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Secretin Injection is a synthetic injectable polypeptide drug developed on the basis of natural secretin. Its core advantages lie in rapid onset of action and precise targeting, which make up for the shortcomings of oral preparations such as low bioavailability and slow onset. It is an important clinical dosage form for the targeted regulation of pancreatic and gastrointestinal functions. Its main component is structurally identical to endogenous secretin secreted by the human intestinal tract. After injection, it is rapidly absorbed into the blood without gastrointestinal metabolism, reaching the peak plasma concentration within 15-30 minutes to exert physiological effects quickly. The core effect of this injection is to stimulate the pancreas to secrete a large amount of pancreatic juice rich in bicarbonate, which neutralizes gastric acid and protects the duodenal mucosa. It also promotes bile secretion to assist in the digestion of fats and proteins.
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Application of The Product in Regulating Water Homeostasis
Water homeostasis is the foundation for the human body to maintain normal physiological functions. It refers to the dynamic balance between water intake and excretion, gastrointestinal absorption and secretion, and renal filtration and reabsorption in the body. Once this balance is disrupted, a series of health problems such as dehydration, edema, and water-electrolyte imbalance will occur, and in severe cases, the normal operation of the circulatory and nervous systems will be affected. As an important regulatory factor in the body, secretin peptide is widely involved in the regulation of water homeostasis.
As an exogenous supplementary preparation, Secretin Injection can precisely mimic the physiological functions of endogenous secretin, act on two core organs-the kidneys and the gastrointestinal tract-in a targeted manner, regulate water absorption and secretion, and help maintain water balance in the body.
Targeted Improvement of Diseases Related to Water Homeostasis Imbalance
Based on its precise regulatory effect on water homeostasis, it is mainly used in clinical practice as an adjuvant therapy for various diseases associated with water homeostasis imbalance, especially for water metabolism disorders caused by insufficient secretion or abnormal function of endogenous secretin, providing new ideas and regimens for the treatment of such diseases.
(1) Adjuvant treatment of chronic diarrhea with dehydration
Patients with chronic diarrhea often experience massive water loss through feces due to abnormal intestinal mucosal secretion and absorption dysfunction, leading to dehydration and electrolyte imbalance. Although conventional fluid replacement therapy can replenish water temporarily, it cannot fundamentally correct the imbalance between intestinal secretion and absorption.
It can reduce excessive intestinal water secretion by regulating the secretory function of the gastrointestinal mucosa, and at the same time promote intestinal water absorption, alleviate diarrhea symptoms, reduce water loss, and thus assist in improving dehydration and lowering the risk of electrolyte imbalance.It is particularly suitable for patients with chronic diarrhea and dehydration caused by inflammatory bowel disease, irritable bowel syndrome and other disorders, effectively reducing the volume of fluid replacement and shortening the course of the disease.
(2) Regulation of postoperative water metabolism disorders
After abdominal surgeries (such as gastrectomy and duodenectomy), patients suffer severe damage to gastrointestinal function and reduced secretion of endogenous secretin, often accompanied by an imbalance between gastrointestinal secretion and absorption, which leads to impaired water absorption, abnormal urine excretion, and subsequent postoperative dehydration or edema.
As an exogenous supplementary preparation, it can quickly replace the function of endogenous secretin, regulate water metabolism in the gastrointestinal tract and kidneys, help patients rapidly restore water homeostasis after surgery, reduce the occurrence of postoperative complications, and promote the recovery of gastrointestinal function. It is especially suitable for patients with persistent diarrhea and abnormal urine output after surgery.
(3) Adjuvant treatment of diseases related to water-electrolyte imbalance
For metabolic alkalosis caused by abnormal secretin receptors or renal dysfunction, the product can promote bicarbonate excretion by activating the CFTR channel of renal β-intercalated cells to correct alkalosis. It also regulates renal reabsorption of water and electrolytes to restore water-electrolyte balance and alleviate symptoms such as fatigue, headache, arrhythmia, nausea and vomiting caused by alkalosis.
In addition, it can be used as an adjuvant therapy for mild dehydration, particularly for patients who cannot receive oral fluid replacement normally (e.g., comatose patients and those with severe vomiting), exerting a rapid regulatory effect through intravenous injection to make up for insufficient water absorption.
Application of The Product in Stimulating Insulin Release
The maintenance of glucose homeostasis is the core of human metabolic health. As a key hormone secreted by pancreatic islet β-cells, insulin is the core regulator of blood glucose levels. Insufficient secretion or defective action of insulin leads to elevated blood glucose and the development of metabolic diseases such as diabetes. Studies have confirmed that it can specifically stimulate pancreatic insulin release during glucose intake, enhance the sensitivity of islet β-cells to glucose, and assist in regulating blood glucose levels.
As an exogenous secretin preparation, Secretin Injection can precisely mimic this physiological process to provide adjuvant support for blood glucose regulation, and it has important application value especially in the adjuvant treatment of diabetes and the maintenance of glucose homeostasis.
Adjuvant Blood Glucose Regulation for Metabolic Health
Based on its precise stimulatory effect on insulin release, it is mainly used in clinical practice for the adjuvant regulation of blood glucose levels, especially for metabolic diseases related to insufficient insulin secretion or reduced sensitivity, providing a new adjuvant regimen for the treatment of such diseases. It can also be used for the adjuvant maintenance of glucose homeostasis in healthy people.
(1) Adjuvant treatment of type 2 diabetes mellitus
The core pathological features of patients with type 2 diabetes mellitus are impaired islet β-cell function, insufficient insulin secretion, and concomitant insulin resistance, leading to elevated blood glucose. Although conventional hypoglycemic drugs can control blood glucose, drug resistance or adverse reactions may occur with long-term use. As an adjuvant therapeutic preparation, the product can directly stimulate islet β-cells to secrete insulin, increase the effective concentration of insulin, and at the same time improve the sensitivity of islet β-cells to glucose to alleviate insulin resistance and assist in lowering blood glucose levels.
It is particularly suitable for patients with type 2 diabetes mellitus who have poor responses to conventional hypoglycemic drugs and mild to moderate insulin secretion deficiency. Clinical studies have found that intravenous administration of an appropriate dose of it to such patients can significantly increase the peak of postprandial insulin secretion, lower the peak of postprandial blood glucose, reduce blood glucose fluctuations, and cause no fasting hypoglycemia, with high safety.
(2) Adjuvant improvement of impaired glucose tolerance
Impaired glucose tolerance is an important manifestation of prediabetes. Patients have normal fasting blood glucose but elevated postprandial blood glucose, and at this time, mild damage to islet β-cell function has occurred with delayed or insufficient insulin secretion. The product can improve the responsiveness of islet β-cells by stimulating insulin release, helping patients secrete insulin rapidly after glucose intake, lowering postprandial blood glucose levels, and delaying the progression of impaired glucose tolerance to type 2 diabetes mellitus.
It is especially suitable for the interventional treatment of high-risk groups for diabetes (e.g., obese patients, those with a family history of diabetes, and hypertensive patients), effectively improving their blood glucose regulation ability and reducing the risk of developing the disease.
(3) Adjuvant blood glucose regulation for pancreatic function-related diseases
Diseases such as chronic pancreatitis and pancreatic tumors can damage the exocrine and endocrine functions of the pancreas, leading to insufficient insulin secretion and secondary hyperglycemia. Secretin Injection can not only be used for the adjuvant diagnosis of such pancreatic diseases (stimulating pancreatic secretion to evaluate pancreatic function) but also assist in regulating patients' blood glucose levels by stimulating insulin release, alleviating blood glucose disorders caused by pancreatic function damage, and reducing further pancreatic damage induced by hyperglycemia, thus providing support for the comprehensive treatment of such diseases.
Chemical Structure of the Active Ingredient
Its active ingredient is synthetic secretin, a polypeptide compound with the chemical molecular formula C₁₃₀H₂₂₀N₄₄O₄₁ and a molecular weight of approximately 3055.41 Da. This polypeptide consists of 27 amino acid residues arranged in a specific sequence, with histidine at the N-terminus and alanine at the C-terminus. It has a linear structure with no intramolecular disulfide bonds, and its amino acid sequence is identical to that of endogenous human secretin. This not only ensures the specificity of its biological activity but also enables it to precisely bind to receptors in target organs to exert its effects after injection.
One-stop Cosmetic Tube Factory in ChinaKey Physicochemical Properties
Secretin polypeptide is a white or off-white powder. It is easily soluble in water, slightly soluble in methanol and ethanol, and insoluble in organic solvents such as acetone and diethyl ether, making it suitable for aqueous vehicles of injectable preparations. Its aqueous solution is weakly acidic with a pH value of 4.5-6.5, which is close to the pH of human blood and can reduce local irritation after injection. This ingredient is sensitive to heat, strong acids and strong bases, and its amino acid residues are prone to degradation at room temperature; therefore, the injectable preparation requires a special manufacturing process to preserve its chemical activity.
Chemical Stability of the Formulation
As an injectable preparation, its chemical stability directly affects therapeutic efficacy and medication safety. When unopened and stored under refrigeration at 2-8℃, it can be stably preserved for 18-24 months with no degradation of the polypeptide structure. If left at room temperature (25℃) for more than 72 hours, the polypeptide is prone to hydrolysis, with breakage of the amino acid sequence, leading to a decrease in biological activity. In addition, light exposure and violent shaking can accelerate its degradation. For this reason, the formulation is mostly packaged in light-resistant ampoules. It should be gently shaken before injection to avoid damage to its chemical structure caused by violent shaking, ensuring stable therapeutic efficacy after administration.
FAQ
What are the product?
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It is used for the stimulation of pancreas secretions to help diagnose or find problems in the pancreas and to help identify the ampulla of Vater and accessory papilla during endoscopy. It is also used to help in the diagnosis of gastrinoma (tumor of the bowel or pancreas).
How is secretin administered?
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It is given to the patient by injection into a vein. After a certain amount of time, samples of fluid are taken from the small intestine through the tube and sent to a lab to test for a response.
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