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URIDINE 5'-MONOPHOSPHATE(UMP), white crystal powder, used as nucleic acid drug intermediates, health food, and biochemical reagents, and used for the manufacture of uridine triphosphate, polyadenuria, fluroiron, and other drugs. Uridine acid is a phosphate of uridine. There are three kinds of uridine 2′-phosphate (2′-uridine), uridine 3 ′ -phosphate (3′-uridine), and uridine 5′-phosphate (5′-uridine) depending on the connection site. It is usually uridine 5′-phosphate in vivo. The data showed that the proportion of uridine in total nucleotides in sows' milk, whether pre-lactating, mid-lactating, or late-lactating, was overwhelming, with even more than 90 % of the chemicalbook value. In addition, the nucleotide contents in the late lactation milk of piglets and sows were compared, and it was found that among the five nucleotides, uridine was the most deficient in piglets, while other nucleotides were less or not deficient. Therefore, if the nucleotide content in pig milk represents the nucleotide requirement of piglets, it can be concluded that among the five nucleotides, piglets lack the most uridine.
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Chemical Formula |
C9H13N2O9P |
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Exact Mass |
324 |
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Molecular Weight |
324 |
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m/z |
324 (100.0%), 325 (9.7%), 326 (1.8%) |
|
Elemental Analysis |
C, 33.35; H, 4.04; N, 8.64; O, 44.42; P, 9.55 |
Melting point 202 °C ( rough estimate ) , Density 1.865 ± 0.06 g / cm3 ( Predicted ) , Storage condition -20 ° C , Solubility H2O : soluble 50 mg / mL, clear, colorless , Solid shape , Acidity coefficient ( pKa ) pK1 : 6.63 ( 25 °C ) , InChIKeyDJCXFVJDGTHFX-XVFCMESISA-N , Safety statement 24 / 25 , WGK Germany 3 , RTECS YU8088000.
URIDINE 5'-MONOPHOSPHATE (UMP) is an important nucleotide derivative that plays multiple critical roles in living organisms. UMP is composed of uracil, ribose, and phosphate groups, and is one of the fundamental units in RNA synthesis. It is also an important intermediate in various biosynthetic pathways. The following is a detailed description of its purpose:
Applications in the field of biomedical sciences
Research has shown that UMP is an orally active mitochondrial ATP dependent potassium channel activator. Mitochondrial ATP dependent potassium channels play an important role in cardiac protection, as their activation can alleviate myocardial ischemia-reperfusion injury and reduce the occurrence of arrhythmia. UMP activates these potassium channels, increases potassium ion efflux, hyperpolarizes the myocardial cell membrane, thereby reducing calcium ion influx and mitigating the damage of calcium overload to myocardial cells. In addition, UMP can also inhibit the opening of mitochondrial permeability transition pores, reduce the release of cytochrome C, inhibit cell apoptosis, and protect cardiomyocytes. In rat experiments, intravenous injection of UMP (30 mg/kg, single dose) showed significant cardioprotective properties. UMP can prevent ischemic injury, reduce myocardial infarction area, and improve cardiac function. Meanwhile, UMP can also prevent the occurrence of some rhythm disorders and maintain the normal rhythm of the heart. These results indicate that UMP has potential application value in the treatment and prevention of heart disease.
Promote intestinal development and reduce diarrhea
UMP plays an important role in intestinal development. Research has shown that UMP can promote the synthesis of CDP choline (cytidine diphosphate choline), which is an important precursor for phosphatidylcholine synthesis. Phosphatidylcholine is one of the main components of the cell membrane and is crucial for maintaining its integrity and function. In the intestine, UMP promotes apoptosis and renewal of intestinal epithelial cells, which is beneficial for the development and maturation of intestinal villi. For example, in the study of IPEC-J2 pig intestinal epithelial cells, UMP (10 mM, 6 h) promoted late stage apoptosis of cells, while oral UMP (476 mg, once daily, 10 days) promoted apoptosis and renewal of pig intestinal villous tip epithelial cells, reducing diarrhea rates. UMP can also enhance the immune function of the intestine. Nucleotides are essential nutrients for the proliferation and differentiation of intestinal immune cells. Supplementing UMP can increase the content of intracellular nucleotides in the intestine, promote the proliferation and differentiation of intestinal lymphocytes, enhance the barrier function of intestinal mucosa, and reduce the invasion of pathogenic bacteria. In addition, UMP can regulate the balance of gut microbiota, promote the growth of beneficial bacteria, inhibit the proliferation of harmful bacteria, and thus maintain gut health.
URIDINE 5'-MONOPHOSPHATE plays an important role in liver detoxification function. The liver combines toxic substances with glucuronic acid to form water-soluble metabolites, which are then excreted from the body. UMP is one of the important precursors for glucuronic acid synthesis. In the liver, UMP can be converted into UDP glucuronic acid (UDPGA) through a series of enzymatic reactions. UDPGA then binds with toxic substances to form glucuronide, which is excreted from the body. Therefore, the supply of UMP directly affects the detoxification ability of the liver. Due to its important role in liver detoxification, UMP is used to treat some liver diseases. For example, UMP can be used as an adjuvant drug for liver disease to treat hepatitis and improve liver function. In addition, UMP can also alleviate liver damage caused by drug-induced liver injury, alcoholic liver disease, and other factors. By supplementing UMP, the detoxification ability of the liver can be enhanced, the repair and regeneration of liver cells can be promoted, and the prognosis of liver diseases can be improved.
Neuroprotection and improvement of cognitive function
UMP has a protective effect in the nervous system and can improve cognitive function. Research has shown that UMP can promote the synthesis of CDP choline in the brain. CDP choline is an important precursor for the synthesis of phosphatidylcholine, which is one of the main components of neuronal cell membranes. In the brain, UMP (0.02-1 mmol/kg, gavage, single dose) can promote the synthesis of CDP choline in the brain of sand rats, increase the content of phosphatidylcholine in the brain, and improve the function of nerve cells. Supplementing UMP can improve memory and learning abilities. In animal experiments, supplementing UMP to aged rats can significantly improve their performance in maze tests and enhance their spatial memory ability.
In addition, UMP can improve the cognitive function of Alzheimer's disease model mice, reduce the deposition of β - amyloid protein, and alleviate neuroinflammatory reactions. These results indicate that UMP has potential application value in the treatment and prevention of neurodegenerative diseases. UMP also has a protective effect on nerve cells. Under conditions of hypoxia, ischemia, and other damage, nerve cells are prone to apoptosis. UMP can protect nerve cells and reduce the occurrence of apoptosis through various pathways. For example, UMP can inhibit oxidative stress response, reduce the production of free radicals, and protect the membrane structure and function of nerve cells; UMP can also regulate the release and uptake of neurotransmitters, maintaining the normal transmission of neural signals.
Immune regulatory effect
UMP is involved in the proliferation and differentiation of immune cells and is crucial for the normal function of the immune system. Nucleotides are essential nutrients for immune cells to synthesize DNA and RNA. Supplementing UMP can increase the content of nucleotides in immune cells, promote their proliferation and differentiation, and enhance the body's immunity. For example, UMP can promote the proliferation of T lymphocytes and B lymphocytes, enhance antibody production, and improve the humoral and cellular immune functions of the body. UMP also participates in the regulation of inflammatory responses. Inflammatory response is an important defense mechanism of the body against pathogenic bacterial infection and damage, but excessive inflammatory response can cause damage to tissues. UMP can alleviate tissue damage caused by inflammatory reactions by regulating the production and release of inflammatory factors. For example, UMP can inhibit the production of pro-inflammatory factors such as tumor necrosis factor - α (TNF - α) and interleukin-6 (IL-6), and increase the production of anti-inflammatory factors such as interleukin-10 (IL-10), thereby exerting anti-inflammatory effects.
The method of synthesizing URIDINE 5'-MONOPHOSPHATE(UMP) in laboratory usually involves a series of chemical reactions, including the synthesis of nucleotides, bases, phosphates and other substances. The following are the detailed steps for synthesizing UMP:
Steps:
first, prepare the required chemical solution. Uracil, sodium phosphate, sodium hydroxide and formate were dissolved in water to prepare a certain concentration of solution. These solutions will be used as the basic raw materials for the synthesis of ump.
the uracil solution is mixed with formate solution, and decarboxylation reaction is carried out under appropriate temperature and pH conditions. This step is a key step in the synthesis of ump. The required nucleotide structure is formed by removing the formic acid group from uracil.
phosphorylation of uracil nucleotides in the reaction solution with phosphate. In the process of phosphorylation, the hydroxyl group on uracil nucleotide reacts with phosphate to produce uridine phosphate. Uridine phosphate is an important intermediate in the synthesis of ump.
during the synthesis process, the buffer solution is used to maintain the pH value of the reaction solution stable. By adding appropriate buffer, the pH of the reaction solution can be adjusted to ensure the smooth progress of the synthesis reaction.
after completing the above reactions, the reaction solution is separated and purified to obtain the target product ump. In the separation process, impurities can be removed by centrifugation and filtration, and then the product can be purified by crystallization or ion exchange.
finally, the quality of the synthesized UMP was detected by chemical analysis. The structure of the product can be confirmed by NMR and MS, and the purity and content of the product can be determined by HPLC.
store the synthesized UMP in a dry place away from light for subsequent use. When using UMP, relevant safety precautions shall be followed and operation under appropriate conditions shall be ensured.
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