Uridine Monophosphate Disodium CAS 3387-36-8

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Uridine Monophosphate Disodium, which is the basic structural unit of RNA (ribonucleic acid), a crucial genetic and energy molecule in living organisms. This white or off-white crystalline powder is significantly enhanced in water solubility and stability by the introduction of two sodium atoms, making it easily absorbed and utilized by living organisms. As a core member of the nucleotide family, it directly participates in the biosynthesis of RNA within cells, thereby influencing protein translation and expression, and is the cornerstone for maintaining cell normal functions, promoting tissue growth and repair. Beyond its fundamental role in genetics, it also plays a key role in the body's energy metabolism, serving as the direct precursor for triphosphate uridine (UTP), which is an activating substrate and energy carrier for various biochemical reactions such as glycogen synthesis and phospholipid metabolism. Based on these core biological functions, uridine diphosphate is widely used in the pharmaceutical, health supplement, and special medical purpose formula food industries, often used to improve liver function, assist in the treatment of liver diseases, promote postoperative recovery, and as a nutritional enhancer to support the development of the brain and nervous system in infants. In the food industry, it is also an efficient flavor enhancer, capable of working synergistically with sodium glutamate to produce a rich umami flavor, commonly found in soy sauce, soup stocks, and other seasonings. In summary, uridine diphosphate is an important bioactive molecule that combines as a basic life component, a regulator of cellular energy metabolism, and a practical food additive. It plays an indispensable role from the microscopic cellular activities to the macroscopic industrial applications.

Disodium pump, also known as uridine monophosphate disodium salt, can be used as an important intermediate in the production of nucleic acid drugs, health food and biochemical reagents. It is also used in the manufacture of uridine diphosphate glucose, uridine triphosphate, polyadenyluridine and other drugs. It plays an important role in the treatment of various major diseases.

Refining method for synthesis of Uridine Monophosphate Disodium:

The crude disodium 5'- urea acid is prepared into an aqueous solution with a mass concentration of 2-4% and a pH of 16-1.7; 5 '- Disodium urate crude solution was first treated with cation exchange resin column, and then with anion exchange resin column; Use mixed eluent to elute, collect eluent, and the concentration of eluent is 70-80g/L; Adjust the pH of eluent to 7.0-7.5, crystallize, filter, rinse and dry with organic solvent. The 5'- uridine disodium solution of the invention does not need to be concentrated, and the product has high purity and high yield

Method for industrial synthesis of 5'- disodium urate:

Install tail gas absorption device, mechanical mixing device and material dropping device in the dry 1000ml four necked bottle. Add 50g cytidine acid and 150ml deionized water, stir and dissolve. Add 50g sodium nitrite, stir and dissolve. Start dropping hydrochloric acid and add 50ml hydrochloric acid in total. After dropping hydrochloric acid, the reaction continues for 2 hours, and the temperature of the whole process is controlled below 50 ℃. The residue of CMP in the sample was 0.27% by HPLC. Adjust the pH value of the reaction solution to 6.4-7.2 with liquid alkali, add twice the amount of 95% ethanol, crystallize and filter to obtain 5 '- disodium uridine. Add an appropriate amount of water into the crude product to dissolve it, adjust the pH value of the reaction solution to 7.0-8.5 with liquid alkali, and then recrystallize it with twice the amount of ethanol, filter and dry it to obtain disodium 5-uridine. HPLC：99.9%,UV：98.0%.

Uridine 5′- monophosphate disodium salt (Uridine Monophosphate Disodium) is an important nucleotide, which plays a variety of roles in organisms. The following are some main uses of ump-na2:

Raw materials for RNA synthesis&Food and beverage additives&Flavoring agent

 

ump-na2 is an important raw material for RNA synthesis in cells. RNA is composed of a series of nucleotides in series, and uridine is one of the four main nucleotides. In the RNA chain, ump-na2 is involved in the formation of information codes required for transcriptional information and protein synthesis. By using ump-na2 as the raw material for RNA synthesis, the length and sequence of RNA can be controlled, which further affects protein synthesis and gene expression. This application makes ump-na2 of great significance in the field of life science research and bioengineering.

ump-na2 has special meat flavor and can be used as food and beverage additives. By adjusting its dosage, the flavor and taste of food can be improved, making it more in line with the taste needs of consumers. Adding ump-na2 to infant formula milk powder and other infant foods can increase the amount of nucleoside acid, make the product closer to the composition of breast milk, and enhance the resistance of infants. In addition, ump-na2 is often used as flavor enhancer and nutritional enhancer in functional foods and beverages.

UUp-na2 can also be used as a flavoring agent in addition to being used as an additive in food and beverages. Because of its special meat flavor, it can be used to produce condiments such as broth and gravy, providing a taste and taste similar to natural meat.

Improve stability&Other biological activities

 

Ump-na2 has good stability and is not easy to decompose under normal temperature and pressure. This feature enables ump-na2 to maintain relatively stable properties during storage and processing, thereby improving the quality and use effect of the product. For example, in the production of enzyme preparations, vitamins and other bioactive substances, the addition of ump-na2 can improve the stability of the product and maintain better performance during storage and use.
In addition to the above uses, ump-na2 also has certain biological activities. For example, it can be used as an intermediate for the synthesis of other nucleotides, bases and other compounds, and participate in various synthetic reactions in organisms. In addition, ump-na2 also has antioxidant, anti-inflammatory and other biological activities, and plays a role in maintaining health. Studies have shown that ump-na2 can inhibit the replication and transmission of some viruses, which provides a potential strategy for antiviral therapy. In addition, ump-na2 has also been used to study the role of pyrimidine synthesis inhibitor 5-azacytidine in cholesterol and lipid metabolism, as well as the effect of nucleotides on the growth of specific intestinal bacteria.

Uridine Monophosphate Disodium (also known as 5 '- UMP-Na ₂) is an important intermediate in nucleic acid metabolism and has wide application value in fields such as biochemistry, medicine, and food industry. The discovery of 5' - UMP-Na ₂ is closely related to nucleic acid research. At the end of the 19th century, Swiss biochemist Friedrich Miescher first isolated "nuclides" (later known as nucleic acids) from pus cells, marking the beginning of nucleic acid chemistry research. In 1909, Phoebus Levene discovered four basic components in yeast nucleic acid while studying it, including a pyrimidine substance, which laid the foundation for the later discovery of uridine. In 1919, Levene's research team first isolated a pyrimidine nucleotide from yeast nucleic acid hydrolysate, which was then called "yeast nucleotide". Through elemental analysis and preliminary chemical property determination, they determined that this substance contains uracil, ribose, and phosphate groups, but their structure and phosphate linkage position have not been accurately determined yet. In 1929, British chemist Alexander Todd began systematic research on the structure of nucleotides. Through improved hydrolysis and separation techniques, Todd successfully obtained relatively pure uridine acid samples from yeast nucleic acid. He used the emerging electrophoresis technology at that time to demonstrate that this substance moved towards the anode in an electric field, indicating that it carried a negative charge and was consistent with the characteristics of phosphate monoesters. In the mid-1930s, with the development of chromatographic technology, German chemists Kossel and Neuburg established a nucleotide separation method based on activated carbon adsorption. Using this technology, they effectively separated uridine from other nucleotides such as adenosine and guanosine for the first time, and preliminarily determined its molecular weight to be 368.2 (anhydrous free acid form). The core issue in the study of 5 '- UMP Na ₂ structure is to determine the connection position of the phosphate group on the ribose. In 1936, Levene and Harris conducted a chemical degradation experiment to convert the ribose portion produced by the hydrolysis of uridine acid into a known compound, demonstrating that the phosphate group was attached to the 5 'carbon atom of ribose. This discovery is the first to clarify the basic structure of uridine-5 '- monophosphate (5' - UMP). In 1947, American chemists Gulland and Smith successfully separated three isomers, 2 ', 3', and 5 '- UMP, using newly developed ion exchange chromatography technology. By comparing their physical and chemical properties, especially their optical rotation and electrophoretic mobility, it was ultimately confirmed that naturally occurring uridylic acid is mainly in the form of 5 '- phosphate ester. In the early 1950s, with the development of X-ray crystallography technology, scientists began to study the crystal structure of nucleotide metal salts. In 1953, the team of British crystallographer Dorothy Crowfoot Hodgkin (known for analyzing the structures of vitamin B12 and penicillin) obtained the first crystal diffraction data of 5 '- UMP disodium salt. They found that two sodium ions coordinated with the phosphate group and the carbonyl oxygen atom on the uracil ring, forming a stable hydrate structure. At the same time, American chemists Lipscomb and Rich conducted pH titration studies and systematically determined the dissociation constants of 5 '- UMP under different pH conditions, elucidating the dissociation behavior of its acidic groups. These works provide a theoretical basis for understanding the form and stability of 5 '- UMP-Na ₂ in solution.

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