Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of laurocapram cas 59227-89-3 in China. Welcome to wholesale bulk high quality laurocapram cas 59227-89-3 for sale here from our factory. Good service and reasonable price are available.
Laurocapram (Azone) is a colorless to light yellow transparent liquid with a special odor. Molecular formula C18H35NO, CAS 59227-89-3. This odor is relatively light and does not bring strong stimulation to users. Due to its colorless and transparent nature, it can easily integrate into various products without changing the original color and texture of the product. It has good solubility and can dissolve in various organic solvents, such as ethanol, propylene glycol, glycerol, etc. At the same time, it can also be partially dissolved in water to form emulsion or micro lotion.
This solubility makes laurazone very convenient to use in the production of cosmetics and personal care products, and can be easily mixed evenly with other ingredients. It has a lower surface tension, which allows it to form a thin film on the surface of the liquid, thereby changing its wetting and spreading properties. This characteristic enables laurazone to play a role in solubilization, emulsification, and penetration in cosmetics and personal care products. It has various excellent physical properties, which make it have broad application prospects in cosmetics and personal care products. By utilizing its good solubility, stability, surface tension and other characteristics, the performance and effectiveness of the product can be effectively improved. Meanwhile, its relatively low safety risk also makes it an indispensable component in many skincare products.
|
Chemical Formula |
C18H35NO |
|
Exact Mass |
281 |
|
Molecular Weight |
281 |
|
m/z |
281 (100.0%), 282 (19.5%), 283 (1.8%) |
|
Elemental Analysis |
C, 76.81; H, 12.53; N, 4.98; O, 5.68 |
Synthetic Laurocapram usually acts with caprolactam and alkylating reagent, such as halogenated dodecane, and brominated dodecane is often used.
1.Catalyst free method. Caprolactam reacts with sodium hydride to form salt, and then condenses with Bromododecane.
This method needs solvent and nitrogen protection. It is reported in the literature that lauryl argon ketone is synthesized by two-step method with sodium alcohol instead of sodium hydride. The improved process still needs nitrogen as protection, solvent, drying and dehydration, etc. the operation requirements are high, the reaction time is longer, and the yield is still low.
2.Phase transfer catalysis
[1] Liquid liquid phase transfer catalysis. It is a caprolactam one-step N-alkylation synthesis method with sodium hydroxide aqueous solution as the deprotizing agent. The commonly used phase transfer catalysts include Benzyltriethylammonium (Teba), tetrabutylammonium bisulfate (tbahs), etc.
The characteristics of this method are: simple process and convenient operation; However, the reaction time is long, the catalyst is expensive, and it is often accompanied by side reactions. The amount of alkali is far beyond the theoretical amount, which is not easy to obtain.
[2] Solid liquid phase transfer method. In this method, caprolactam and Bromododecane are used as reactants, and
NaOH or KOH are used as deprotonants, tetrabutylammonium bromide (TBAB), polyethylene glycol (PEG), triethyl benzyl ammonium bromide (Teba), tetrabutylammonium bisulfate (tbahs) and other phase transfer catalysts are used for the one-step synthesis of lauridone.
The reaction conditions of this method are mild, without nitrogen protection, and convenient for industrialization.
[3] Synergistic catalytic synthesis. In this method, potassium fluoride and tetrabutylammonium bromide were used to catalyze the reaction in benzene as solvent for 5h at low temperature of 50~60c, and the yield was 85%
[4] Ultrasonic wave is used in the synthesis of laurazone. Kongrongzu et al. Synthesized laurazone by ultrasonic radiation, and studied the effect of ultrasonic on the N-alkylation of caprolactam. Experiments show that aromatic halocarbons hardly react, the yield of brominated hydrocarbons below C is high, and the yield of long-chain halocarbons is not ideal. The specific reaction is shown in the reaction formula in [3] above- It is generally believed that ultrasound produces cavity effect in the system, locally forms high temperature and pressure, and releases energy to promote molecular reaction. Its mechanical oscillation and diffusion are also conducive to the full contact of reactants, so as to promote the reaction.
Laurocapram is a new skin penetrant first reported by American Stoughton in the early 1980s. Its chemical name is 1-n-dodecyl azacycloheptyl-2-one. Azone for short. Azone is colorless, tasteless, non-toxic and non irritating oily transparent liquid at room temperature. It has lubricity, easy coating and strong permeability. It is also an organic chemical with a wide range of uses, and its efficient permeability promotion, non-toxic safety and other characteristics have attracted more and more attention. It can promote the permeability of hydrophilic and hydrophobic compounds.
Azone is a multifunctional compound that has been widely used in many fields due to its unique physical and chemical properties. The following is a detailed description of the uses of laurel ketone, striving for comprehensiveness and depth.
The application in cosmetics and personal care products is particularly prominent. Its main uses include:
(1) Moisturizers: have good moisturizing properties, can absorb and lock in skin moisture, maintain skin moisture and elasticity. This makes it an important moisturizing ingredient in many cosmetics, skincare products, and shampoo products.
(2) Penetrant: It can effectively promote other ingredients to penetrate deep into the skin, thereby improving the efficacy of the product.
Therefore, in topical medications such as creams and ointments, it is often used as an adjuvant to help improve the permeability and absorption rate of drugs.
(3) Cleaning agent: It has a cleansing effect and can effectively remove dirt and oil from the skin surface, keeping the skin fresh. At the same time, it can also dissolve dead skin cells on the skin, promoting skin metabolism.
(4) Skin conditioner: It can also be used as a skin conditioner to improve the texture and appearance of the skin. It can promote the regeneration and repair of skin cells, making the skin smoother and more delicate.
Azone also plays an important role in the pharmaceutical field:
(1) Antibacterial agents: have certain antibacterial effects, especially significant inhibitory effects on Gram positive and Gram negative bacteria. This makes it widely used as an antibacterial agent in the pharmaceutical field, helping to prevent and treat bacterial infections.
(2) Antimicrobial agents: They can also remove bacteria from the skin and alleviate symptoms of skin diseases caused by bacterial infections, such as acne and dermatitis. By inhibiting the growth and reproduction of bacteria, laurocapram can effectively alleviate skin inflammation and infection.
(3) Drug application enhancer: It can promote the absorption of drugs by the skin and enhance the therapeutic effect of drugs. When medication is applied to the skin, it can increase the permeability of the medication on the surface of the skin, allowing it to enter deeper layers of the skin more quickly, thereby improving the therapeutic effect of the medication.
Azone also has certain applications in the agricultural field:
(1) Plant growth regulator: can be used as an absorbent for plant growth regulators, promoting the absorption and utilization of nutrients by plants. By improving the absorption efficiency of nutrients by plants, it can promote plant growth and development, and increase crop yield and quality.
(2) Promoter of bactericidal insecticides: It can also be used as a promoter of bactericidal insecticides, helping to improve the permeability and absorption rate of pesticides on plant surfaces. By increasing the distribution and concentration of pesticides in plants, it can enhance their bactericidal and insecticidal effects, and improve the disease and pest resistance of crops.
Coloring promoter: can be used as a coloring promoter in the leather and printing and dyeing fields, helping to improve the coloring effect and fastness of dyes. By increasing the permeability and adsorption of dyes on the surface of leather or fabric, it can make the dyes more evenly distributed on the material surface, improving the color and aesthetics of the product.
Solvent and cleaning aid: It is a low toxicity, odorless, colorless, and transparent liquid commonly used as a solvent and cleaning aid. It has good solubility and cleaning effect, and can be used for industrial cleaning work such as cleaning machinery and equipment, removing oil stains, etc.
During the tertiary oil recovery stage, the increase in crude oil viscosity and residual oil saturation are key factors that constrain the recovery rate. Azone improves oil recovery efficiency through the following methods:
Reduced interfacial tension: Azone molecules adsorb at the oil-water interface, forming a mixed film that reduces the interfacial tension from 30-50 mN/m to 1-3 mN/m, promoting the detachment of oil droplets from the rock surface.
Emulsification effect: It interacts with asphaltene and gum in crude oil to form a water in oil emulsion, reducing the viscosity of crude oil (experiments have shown that 0.5% azone can reduce the viscosity of high viscosity crude oil by 60% -70%);
Wetting reversal: Changing the wettability of the rock surface, making the oleophilic surface hydrophilic and reducing the loss of crude oil adsorption.
In long-distance oil pipelines, energy loss is caused by friction between crude oil and the pipe wall. Laurocapram reduces frictional resistance through the following pathways:Boundary layer turbulence suppression: forming an adsorption film on the pipe wall to reduce momentum transfer between the turbulent core and near wall regions; Wax crystal dispersion: binds with paraffin molecules to prevent wax crystal aggregation and deposition, maintaining pipeline fluidity.
Wax prevention effect: Adding 0.1% -0.2% azone to waxy crude oil can reduce the wax deposition rate by more than 50% and extend the cleaning cycle by 2-3 times.
Heavy oil cracking: as a solvent, it participates in the thermal cracking reaction of residual oil, promotes the ring opening of polycyclic aromatic hydrocarbons, and improves the yield of light oil; Lubricating oil refining: compounding with furfural and phenols to selectively extract non ideal components from lubricating base oil; Asphalt modification: By blending modification, the penetration of asphalt is reduced and high-temperature stability is improved.
Technical advantages: Compared to traditional solvents such as toluene and xylene, azone has lower volatility and higher selectivity, reducing VOCs emissions by 30% -40%.
Drilling tool lubrication: forms a lubricating film in the drilling fluid, reducing the friction coefficient between the drill rod and the wellbore wall (from 0.25 to below 0.10);
Wellbore stability: By adsorbing on the surface of shale, it inhibits hydration expansion and prevents wellbore collapse.
On site application:
In deep and ultra deep well drilling, azone based drilling fluid can increase drilling speed by 15% -20% and reduce accident rates by 40%.
The discovery of azone originated from the research and development of transdermal drug delivery systems at Nelson Pharmaceutical Company in the United States during the 1970s and 1980s.
The synthesis of its basic molecule can be traced back to 1953, when Swain et al. reported it in the Journal of Organic Chemistry, although its transdermal penetration-enhancing activity was not identified at that time.
In 1976, Rajadhyaksha, a researcher at the company, first discovered its potent transdermal enhancement effect and filed a core patent (US 3989816).
From 1982 to 1983, dermatologist Stoughton systematically confirmed through clinical and skin physiological studies that it could significantly increase the transdermal absorption of drugs, formally establishing its status as a novel transdermal penetration enhancer.
In 1983, Nelson optimized the industrial synthesis process (US 4422970), achieving high-yield preparation using caprolactam and 1-bromododecane as raw materials.
In the same year, azone was launched into the pharmaceutical and cosmetic markets under the name azone, becoming the world's first widely used synthetic high-efficiency transdermal penetration enhancer and ushering in a new era of penetration enhancement technology for topical preparations.
Hot Tags: laurocapram cas 59227-89-3, suppliers, manufacturers, factory, wholesale, buy, price, bulk, for sale, Hinokitiol powder, Sodium Polyacrylate Solution CAS 9003 04 7, s allyl l cysteine, Pure Erythritol Powder CAS 149 32 6, Cyclohexyldimethoxymethylsilane, Sodium N cyclohexylsulfamate CAS 139 05 9