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Lidocaine Spray 1mg is a commonly used local anesthetic with high safety and good efficacy, whose main active component is lidocaine. Specifically, lidocaine exerts a rapid local anesthetic effect by selectively inhibiting the sodium ion channels on the nerve cell membranes, which can block the generation and conduction of nerve impulses, thereby relieving pain without affecting the normal function of surrounding tissues. This drug is widely used for surface anesthesia of mucous membranes such as the mouth, nasal cavity and throat, such as before oral examinations, nasal endoscopies and throat surgeries, to reduce discomfort caused by operations. It is also applicable to pain relief caused by mild trauma, mosquito bites, skin scratches and other minor skin injuries.
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Lidocaine COA
Basic Information and Pharmacological Effects of Lidocaine Spray
Basic Information
Lidocaine Spray 1mg is usually present in the form of a spray, containing 1mg of lidocaine per spray. It appears as a colorless or almost colorless clear liquid and is contained in a container equipped with a spray device for convenient use.
Pharmacological Effects
Lidocaine inhibits the generation and conduction of action potentials by suppressing the sodium ion channels in the nerve cell membrane and preventing the influx of sodium ions. When the drug is sprayed on the surface of the skin or mucous membranes, it can quickly penetrate into the local tissue, reducing the excitability of nerve endings and achieving the effect of local anesthesia. In addition, lidocaine also has a certain anti-arrhythmic effect, but its clinical use as an arrhythmic drug has gradually decreased at present.
Clinical Application
Lidocaine Spray 1mg is widely used for surface anesthesia of mucosal areas such as the oral cavity, nasal cavity and throat, such as anesthesia before operations like oral examination, tooth extraction and laryngoscopy. At the same time, it can also be used to relieve pain caused by mild trauma, mosquito bites, etc.
Topical Anesthesia Before Oral and Oropharyngeal Procedures
The oral and oropharyngeal mucosa is rich in nerve endings and highly sensitive to pain. Various dental procedures (e.g., tooth extraction, filling, gingival surgery) and pharyngeal examinations (e.g., laryngoscopy, gastroscopy) often cause obvious pain, nausea, vomiting, and other discomforts, affecting procedural progress and patient experience. Lidocaine Spray 1mg provides rapid mucosal anesthesia of the oral cavity and pharynx via topical spraying, blocking pain conduction and inhibiting reflex responses. It is one of the preferred local anesthetics before such procedures, covering routine dental treatment to endoscopic examinations. Its convenient administration and rapid onset significantly improve diagnostic and therapeutic efficiency and patient comfort.
Application Before Dental Procedures
Dental procedures such as tooth extraction, filling, gingival surgery, and periodontal scaling involve contact with the gingiva, dental pulp, or oral mucosa, easily stimulating nerve endings and causing severe pain. Some patients may exhibit restlessness or resistance, increasing procedural difficulty. Lidocaine Spray 1mg selectively anesthetizes the mucosa of the target area, reduces pain sensitivity, minimizes discomfort, and ensures smooth treatment.
Application Before Tooth Extraction
First, clean the patient's oral cavity to remove food residues and secretions, ensuring the mucosal surface is dry and intact. Adjust the spraying angle according to the extraction site (anterior or posterior teeth), and spray Lidocaine Spray 1mg evenly onto the gingival mucosa and around the extraction wound, 1–2 sprays per application; repeat once if necessary to ensure uniform coverage. Instruct the patient to close the mouth and avoid swallowing the drug. Onset occurs within 1–3 minutes, with anesthesia lasting 1–2 hours, sufficient for single-tooth extraction. For children or patients with very low pain tolerance, reduce the single spray dose and increase frequency to avoid overdose, while reassuring the patient to reduce anxiety.
Application Before Dental Restoration and Gingival Surgery
For dental restorations involving deep caries or exposed pulp, spray the drug directly onto the mucosa around the cavity and the pulp surface, 1 spray per application. Perform drilling and filling only after anesthesia takes effect to avoid pulpal pain. Before gingival surgery (e.g., gingivectomy, gingivoplasty), spray evenly along the gingival margin, 2–3 sprays, to cover the entire surgical field. Incision and dissection are then performed with reduced pain and bleeding. The same method applies to periodontal scaling and root canal therapy to relieve discomfort.
Precautions: Transient stinging may occur if the mucosa has ulcers, erosions, or inflammation. Inform patients in advance and reduce the dose. Use cautiously in patients with severe oral ulcers or mucosal erosion; switch to alternative anesthesia if needed.
Application Before Pharyngeal Examinations and Procedures
Laryngoscopy, gastroscopy, tracheal intubation, and other pharyngeal procedures stimulate the gag receptors in the pharyngeal mucosa, triggering nausea, vomiting, coughing, and other reflexes. These reactions increase patient distress, obstruct the surgical view, and impede procedure performance. Lidocaine Spray 1mg anesthetizes the pharyngeal mucosa, suppresses the gag and cough reflexes, reduces pain sensitivity, and facilitates smooth insertion, especially as premedication for gastroscopy and laryngoscopy.
Application Before Gastroscopy
Fasting is required 15–30 minutes before examination. The patient tilts the head backward to fully expose the pharynx. The operator holds Lidocaine Spray 1mg and sprays 2–3 times toward the mid-pharynx (clinical formulation is usually 2%, single spray dose approximately 20–30 mg). Instruct the patient to maintain the head-back position for 1–2 minutes to allow adequate mucosal adhesion. Onset occurs within 1–3 minutes, with obvious pharyngeal numbness and blunted pain and gag reflexes. Endoscope insertion becomes smoother, with less irritation and discomfort.
Application Before Laryngoscopy and Tracheal Intubation
For indirect and fiberoptic laryngoscopy, the procedure is similar to gastroscopy, with adjustment of spraying angle. For indirect laryngoscopy, spray the pharynx and base of the tongue, 1–2 sprays. For fiberoptic laryngoscopy, additionally spray the nasal mucosa to reduce irritation during passage. Before tracheal intubation, spray the pharynx and tracheal mucosa to attenuate coughing and pain, especially for emergency or awake intubation.
Precautions: Avoid spraying into the trachea to prevent coughing or dyspnea. Use cautiously in patients with dysphagia or pharyngeal obstruction to avoid accumulation and risk of aspiration. After anesthesia, swallowing is impaired; food and drink are prohibited for 1–2 hours post-procedure to prevent aspiration.
Topical Anesthesia Before Nasal and Upper Respiratory Tract Procedures
The nasal and upper respiratory mucosa is thin, highly vascular, and densely innervated, adjacent to critical structures such as the orbits and skull base. Procedures including nasal endoscopy, sinus paracentesis, and nasal biopsy often cause pain and bleeding, and patient restlessness may increase procedural risk. Lidocaine Spray 1mg provides rapid topical anesthesia via spraying, reduces pain sensitivity, mildly constricts local blood vessels, minimizes bleeding, and improves safety. It is widely used in nasal endoscopic surgery, sinus paracentesis, and minor nasal procedures with reliable efficacy and precise dosing.
Application Before Nasal Endoscopic Surgery
Nasal endoscopic surgery is a minimally invasive procedure for sinusitis, nasal polyps, and deviated nasal septum. The narrow surgical field and rich innervation predispose to pain and bleeding. Lidocaine Spray 1mg is used preoperatively in combination with a vasoconstrictor (e.g., epinephrine) to achieve anesthesia and reduce bleeding, providing a clear surgical view.
Application Protocol
Clean the nasal cavity 30 minutes before surgery to remove secretions, crusts, and blood. Mix 2% Lidocaine Spray 1mg with dilute epinephrine (typically 1:100 000, adjusted for patient condition). Spray evenly into both nasal cavities, 1–2 sprays per side. Instruct the patient to gently press the alae nasi to promote distribution. Repeat after 5–10 minutes if needed. Onset occurs in 2–5 minutes, with mucosal numbness, reduced pain, and vasoconstriction.
Slightly different applications apply to different procedures:
For sinusitis and polyps: focus on the ostia and perilesional mucosa.
For septoplasty: spray both sides of the nasal septum to cover the incision and correction site.
For nasal tumor biopsy: target the peritumoral mucosa to ensure adequate anesthesia of the biopsy site.
Precautions: Strictly control total dose to avoid adverse effects (dizziness, tinnitus, blood pressure fluctuations). Screen for hypertension or heart disease before using epinephrine. Avoid spraying into the orbits. Supplemental spraying may be given intraoperatively if anesthesia diminishes, without exceeding the maximum safe dose.
Application Before Sinus Paracentesis and Minor Nasal Procedures
Sinus paracentesis is used for acute or acute-on-chronic sinusitis to aspirate pus and inject medication. The procedure involves puncturing the sinus mucosa and may cause pain, bleeding, dizziness, or nausea. Lidocaine Spray 1mg provides topical anesthesia before puncture, improving comfort and success rate.
Application: Clean the nasal cavity and identify the puncture site (maxillary, frontal, or ethmoid sinus). Dry the mucosa with a cotton swab. Spray Lidocaine Spray 1mg (2%) 1–2 times onto the target area and press gently for 1–2 minutes. Onset occurs in 1–3 minutes, reducing pain and bleeding during puncture. For sensitive patients, repeat 5 minutes before the procedure.
The spray is also used for:
Nasal foreign body removal: anesthetize surrounding mucosa to reduce pain and sneezing.
Nasal biopsy: spray the biopsy site to avoid severe pain.
Nasal packing: reduce discomfort from packing materials.
Dosing and Precautions: Single nasal dose is usually 20–60 mg (1–3 sprays of 2% solution). Maximum single dose ≤ 500 mg; daily maximum ≤ 1000 mg. Reduce dose in patients with damaged or inflamed mucosa. Avoid nose-blowing or picking for 1–2 hours post-procedure. Discontinue and rinse with normal saline if allergic reactions (itching, redness, swelling) occur.
Topical Anesthesia Before Minor Dermatological Surgery
Minor dermatological procedures include lipoma excision, wound suture, abscess incision and drainage, skin biopsy, and nevus excision. Although superficial and limited in scope, the skin is highly innervated and painful without anesthesia. Lidocaine Spray 1mg (5% formulation) is a preferred topical anesthetic due to rapid onset, ease of use, and controllable coverage. It is sprayed directly onto the surgical area, blocking pain without injection, making it especially suitable for children, the elderly, and sensitive patients.
Compared with injectable local anesthetics, Lidocaine Spray 1mg offers:
Simpler administration without injection skills
No puncture wound, reducing bleeding and infection
Rapid onset (2–5 minutes)
Controllable coverage and dose
Application in Common Minor Dermatological Surgeries
Before Lipoma Excision
Clean and disinfect the surgical area with povidone-iodine and dry thoroughly. Hold the spray 5–10 cm from the skin and spray the lipoma and surrounding 1–2 cm margin, 1–2 times. Cover with sterile gauze and press gently for 1–2 minutes. Onset in 2–5 minutes allows painless incision, dissection, and excision. Increase sprays for larger lesions while controlling total dose.
Before Wound Suture
Clean and disinfect the wound edges. Spray 5% Lidocaine Spray 1mg onto the wound margins and surrounding skin, 1 spray per application. For long or deep wounds, spray both sides. Onset in 1–3 minutes enables rapid suturing with less pain and restlessness. Avoid direct spraying into the wound interior to prevent irritation or inflammation.
Before Abscess Incision and Drainage
Disinfect the abscess surface and mark the incision site. Spray 2 times onto the incision and surrounding 2 cm area. Press for 1–2 minutes; onset in 3–5 minutes reduces pain and bleeding during incision and facilitates drainage.
The same method applies to skin biopsy, nevus excision, and cryotherapy for warts:
Biopsy: spray the target site.
Nevus excision: cover the excision area.
Cryotherapy: spray the lesion to reduce stinging.
adverse reaction
Lidocaine Spray 1mg is a local anesthetic widely used for surface anesthesia of skin and mucosa, such as skin anesthesia before burns, trauma, venipuncture, blood collection, and anesthesia before laryngoscopy. It produces local anesthetic effects by blocking nerve impulse transmission, and has the advantages of fast onset, moderate action time, and convenient use.
Pharmacological characteristics and metabolic pathways
Pharmacological action
Lidocaine belongs to the amide class of local anesthetics, which inhibits voltage-gated sodium channels, blocks the permeability of nerve cell membranes to sodium ions, thereby preventing the generation and conduction of action potentials and achieving local anesthetic effects. The duration of its anesthetic effect is usually tens of minutes to 1-2 hours, suitable for short-term medical procedures or relief of intermittent pain.
Metabolic pathway
Lidocaine is mainly metabolized in the liver, oxidized by cytochrome P450 enzymes (such as CYP3A4) to monoethylglycylbenzoic acid (MEGX) and glycylbenzoic acid (GX), and ultimately excreted as inactive metabolites through the kidneys. A small amount (about 5% -10%) is excreted in its original form through urine. People with liver dysfunction have slower metabolism, which may increase the risk of drug accumulation.
FAQ
How strong is 1% lidocaine?
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Lidocaine 1 % means a 1:100 dilution. That means 10 mg : 1ml. 2ml of the solution will contain 2 (10mg) = 20 mg of lidocaine.
How long does it take for 1% lidocaine to wear off?
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The time it takes for an anesthetic to wear off varies by type. For instance, plain lidocaine typically lasts about one to two hours, while lidocaine with epinephrine (a vasoconstrictor) can extend the numbing effect to two to four hours.
What is the maximum strength of lidocaine spray?
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Aspercreme Lidocaine Dry Spray contains 4% lidocaine, the maximum concentration of lidocaine available without a prescription. * It's designed to numb aggravated nerves and block the pain. *Among OTC topical analgesics.
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