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Calcium phosphate monobasic is an inorganic compound with the chemical formula Ca (H2PO4) 2 and CAS 7758-23-8. It is a white crystalline powder. Easy to dissolve in hydrochloric acid and nitric acid, slightly soluble in cold water, almost insoluble in ethanol. Mainly used as a leavening agent and calcium fortifier for food, a flavoring agent for wine, a fermentation promoter, etc. In the medical field, as a calcium supplement, it helps prevent and treat diseases caused by calcium deficiency, regulate bone growth and development, enhance immunity, and improve sleep quality; In the industrial field, it is widely used in feed additives, plastic stabilizers, analytical reagents, refractory industry, sewage treatment, glass production and other fields; In the field of agriculture, as a phosphate fertilizer, it plays an important role in the growth and development of crops.

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Chemical Formula |
CaH4O8P2 |
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Exact Mass |
234 |
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Molecular Weight |
234 |
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m/z |
234 (100.0%), 238 (2.2%), 236 (1.6%) |
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Elemental Analysis |
Ca, 17.12; H, 1.72; O, 54.69; P, 26.47 |
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Calcium phosphate monobasic, as an important inorganic compound, has a wide range of applications. In the food industry, it can be used as a leavening agent, dough conditioner, buffering agent, nutritional supplement, emulsifier, stabilizer, wine flavoring agent, and fermentation promoter to improve the texture and nutritional value of food.
Food sector
(1) Leavening agent and dough conditioner
It is often used as a leavening agent and dough conditioner in the food industry. It can improve the texture of food, making it softer and more delicious. Dihydrogen phosphate plays an important role in the production process of flour, cakes, pastries, baked goods, fried foods, cookies, and other foods. It can increase the chelating metal ions and pH value of food, enhance ion strength, and thus improve the adhesion and water holding capacity of food. For example, in bread making, adding an appropriate amount of calcium dihydrogen phosphate can expand the volume of bread, make the internal structure more delicate, and improve the taste. According to Chinese regulations, the maximum usage amount for bread, biscuits, and baking powder is 4.0g/kg (calculated as phosphoric acid); Solid beverage is 8.0g/kg; Wheat flour can be used in moderation according to production needs.
(2) Buffering agent
It can also be used as a buffering agent to regulate the acidity and alkalinity of food and maintain its stability. In some foods that require high acidity and alkalinity, such as dairy products, beverages, etc., adding can prevent quality changes during processing and storage due to changes in acidity and alkalinity, and extend the shelf life of the food.
(3) Nutritional supplements
As a nutritional supplement, it can provide calcium elements to food and increase its nutritional value. Calcium is one of the essential minerals for the human body and is crucial for the healthy development of bones and teeth. Adding it to foods such as milk powder, cold drinks, and ice cream can allow consumers to consume sufficient calcium while enjoying delicious food, meeting the body's nutritional needs.

(4) Emulsifiers and stabilizers
It has emulsifying and stabilizing effects, which can better mix ingredients such as oil and water in food, forming a uniform emulsion or suspension. Adding ingredients to dairy products, seasonings, and other foods can improve their stability and taste, preventing the occurrence of layering and sedimentation.
(5) Seasoning agents and fermentation promoters for wine
In the process of making wine, it can be used as a seasoning to improve the flavor of the wine. It can regulate the acidity and alkalinity of wine, making the taste more mellow. Meanwhile, calcium dihydrogen phosphate can also promote the fermentation process of wine, improve fermentation efficiency, and increase the yield and quality of wine.
Medical field
(1) Calcium supplements
As one of the calcium supplements, moderate supplementation of calcium phosphate monobasic can help the human body supplement calcium, prevent and treat related diseases or symptoms caused by calcium deficiency. Calcium is the main component of human bones and teeth, playing an important role in maintaining the strength and density of bones. As people age, their ability to absorb calcium gradually decreases, making them more susceptible to diseases such as osteoporosis, skeletal dysplasia, and rickets. Moderate supplementation can increase calcium intake, promote bone growth and development, and prevent and treat these diseases.
(2) Regulating bone growth and development
It plays an important regulatory role in the growth and development of human bones. During childhood and adolescence, bones are in a rapid growth and development stage, requiring a large amount of calcium to support bone growth. It can provide sufficient calcium source for the body, promote the proliferation and differentiation of bone cells, and make bones stronger and healthier.
(3) Enhancing immunity and improving sleep quality
Helps maintain the body's acid-base balance and metabolism, thereby promoting growth and development, and enhancing immunity. It can also improve sleep quality and relieve fatigue. Calcium is involved in the synthesis and release of neurotransmitters, playing an important role in the normal function of the nervous system. Moderate supplementation can regulate the excitability of the nervous system, making it easier for people to fall asleep and improving sleep quality.
Industrial sector
(1) Feed additives
Widely used as a feed additive for aquaculture animals and livestock breeding animals. As a feed additive, it can enhance the nutritional value of feed and promote animal growth performance. The amount of additives in feed is generally between 1% and 2%. It can provide mineral elements such as calcium and phosphorus for animals to meet their growth and development needs. Calcium and phosphorus are important components of animal bones and teeth, and have a significant impact on animal bone development, muscle growth, and reproductive performance. In aquaculture, adding can promote the growth of fish and improve their disease resistance; In animal husbandry, it is possible to increase the weight of livestock and improve the yield and quality of meat, eggs, and milk.
(2) Plastic stabilizer
Can be used in the plastic industry as a stabilizer. It can improve the thermal and photostability of plastics, preventing degradation and aging of plastics during processing and use. In the production process of plastic products, adding an appropriate amount can prolong the service life of plastic products and improve product quality.
(3) Analytical reagents
In the laboratory, calcium dihydrogen phosphate can be used as an analytical reagent. It can be used to determine the concentration of calcium ions, phosphate ions, etc. in a solution. Due to its stable chemical properties and high purity, it is widely used in fields such as chemical analysis and environmental monitoring.

(4) Other industrial applications
It can also be used in refractory industry, sewage treatment and other fields, as well as as as an additive for producing glass. In the refractory industry, it can be used as a binder to improve the strength and high temperature resistance of refractory materials; In sewage treatment, it can serve as a flocculant to remove suspended solids and impurities from water; In glass manufacturing, adding can improve the performance of glass, enhance its transparency and chemical stability.
In the field of agriculture
(1) Phosphate fertilizer
It is a common phosphate fertilizer. Phosphate fertilizer mainly has the functions of strengthening fruits, drought resistance, and cold resistance during the growth process of crops. In fruit tree cultivation, phosphorus fertilizer can promote fruit plumpness, bright color, and improve fruit quality. Moreover, in arid or cold environments, crops treated with phosphorus fertilizer can better adapt, improve their stress resistance, and reduce the damage caused by environmental stress. Phosphorus is one of the three essential nutrients for plant growth and development, and it participates in physiological processes such as photosynthesis, respiration, and energy metabolism. Phosphorus can be absorbed and utilized by plant roots, promoting their growth and development, and enhancing their ability to absorb nutrients.
(2) Scientific and rational use of fertilizers and pesticides
In agricultural production, Calcium phosphate monobasic is necessary to use fertilizers and pesticides scientifically and reasonably in order to achieve sustainable development of agriculture, ensure high yield and high quality of crops, and protect our ecological environment. Although phosphorus fertilizer plays an important role in crop growth, excessive use can also bring some negative effects, such as soil acidification and eutrophication of water bodies. Therefore, when using calcium dihydrogen phosphate, the amount and method of use should be reasonably determined based on factors such as soil fertility and crop demand.
adverse reaction
Calcium Phosphate Monobasic (monohydrate calcium dihydrogen phosphate, chemical formula: Ca (H ₂ PO ₄) ₂ · H ₂ O) is a widely used inorganic compound, commonly used in food additives, feed supplements, pharmaceutical preparations, and industrial fields. As an important member of calcium phosphate compounds, their safety and adverse reactions have attracted much attention.
Acute toxic reaction
Oral exposure
According to animal experimental data, the oral acute toxicity of calcium dihydrogen phosphate monohydrate is relatively low. The oral median lethal dose (LD ₅₀) for rats is 17500 mg/kg, indicating a high threshold for severe toxicity induced by a single high-dose intake. However, cases of acute poisoning in humans are extremely rare, mainly due to daily exposure doses far below the experimental threshold. However, it should be noted that excessive intake may cause gastrointestinal irritation, manifested as nausea, vomiting, abdominal pain, or diarrhea, which usually subside on their own after discontinuation of the medication.
Inhalation exposure
Inhalation of dust may cause respiratory irritation, especially when exposed to high concentrations of dust in occupational environments for a long time. Animal experiments have shown that inhaling calcium dihydrogen phosphate dust can cause respiratory inflammation, clinically manifested as coughing, shortness of breath, or discomfort in the throat. It is recommended to wear dust masks in high dust workplaces and regularly monitor the concentration of particulate matter in the air.
Skin and eye contact
Direct contact with calcium dihydrogen phosphate powder or solution may cause skin dryness, erythema, or mild burning sensation, but severe skin damage is rare. Eye contact may cause conjunctivitis or corneal irritation, manifested as redness, tearing, or foreign body sensation. The Safety Data Sheet (SDS) clearly indicates that it causes "serious eye damage" (H318) and "skin irritation" (H315), emphasizing the need to immediately rinse with plenty of water and seek medical assistance after contact.
Local irritation and allergic reactions
Respiratory irritation
Long term inhalation of calcium dihydrogen phosphate dust may induce chronic respiratory inflammation, manifested as persistent cough, dry throat, or chest tightness. Occupational exposure studies have shown that some individuals in industries such as feed processing and fertilizer production exhibit airway hyperresponsiveness, which may be related to the deposition of small particles (PM2.5) in the alveoli of dust. It is recommended that companies optimize their ventilation systems to reduce dust suspension in the air.
Skin allergies
Although calcium dihydrogen phosphate itself is not a typical allergen, a very small number of sensitive individuals may develop contact dermatitis due to repeated exposure. Symptoms include redness, itching, or blisters, which are more common in exposed areas such as the hands or forearms. If such symptoms occur, contact should be immediately stopped and antihistamines should be used to relieve them.
Eye injuries
When the eyes are directly exposed to calcium dihydrogen phosphate powder or high concentration solution, it may cause corneal epithelial damage, manifested as blurred vision, photophobia, or tearing. Animal experiments have confirmed that its Eye Irritation Index (ESI) is 3.2 out of 4, indicating moderate irritation. Emergency treatment requires continuous flushing with physiological saline for at least 15 minutes and seeking medical attention as soon as possible.
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