Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of terbinafine hydrochloride cream 1% in China. Welcome to wholesale bulk high quality terbinafine hydrochloride cream 1% for sale here from our factory. Good service and reasonable price are available.
Terbinafine Hydrochloride Cream 1% is a broad-spectrum topical antifungal agent belonging to the allylamine class of pharmaceutical compounds, with terbinafine hydrochloride as its primary active ingredient. This formulation acts by selectively inhibiting the fungal enzyme squalene epoxidase, thereby interrupting the biosynthesis of ergosterol-a critical structural component of the fungal cell membrane. The disruption of ergosterol synthesis compromises the integrity and stability of the fungal cell membrane, ultimately leading to either fungal cell death or the suppression of fungal growth and proliferation. It demonstrates potent fungicidal activity against a wide range of dermatophytes, including Trichophyton rubrum and Trichophyton mentagrophytes, while exerting primarily fungistatic effects against various yeast species, such as Candida albicans.
Mainly used to treat superficial skin diseases caused by fungal infections, including tinea pedis, tinea pedis, tinea corporis, tinea pedis, tinea pedis, tinea versicolor, and candidiasis. It has strong permeability and can quickly act on lesions. It is usually applied 1-2 times a day, and the course of treatment depends on the type and severity of infection. Tinea corporis and tinea pedis generally require continuous use for 1-2 weeks, while tinea pedis requires 2-4 weeks. After the symptoms disappear, it is recommended to continue using the medication for 1-2 weeks to consolidate the therapeutic effect and prevent recurrence.
Additional information of chemical compound:
| Product Name | Terbinafine Hydrochloride Cream 1% | Terbinafine Hydrochloride Powder | Terbinafine Hydrochloride Tablet | Terbinafine Hydrochloride Lotion | Terbinafine Hydrochloride Spray |
| Product Type | Ointment | Powder | Tablets | Liquid | Spray |
| Product Purity | ≥99% | ≥99% | ≥99% | ≥99% | ≥99% |
| Product Specifications | Customizable | Customizable | Customizable | Customizable | Customizable |
| Product Package | Customizable | Customizable | Customizable | Customizable | Customizable |
Our product form
terbinafine hydrochloride +. COA
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Certificate of Analysis |
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Compound name |
Terbinafine Hydrochloride | |
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CAS No. |
78628-80-5 | |
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Grade |
Pharmaceutical grade | |
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Quantity |
Customized | |
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Packaging standard |
Customized | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
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Lot No. |
20250109001 |
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MFG |
Jan 12th 2025 |
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EXP |
Jan 8th 2029 |
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Structure |
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| TEST STANDARD | GB/T24768-2009 Industry. Stnndard | |
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Item |
Enterprise standard |
Analysis result |
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Appearance |
White or almost white powder |
Conformed |
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Water content |
≤4.5% |
0.30% |
| Loss on drying |
≤1.0% |
0.15% |
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Heavy Metals |
Pb≤0.5ppm |
N.D. |
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As≤0.5ppm |
N.D. | |
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Hg≤0.5ppm |
N.D. | |
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Cd≤0.5ppm |
N.D. | |
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Purity (HPLC) |
≥99.0% |
99.5% |
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Single impurity |
<0.8% |
0.48% |
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Residue on ignition |
<0.20% |
0.064% |
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Total microbial count |
≤750cfu/g |
80 |
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E. Coli |
≤2MPN/g |
N.D. |
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Salmonella |
N.D. | N.D. |
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Ethanol (by GC) |
≤5000ppm |
400ppm |
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Storage |
Store in a sealed, dark and dry place at-20 degrees |
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Chronic paronychia type: Psoriatic nail changes need to be ruled out, and treatment should last for 4-6 weeks
Generalized cutaneous candidiasis: more common in immunocompromised patients, requiring the combination of oral fluconazole
Yeast infection
(1) Candidiasis of the skin
Terbinafine Hydrochloride Cream 1% is common in obese children, patients with diabetes, and those who use broad-spectrum antibiotics for a long time. Clinical classification:
Interstitial rash type: It is more common in folds such as armpits and groin, presenting as well-defined erythema with satellite shaped papules
(2) Tinea versicolor (sweat spots)
Caused by Malassezia, it is highly prevalent in summer and manifests as hypopigmentation or pigmentation spots. Medication specificity:
Continuous medication is required until 2 weeks after the complete disappearance of the skin lesion to prevent recurrence
It is recommended to use once a month as preventive treatment in summer
Clothes should be boiled and disinfected to avoid cross infection among family members
Medication for special areas
(1) Onychomycosis (onychomycosis)
Although it is an external preparation, its permeability to the deck is limited. In clinical practice, a combination of "chemical exfoliation+external application" is used:
First, use 40% urea paste to package and soften the affected nail
After trimming and removing the thickened deck, apply emulsifible twice a day
Combined with oral Terbinafine tablets (250mg/day, 12 weeks of treatment), the cure rate can be improved
(2) Facial fungal infection
Facial skin is thin and tender, prone to irritation reactions. Key points for medication:
Select 0.25% gel dosage form for initial concentration
Once a day, apply a small amount before bedtime
Avoid co administration with drugs such as retinoids and benzoyl peroxide
(3) Mucosal site infection
Although the instructions clearly prohibit its use on the mucous membranes of the eyes, mouth, and nose, there are clinical scenarios where medication is used beyond the instructions:
Oral candidiasis: Prepare 2% Terbinafine mouthwash (to be self-made by the hospital)
Vulvar vaginal candidiasis: combined with 1% cream applied externally to relieve itching in the external genitalia;Eye fungal infection: limited to animal experimental research, extremely high risk for human application.
Combination therapy scenario
1. Combined use with antibiotics
When fungal infection is combined with bacterial infection (such as secondary streptococcal infection in tinea pedis), sequential therapy should be used:
Soak in a 1:5000 potassium permanganate solution twice a day
Apply Mopirocin paste to control bacterial infections
Stop using antibiotics after 48 hours and switch to terbinafine cream
2. Used in combination with keratolytic agents
Hyperkeratotic tinea pedis often requires a combination of salicylic acid preparations:
17% Salicylic Acid paste packaged every night to soften keratin
Apply Terbinafine emulsifible after morning cleaning
The treatment course needs to be extended to 6 weeks
3. Used in combination with immune modulators
Patients with chronic recurrent tinea corporis can use a combination of:
0.1% tacrolimus paste (twice a week)
Regulating the local immune microenvironment
Need to monitor blood drug concentration to prevent systemic absorption
Preventive medication scenario
Prevention of transmission within the family
When a family member is diagnosed with tinea pedis:
Other members are required to use terbinafine hydrochloride cream 1% daily for preventive foot application
Lasting for 2 weeks can reduce the risk of infection by 68%
Shoes and socks need to be disinfected simultaneously (soaked in 60 ℃ hot water for 30 minutes)
Occupational exposure prevention
High risk occupational groups such as hairdressers and swimming coaches:
Apply cream between fingers and toes after daily work
Combined use of hand emulsifible containing terbinafine
Perform fungal microscopy screening every 3 months
Prevention of iatrogenic infections
Dermatology Clinic of the Hospital:
Laying disposable isolation film on the diagnosis and treatment bed
Medical personnel need to apply emulsifible to their hands after coming into contact with patients
The diagnostic and therapeutic equipment is sterilized using hydrogen peroxide plasma
Medication Misunderstandings and Solutions
Insufficient treatment leads to recurrence
Clinical statistics show that:
32% of patients stop taking medication on their own after symptoms disappear
The recurrence rate in the early stopping group was as high as 74%, while in the foot therapy group it was only 12%
Solution: Adopt the "3+1" plan (continue medication for 1 week after symptoms disappear)
Neglecting drug interactions
Terbinafine is a CYP2D6 inhibitor that can increase the blood concentrations of the following drugs:
Tricyclic antidepressants (such as amitriptyline)
Beta blockers (such as metoprolol)
Class IC antiarrhythmic drugs (such as propafenone)
Solution: When used in combination, electrocardiogram and blood drug concentration need to be monitored
Terbinafine Hydrochloride Cream 1%, as a broad-spectrum antifungal drug of acrylamide, has a strong killing effect on skin fungi such as Trichophyton rubrum and Trichophyton rubrum by inhibiting squalene cyclooxygenase and disrupting fungal cell membrane structure.
Preparation before medication
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Skin lesion assessment:
Use Wood lamp or fungal microscopy to confirm the diagnosis of tinea corporis, observe the morphology of the skin lesion (circular erythema, edge scales), distribution range (diameter>5cm, need to expand the application area), and signs of secondary infection (exudation, pustules).
Cleaning treatment:
Clean the affected area with 38-40 ℃ warm water and avoid using alkaline soap or alcohol based cleaning agents. For hyperkeratotic skin lesions, 10% urea paste can be used to soften the keratin for 20 minutes before washing.
Drying treatment:
Use sterile gauze to gently pat and absorb moisture, or use a low-level air cooler to dry, ensuring that the skin is completely dry before applying the medication.
1. Skin assessment and cleansing
Dose calculation:
Select the dosage based on the area of skin lesions
01
Diameter<3cm:
Take a pea sized sample (approximately 0.5g)
02
Diameter 3-5cm:
Take the size of peanuts (about 1g)
03
Diameter>5cm:
Take hazelnut size (approximately 1.5g)
04
Container preparation:
Apply with sterile swabs or dispensers; avoid touching the tube opening
05
Standardized application technology
Center outward method: Starting from the center of the lesion, apply in a clockwise or counterclockwise circle, covering a range of 2cm beyond the edge of the lesion.
Layered application method:
First layer: Apply a thin layer of emulsifible to form a protective film
Second layer: After a 5-minute interval, apply again using the above method
Suitable for thick scaly or hyperkeratotic skin lesions
Massage absorption: After application, gently massage with fingertips for 30-60 seconds until the medication is completely absorbed and there is no residue on the skin surface.
Combination therapy technology
Anti bacterial combination:
Morning: Apply 2% mupirocin paste first, and then apply terbinafine hydrochloride cream after a 2-hour interval
Evening: Operate in reverse order to ensure that there is a gap of at least 4 hours between the two medications
Keratinolysis combined:
Night: Pack 17% salicylic acid paste for 2 hours
Apply Terbinafine Hydrochloride cream immediately after morning cleaning
Need to monitor blood drug concentration to prevent systemic absorption
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