Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of azithromycin cas 83905-01-5 in China. Welcome to wholesale bulk high quality azithromycin cas 83905-01-5 for sale here from our factory. Good service and reasonable price are available.
Azithromycin is a macrolide antibiotic primarily used to treat various bacterial infections. Its main component is a semi synthetic fifteen membered cyclic ester antibiotic, which appears as a white or off white crystalline powder, odorless, bitter in taste, and slightly hygroscopic. It is soluble in methanol, acetone, anhydrous ethanol, or dilute hydrochloric acid, soluble in acetonitrile, and almost insoluble in water. It interferes with the protein synthesis of sensitive microorganisms by binding to their 50s ribosome subunits, thereby inhibiting bacterial growth and reproduction. The antibacterial spectrum of this substance is similar to erythromycin, but its effect on certain bacteria such as Haemophilus influenzae and Neisseria gonorrhoeae is stronger than erythromycin.
Additional information of chemical compound:
|
Chemical Formula |
C38H72N2O12 |
|
Exact Mass |
748.51 |
|
Molecular Weight |
749.00 |
|
m/z |
748.51(100.0%),749.51 (41.1%), 750.52 (8.2%), 750.51 (2.5%), 751.52 (1.1%), 751.52 (1.0%) |
|
Elemental Analysis |
C, 60.94; H, 9.69; N, 3.74; O, 25.63 |
|
Melting point |
113-115°C |
|
Boiling point |
822.1±65.0 °C(Predicted) |
|
Density |
1.18±0.1 g/cm3(Predicted) |
|
Storage conditions |
2-8℃ |
It has certain antibacterial activity against Gram positive bacteria, Gram negative bacteria, and some anaerobic bacteria. It can treat various mild to moderate infections caused by designated microbial sensitive strains.
|
|
|
Azithromycin is a macrolide antibiotic, which has a wide antibacterial spectrum and unique pharmacokinetic characteristics. Therefore, it is widely used in the treatment of a variety of infectious diseases clinically. The following is a detailed explanation of its purpose:
antibacterial mechanism
It inhibits bacterial protein synthesis and produces antibacterial effects by blocking the process of bacterial peptide conversion. It binds to the bacterial 50S ribosomal subunit, preventing the extension of the peptide chain, leading to bacterial growth arrest and death. This mechanism enables azithromycin to effectively combat a variety of Gram positive bacteria, Gram negative bacteria, anaerobic bacteria, and other types of microorganisms.
indication
Respiratory tract infections&skin and soft tissue infections
Can be used to treat upper respiratory tract infections such as acute pharyngitis and acute tonsillitis caused by sensitive bacteria. Its therapeutic effect is significant, and taking it only once a day for 3 consecutive days can achieve the therapeutic effect of taking other antibiotics for 7-10 days. It has good compliance and is particularly suitable for children. It is a commonly used medication for treating lower respiratory tract infections such as bronchitis and pneumonia.
It has good activity against common respiratory bacteria such as Streptococcus pneumoniae, and is particularly suitable for the treatment of community-acquired pneumonia. In addition, azithromycin is commonly used to treat lower respiratory tract infections in children infected with mycoplasma, chlamydia, or beta lactam resistant bacteria. It has shown good efficacy against skin pathogens such as Staphylococcus epidermidis and can be used to treat skin and soft tissue infections such as cellulitis and pustules.
Sexually transmitted diseases&other infections
Azithromycin is a commonly used medication for the treatment of sexually transmitted diseases such as simple genital infections caused by Chlamydia trachomatis and non gonococcal urethritis. Its single dose therapy is very convenient and effective in treating such diseases. It can also be used to treat infections such as acute otitis media and sinusitis. Azithromycin also has certain application value for the prevention of certain bacterial infections, especially for patients with specific immune deficiencies.
Applications in Otorhinolaryngological Infections (Taking Otitis Media as an Example)
Azithromycin is a commonly used drug for the treatment of bacterial infections of the otorhinolaryngological tract, with outstanding efficacy in the management of acute otitis media, especially for acute suppurative otitis media in children and adults. Acute otitis media is mostly caused by infections with pathogens such as Streptococcus pneumoniae and Haemophilus influenzae. Azithromycin exerts its antibacterial effect by inhibiting bacterial protein synthesis, and it can rapidly penetrate the middle ear mucosa to reach an effective therapeutic concentration in the middle ear cavity, quickly relieving symptoms such as ear pain, aural fullness and otorrhea.
In clinical practice, oral formulations are suitable for adults and children with a body weight of ≥45 kg, featuring a short treatment course and high patient compliance; the dosage for children needs to be adjusted according to body weight to avoid overuse. In addition, azithromycin can be used as an adjuvant therapy for other otorhinolaryngological infections. For example, in cases complicated with sinusitis or pharyngitis, its broad-spectrum antibacterial effect can cover pathogenic bacteria, reducing the risk of infection spread and improving treatment outcomes.
Applications in Enteritis and Dysentery
Azithromycin has an inhibitory effect on a variety of intestinal pathogenic bacteria and can be used to treat enteritis and dysentery caused by susceptible pathogens, particularly for bacterial enteritis and bacillary dysentery. Enteritis and dysentery are mostly induced by infections with pathogens such as Shigella, Salmonella and Escherichia coli, with clinical manifestations including abdominal pain, diarrhea, and mucopurulent and bloody stool. Azithromycin can selectively inhibit the proliferation of such bacteria and block the progression of infection. Compared with other antibiotics, azithromycin is rapidly absorbed after oral administration and can maintain a high drug concentration in the intestinal mucosa, acting directly on the infected site with a quick onset of action.
In clinical application, the treatment course should be adjusted according to the severity of the infection: 3–5 days for mild infections, and appropriately prolonged for severe infections. Meanwhile, medication should be tailored to the improvement of patients' symptoms to avoid blind use. It should be noted that azithromycin is ineffective for viral enteritis, and rational medication should be administered after a clear diagnosis of the etiology.
Adverse reactions
Azithromycin is a macrolide antibiotic, which is widely used in the treatment of many infectious diseases. However, like other drugs, azithromycin may also cause a series of adverse reactions during use. The following will elaborate on its adverse reactions, including their types, mechanisms of occurrence, clinical manifestations, treatment measures, and preventive measures:
Types of adverse reactions
Adverse reactions in the gastrointestinal system
Symptoms: Nausea, vomiting, abdominal pain, diarrhea, indigestion, gastrointestinal bloating, etc.
Mechanism of occurrence: Azithromycin can inhibit the growth of normal gut microbiota, leading to an imbalance of gut microbiota and subsequently causing gastrointestinal symptoms. In addition, azithromycin may also irritate the gastric mucosa and exacerbate gastrointestinal discomfort.
Incidence: Gastrointestinal reactions are the most common adverse reactions of azithromycin, with a relatively high incidence rate.
Allergic reaction
Symptoms: rash, itching, urticaria, photosensitivity, angioedema, bronchospasm, anaphylactic shock, etc.
Mechanism of occurrence: Azithromycin belongs to the macrolide antibiotic class, and its molecular structure is similar to the antibodies produced by the human immune system, which can easily cause allergic reactions.
Severity: Allergic reactions can be mild or severe, and in severe cases can be life-threatening.
Neurological adverse reactions
Symptoms: Dizziness, headache, drowsiness, vertigo, convulsions, hyperkinesia, delayed response, emotional agitation, etc.
Mechanism of occurrence: Azithromycin may cause neurological symptoms by affecting the transmission of neurotransmitters or interfering with the normal function of the nervous system.
Incidence: Neurological adverse reactions are relatively rare among azithromycin users, but once they occur, they may have a significant impact on the patient's quality of life.
Cardiovascular system adverse reactions
Symptoms: palpitations, chest pain, hypotension, and tip twisting ventricular tachycardia.
Mechanism of occurrence: This substance may prolong the QT interval and increase the risk of arrhythmia. For patients with heart disease, this risk may be higher.
Severity: Adverse cardiovascular reactions may be life-threatening and require close monitoring and timely treatment.
Damage to liver and kidney function
Symptoms: Abnormal liver function (such as elevated transaminase, jaundice, etc.), renal dysfunction (such as elevated creatinine, proteinuria, etc.).
Mechanism of occurrence: Toxic metabolites may be produced during metabolism in the body, which need to be excreted through the liver and kidneys. Long term or high-dose use of azithromycin may cause damage to liver and kidney function.
Incidence: Liver and kidney function impairment is relatively rare among azithromycin users, but once it occurs, it may have a serious impact on patients.
Adverse reactions in the blood system
Symptoms: leukopenia, thrombocytopenia, neutropenia, etc.
Mechanism of occurrence: Azithromycin may affect bone marrow hematopoietic function, leading to abnormalities in the blood system.
Incidence: Adverse reactions in the blood system are relatively rare among azithromycin users, but once they occur, close monitoring and timely treatment are necessary.
Dysbacteriosis
Symptoms: Long term use may lead to dysbiosis of the gut microbiota, which in turn can cause fungal infections such as candidiasis.
Mechanism of occurrence: It inhibits the growth of normal gut microbiota, disrupts the balance of gut microbiota, and provides growth opportunities for pathogens such as fungi.
Incidence: Microbial dysbiosis is more common in patients who have been using azithromycin for a long time.
Other general adverse reactions
Symptoms: fatigue, abnormal sensation, fatigue, general discomfort, pain at the injection site, local inflammation, etc.
Mechanism of occurrence: These adverse reactions may be related to the pharmacological effects, individual differences, or administration methods of azithromycin.
Incidence: These adverse reactions are relatively rare among azithromycin users, but may also cause discomfort to patients.
Measures for handling adverse reactions
Mild adverse reactions
Gastrointestinal reactions: For mild symptoms such as nausea, vomiting, abdominal pain, diarrhea, etc., try taking it after meals to reduce irritation to the gastrointestinal tract. If necessary, medication such as omeprazole can be taken under the guidance of a doctor to alleviate symptoms. For mild symptoms such as rash and itching, local application of calamine lotion or oral administration of antihistamines such as loratadine can be attempted. Meanwhile, it is important to closely monitor changes in symptoms and seek medical attention promptly if symptoms continue to worsen. For general adverse reactions such as fatigue, abnormal sensation, and fatigue, it is recommended to try resting, adjusting diet, and other methods to alleviate the symptoms. If the symptoms persist or worsen, seek medical attention promptly.
Severe adverse reactions
If severe allergic reactions such as difficulty breathing and anaphylactic shock occur, medication should be stopped immediately and medical treatment should be sought. Doctors may administer medications such as adrenaline and glucocorticoids for emergency treatment. If symptoms such as palpitations, chest pain, and low blood pressure occur, seek medical attention immediately and undergo relevant examinations such as electrocardiograms. When necessary, doctors may administer antiarrhythmic drugs or perform other emergency treatments. If symptoms such as abnormal liver function and renal dysfunction occur, medication should be stopped immediately and medical examination should be sought. Doctors may adjust treatment plans or provide targeted treatments such as liver protection and kidney preservation based on the examination results.
Preventive measures for adverse reactions
Strictly follow the doctor's advice when taking medication
Patients should strictly follow the doctor's guidance on dosage, medication time, administration method, etc. Do not increase or decrease the dosage or change the medication method on your own.
Understand drug contraindications and precautions
Before use, patients should be aware of the contraindications and precautions of the medication. For example, it is contraindicated for individuals allergic to azithromycin; Use with caution in patients with liver dysfunction; Avoid co administration with certain medications such as antacids, ergots, etc.
Close monitoring of adverse reactions
During use, patients should closely monitor changes in their own symptoms. If any discomfort symptoms occur, seek medical attention promptly and inform the doctor that azithromycin is being used.
Avoid long-term extensive use
Long term use may increase the risk of adverse reactions. Therefore, unless specifically instructed by a doctor, long-term extensive use should be avoided.
FAQ
Why is azithromycin given for 3 days only?
+
-
Generally, the usual dose of azithromycin is 500 mg once a day for 3 to 10 days; studies have shown that azithromycin is the most biologically effective antibiotic to treat mild and moderate infections within 3 days when compared to that rest of antibiotics, such as amoxiclav (amoxicillin and potassium clavulanate).
What should I avoid while taking azithromycin?
+
-
Cautions with other medicines antacids for indigestion. ergotamine or dihydroergotamine – for migraine. warfarin, to help prevent blood clots. ciclosporin or tacrolimus – medicines to stop your immune system overreacting.
How long does it take azithromycin to work?
+
-
Macrolide antibiotics are two common choices. Azithromycin starts working about 2 to 3 hours after your first dose. Erythromycin takes about 1 hour to begin working. It typically takes a few days before you start feeling better after starting a macrolide antibiotic.
Which license do lneed?
+
-
304 stainless steel meets the international requirements of food grade,316 stainless steel is not only food grade or medical grade. However,the use of this medical grade as a production cup will not bring additional benefits to everyone. Why is it called 304 or 316? This is mainly defined according to the material composition. 316 stainless steel is not similar to mineral materials,after use can release some substances to promote human absorption.
Hot Tags: azithromycin cas 83905-01-5, suppliers, manufacturers, factory, wholesale, buy, price, bulk, for sale, 4 4 4 4 6 diphenyl 1 3 5 triazin 2 yl phenyl naphthalen 1 yl biphenyl 4 carbonitrile, 2 3 4 benzo 1 2 d thiophene, 1 3 5 Triazine 2 chloro 4 6 di phenyl 2 3 4 5 6 d5 , 9 chloro 11H benzo a fluorene, CAS 2252237 87 7, 12 chlorobenzo a acridine