Semax Tablet is an oral formulation drug/health supplement based on the synthetic neuropeptide Semax (methylthio-γ-glutamyl-p-hydroxyphenyl-prolyl-glycyl-proline). The core component Semax was originally developed by Russian scientists as an active short peptide with neuroprotective, cognitive-enhancing and anti-ischemic effects. Traditional Semax is administered via nasal spray to avoid degradation in the gastrointestinal tract, while the tablet form employs a special enteric coating technology to protect the peptide from being damaged when passing through the acidic environment of the stomach, allowing it to be effectively absorbed in the intestine. This drug mainly acts on the central nervous system by regulating the levels of neurotrophic factors (such as BDNF), influencing the endogenous opioid system, and optimizing metabolic processes. Its claimed indications include enhancing cognitive function, improving memory and attention, improving learning ability, and being used as an adjunctive treatment for stroke, cerebral circulation disorders, neurodegenerative diseases, and alleviating mental fatigue and stress. Although it is available as a prescription drug or health supplement in some countries, the bioavailability and specific efficacy of its oral form still require more clinical research for full validation. Consumers should consult medical professionals before using it.
 |
 |
Semax Powder COA
Mechanism of action
The core mechanism of action of Semax Tablet revolves around its characteristics as an analogue of the adrenocorticotropic hormone (ACTH) fragment. It achieves neuroprotection, cognitive enhancement and anti-inflammatory effects by regulating the neurotransmitter system, the expression of neurotrophic factors and synaptic plasticity through multiple pathways. The following analysis is conducted from four dimensions: molecular level, neurotransmitter regulation, activation of neurotrophic factors, and neural plasticity:
Molecular Structure and Blood-Brain Barrier Permeability
Semax is a heptapeppeptide compound with a chemical structure of Met-Glu-His-Phe-Pro-Gly Pro, which is highly similar to the ACTH (4-10) fragment. Its molecular design enables it to pass through the blood-brain barrier and directly act on the central nervous system, avoiding systemic side effects. This characteristic gives Semax a unique advantage in the fields of neuroprotection and cognitive enhancement.
Regulation of Neurotransmitter Systems
The dopaminergic system is activated
Semax can activate the dopaminergic brain system, enhance the release and metabolism of dopamine, thereby improving attention, motivation and reward mechanisms. This effect is particularly significant in patients with attention deficit hyperactivity disorder (ADHD), which can enhance their concentration and information processing speed.
5-hydroxytryptamine can regulate the system
Semax reduces the behavioral effects of chronic stress exposure and enhances anti-anxiety and anti-depression effects by regulating the metabolism of 5-hydroxytryptamine (5-HT). This mechanism makes it have potential application value in emotion regulation and psychological stress management.
The norepinephrine system has an impact
Semax can regulate the release of norepinephrine, enhance alertness and stress response ability. This effect can enhance the body's adaptability and reduce the risk of nerve injury under extreme conditions (such as hypoxia and cerebral ischemia).
Activation of neurotrophic factors
The expression of brain-derived neurotrophic factor (BDNF) was upregulated
Semax promotes the growth and differentiation of new neurons and synapses by increasing the expression of BDNF mRNA. Studies have shown that Semax can increase the expression of BDNF mRNA by 500% and significantly enhance the level of BDNF. BDNF is a key factor for neuronal survival, differentiation and synaptic formation. This effect of Semax makes it play a core role in neural repair and cognitive enhancement.
Activation of nerve growth factor (NGF)
Semax can activate the expression of NGF and promote the survival and regeneration of neurons. In the rat experiment, 90 minutes after Semax administration, the expression levels of BDNF and NGF significantly increased, indicating their dual roles in neuroprotection and repair.
Enhanced neural plasticity
Synaptic plasticity enhancement
Semax enhances the expression of BDNF and NGF, promotes the formation and strengthening of synapses, and improves neural plasticity. This effect is particularly important in the formation and learning of long-term memory and can enhance the ability of information processing and storage.
Nerve regeneration and improvement of cerebral blood flow
Semax can promote neural regeneration, improve cerebral blood flow and reduce neuronal damage. In the ischemic stroke model, Semax showed that it could reduce the infarct area and improve the neurological function score, indicating its potential in neural repair.
Anti-inflammation and Immune Regulation
Anti-inflammatory effect
Semax alleviates neuroinflammatory responses by inhibiting the release of inflammatory factors. In models of cerebral ischemia and craniocerebral injury, Semax can reduce the expression of inflammatory mediators and protect neurons from inflammatory damage.
Immune regulation
Semax can regulate the function of the immune system and enhance the body's disease resistance. In the neural repair after autoimmune diseases or infections, the immunomodulatory effect of Semax can promote the recovery of neural function.
Other Mechanisms
Enkephalin decomposition inhibition
Semax can inhibit the decomposition of enkephalin and reduce the risk of neuronal injury. This effect is particularly important in cerebral ischemia and craniocerebral injury, protecting neurons from damage caused by hypoxia and ischemia.
Antagonism of melanocortin receptors
Semax competitively antagonizes the effects of the total agonist of melanocortin receptors, α -melanocyte-stimulating hormone (α-MSH), on MC4 and MC5 receptors. It may act as an antagonist or partial agonist of these receptors, regulating the neurotransmitter system and energy metabolism.
Clinical Application and Mechanism Verification
Cerebral ischemia and Stroke: In a double-blind controlled trial involving 160 stroke patients, Semax significantly improved the neurological function recovery of the patients and reduced cognitive impairment after cerebral ischemia. This effect is closely related to its anti-inflammatory, neuroprotective and neurotrophic factor activation mechanisms.
Craniocerebral injury: Semax can enhance the consolidation of memory traces after neurosurgical intervention and improve patients' adaptability to damaging effects such as hypoxia and cerebral ischemia. This effect is related to the enhancement of synaptic plasticity and the mechanism of neural regeneration.
ADHD: Semax's cognitive-enhancing properties make it a potential therapeutic drug for ADHD, which can improve attention and information processing abilities. This effect is related to the activation of its dopaminergic system and the upregulation mechanism of BDNF expression.
Learning and memory disorders: Semax can improve the recall effect of learned materials and enhance the ability to form long-term memory. This effect is related to the enhancement of synaptic plasticity and the mechanism of neural regeneration.
Semax has a protective effect on the optic nerve and can improve retinal function. This effect is related to the activation of its neurotrophic factor and the anti-inflammatory mechanism.
Indications
Semax Tablet, as a drug based on neuropeptide active ingredients, has core indications covering multiple fields such as neural repair, cognitive enhancement, psychological function support and optic nerve optimization. The following analysis is conducted from the dimensions of clinical application, mechanism verification and potential advantages:
Neural Repair and Brain Protection
Cerebral ischemia and stroke recovery
Semax has shown in the ischemic stroke model that it can reduce the infarct area, improve the neurological function score, promote nerve regeneration and improve cerebral blood flow. In a double-blind controlled trial involving 160 stroke patients, Semax significantly improved neurological function recovery and reduced cognitive impairment, especially showing remarkable efficacy during the recovery period of stroke. Its mechanism is closely related to antioxidation, anti-inflammation and regulation of neurotrophic factors (such as BDNF), by reducing neuronal damage, promoting synaptic plasticity and accelerating the reconstruction of neural function.
Craniocerebral injury and Neurosurgical intervention
Semax can enhance the consolidation of memory traces after neurosurgical intervention and improve the adaptability of patients to damaging effects such as hypoxia and cerebral ischemia. During the acute phase of traumatic brain injury, a 1% concentration of Semax can take effect rapidly, preventing nerve cell damage and minimizing the consequences of acute cerebral blood supply interruption. Its mechanism of action includes regulating the expression of neurotransmitter systems (such as dopaminergic and serotonin systems) and neurotrophic factors, and promoting neural repair and functional recovery.
Adjuvant therapy for neurodegenerative diseases
In patients with motor neuron disease, Semax significantly improves the overall assessment of quality of life, especially in terms of emotional state and motivation. Although its effect in curing the disease itself is limited, it can significantly improve patients' perception of overcoming pain and enhance their psychological adaptability. Its mechanism is related to the activation of neurotrophic factors, anti-inflammatory and neuroprotective effects, providing adjuvant treatment options for patients with neurodegenerative diseases.
Cognitive Enhancement and Psychological Function Support
Attention Deficit Hyperactivity Disorder (ADHD)
The cognitive-enhancing property of Semax makes it a potential therapeutic drug for ADHD. It enhances attention and information processing speed and improves executive function by regulating the dopaminergic system. Among pediatric patients, Semax can reduce ADHD symptoms, help children adapt to new schools and psychological pressure, increase persistence, enhance the ability to remember new materials, and reduce emotional instability.
Learning and memory impairments and high-intensity mental labor
Semax can improve the recall effect of the learned materials and enhance the ability to form long-term memory. By enhancing the level of BDNF, it promotes synaptic plasticity and neural regeneration, and is suitable for high-intensity mental workers such as students and researchers. In long-term use, Semax can significantly increase the speed of information processing and mental clarity, reduce anxiety levels, and enhance work and study efficiency.
Psychological stress and anxiety management
Semax has anti-anxiety properties, which can alleviate stress responses and enhance mental clarity. It weakens the behavioral effects of chronic stress exposure and enhances emotional stability by regulating the serotonin system. Under extreme conditions (such as hypoxia and cerebral ischemia), Semax can enhance the body's adaptability and reduce the risk of nerve damage, making it suitable for people who are in a high-pressure environment for a long time.
Optic Nerve Optimization and Ophthalmic Diseases
Optic atrophy and neuritis
Semax has a protective effect on the optic nerve and can improve retinal function. In diseases such as optic atrophy and neuritis, Semax slows down the degeneration of the optic nerve and protects vision by promoting the expression of neurotrophic factors, anti-inflammation and improving microcirculation. Its nasal drop form can act rapidly on the central nervous system, avoiding systemic side effects and is suitable for patients with optic nerve diseases.
Inflammation, poisoning and allergic causes of optic neuropathy
Semax can regulate the function of the immune system, alleviate inflammatory responses, and is suitable for optic neuropathy caused by inflammation, poisoning and allergic factors. It improves optic nerve function and reduces visual impairment by inhibiting the release of inflammatory factors and promoting nerve repair. In ophthalmic clinical practice, Semax has been used in the treatment of diseases such as herpes zoster and paralytic keratitis.
Pediatric Indications and Special Populations
Intellectual disability and cerebellar dysfunction
Semax can be used as a therapeutic drug for children with intellectual disabilities (aged 7 and above) to improve cerebellar dysfunction (including ADHD). In the clinic study at the Pediatric Medical University, Semax was given to children (starting from 3-6 months) with good clinical outcomes and no significant side effects. It helps children adapt to the learning and social environment by promoting neural development and enhancing cognitive functions.
Developmental delay and adaptation to psychological stress
For children with delayed psychological and speech development (CRA) problems, Semax can reduce symptoms such as impaired attention and distraction, and enhance learning and memory abilities. It promotes brain development and functional normalization by regulating the expression of neurotransmitter systems and neurotrophic factors, and is suitable for children with impaired attention and concentration in correctional schools.
Other Indications and Potential Applications
Prevention of circulatory disorders and cognitive impairments
Semax at a concentration of 1% can be used for the prevention and treatment of circulatory disorders and cognitive impairments, including conditions after ischemic stroke. As an "emergency" drug after stroke, it can prevent nerve cell damage and minimize the consequences of acute interruption of cerebral blood supply. In addition, Semax can prevent repeated strokes, eliminate postpartum depression and improve the quality of life of patients.
Immune regulation and autoimmune diseases
Semax Tablet can regulate the function of the immune system and is suitable for neural repair after autoimmune diseases or infections. It improves nerve function by inhibiting the release of inflammatory factors, promoting nerve regeneration, reducing nerve damage and enhancing nerve function. In animal models, Semax has shown that it can regulate immune responses and alleviate inflammatory damage caused by "social" stress.
Hot Tags: semax tablet, suppliers, manufacturers, factory, wholesale, buy, price, bulk, for sale, CAS 1252259 63 4, CAS 3114 55 4, CAS 715 50 4, 9 4 4 4 5 5 TETRAMETHYL 1 3 2 DIOXABOROLAN 2 YL 1 1 BIPHENYL 3 YL 9H CARBAZOLE, Dibenzofuran 3 chloro 7 fluoro , 1 3 5 Triazine 2 chloro 4 6 di phenyl 2 3 4 5 6 d5