Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of acetyl tetrapeptide-5 eye cream in China. Welcome to wholesale bulk high quality acetyl tetrapeptide-5 eye cream for sale here from our factory. Good service and reasonable price are available.
Acetyl tetrapeptide-5 eye cream is a professional eye care product designed to fundamentally address core periocular concerns including aging, puffiness and dark circles, tailored to the delicate, fragile and overtaxed tissue around the eyes. Its core active ingredient delivers skincare benefits via a dual-action mechanism. On one hand, it blocks cutaneous glycation, repairs collagen structures and fades long-term aging signs. On the other hand, it regulates both blood and lymphatic microcirculation around the eyes to eliminate accumulated fluid and metabolic wastes, resolving eye area issues triggered by late nights, aging and irregular routines from a physiological root.
It stands as a high-performance anti-aging eye treatment in the premium skincare segment with well-defined mechanisms and ample clinical evidence.
Our Products Form



Acetyl Tetrapeptide-5 COA
![]() |
||
| Certificate of Analysis | ||
| Compound name | Acetyl Tetrapeptide-5 | |
| Grade | Pharmaceutical grade | |
| CAS No. | 820959-17-9 | |
| Quantity | 34g | |
| Packaging standard | PE bag+Al foil bag | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202601090056 | |
| MFG | Jan 9th 2026 | |
| EXP | Jan 8th 2029 | |
| Structure | ![]() |
|
| Item | Enterprise standard | Analysis result |
| Appearance | White or almost white powder | Conformed |
| Water content | ≤5.0% | 0.22% |
| Loss on drying | ≤1.0% | 0.45% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | ≥99.0% | 99.98% |
| Single impurity | <0.8% | 0.57% |
| Total microbial count | ≤750cfu/g | 500 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 750ppm |
| Storage | Store in a sealed, dark, and dry place below 2-8°C | |
|
|
||
|
|
||
| Chemical Formula | C20H28N8O7 |
| Exact Mass | 492.21 |
| Molecular Weight | 492.49 |
| m/z | 492.21 (100.0%), 493.21 (21.6%), 493.21 (3.0%), 494.21 (2.2%), 494.21 (1.4%) |
| Elemental Analysis | C, 48.78; H, 5.73; N, 22.75; O, 22.74 |

Reduce Periorbital Puffiness & Edematous Eye Bags
Reducing periorbital puffiness and improving edematous eye bags is the core and most visible efficacy of acetyl tetrapeptide-5 eye cream, as well as its key advantage that distinguishes this active ingredient from conventional skincare actives. The tissue around the eyes is the thinnest across the human body, featuring the densest capillaries and weakest lymphatic circulation. Late nights, excessive water intake before bedtime, prolonged eye strain, irregular schedules and other factors abnormally elevate the permeability of periorbital capillaries.


Excess interstitial fluid and metabolic waste fail to be drained by the lymphatic system in a timely manner, accumulating in the subcutaneous tissue around the eyes and resulting in morning puffiness and temporary edematous eye bags. Long-term repeated buildup will further develop into persistent under-eye bags.
As an active peptide targeting periorbital microcirculation, it precisely inhibits angiotensin-converting enzyme activity, effectively tightens capillary walls around the eyes and lowers abnormal vascular permeability to fundamentally reduce interstitial fluid leakage and water retention. Meanwhile, this ingredient actively stimulates superficial periorbital lymphatic circulation, accelerating the elimination of trapped fluid, lactic acid and metabolic waste to rapidly relieve eye swelling.
Clinical test data demonstrates that consistent use of this eye cream for 14 days visibly alleviates morning eye puffiness. After 60 consecutive days of application, the volume of puffy under-eye bags is markedly reduced, diminishing the swollen, fatigued appearance of the eyes and creating a firmer, smoother periorbital contour. It also delivers excellent instant relief for sudden eye puffiness triggered by irregular sleep schedules.

Fade Multiple Types of Dark Circles & Brighten Periorbital Complexion

Dark circles fall into three categories: vascular, pigmented and glycation-induced dullness. Most eye creams only improve pigmented dark circles, whereas the product comprehensively targets all three types via multi-mechanism action to achieve even brightening around the eyes.
For the most prevalent vascular dark circles-the bluish-black discoloration caused by sluggish periorbital blood circulation and lowered blood oxygen levels from overstrained eyes and late nights-the product optimizes microvascular blood flow around the eyes, unclogs blood stasis, ameliorates local microcirculation disorders and gradually fades bluish dullness.
For pigmented dark circles stemming from UV exposure and residual inflammation, the ingredient gently suppresses abnormal melanocyte hyperactivity to cut melanin deposition, while accelerating the turnover of surface dead keratinocytes to lighten pigmentation around the eyes.
For yellowish-black dull dark circles triggered by cutaneous non-enzymatic glycation, a primary driver of age-related dark circles, acetyl tetrapeptide-5 eye cream boasts outstanding anti-glycation performance.

It effectively blocks cutaneous protein glycation and inhibits the formation and accumulation of advanced glycation end products (AGEs), preventing collagen and elastin from yellowing and embrittling due to glycation. This mitigates yellowing, dullness and cloudiness around the eyes to resolve age-related dark circles at the source. Long-term use gradually fades stubborn dark circles, evens periorbital cutaneous tone and eliminates a worn-out eye appearance.
Anti-Glycation & Anti-Aging, Firm Sagging Periorbital Skin
Beyond free radical oxidation, glycation damage stands as a core trigger of periorbital cutaneous aging-a skincare pain point overlooked by most anti-aging eye creams. It adopts a dual anti-aging mechanism combining antioxidant and anti-glycation effects to precisely address early and mature signs of eye aging.
With advancing age, cutaneous metabolism slows down, collagen and elastin around the eyes continuously deplete, and glycation reactions intensify. This hardens and fractures elastic fibers, robbing periorbital skin of structural support and leading to sagging, fine lines, dry lines and drooping eyelids.


Acetyl Tetrapeptide-5 precisely targets the cutaneous non-enzymatic glycation process, blocking the binding of sugar molecules to cutaneous proteins and reducing AGE buildup to preserve the integrity and vitality of collagen and elastic fibers and prevent fiber hardening, aging and deactivation. As a small-molecule peptide, it penetrates the dermal layer to transmit cutaneous repair signals, boost fibroblast activity and mildly stimulate de novo synthesis of collagen and elastin.
This gradually thickens the delicate periorbital cutaneous barrier and elevates cutaneous firmness and elasticity.
Consistent use effectively smooths superficial dry lines and fine lines around the eyes, slows the progression of dynamic wrinkles into permanent static creases, improves sagging upper eyelids and lax periorbital skin, maintains a firm, plump youthful eye contour long-term and delays ocular cutaneous aging.

Repair Periorbital Skin Barrier & Stabilize Delicate Skin Long-Term

Devoid of sebaceous and sweat glands for protection, the tissue around the eyes possesses far weaker water-locking capacity and barrier defense than other facial areas. Chronic dryness, external irritants, frequent rubbing and leftover makeup damage the periorbital cutaneous barrier, triggering flakiness, sensitive redness, frequent dry lines and impaired moisture retention. Barrier damage is also a major contributor to recurring aggravated eye concerns.
Formulated gently to suit periorbital skin, it's core active ingredient delivers dual repair and moisturizing benefits. It forms a thin, breathable protective film on the cutaneous surface to mitigate damage from environmental irritants, while locking in internal cutaneous moisture to relieve periorbital dryness.
Additionally, the ingredient repairs impaired cutaneous microcirculation, corrects metabolic dysregulation around the eyes, gradually reinforces the fragile keratin barrier and boosts the skin's inherent defense and moisture retention capabilities.
Unlike ordinary eye creams that only provide superficial hydration, this product improves periorbital cutaneous condition from within, addressing the root causes of dryness, sensitivity and fragility. It sustains healthy, stable cutaneous metabolism around the eyes to prevent recurring eye issues, laying a solid cutaneous foundation for anti-aging, brightening and puffiness reduction treatments for the eye area.

Relieve Eye Strain & Alleviate Subhealthy Periorbital Conditions

In modern lifestyles characterized by heavy screen time and prolonged desk work, sustained tension of periorbital muscles and blocked microcirculation not only induce various cutaneous problems but also trigger subhealthy symptoms including eye soreness, dryness and fatigue, creating a vicious cycle of tired-looking eyes.
By regulating periorbital blood circulation and lymphatic metabolism, acetyl tetrapeptide-5 eye cream effectively relaxes tense periorbital smooth muscles, eases muscle stiffness and soreness, and alleviates dry, fatigued eyes caused by overuse.
It rapidly unclogs stagnant blood, qi and metabolic waste around the eyes to cut buildup of fatigue-inducing substances, delivering instant visual relief from worn-out eyes as well as physiological comfort, realizing dual skincare and eye care benefits.
Daily application with massage relaxes periorbital skin and muscles to ease strain from extended eye use. Suitable for office workers, students and frequent late-night users for daily maintenance, it continuously improves dull, exhausted eye appearance.
The product (marketed as Eyeseryl) is a synthetic bioactive peptide exclusively developed for periorbital cutaneous repair. Created by a European professional skincare biotechnology research team in the early 2000s, it is a targeted active ingredient designed to counteract periorbital microcirculation disorders and glycation-mediated cutaneous aging.
By dissecting the two core mechanisms of eye cutaneous aging and leveraging the targeted molecular properties of peptides, the research team screened and optimized amino acid sequences to synthesize the product with superior cutaneous compatibility and high bioactivity.
Upon its launch, its precise dual-pathway repair mechanism cemented its status as a groundbreaking active in performance eye skincare. Subsequent in vitro assays and human cutaneous clinical tests verified its safety and efficacy, leading to its official inclusion in the roster of cosmetic-compliant raw materials.
It has since been widely incorporated into premium functional eye creams and become a benchmark core ingredient for mitigating eye bags, dark circles and ocular aging.
References
- Guangzhou Tongjun Pharmaceutical Technology Co., Ltd. Bright Eye Peptide | Acetyl Tetrapeptide-5: Resolving Two Major Issues of Eye Bags & Dark Circles[EB/OL]. 15 Jan 2026.
- Benchchem. Formulating Acetyl Tetrapeptide-5 for Topical Delivery Systems: Application Notes and Protocols[R]. 2026.
- Hangzhou Gutuo Biotechnology Co., Ltd. The Periocular Skincare Secret Hidden in Cosmetic Actives - Acetyl Tetrapeptide-5[EB/OL]. 03 Mar 2026.
- Kopeptide Biotechnology. Mechanism of Action and Efficacy Description of Acetyl Tetrapeptide-5[EB/OL]. 20 Mar 2026.
- Peptidejournal. Acetyl Tetrapeptide-5 (Eyeseryl): Eye Peptide[EB/OL]. 10 Jan 2026.
FAQ
What is the study of the product?
+
-
The product is a synthetic pentapeptide compound with the sequence Ac-βAla-His-Ser-His. Studies have shown that it reduces eye puffiness and dark circles, and delays skin sagging or eyelid drooping. Its mechanism is related to the inhibition of angiotensin-converting enzyme.
Is the product safe?
+
-
The product is considered safe and non-toxic for topical use in cosmetics. It is well-tolerated by most skin types, including sensitive skin.
Hot Tags: acetyl tetrapeptide-5 eye cream, suppliers, manufacturers, factory, wholesale, buy, price, bulk, for sale











