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Thymoquinone powder, white crystal or powder with a spicy smell, chemical reagents, organic intermediates, is the seed of Ranunculaceae black grass plants, and is the main monoterpene phenol existing in the essential oil. The essential oil is separated from plants belonging to Labiatae and other plants such as Verbenaceae, Scrophulariaceae, Ranunculaceae. Has antioxidant, anti-inflammatory, antibacterial and antifungal effects. It is slightly soluble in water and easily soluble in organic solvents such as glacial acetic acid, paraffin oil, ethanol, ether, chloroform, ethyl acetate, carbon disulfide and olive oil.We are thymoquinone supplier, producing best black seed oil with highest thymoquinone. For specific thymoquinone price, please send an email.
|
Chemical Formula |
C10H12O2 |
|
Exact Mass |
164 |
|
Molecular Weight |
164 |
|
m/z |
164 (100.0%), 165 (10.8%) |
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Elemental Analysis |
C, 73.15; H, 7.37; O, 19.49 |
|
Melting point |
45-47 ° C (lit.) |
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Boiling point |
230-232 ° C (lit.) |
|
Density |
1.0326 (rough estimate) |
|
Flash point |
Flash point 219 ° f |
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Refractive index |
1.5155 (estimated) |
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Sealed in dry, room temperature, Warning word, Hazard description h302-h315-h319-h335, Precautions p261-p305 + P351 + p338-p264-p270-p280-p301 + p312 + p330-p302 + p352 + p332 + P313 + p362 + p364-p305 + P351 + P338 + P337 + p313-p501, Dangerous goods sign xn, Hazard category code 22-36 / 37 / 38, Safety instructions 26-3, Germany 1, RTECS No. lr0350000, F 3-9, TSCA Yes
The preparation method :
( 1 ) Using thymol as raw material, chlorosulfonic acid as sulfonation agent, chromic acid solution as oxidant, dichloromethane, chloroform as solvent, the thyquinone ( 2-isopropyl-5-methyl-1,4-benzoquinone ) was synthesized by sulfonation-oxidation reaction.After alkali washing, water washing, filtration, crystallization, distillation, cooling and curing, the thyquinone ( 2-isopropyl-5-methyl-1,4-benzoquinone ) was obtained.The original auxiliary material of the invention is easy to obtain, the reaction condition is mild, the operation is safe and simple, the conversion rate is high, the product quality is stable, and the product is clean and environmentally friendly.
( 2 ) Using thymol as substrate, concentrated sulfuric acid as sulfonation agent, manganese dioxide as oxidant, water as solvent, thyquinone was obtained by distillation, filtration and drying ; the molar ratio of thymol to concentrated sulfuric acid is 1 : 3 ~ 3.5. The molar ratio of concentrated sulfuric acid to manganese dioxide is 1 : 1 ~ 1.5 ; ( 1 ) 90kg thymol and 600L solvent oil were added into 1500L reactor, stirring was started, heating up to 60 ~ 65 °C ; ( 2 ) Extract 186Kg concentrated sulfuric acid into the high tank, slowly drop into the reactor, drop heat, control drop temperature at 7085 °C ; by changing the reaction route or optimizing the synthesis method, the synthesis process which is convenient for industrialization is formed. The operation is simple, the process control is rigorous and reliable, and the yield is high.
Thymoquinone powder (CAS number: 490-91-5) is a natural quinone compound extracted from plants such as Nigella sativa. It has various biological activities and has shown wide potential applications in the fields of medicine, health products, cosmetics, and food additives.
Antioxidant effect: Clearing free radicals and protecting cells from oxidative damage
Its antioxidant capacity is one of its most prominent characteristics. The conjugated double bonds and carbonyl groups in its molecular structure can efficiently capture and neutralize free radicals (such as superoxide anions, hydroxyl radicals, etc.), thereby reducing oxidative stress damage to cells. Research shows:
Mechanism: By upregulating the activity of antioxidant enzymes such as superoxide dismutase (SOD) and catalase (CAT), the cell's own antioxidant defense system is enhanced. At the same time, it can also inhibit lipid peroxidation reactions and reduce the production of oxidative products such as malondialdehyde (MDA).
Application:
Delaying aging: Oxidative stress is an important driving factor of aging, and its antioxidant effect can slow down aging related processes such as skin aging and organ dysfunction.
Protecting the liver: In drug or toxin induced liver injury models such as carbon tetrachloride and doxorubicin, liver cell necrosis and fibrosis are significantly reduced by clearing free radicals and inhibiting the release of inflammatory factors.
Cardiovascular protection: it can inhibit the oxidative modification of low-density lipoprotein (LDL), reduce the formation of atherosclerotic plaque, and reduce the risk of cardiovascular disease.
Anti inflammatory effect: Inhibit inflammatory signaling pathways and alleviate inflammatory diseases
Inflammation is the common pathological basis of various chronic diseases, and through multi-target regulation of inflammatory response, it exhibits a wide range of anti-inflammatory activities:
Mechanism:
Inhibition of NF - κ B pathway: It can block the activation of I κ B kinase (IKK), prevent NF - κ B nuclear translocation, and thus inhibit the expression of pro-inflammatory factors such as tumor necrosis factor - α (TNF - α) and interleukin-6 (IL-6).
Inhibition of MAPK pathway: It reduces the production of inflammatory mediators by inhibiting the phosphorylation of mitogen activated protein kinases such as p38 and JNK.
Regulating COX/LOX enzyme: It can inhibit the activity of cyclooxygenase (COX-2) and 5-lipoxygenase (5-LOX), reduce the levels of inflammatory mediators such as prostaglandin E2 (PGE2) and leukotriene B4 (LTB4).
Application:
Arthritis: In rheumatoid arthritis models, joint swelling and pain are relieved by inhibiting synovitis and bone destruction.
Inflammatory bowel disease: can alleviate intestinal inflammation in patients with ulcerative colitis and Crohn's disease, and promote mucosal repair.
Asthma: Improving asthma symptoms by inhibiting airway inflammatory cell infiltration and mucus secretion.
Anti cancer effect: induces apoptosis of cancer cells, inhibits tumor growth and metastasis
Thymoquinone powder anticancer activity is one of its research hotspots. It has significant inhibitory effects on a variety of tumor cells (such as lung cancer, breast cancer, pancreatic cancer, glioblastoma, etc.):
Mechanism:
Inducing apoptosis: By upregulating the expression of pro apoptotic proteins (such as Bax, Bak) and downregulating anti apoptotic proteins (such as Bcl-2, Bcl xL), activating the caspase cascade reaction, cancer cell apoptosis is induced.
Inhibition of proliferation: It can block the expression of cell cycle proteins such as cyclin D1 and CDK4, causing cancer cells to stagnate in the G0/G1 or G2/M phase and inhibiting their proliferation.
Anti angiogenesis: By downregulating the expression of vascular endothelial growth factor (VEGF) and its receptor (VEGFR2), it inhibits the formation of tumor neovascularization and cuts off the nutritional supply to the tumor.
Reverse drug resistance: It can inhibit the expression of resistance proteins such as P-glycoprotein (P-gp), enhance the accumulation of chemotherapy drugs (such as cisplatin and doxorubicin) in cancer cells, and reverse multidrug resistance.
Application:
Pancreatic cancer: it can induce apoptosis of pancreatic cancer cells, inhibit their invasion and metastasis, and has synergistic effect with gemcitabine and other chemotherapy drugs.
Glioblastoma: Inducing cancer cell apoptosis and inhibiting tumor stem cell self-renewal by regulating the Bax/Bcl-2 protein ratio.
Lung cancer: Interacts with the PPAR - γ pathway in non-small cell lung cancer cells to enhance radiotherapy sensitivity.
Antibacterial and antiviral effects: inhibiting the growth and replication of pathogenic microorganisms
Bailiquinone has inhibitory effects on various pathogenic microorganisms, including bacteria, viruses, fungi, and parasites.
Antibacterial:
Mechanism: It can damage the integrity of bacterial cell membranes, leading to leakage of cellular contents; Simultaneously inhibiting the formation of bacterial biofilm and enhancing the permeability of antibiotics.
Application: It has inhibitory effects on Gram positive and Gram negative bacteria such as Staphylococcus aureus, Pseudomonas aeruginosa, and Bacillus cereus, and can be used to treat skin infections, respiratory infections, etc.
Antiviral:
Mechanism: It can inhibit key processes such as virus adsorption, entry, and replication, regulate host immune response, and enhance antiviral ability.
Application: It has inhibitory effects on hepatitis virus, EB virus, herpes virus, etc., and may be used as an adjuvant therapy for viral infections.
Metabolic regulation effect: improve glucose and lipid metabolism, assist in the treatment of metabolic diseases
Thymoquinone powder shows potential application value in metabolic regulation, especially in the auxiliary treatment of metabolic syndrome related diseases such as diabetes and obesity:
Mechanism:
Enhance insulin sensitivity: By activating the AMPK signaling pathway, promote the translocation of glucose transporter protein (GLUT4), and increase the uptake of glucose by muscles and adipose tissue.
Regulating lipid metabolism: can inhibit the activity of fat synthesis related enzymes (such as fatty acid synthase and acetyl CoA carboxylase), reducing fat accumulation; Simultaneously promoting beta oxidation of fatty acids and reducing blood lipid levels.
Protecting pancreatic beta cells: Through antioxidant and anti-inflammatory effects, reducing damage to pancreatic beta cells, promoting their regeneration and functional recovery.
Application:
Diabetes: animal experiments show that it can reduce fasting blood glucose and glycosylated hemoglobin (HbA1c) levels and improve insulin resistance.
Obesity: By regulating lipid metabolism and energy balance, it reduces weight gain and fat tissue accumulation.
Neuroprotective effect: Inhibit neuroinflammation and delay the progression of neurodegenerative diseases
It has a protective effect on the nervous system and may be used as an adjuvant therapy for neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.
Mechanism:
Inhibition of neuroinflammation: By inhibiting the activation of microglia and astrocytes, reducing the release of inflammatory factors such as TNF - α and IL-1 β, and alleviating neuroinflammatory damage.
Clearing β - amyloid protein (A β): can promote the degradation and clearance of A β, reduce its deposition in the brain, and improve the pathological characteristics of Alzheimer's disease.
Antioxidant stress: protects neurons from oxidative damage by clearing free radicals and upregulating the expression of antioxidant enzymes.
Application:
Alzheimer's disease: can improve cognitive dysfunction induced by A β and restore neuronal vitality.
Parkinson's disease: Delaying disease progression by inhibiting the aggregation of alpha synuclein and neuronal death.
Other applications: promoting hair growth, improving fertility, etc
Thymoquinone powder also has various other biological activities and may be used in the following fields:
Promoting hair growth: By inhibiting the activity of 5 α - reductase and reducing the production of dihydrotestosterone (DHT), androgenic alopecia can be alleviated; Simultaneously promoting the proliferation of hair follicle cells and prolonging the hair growth period.
Improving fertility: It can regulate sex hormone levels, improve sperm quality and ovarian function, and may be used to treat male infertility and female premature ovarian failure.
Hepatoprotective effect: In addition to antioxidant and anti-inflammatory properties, resveratrol can also promote liver cell regeneration, improve liver function, and may be used as an adjuvant therapy for drug-induced liver injury and fatty liver.
FAQ
What does thymoquinone do in the body?
It is concluded that thymoquinone has evidently proved its activity as hepatoprotective, anti-inflammatory, antioxidant, cytotoxic and anti-cancer chemical, with specific mechanisms of action, which provide support to consider this compound as an emerging drug.
What happens to your body when you start taking black seed oil?
Black seed and TQ are shown to possess multiple useful effects for the treatment of patients with several diseases, such as inflammatory and auto-immune disorders, as well as metabolic syndrome. Also, other advantages, including antimicrobial, anti-nociceptive and anti-epileptic properties, have been documented.
What is the best source of thymoquinone?
Black Seed Oil Extract (6-7% Thymoquinone) - 1 fl oz (30 mL) At 6-7% Thymoquinone, this is the best Black Seed Oil with highest Thymoquinone available.
What effects does thymoquinone have on the brain?
Thymoquinone improved synaptic vesicle recycling inhibition in primary hippocampal and cortical neurons. Thymoquinone also reversed the loss of spontaneous firing activity and inhibited Aβ1-42 aggregation in vitro. These beneficial effects may contribute to the protection against Aβ-induced neurotoxicity.
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