrition (nutritional cream, nutrient solution), and immune enhancers (sheep placental transfer factor). For cats with jaundice, drugs such as bile acids and Dannos can also be used to protect the liver, eliminate ascites and jaundice.
Potential Other Applications
As research deepens, scientists have discovered that the antiviral activity of GS-441524 is not limited to FIPV, and it also demonstrates potential application value in multiple other fields. The following is a detailed description of it:
Canine coronavirus (CCV) is a virus that causes intestinal diseases in dogs, leading to symptoms such as diarrhea and vomiting. Although most dogs are capable of self-healing, CCV infection can be fatal for puppies or immunocompromised dogs. Due to its significant inhibitory effect on feline coronavirus, scientists speculate that GS-441524 may also have a similar effect on canine coronavirus. At present, there is a lack of systematic clinical trial data on the specific application effect of GS-441524 in the treatment of canine coronavirus infection. However, some veterinarians have started trying to use GS-441524 to treat cases of canine coronavirus infection and have reported positive treatment outcomes. Besides cats and dogs, other animals may also be infected with coronavirus and cause diseases. For example, domestic animals such as pigs, cows, sheep, and certain wild animals may become hosts of the coronavirus. The broad-spectrum antiviral activity of GS-441524 suggests that it may also have therapeutic effects on coronavirus infections in these animals.
Custom Notebook Solutions
Feline calicivirus (FCV) is a common virus in felines that can cause diseases such as stomatitis and pneumonia in cats. Although FCV usually does not cause death in cats, cats with severe conditions may experience serious clinical symptoms such as oral ulcers, difficulty breathing, etc. Studies have shown that GS-441524 also has a certain inhibitory effect on feline calicivirus. Feline immunodeficiency virus (FIV) is a chronic viral infectious disease in felines, which has similar infection mechanism and clinical manifestations to human AIDS virus (HIV). FIV infection can cause symptoms such as immunodeficiency and opportunistic infections in cats, seriously affecting their quality of life and lifespan. At present, the application of GS-441524 in the treatment of feline immunodeficiency virus infection is still in the preliminary research stage. There are studies indicating that GS-441524 may have a certain inhibitory effect on FIV, but its specific mechanism and effect still need further investigation. Feline herpesvirus (FHV) is a common virus in feline animals, which can cause diseases such as conjunctivitis, keratitis, and rhinitis in cats. FHV infection is widely present in cat populations and poses a serious threat to the health of cats. Due to its inhibitory effect on various RNA viruses, scientists speculate that GS-441524 may also have a certain therapeutic effect on FHV.
Multiple in vitro experiments have shown that GS-441524 Injection has significant inhibitory effects on various human coronaviruses. For example, research has found that GS-441524 can effectively inhibit the replication of severe acute respiratory syndrome coronavirus (SARS CoV) and Middle East respiratory syndrome coronavirus (MERS CoV) in Vero E6 cell line. These viruses and the novel coronavirus (SARS-CoV-2) belong to the coronaviridae family, and have similar structures and replication mechanisms. Therefore, the inhibitory effect of GS-441524 on SARS-CoV and MERS CoV suggests that it may also have potential therapeutic effects on SARS-CoV-2. Further research indicates that GS-441524 also has a significant inhibitory effect on SARS-CoV-2. In vitro experiments have shown that GS-441524 can dose dependently inhibit the replication of SARS-CoV-2 in various cell lines, including Vero E6, Calu-3 (human lung adenocarcinoma), and Caco-2 (colorectal adenocarcinoma). These research results indicate that GS-441524 has high antiviral activity against SARS-CoV-2 in vitro.
The use of human coronavirus treatment
Scientists use animal models to evaluate the efficacy of GS-441524 in the treatment of human coronavirus. For example, studies have utilized adenovirus associated virus (AAV) vectors expressing human angiotensin-converting enzyme 2 (ACE2) to construct transduced mouse models to support SARS-CoV-2 infection and pathogenesis. The research results show that administration of GS-441524 before infection can significantly reduce the viral load in the lungs of mice and alleviate lung pathological damage. These research results indicate that GS-441524 has a significant therapeutic effect on SARS-CoV-2 infection in animal models.
Comparison of the advantages and disadvantages of GS-441524 injection oil and water agents
GS-441524 Injection (abbreviated as 441) has two main types of drug forms: oil and water. Here are the advantages and disadvantages of its two dosage forms:
oiling agent
The oil formula is stable, not easily volatile, and can maintain the activity of the drug for a long time. This makes the oil agent more advantageous in storage and transportation, ensuring the quality and efficacy of the drug. The absorption rate of oil in the body is relatively slow, but once absorbed, its efficacy can last for a long time. For diseases that require long-term treatment, this helps reduce medication frequency and improve patient compliance. It usually requires deep subcutaneous injection to ensure that the drug can be fully absorbed and exert its therapeutic effect.
Oil can quickly reach the ideal concentration in the cat's body, thereby rapidly inhibiting virus replication and relieving the condition. Due to the long-lasting efficacy of oil agents in the body, they can better maintain drug concentration, thereby reducing the recurrence rate of diseases to a certain extent. It has a lot of clinical data in the treatment of cat transmitted abdomen and is a commonly used treatment method. Its stability and persistence give the oil a significant advantage in diseases that require long-term treatment.
Oil injection may cause strong pain, which may cause discomfort to cats and even lead to swelling or skin ulceration at the injection site. Due to the irritant nature of the oil, local inflammatory reactions such as redness, swelling, and pain may occur at the injection site. And the price of the oil agent is usually between 150-200/6ml (20 concentration), although relatively reasonable, there is still some price fluctuation.
aqueous solution
The absorption rate of water-based agents in the body is relatively fast, and they can quickly reach the therapeutic concentration, thus quickly exerting their therapeutic effects. Water agents can be administered not only by subcutaneous injection, but also by intravenous injection, which makes the administration method of water agents more flexible. Compared with oil agents, water agents have relatively poor stability and require higher production processes and storage conditions.
The pain caused by water injection is relatively low, which helps reduce discomfort in cats and improve treatment compliance. Due to the low irritancy of water agents, the probability of skin problems occurring at the injection site is relatively low. Moreover, water-based agents can better dissolve powders and are more easily absorbed by the bloodstream, thereby improving the bioavailability of drugs. With the continuous advancement of technology, the shelf life of water agents has broken through and can now reach about 4 months.
However, due to the relatively poor stability of water agents, their efficacy may be affected by production processes and storage conditions, resulting in less stable therapeutic effects than oil agents. During storage and use, water-based agents may precipitate crystals, which may affect the efficacy and safety of the drug. Compared to oil-based agents, water-based agents are usually more expensive, which may increase the economic burden on patients.
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