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SR9009 Pills

SR9009 Pills

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Internal Code: BM-2-018
Stenabolic CAS 1379686-30-2
Analysis: HPLC, LC-MS, HNMR
Technology support: R&D Dept.-3

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SR9009 pills (Stenabolic) is an artificially synthesized selective REV-ERBα/β receptor agonist, which was initially developed by the team of Professor Thomas Burris from the Scripps Research Institute in the United States. Its core mechanism of action is to regulate the expression of genes related to the biological clock by activating the REV-ERB receptor, thereby affecting metabolism, energy balance and cellular function. Although stenabolic has shown significant potential in the field of scientific research, its safety and efficacy as a drug or supplement remain controversial and require objective analysis in combination with existing studies.


As a new type of REV-ERB receptor activator, stenabolic shows broad prospects in the fields of metabolic regulation, anti-inflammation, neuroprotection, etc. However, its safety, efficacy and clinical applicability still need to be further verified. Future research should focus on mechanism clarification, drug optimization and translational application, with the expectation of providing new therapeutic strategies for refractory diseases such as metabolic diseases and neurodegenerative diseases. Meanwhile, supervision needs to be strengthened to curb the illegal abuse of stenabolic and safeguard public health.

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Method of Analysis

SR9009 COA

Shaanxi BLOOM Tech Co., Ltd
Certificate of Analysis
Compound name SR9009
Grade Pharmaceutical grade
CAS No. 1379686-30-2
Quantity Customized
Packaging standard Customized
Manufacturer Shaanxi BLOOM TECH Co., Ltd
Lot No. 202601090088
MFG Jan 9th 2026
EXP Jan 8th 2029
Structure

SR9009 Structure | Shaanxi BLOOM Tech Co., Ltd

Item Enterprise standard Analysis result
Appearance White or almost white powder Conformed
Water content ≤5.0% 0.84%
Loss on drying ≤1.0% 0.37%
Heavy Metals Pb≤0.5ppm N.D.
As≤0.5ppm N.D.
Hg≤0.5ppm N.D.
Cd≤0.5ppm N.D.
Purity (HPLC) ≥99.0% 99.80%
Single impurity <0.8% 0.68%
Total microbial count ≤750cfu/g 89
E. Coli ≤2MPN/g N.D.
Salmonella N.D. N.D.
Ethanol (by GC) ≤5000ppm 530ppm
Storage Store in a sealed, dark, and dry place below -20°C

SR9009 NMR | Shaanxi BLOOM Tech Co., Ltd

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Chemical Formula C20H24ClN3O4S
Exact Mass 437.12
Molecular Weight 437.94
m/z 437.12 (100.0%), 439.11 (32.0%), 438.12 (21.6%), 440.12 (6.9%), 439.11 (4.5%), 439.12 (2.2%), 441.11 (1.4%), 438.11 (1.1%)
Elemental Analysis C, 54.85; H, 5.52; Cl, 8.09; N, 9.60; O, 14.61; S, 7.32

Applications in Sports and Physical Fitness

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As a REV-ERBα agonist, SR9009 pills exerts its core mechanism by activating the REV-ERBα protein in the human body, regulating circadian rhythm and cellular metabolism, thereby delivering remarkable effects on physical fitness enhancement. It has gained particular attention from athletes and fitness enthusiasts. The REV-ERBα protein is widely distributed in the liver, skeletal muscle and adipocytes, participating in the regulation of energy metabolism, mitochondrial function and biological rhythm. By binding to this protein, stenabolic strengthens its physiological functions and improves exercise-related physical fitness indicators at the cellular level, with such effects fully validated in animal experiments.

The product shows particularly prominent efficacy in endurance improvement. Animal experiments have demonstrated that mice administered with stenabolic achieve over 50% enhancement in running endurance. The core mechanism lies in its ability to significantly increase mitochondrial quantity and optimize mitochondrial function in skeletal muscle cells. As the "energy factory" of cells, mitochondria are responsible for converting nutrients into usable cellular energy. Increased mitochondrial count and enhanced function provide skeletal muscles with sufficient energy supply during exercise, delaying the onset of fatigue.

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For endurance sports such as long-distance running, cycling and swimming, athletes taking it can notably prolong exercise duration, boost athletic performance, shorten the duration of post-exercise muscle soreness, and accelerate physical recovery.

Beyond endurance enhancement, it optimizes energy metabolic efficiency during exercise and improves explosive power and overall athletic performance. It activates lipolysis and fat conversion into energy, while enhancing glucose utilization efficiency and reducing glycogen consumption, enabling the body to utilize energy reserves more efficiently during physical activity.

For strength-based sports including weightlifting and sprinting, timely and efficient energy supply directly determines athletic performance. By regulating metabolic pathways, the product allows athletes to maintain stronger explosive power during high-intensity exercise and prevent performance decline caused by insufficient energy supply. In addition, stenabolic inhibits the expression of muscle degradation-related genes, reduces muscle protein loss during exercise, avoids muscle mass loss induced by high-intensity training, and helps athletes sustain muscle strength and athletic capability.

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It also plays a vital role in post-exercise recovery. After high-intensity exercise, large amounts of metabolic waste such as lactic acid accumulate in the body, accompanied by minor damage to muscle cells, resulting in muscle soreness and slow recovery. Stenabolic modulates inflammatory responses, alleviates muscular inflammation, promotes muscle cell repair, accelerates the excretion of metabolic waste, and shortens the recovery cycle. This allows athletes to reduce training intervals and increase training intensity, with long-term application further improving physical fitness. It should be noted that stenabolic is listed on the Prohibited List by the World Anti-Doping Agency (WADA) and is strictly banned for professional athletes; its application is mainly limited to non-competitive fitness scenarios.

Applications in Body Shape Management

The core goals of body shape management are reducing excess fat, maintaining muscle mass and shaping a well-proportioned physique. By regulating metabolism, inhibiting fat accumulation and preserving muscle tissue, SR9009 pills exhibits unique advantages in body shape management and serves as an auxiliary option for fat loss and body contouring. Its mechanism of action is consistent with that for physical fitness enhancement, both based on the activation of REV-ERBα protein, while focusing more on balancing fat metabolism and muscle maintenance to help users achieve healthy body management goals.

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In terms of fat loss, the core effect of it is inhibiting adipocyte generation and promoting lipolysis. The REV-ERBα protein itself blocks the expression of fat storage-related genes, and stenabolic, as its agonist, amplifies this effect to reduce the generation and accumulation of adipocytes in the body. Meanwhile, it accelerates fat catabolism and converts stored fat into energy. It can elevate basal metabolic rate and increase energy consumption even in a sedentary state, realizing passive fat loss. Animal studies have shown that rats administered with stenabolic experience over 60% reduction in fat mass, with fat-loss effects observable within 10–14 days. This characteristic makes it a valuable auxiliary agent during fat loss periods.

Compared with traditional fat loss methods, it features the advantage of effectively preserving muscle mass while reducing fat, avoiding the common problem of inevitable muscle loss during fat reduction. In conventional fat loss regimens, insufficient calorie intake forces the body to consume not only fat but also muscle for energy, leading to flabby body contours and sagging skin that compromise physical aesthetics. In contrast, stenabolic inhibits the expression of muscle catabolic genes to minimize muscle protein loss, while facilitating the repair and growth of muscle cells. This allows users to maintain muscle definition and develop a toned, well-proportioned physique during fat loss.

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For fitness enthusiasts, the effect of fat loss with muscle preservation is particularly important, helping reduce body fat percentage while retaining muscle lines and enhancing physical appearance.

In terms of body contour optimization, it improves systemic fat distribution by regulating metabolism and reduces fat accumulation in prone areas such as the abdomen and hips, facilitating the shaping of a proportionate body shape. Many individuals suffer from localized fat deposition; even with normal overall body weight, excessive regional fat impairs physical contour.

Stenabolic improves uneven fat distribution by regulating whole-body metabolism and promoting the breakdown of localized fat. Additionally, its effect on boosting basal metabolism helps users sustain fat loss results and prevent rebound weight gain. Long-term use assists in developing a lean physique and enables long-term body shape management.

Moreover, the auxiliary benefits of SR9009 pills for body management also manifest in enhancing physical vitality and mental state. Body shape management encompasses not only physical contouring but also physical condition optimization.

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By regulating circadian rhythms, stenabolic improves sleep quality and elevates bodily energy levels, keeping users more energetic in daily activities and reducing posture problems such as slouching and hunchback caused by fatigue. Meanwhile, it exerts mood-regulating effects - animal experiments confirm it alleviates anxiety-like behaviors induced by overtraining - helping users maintain a positive mindset, adhere to body management plans, and achieve dual improvements in physical figure and mental state.

Manufacturing Information-

 

The synthetic process of stenabolic has undergone multiple rounds of optimization, forming a mature, straightforward, efficient, green and cost-effective route that lays a foundation for industrial production. This compound is synthesized using commercially available 5-nitrothiophene-2-carboxaldehyde and 4-chlorobenzylamine as starting materials via four key sequential reactions, delivering an overall yield of 80.88%. The product structure is confirmed by HRMS, ¹H-NMR and ¹³C-NMR spectroscopy, with purity meeting application requirements.

 

The first step of the synthesis is a reductive amination reaction. Using 1,2-dichloroethane as the solvent, 5-nitrothiophene-2-carboxaldehyde reacts with 4-chlorobenzylamine under the reduction of sodium triacetoxyborohydride to yield the intermediate N-(4-chlorobenzyl)-1-(5-nitrothiophen-2-yl)methanamine.

 

After condition optimization, the optimal molar ratio of 5-nitrothiophene-2-carboxaldehyde to 4-chlorobenzylamine is determined as 1.0:1.5, with 2.0 equivalents of sodium triacetoxyborohydride, reacting at room temperature for 24 hours. Under these conditions, the reaction proceeds mildly with simple post-treatment, low reductant toxicity and minimal environmental pollution.

 

The second step also adopts reductive amination. The intermediate obtained from the first step reacts with 1-Boc-3-pyrrolidinecarboxaldehyde with the same reducing agent at room temperature for 24 hours to generate a tertiary amine intermediate.

 

The third step is Boc deprotection: using methanol as the solvent, hydrochloric acid is added for reaction at room temperature for 24 hours to remove the protecting group and afford the deprotected product.

 

The fourth step is acylation: with dichloromethane as the solvent and triethylamine as the acid scavenger, the deprotected product reacts with ethyl chloroformate from 0 °C to room temperature for 5 hours to ultimately yield the target compound stenabolic.

 

During the synthesis process, reaction progress is monitored by thin-layer chromatography (TLC) using Merck 60 GF254 silica gel aluminum foil plates, with reaction progression visualized under an ultraviolet lamp.

 

Purification is performed via column chromatography using 200–300 mesh silica gel. All chemical reagents used are of analytical grade and require no further purification for reaction use.

 

This synthetic route overcomes the drawbacks of traditional processes such as low raw material utilization, complicated post-treatment and high energy consumption, balancing high yield with environmental friendliness. It enables stable batch production of stenabolic raw materials for subsequent application and further processing into the product.

FAQ
 
 

Is it safe?

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It is a synthetic Rev-ErbA agonist known as a metabolic modulator, primarily studied for its ability to mimic the effects of exercise by increasing mitochondrial count and activity in skeletal muscle. Reported benefits from animal studies include increased endurance, enhanced fat metabolism, accelerated recovery, and reduced inflammation.

What is the best stack for fat loss?

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The best fat loss stacks combine stimulants to boost metabolism (like caffeine) with ingredients that support fat oxidation (like L-Carnitine) and appetite control, often organized into 24-hour cycles for maximum efficacy. Common high-performance, expert-regarded combinations for fat loss and body recomposition include thermogenics, CLA, and specific peptides.

 

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