Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of acriflavine tablets in China. Welcome to wholesale bulk high quality acriflavine tablets for sale here from our factory. Good service and reasonable price are available.
Acriflavine tablets are a type of compound with multiple biological activities, widely used in fields such as medicine and biological research. As a formulation form, it may play an important role in the prevention and treatment of specific diseases. From a chemical perspective, acridine yellow hydrochloride belongs to the acridine class of dyes, exhibiting specific colors and corresponding physical properties such as melting points. It is soluble in solvents such as water and ethanol, which facilitates the preparation of its formulations. In terms of pharmacological effects, it has multiple functions. In the field of antibacterial, it can embed double stranded bacterial DNA, interfere with bacterial DNA replication and transcription processes, and thereby inhibit bacterial growth and reproduction; It also has inhibitory effects on certain parasites, can interfere with their metabolism or damage their cellular structure, and has certain value in preventing and treating specific parasitic diseases; In addition, it also has anti-tumor potential, can inhibit the activity of HIF-1 α (hypoxia inducible factor-1 α), hinder tumor angiogenesis and growth, and has attracted attention in tumor treatment research.
Its application scenarios have certain limitations. In medicine, although it can be used for microbiological experiments in laboratory research, such as preparing and selecting culture media to screen specific microorganisms, or as a staining agent for cell biology experiments, it is less commonly used in routine human clinical treatment, mainly because it may have toxicity and side effects, be irritating to the eyes, skin, and mucous membranes, and may also cause allergic reactions, gastrointestinal discomfort, etc. In the field of veterinary medicine, it can be used to prevent and treat animal parasitic diseases, but strict adherence to veterinary guidance is required.
In terms of safety, caution should be exercised when using it, as there are many contraindications, such as prohibition for individuals with allergies, severe liver and kidney function damage, pregnant and lactating women, children, etc. During the medication process, adverse reactions such as cardiovascular risk and severe skin reactions may also occur.
Our product
Additional information of chemical compound:
| Product Name | Acriflavine Cream | Acriflavine Powder | Acriflavine Tablets |
| Product Type | Cream | Powder | Tablets |
| Product Purity | ≥99% | ≥99% | ≥99% |
| Product Specifications | Customizable | Customizable | Customizable |
| Product Package | Customizable | Customizable | Customizable |
Our Product
Acriflavine+. COA
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Certificate of Analysis |
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Compound name |
Acriflavine | |
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CAS No. |
590-63-6 | |
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Grade |
Pharmaceutical grade | |
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Quantity |
Customized | |
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Packaging standard |
Customized | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
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Lot No. |
20250109001 |
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MFG |
Jan 12th 2025 |
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EXP |
Jan 8th 2029 |
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Structure |
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| TEST STANDARD | GB/T24768-2009 Industry. Stnndard | |
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Item |
Enterprise standard |
Analysis result |
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Appearance |
White or almost white powder |
Conformed |
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Water content |
≤4.5% |
0.30% |
| Loss on drying |
≤1.0% |
0.15% |
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Heavy Metals |
Pb≤0.5ppm |
N.D. |
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As≤0.5ppm |
N.D. | |
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Hg≤0.5ppm |
N.D. | |
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Cd≤0.5ppm |
N.D. | |
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Purity (HPLC) |
≥99.0% |
99.5% |
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Single impurity |
<0.8% |
0.48% |
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Residue on ignition |
<0.20% |
0.064% |
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Total microbial count |
≤750cfu/g |
80 |
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E. Coli |
≤2MPN/g |
N.D. |
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Salmonella |
N.D. | N.D. |
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Ethanol (by GC) |
≤5000ppm |
400ppm |
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Storage |
Store in a sealed, dark and dry place at-20 degrees |
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Acriflavine, as a drug with a long history, has specific application scenarios in the fields of medicine and microbiology in its tablet form (Acriflavine Tablets).
Animal parasitic diseases:
Widely used in veterinary medicine for the prevention and treatment of parasitic diseases such as pear shaped worms and Babesia. For example, it has significant therapeutic effects on Babesia equi and Babesia bovis.
Its tablet form may be used for oral administration, but attention should be paid to dosage and duration of treatment to avoid toxic reactions.
Human parasitic diseases:
At present, its application in the treatment of human parasitic diseases is relatively limited, but it may be used in some areas to treat diseases such as erythroptosis. However, its efficacy and safety need further verification.
Application in Microbiology Experiments
Selective inhibitors:
Can be used to prepare selection media and screen specific microorganisms. For example, in microbiology research, Acriflavine can be used as a selective inhibitor to inhibit the growth of certain microorganisms, thereby isolating target strains.
Its inhibitory effect on Escherichia coli factor F can be used to study the transfer and recombination of bacterial genetic material.
Dyeing purpose:
Can be used for staining in cell biology experiments, such as labeling high molecular weight RNA or nuclear structures, for easy microscopic observation.
Anti tumor research:
By inhibiting HIF-1 α activity, it may have inhibitory effects on certain tumors such as glioblastoma and chronic myeloid leukemia. However, the application of its tablet form in the treatment of human tumors has not been widely recognized.
In animal experiments, it can inhibit tumor growth and angiogenesis, but its clinical translation still requires extensive research.
Photodynamic therapy:
The photodynamic therapy properties may be used for the treatment of certain superficial tumors, but specific light sources and devices need to be combined, and tablet form may not be suitable for direct application.
Treatment of local infections
Skin and mucosal infections:
Acriflavine solution or cream form is commonly used for local antibacterial treatment, such as wound infections, skin ulcers, etc. However, its tablet form may not be directly used for local treatment, but can exert systemic antibacterial effects through oral administration.
Attention should be paid to the high toxicity to aquatic organisms, and waste should be disposed of according to hazardous material regulations to avoid environmental pollution.
(1) Human clinical applications
At present, the application of tablet form in human clinical practice is very limited, mainly due to:
Highly toxic: Acriflavine tablets is irritating to the eyes, skin, and mucous membranes, and long-term use may cause serious adverse reactions.
Abundant alternative drugs: In modern medicine, there are various types of antibacterial, antiparasitic, and anti-tumor drugs, and their clinical demand is relatively low.
Insufficient research: There are few clinical studies on its efficacy and safety that have not been fully validated.
(2) Application of Veterinary Medicine
In veterinary medicine, tablet or injection forms are still used to prevent and treat certain parasitic diseases, such as Babesiosis. However, its use must strictly follow veterinary guidance to avoid drug residue and resistance issues.
(3) Laboratory research
It has important applications in microbiology and cell biology experiments, but its tablet form is usually not directly used for laboratory research, and its solution or powder form is more commonly used.
Synergies
Mechanism: When used in combination with other antibacterial drugs, this substance may have a synergistic effect, enhancing the antibacterial effect. For example, when used in combination with beta lactam antibiotics, it may inhibit bacterial growth and reproduction through different mechanisms of action, thereby improving antibacterial efficacy.
Clinical application: However, in clinical application, careful selection of combination therapy is necessary to avoid adverse reactions and interactions between drugs.
antagonism
Mechanism: Currently, no significant antagonistic effect has been found between Acriflavine and other antibacterial drugs. But in some cases, drug interactions may affect the efficacy and safety of drugs. For example, if multiple drugs with similar antibacterial spectra are used simultaneously, it may lead to competitive inhibition of drugs and reduce their efficacy.
Interactions with other drugs
Affects drug metabolism
Mechanism: It may affect the activity of certain drug metabolizing enzymes in the liver, thereby affecting the metabolism of other drugs. For example, it may inhibit the activity of cytochrome P450 enzyme, leading to an increase in the concentration of some drugs metabolized by this enzyme in the body, increasing the risk of adverse reactions.
Clinical application: When using acriflavine, it is important to pay attention to whether the patient is also taking other medications to avoid drug interactions.
Affects drug excretion
Mechanism: This substance and its metabolites are mainly excreted through the kidneys. If some drugs that affect kidney function are used simultaneously, it may affect excretion and lead to drug accumulation in the body.
Enhance therapeutic efficacy
Mechanism: When used in combination with some anti-tumor drugs, this substance may enhance anti-tumor efficacy. For example, the combination of Acriflavine and chemotherapy drugs may enhance the sensitivity of chemotherapy drugs and increase anti-tumor efficacy by inhibiting the resistance mechanism of tumor cells.
Clinical application: However, combination therapy may also increase the risk of adverse reactions and should be used reasonably under the guidance of a doctor.
Increase adverse reactions
Mechanism: When used in combination with certain anti-tumor drugs, it may increase the incidence of adverse reactions. For example, when used in combination with some anti-tumor drugs that have bone marrow suppressive effects, it may exacerbate bone marrow suppression, leading to adverse reactions such as leukopenia and thrombocytopenia.
Future research directions
HIF-1 α inhibitors:
Further investigate the inhibitory effect of HIF-1 α and explore its potential in tumor therapy.
Develop novel HIF-1 α inhibitors to reduce their toxicity.
Photodynamic therapy optimization:
Combining nanotechnology to develop photosensitizer carriers and improve their targeting and therapeutic effects.
Study the combined application with other photosensitizers to enhance the efficacy of photodynamic therapy.
Structural modification:
Chemical modification is carried out to reduce its toxicity and enhance its antibacterial and antiparasitic activity.
Develop new acridine derivatives and expand their clinical applications.
Combination therapy:
Research the combination application with other antibacterial or antiparasitic drugs to improve efficacy and reduce drug resistance.
Toxicological research:
Conduct long-term toxicology research to evaluate its potential effects on various organs of the human body.
Study metabolic pathways and excretion mechanisms, optimize medication regimens.
Clinical trials:
Evaluate the efficacy and safety of Acriflavine tablets in rigorously designed clinical trials to provide a basis for its clinical application.
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