L-Carnitine Fumarate Powder CAS 90471-79-7

L-Carnitine Fumarate Powder, the main component of L-carnitine fumarate, a stable form of L-carnitine, a white or gray white hygroscopic crystalline powder with deliquescence. It is easily soluble in water, ethanol, methanol, and formic acid, but almost insoluble in acetone and ether. It has a certain antioxidant effect and can help reduce the production and damage of free radicals in the human body, thereby preventing aging and the occurrence of diseases. It can be used as a food and feed additive. L-carnitine fumarate can be used in solid formulations. L-carnitine derivative is fumarate L-carnitine, which is a food additive. It is used in food, beverages, and health products. It can promote the growth and repair of muscle tissue, improve muscle quality and strength. In addition, it can also alleviate symptoms such as muscle soreness and delay muscle fatigue, which is beneficial for improving exercise performance. Helps to enhance physical strength and endurance. It can promote muscle energy synthesis and increase parameters such as the body's maximum oxygen uptake per minute (VO2max). Therefore, it is used as a raw material for functional foods, such as power meals, energy bars, etc. It can provide additional nutrients and energy, which helps the body recover and replenish.

L-Carnitine fumarate is a compound with the molecular formula C11H19NO7. It is composed of L-carnitine and fumaric acid, with two chiral centers.

Due to the molecular structural characteristics of carnitine fumarate, it helps promote the metabolism and transportation of fat in the body. Therefore, it is used as an ingredient in certain weight loss products and is widely used in fields such as nutritional and health products, pharmaceutical formulas, etc.

L-Carnitine Fumarate, has shown wide application value in food, medicine, health products, industry, and special fields due to its unique chemical structure and physiological activity.

Sports nutrition products

 

Sports drinks/protein powder: Adding 0.5% -0.8% L-carnitine fumarate can improve the efficiency of fatty acid oxidation during exercise, reduce muscle glycogen consumption, and delay fatigue. Research has shown that athletes who supplement with this substance after high-intensity training experience significantly reduced fatigue.
Weight loss foods: as auxiliary ingredients, combined with dietary fiber, vitamins, etc., can improve fat metabolism efficiency. Its mechanism of action is to promote the entry of long-chain fatty acids into mitochondria for beta oxidation, converting them into energy, rather than directly decomposing fat.

Other functional foods

 

Dairy products: Add a small amount to yogurt and cheese to enhance the "energy metabolism related nutrition" label.
Baking food: Adding it to bread and cookies can improve the taste and give the product healthy attributes.
Beverages: Used for lactic acid bacteria drinks, etc., to enhance product functionality and value.

Treatment of Carnitine Deficiency

 

Primary or secondary carnitine deficiency (such as genetic carnitine transport disorders and long-term dialysis patients) requires exogenous supplementation of L-carnitine. Due to its high stability, it has become the preferred drug ingredient and can significantly improve symptoms such as muscle weakness and arrhythmia in patients.

Adjuvant treatment for kidney disease

 

Chronic kidney disease patients often suffer from carnitine deficiency. Supplementing with carnitine can reduce muscle protein breakdown, improve anemia and nutritional status. Clinical trials have shown that when combined with dialysis treatment, patients' hemoglobin levels increase by 15% -20%.

Cardiovascular disease management

 

Cardiac dysfunction: By promoting fatty acid oxidation, reducing myocardial dependence on glucose, and improving cardiac energy metabolism. Long term supplementation can reduce the risk of myocardial cell damage and increase cardiac output.
Lipid regulation: reduce the levels of triglycerides and low-density lipoprotein (LDL) in the blood, and reduce the risk of atherosclerosis. A study on patients with coronary heart disease showed that supplementing with 2 grams of L-carnitine fumarate daily resulted in a 25% decrease in triglyceride levels after 6 months.

Cancer adjuvant therapy

 

Chemotherapy patients often have insufficient intake of carnitine due to decreased appetite. Supplementing with carnitine can alleviate muscle depletion and enhance immunity. Animal experiments have shown that carnitine deficiency accelerates tumor growth, while exogenous supplementation can inhibit this process.

Weight loss nutritional supplements

 

As a 'fat burning agent', it accelerates energy production by promoting the transport of fatty acids to mitochondria. It is necessary to cooperate with aerobic exercise (such as running, swimming) and low calorie diet, and the recommended daily intake should not exceed 2 grams. Clinical data shows that when combined with exercise intervention, subjects' body fat percentage decreased by an average of 3% -5%.

Sports endurance improvement

 

Athletes who accelerate muscle glycogen consumption during high-intensity training are prone to fatigue. Supplementing with this substance can prolong exercise time by 10% -15% and improve endurance performance. The mechanism is to reduce lactate accumulation and delay the transmission of muscle fatigue signals.

Cardiovascular and cerebrovascular health maintenance

 

Cardiac support: improves myocardial energy metabolism and reduces the risk of arrhythmia. For the elderly population, supplementing 1 gram daily can reduce the frequency of angina attacks.
Brain function optimization: promotes energy supply to brain cells, improves memory and cognitive function. Animal experiments have shown that long-term supplementation can enhance the activity of hippocampal neurons.

 

Chemical synthesis raw materials

 

As an intermediate for synthesizing other carnitine derivatives such as acetyl L-carnitine and acetyl L-carnitine, it participates in drug preparation. For example, acetyl-L-carnitine is used to treat neurological disorders, and its synthesis requires L-carnitine fumarate as the raw material.

Catalyst carrier

 

In catalytic reactions, it can be loaded onto the surface of a carrier to improve reaction efficiency. For example, in the synthesis of unsaturated resins, it acts as a catalyst to promote polymerization reactions and shorten production cycles.

Preparation of functional materials

 

Biodegradable plastics: used as fillers or modifiers to enhance material flexibility and degradation rate. Adding 3% -5% L-carnitine fumarate can increase the elongation at break of polylactic acid (PLA) plastics by 20%.
Environmentally friendly adhesive: As a crosslinking agent, it improves bonding strength and weather resistance. Adding 2% -8% to wood adhesive can improve water resistance to 72 hours without peeling.

Textile industry

 

Dye dispersant: After being formulated into a treatment solution, it is applied to textiles through immersion rolling, spraying, and other methods to assist in the uniform dispersion of dyes and improve color uniformity. For example, adding 1% -2% in cotton fabric dyeing can reduce color difference by 30%.
Fixing agent: Adding 0.5% -1.5% in the finishing of synthetic fiber fabrics can improve color fastness by 1-2 levels and reduce washing fading.
agricultural sector

 

Feed additives: promote animal fat metabolism and improve meat quality. Adding 0.1% -0.3% to pig feed can reduce backfat thickness by 15% and increase lean meat percentage.
Plant growth regulator: As a carrier of trace elements, it enhances plant stress resistance. Experiments have shown that under drought conditions, the addition of L-carnitine fumarate increases crop survival by 20%.

We are the supplier of L-Carnitine Fumarate Powder.

Remark: BLOOM TECH(Since 2008), ACHIEVE CHEM-TECH is the subsidiary of us.

The invention relates to a preparation method for improving the fluidity of L-carnitine fumarate Based on the solution cooling crystallization technology, by adjusting the initial concentration of the solution, solvent ratio, cooling curve, the size and input amount of crystal seed, finally adopting the segmented cooling curve, adding crystal seed for many times combined with ultrasonic interference, a rectangular flake L-carnitine fumarate with a certain thickness was prepared The L-carnitine fumarate product obtained by this method is monodisperse and non-coalescing, with rectangular flake crystals with a certain thickness, large particle size D50: 580 ~ 650 microns, excellent fluidity and angle of repose < 32 ° It overcomes the problems of poor fluidity and easy coalescence of the existing L-carnitine fumarate, and the quality yield is more than 80%, which is suitable for large-scale industrial production.

L-Carnitine Fumarate Powder is a compound formed from L-carnitine and fumaric acid, and its reaction properties are closely related to its chemical structure.

L-Carnitine fumarate can be decomposed into L-carnitine and fumaric acid through hydrolysis reactions. Hydrolysis reaction refers to a chemical reaction that breaks down a compound into two or more compounds. Hydrolysis reactions usually require heating or bringing the compound into contact with water, and the reason for the hydrolysis reaction is the addition of hydrolysis agents such as water, acid, or base in the reaction. The following is the hydrolysis reaction equation for L-Carnitine fumarate:

C₁₁H₁₉NO₇ + H₂O → C₇H₁₅NO₃ + C₄H₄O₄

L-Carnitine fumarate can also react with oxygen or other oxidants through oxidation reactions. Oxidation reaction refers to the chemical reaction that oxidizes the chemical bonds or functional groups of a compound to a higher oxidation state. Oxidation reactions usually require the presence of strong oxidants such as hydrogen peroxide, sulfuric acid, potassium permanganate, etc. The following is the equation for the oxidation reaction of L-Carnitine fumarate:

C₁₁H₁₉NO₇ + 3O₂ → 11CO₂ + 8H₂O + NH₃

L-Carnitine fumarate can form acylation products with carboxylic acids or their derivatives through acylation reactions. Acylation reaction refers to the chemical reaction in which compounds containing hydroxyl or amino groups form ester bonds with carboxylic acids or their derivatives. Acylation reactions usually require the presence of catalysts such as dimethylaminoimidazole (DMAP), N, N-diisopropylethylenediamine (DIPEA), etc. The following is the equation for the acylation reaction of L-Carnitine fumarate:

C₁₁H₁₉NO₇ + R-COOH → C₁₁H₁₉NO₇-R + H₂O

L-Carnitine fumarate can react with hydrogen or other reducing agents through a reduction reaction. Reduction reaction refers to a chemical reaction that reduces the chemical bonds or functional groups of a compound to a lower oxidation state. Reduction reactions usually require the presence of strong reducing agents, such as hydrogen gas, sulfoxide, catechol, etc. The following is the equation for the reduction reaction of L-Carnitine fumarate:

C₁₁H₁₉NO₇ + 4H₂ → C₁₁H₃₃NO₇

L-Carnitine fumarate can react with other compounds through addition reactions. Addition reaction refers to a chemical reaction in which atoms, ions, or molecules are added to the double bond of an unsaturated compound. Addition reactions usually require the presence of electrophilic reagents, such as bromine, chlorine, formaldehyde, succinyldihydrazine, etc. The following is the equation for the addition reaction of L-Carnitine fumarate:

C₁₁H₁₉NO₇ + Br₂ → C₁₁H₁₇BrN₂O₆ + HBr

L-Carnitine fumarate can generate aldehydes or ketones through reduction elimination reactions. Reduction elimination reaction refers to the reaction in which compounds containing hydroxyl or amino groups lose water or ammonia molecules after reduction. The reduction elimination reaction usually requires the presence of strong reducing agents, such as lithium aluminum hydride, alumina silicon, and triethylamine borohydride sodium. The following is the equation for the reduction elimination reaction of L-Carnitine Fumarate Powder:

C₁₁H₁₉NO₇ + LiAlH₄ → C₁₁H₂₁NO₂

In summary, L-Carnitine fumarate has various reaction properties, including hydrolysis reaction, oxidation reaction, acylation reaction, reduction reaction, addition reaction, and reduction elimination reaction. The differences in these reaction properties make L-Carnitine fumarate widely applicable and potential reaction pathways.

1.General safety

• L-carnitine itself is a naturally occurring substance in the human body, mainly derived from red meat, and plays a role in transporting fatty acids for oxidation in the body.
• L-carnitine fumarate, as a form of L-carnitine, is generally considered safe when consumed in moderation.

2.Possible side effects
Although L-Carnitine Fumarate is usually safe when used in moderation, excessive intake or improper use may cause some side effects. These side effects may include but are not limited to:

• Gastrointestinal discomfort: such as nausea, vomiting, diarrhea, etc.
• Allergic reactions: Some individuals may have allergic reactions to L-carnitine or its derivatives, manifested as rash, itching, and other symptoms.
• Impact on sleep: Excessive intake of L-carnitine may affect sleep quality, leading to insomnia or restless sleep.
• Other: Long term high intake of L-carnitine may cause burden on the liver and kidneys, although this situation is rare.

3.Precautions
Before use, it is recommended to consult a doctor or nutritionist to ensure that it is suitable for your health condition. Follow the product instructions and recommended dosage to avoid excessive intake. If you experience any discomfort or allergic reactions while using L-Carnitine Fumarate, please stop using it immediately and seek medical attention.

4.Special populations
Pregnant and lactating women should avoid using L-Carnitine Fumarate to prevent adverse effects on the fetus or infant.
Children: The safety and efficacy of L-Carnitine Fumarate in children have not been fully studied, therefore its use is not recommended.

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